Gene Symbol | WNT2B |
Entrez Gene ID | 374243 |
Full Name | Wnt family member 2B |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
ORF » Species Summary » Gallus gallus » WNT2B cDNA ORF clone
gRNAs
Gene Symbol | WNT2B |
Entrez Gene ID | 374243 |
Full Name | Wnt family member 2B |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
mRNA | Protein | Name |
---|---|---|
NM_204336.2 | NP_989667.2 | protein Wnt-2b precursor |
WNT2B | XP_001107861.1 | |
Mus musculus (house mouse) | Wnt2b | NP_033546.2 |
Danio rerio (zebrafish) | wnt2bb | NP_001037809.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100491761 | XP_004910783.1 |
Canis lupus familiaris (dog) | LOC483220 | XP_005630937.1 |
Bos taurus (cattle) | WNT2B | NP_001092833.1 |
Homo sapiens (human) | WNT2B | NP_078613.1 |
Gallus gallus (chicken) | WNT2B | NP_989667.1 |
Pan troglodytes (chimpanzee) | WNT2B | XP_513634.3 |
Rattus norvegicus (Norway rat) | Wnt2b | NP_001178777.1 |
Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.
Ohta K, Ito A, Kuriyama S, Lupo G, Kosaka M, Ohnuma S, Nakagawa S, Tanaka H
Proceedings of the National Academy of Sciences of the United States of America108(36)14962-7(2011 Sep)
Neural crest cells organize the eye via TGF-? and canonical Wnt signalling.
Grocott T, Johnson S, Bailey AP, Streit A
Nature communications2265(2011)
The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium.
Kitamoto J, Hyer J
Molecular vision162701-17(2010 Dec)
Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.
Cho SH, Cepko CL
Development (Cambridge, England)133(16)3167-77(2006 Aug)
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H
Journal of cellular physiology208(1)77-86(2006 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye
Title: Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.
Neural crest-derived TGFbs activate both Smad3 and Wnt2b signalling in the adjacent ectoderm to position the lens next to the retina.
Title: Neural crest cells organize the eye via TGF-? and canonical Wnt signalling.
The anterior optic cup domain, as described in part by Wnt2b expression, is specified through the elaboration of a border within the optic neuroepithelium rather than through interactions with the surrounding environment.
Title: The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium.
The expression of Wnt2b or constitutively active beta-catenin inhibited retinal progenitor gene (RPG) expression and the differentiation of retinal neurons.
Title: Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.
Wnt2b maintains the naive state of marginal progenitor cells by attenuating the expression of both proneural and neurogenic genes
Title: Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes.
The following WNT2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WNT2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OGa28314 | |
Clone ID Related Accession (Same CDS sequence) | NM_204336.2 | |
Accession Version | NM_204336.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Gallus gallus(chicken) | |
Product | protein Wnt-2b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AADN05000168.1 and AF346628.1. On Mar 27, 2015 this sequence version replaced NM_204336.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX935899.1, AF346628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2201357, SAMEA2201358 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTCAGTC CAAACCGCCT GGCAGCGTCT CCTGGGATTG CCGTGGCCCC CGGGCGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_989667.2 |
CDS | 41..1198 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCTCAGTC CAAACCGCCT GGCAGCGTCT CCTGGGATTG CCGTGGCCCC CGGGCGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4. |
Neural crest cells organize the eye via TGF-? and canonical Wnt signalling. |
The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium. |
Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. |
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. |