Su(fu) cDNA ORF clone, Drosophila melanogaster(fruit fly)
| Gene Symbol | Su(fu) |
| Entrez Gene ID | 41565 |
| Full Name | Suppressor of fused |
| Synonyms | CG6054,Dmel\CG6054,SU(FU),SUFU,Su(Fu),SuFu,Sufu,dSufu,su(fu),sufu |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_080502.5 | NP_536750.2 | suppressor of fused |
| Homo sapiens (human) | SUFU | NP_057253.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001948 | XP_321114.1 |
| Pan troglodytes (chimpanzee) | SUFU | XP_001171637.1 |
| Bos taurus (cattle) | SUFU | NP_001091552.1 |
| Rattus norvegicus (Norway rat) | Sufu | NP_001020070.1 |
| Danio rerio (zebrafish) | sufu | NP_958466.1 |
| Mus musculus (house mouse) | Sufu | NP_056567.2 |
| Gallus gallus (chicken) | SUFU | NP_989595.1 |
| SUFU | XP_001113024.1 | |
| Canis lupus familiaris (dog) | SUFU | XP_005637731.1 |
| Drosophila melanogaster (fruit fly) | Su(fu) | NP_536750.2 |
| Xenopus tropicalis (tropical clawed frog) | sufu | NP_001123387.1 |
Related articles in PubMed
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Sufu can sequester Ci/Gli in the cytoplasm through binding to an N-terminal site while inhibiting Ci/Gli activity in the nucleus depending on a C-terminal Sufu-interacting site.
Title: Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction.
A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response
Title: A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
Drosophila Hedgehog signaling promotes downregulation of Su(fu) through its target protein HIB (Hh-induced BTB protein).
Title: Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.
Suppressor of fused (Sufu) opposes Trn-mediated Ci nuclear import by masking its PY-nuclear localization sequence.
Title: Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kap?2 in Hedgehog signaling.
The 'closed' form of Sufu is stabilized by Gli binding and inhibited by Hh treatment, whereas the 'open' state of Sufu is promoted by Gli-dissociation and Hh signaling.
Title: Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
The following Su(fu) gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Su(fu) cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OFa04714 | |
| Clone ID Related Accession (Same CDS sequence) | NM_080502.5 | |
| Accession Version | NM_080502.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-24 | |
| Organism | Drosophila melanogaster(fruit fly) | |
| Product | suppressor of fused | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_080502.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## | |
1 | ATGGCCGAGG CGAATTTGGA CAAAAAACCT GAGGTGAAGC CTCCGCCGGG CCTTAAGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_536750.2 |
| CDS | 31..1437 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_080502.5 |
ORF Insert Sequence:
1 | ATGGCCGAGG CGAATTTGGA CAAAAAACCT GAGGTGAAGC CTCCGCCGGG CCTTAAGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
|
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
|
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
|
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
|
Combined evidence annotation of transposable elements in genome sequences. |