Gene Symbol | clu |
Entrez Gene ID | 36793 |
Full Name | clueless |
Synonyms | CG8443,Clu,Dmel\CG8443,anon-WO0118547.143 |
General protein information |
|
Gene Type | protein-coding |
Organism | Drosophila melanogaster(fruit fly) |
Genome |
ORF » Species Summary » Drosophila melanogaster » clu cDNA ORF clone
Gene Symbol | clu |
Entrez Gene ID | 36793 |
Full Name | clueless |
Synonyms | CG8443,Clu,Dmel\CG8443,anon-WO0118547.143 |
General protein information |
|
Gene Type | protein-coding |
Organism | Drosophila melanogaster(fruit fly) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_137251.3 | NP_611095.1 | clueless, isoform A |
NM_001274092.1 | NP_001261021.1 | clueless, isoform B |
Mus musculus (house mouse) | Cluh | NP_001074627.1 |
Gallus gallus (chicken) | KIAA0664 | XP_415920.4 |
Schizosaccharomyces pombe (fission yeast) | SPBC530.06c | NP_595319.2 |
Canis lupus familiaris (dog) | KIAA0664 | XP_548323.2 |
Danio rerio (zebrafish) | cluha | NP_001071028.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06261 | XP_003717331.1 |
Xenopus tropicalis (tropical clawed frog) | cluh | NP_001072577.1 |
Homo sapiens (human) | CLUH | NP_056044.3 |
Pan troglodytes (chimpanzee) | KIAA0664 | XP_003952989.1 |
Rattus norvegicus (Norway rat) | Cluh | XP_006246920.1 |
Drosophila melanogaster (fruit fly) | clu | NP_611095.1 |
Anopheles gambiae (African malaria mosquito) | K0664_ANOGA | XP_320668.4 |
Oryza sativa (rice) | Os02g0717400 | NP_001047932.1 |
LOC704219 | XP_002800295.1 | |
Bos taurus (cattle) | KIAA0664 | XP_005220213.1 |
Caenorhabditis elegans (roundworm) | clu-1 | NP_499097.1 |
Neurospora crassa | NCU00021 | XP_957008.2 |
Arabidopsis thaliana (thale cress) | AT3G52140 | NP_001190066.1 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance.
Title: Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.
Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.
Title: Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.
Clueless (clu) is a novel regulator of aPKC activity.
Title: Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains.
The results suggest Clu functions upstream of electron transport and oxidative phosphorylation, has a role in suppressing oxidative damage in the cell, and that lack of Clu's specific function causes mitochondria to mislocalize.
Title: Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage.
strong clu mutations resemble park mutations in their effects on mitochondrial function and that the two genes interact genetically
Title: Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.
The following clu gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the clu cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OFa12297 | |
Clone ID Related Accession (Same CDS sequence) | NM_001274092.1 | |
Accession Version | NM_001274092.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-24 | |
Organism | Drosophila melanogaster(fruit fly) | |
Product | clueless, isoform B | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## |
1 | ATGGAGCTGG TGCAGGAAAT CCACCAGCTG CTGATGGACC GCGAAGAGAC GTGCCATCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001261021.1 |
CDS | 530..4399 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001274092.1 |
1 | ATGGAGCTGG TGCAGGAAAT CCACCAGCTG CTGATGGACC GCGAAGAGAC GTGCCATCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OFa10180 | |
Clone ID Related Accession (Same CDS sequence) | NM_137251.3 | |
Accession Version | NM_137251.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4347bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-24 | |
Organism | Drosophila melanogaster(fruit fly) | |
Product | clueless, isoform A | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jan 16, 2013 this sequence version replaced NM_137251.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## |
1 | ATGGCGCTTG AAACGGAGGC GAAGAATTCA AATGCAACGG CCACGGGCGA TGCAACAGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_611095.1 |
CDS | 340..4686 |
Translation |
Target ORF information:
Target ORF information:
|
NM_137251.3 |
1 | ATGGCGCTTG AAACGGAGGC GAAGAATTCA AATGCAACGG CCACGGGCGA TGCAACAGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
Combined evidence annotation of transposable elements in genome sequences. |