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Su(fu) cDNA ORF clone, Drosophila melanogaster(fruit fly)

Summary

Gene Symbol Su(fu)
Entrez Gene ID 41565
Full Name Suppressor of fused
Synonyms CG6054,Dmel\CG6054,SU(FU),SUFU,Su(Fu),SuFu,Sufu,dSufu,su(fu),sufu
General protein information
Preferred Names

Suppressor of fused

Names

CG6054 gene product from transcript CG6054-RA
CG6054-PA
Su(fu)-PA
suppressor of fused
Gene Type protein-coding
Organism Drosophila melanogaster(fruit fly)
Genome

3R

87C5-87C5

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_080502.5 NP_536750.2 suppressor of fused

Pathways from BioSystems


Homologies


Homo sapiens (human) SUFU NP_057253.2
Anopheles gambiae (African malaria mosquito) AgaP_AGAP001948 XP_321114.1
Pan troglodytes (chimpanzee) SUFU XP_001171637.1
Bos taurus (cattle) SUFU NP_001091552.1
Rattus norvegicus (Norway rat) Sufu NP_001020070.1
Danio rerio (zebrafish) sufu NP_958466.1
Mus musculus (house mouse) Sufu NP_056567.2
Gallus gallus (chicken) SUFU NP_989595.1
SUFU XP_001113024.1
Canis lupus familiaris (dog) SUFU XP_005637731.1
Drosophila melanogaster (fruit fly) Su(fu) NP_536750.2
Xenopus tropicalis (tropical clawed frog) sufu NP_001123387.1

Gene Ontology


Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sufu can sequester Ci/Gli in the cytoplasm through binding to an N-terminal site while inhibiting Ci/Gli activity in the nucleus depending on a C-terminal Sufu-interacting site.
Title: Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction.

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response
Title: A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.

Drosophila Hedgehog signaling promotes downregulation of Su(fu) through its target protein HIB (Hh-induced BTB protein).
Title: Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.

Suppressor of fused (Sufu) opposes Trn-mediated Ci nuclear import by masking its PY-nuclear localization sequence.
Title: Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kap?2 in Hedgehog signaling.

The 'closed' form of Sufu is stabilized by Gli binding and inhibited by Hh treatment, whereas the 'open' state of Sufu is promoted by Gli-dissociation and Hh signaling.
Title: Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

The following Su(fu) gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Su(fu) cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OFa04714 NM_080502.5
Latest version!		 Drosophila melanogaster suppressor of fused (Su(fu)), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $258.30
$369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OFa04714
Clone ID Related Accession (Same CDS sequence) NM_080502.5
Accession Version NM_080502.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1407bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-04-24
Organism Drosophila melanogaster(fruit fly)
Product suppressor of fused
Comment Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_080502.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGCCGAGG CGAATTTGGA CAAAAAACCT GAGGTGAAGC CTCCGCCGGG CCTTAAGGCC 
ATCATAGACC ACCTCGGGCA GGTGTACCCC AACCAGCCGA ACCCGCTGCA GGTGACCACA 
CTGCTCAAGT ACTGGCTGGG CGGTCAGGAT CCGTTGGACT ACATTAGCAT GTACAACTAT 
CCCGGAGATG TGGATAGGAA CGTTCCGCCG CACTGGCACT ACATTAGTTT CGGACTCAGC 
GACCTACACG GGGACGAGCG AGTCCACTTG CGCGAGGAGG GCGTCACTCG GTCTGGCATG 
GGGTTCGAGT TGACCTTTCG CTTGGCCAAA ACAGAAATAG AGCTAAAGCA GCAGATTGAG 
AACCCGGAAA AGCCCCAAAG ACCGCCCACC TGGCCGGCGA ACCTGTTGCA GGCCATCGGA 
CGCTATTGTT TTCAAACAGG CAACGGGTTG TGCTTCGGAG ACAACATCCC GTGGCGCAAG 
AGTCTGGATG GCAGTACCAC TTCCAAGCTA CAGAACCTGC TCGTCGCCCA GGACCCGCAG 
TTGGGCTGCA TCGACACTCC CACGGGCACG GTGGACTTCT GCCAGATCGT CGGCGTCTTT 
GACGACGAAC TTGAGCAGGC ATCGCGTTGG AACGGGCGCG GTGTGCTCAA CTTCCTTCGC 
CAAGATATGC AAACTGGCGG TGATTGGCTG GTGACTAACA TGGATCGCCA GATGAGCGTC 
TTCGAACTGT TTCCCGAAAC GCTGCTAAAC CTACAGGACG ATCTGGAGAA GCAGGGTTCC 
GATCTGGCCG GCGTTAATGC AGATTTTACG TTCCGTGAGC TGAAACCTAC CAAGGAGGTG 
AAGGAGGAGG TGGATTTCCA GGCGCTGAGC GAGAAGTGCG CCAACGACGA AAACAATCGG 
CAGCTGACGG ATACGCAAAT GAAACGCGAG GAACCAAGCT TTCCACAATC CATGTCGATG 
AGCAGCAATT CGCTGCACAA GTCCTGTCCC CTGGACTTTC AAGCGCAGGC ACCAAACTGC 
ATTTCACTGG ACGGTATTGA GATTACCCTC GCACCTGGTG TGGCCAAGTA CCTCCTACTG 
GCCATCAAGG ATCGCATCCG ACATGGGCGC CACTTCACCT TCAAGGCTCA GCATCTGGCG 
CTCACTTTGG TGGCGGAATC CGTCACCGGC TCGGCGGTGA CAGTGAACGA ACCGTACGGC 
GTGCTGGGCT ACTGGATTCA GGTCCTGATT CCCGATGAAC TGGTGCCGCG CCTGATGGAA 
GACTTCCGCA GCGCGGGCCT AGACGAGAAA TGCGAGCCCA AGGAGCGACT GGAGCTCGAG 
TGGCCCGACA AGAATCTGAA GCTGATCATC GACCAGCCGG AACCTGTGCT GCCCATGTCG 
CTCGACGCTG CTCCTCTGAA AATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_536750.2
CDS31..1437
Translation

Target ORF information:

RefSeq Version NM_080502.5
Organism Drosophila melanogaster(fruit fly)
Definition Drosophila melanogaster suppressor of fused (Su(fu)), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_080502.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGCCGAGG CGAATTTGGA CAAAAAACCT GAGGTGAAGC CTCCGCCGGG CCTTAAGGCC 
ATCATAGACC ACCTCGGGCA GGTGTACCCC AACCAGCCGA ACCCGCTGCA GGTGACCACA 
CTGCTCAAGT ACTGGCTGGG CGGTCAGGAT CCGTTGGACT ACATTAGCAT GTACAACTAT 
CCCGGAGATG TGGATAGGAA CGTTCCGCCG CACTGGCACT ACATTAGTTT CGGACTCAGC 
GACCTACACG GGGACGAGCG AGTCCACTTG CGCGAGGAGG GCGTCACTCG GTCTGGCATG 
GGGTTCGAGT TGACCTTTCG CTTGGCCAAA ACAGAAATAG AGCTAAAGCA GCAGATTGAG 
AACCCGGAAA AGCCCCAAAG ACCGCCCACC TGGCCGGCGA ACCTGTTGCA GGCCATCGGA 
CGCTATTGTT TTCAAACAGG CAACGGGTTG TGCTTCGGAG ACAACATCCC GTGGCGCAAG 
AGTCTGGATG GCAGTACCAC TTCCAAGCTA CAGAACCTGC TCGTCGCCCA GGACCCGCAG 
TTGGGCTGCA TCGACACTCC CACGGGCACG GTGGACTTCT GCCAGATCGT CGGCGTCTTT 
GACGACGAAC TTGAGCAGGC ATCGCGTTGG AACGGGCGCG GTGTGCTCAA CTTCCTTCGC 
CAAGATATGC AAACTGGCGG TGATTGGCTG GTGACTAACA TGGATCGCCA GATGAGCGTC 
TTCGAACTGT TTCCCGAAAC GCTGCTAAAC CTACAGGACG ATCTGGAGAA GCAGGGTTCC 
GATCTGGCCG GCGTTAATGC AGATTTTACG TTCCGTGAGC TGAAACCTAC CAAGGAGGTG 
AAGGAGGAGG TGGATTTCCA GGCGCTGAGC GAGAAGTGCG CCAACGACGA AAACAATCGG 
CAGCTGACGG ATACGCAAAT GAAACGCGAG GAACCAAGCT TTCCACAATC CATGTCGATG 
AGCAGCAATT CGCTGCACAA GTCCTGTCCC CTGGACTTTC AAGCGCAGGC ACCAAACTGC 
ATTTCACTGG ACGGTATTGA GATTACCCTC GCACCTGGTG TGGCCAAGTA CCTCCTACTG 
GCCATCAAGG ATCGCATCCG ACATGGGCGC CACTTCACCT TCAAGGCTCA GCATCTGGCG 
CTCACTTTGG TGGCGGAATC CGTCACCGGC TCGGCGGTGA CAGTGAACGA ACCGTACGGC 
GTGCTGGGCT ACTGGATTCA GGTCCTGATT CCCGATGAAC TGGTGCCGCG CCTGATGGAA 
GACTTCCGCA GCGCGGGCCT AGACGAGAAA TGCGAGCCCA AGGAGCGACT GGAGCTCGAG 
TGGCCCGACA AGAATCTGAA GCTGATCATC GACCAGCCGG AACCTGTGCT GCCCATGTCG 
CTCGACGCTG CTCCTCTGAA AATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,


book

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,


book

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE


book

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH


book

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D