Gene Symbol | HMGCR |
Entrez Gene ID | 395145 |
Full Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
Synonyms | HMGR |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
ORF » Species Summary » Gallus gallus » HMGCR cDNA ORF clone
Gene Symbol | HMGCR |
Entrez Gene ID | 395145 |
Full Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
Synonyms | HMGR |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
mRNA | Protein | Name |
---|---|---|
XM_015277227.2 | XP_015132713.1 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 |
XM_015277227.1 | XP_015132713.1 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2 |
XM_015277226.1 | XP_015132712.1 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 |
NM_204485.2 | NP_989816.2 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
Homo sapiens (human) | HMGCR | NP_000850.1 |
Gallus gallus (chicken) | HMGCR | NP_989816.1 |
Caenorhabditis elegans (roundworm) | hmgr-1 | NP_498626.2 |
Saccharomyces cerevisiae (baker's yeast) | HMG2 | NP_013555.1 |
Kluyveromyces lactis | KLLA0B04642g | XP_451740.1 |
Pan troglodytes (chimpanzee) | HMGCR | XP_001148405.2 |
Bos taurus (cattle) | HMGCR | NP_001099083.1 |
Xenopus tropicalis (tropical clawed frog) | hmgcr | XP_004910453.1 |
HMGCR | XP_002804463.1 | |
Canis lupus familiaris (dog) | HMGCR | XP_536323.3 |
Drosophila melanogaster (fruit fly) | Hmgcr | NP_732900.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08975 | XP_003714014.1 |
Neurospora crassa | NCU00712 | XP_964546.1 |
Arabidopsis thaliana (thale cress) | HMG1 | NP_177775.2 |
Oryza sativa (rice) | Os09g0492700 | NP_001063541.1 |
Oryza sativa (rice) | Os08g0512700 | NP_001062221.1 |
Mus musculus (house mouse) | Hmgcr | NP_032281.2 |
Rattus norvegicus (Norway rat) | Hmgcr | NP_037266.2 |
Danio rerio (zebrafish) | hmgcra | NP_001073446.1 |
Arabidopsis thaliana (thale cress) | HMG2 | NP_179329.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002288 | XP_307890.5 |
Saccharomyces cerevisiae (baker's yeast) | HMG1 | NP_013636.1 |
Eremothecium gossypii | AGOS_AER152W | NP_985010.2 |
Schizosaccharomyces pombe (fission yeast) | hmg1 | NP_588235.1 |
Three novel single nucleotide polymorphisms of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with egg-production in chicken.
Han C, An G, Du X
Folia biologica62(3)203-9(2014)
Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach.
Wang HT, Li YH, Chou IP, Hsieh YH, Chen BJ, Chen CY
Journal of the science of food and agriculture93(2)284-92(2013 Jan)
Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken.
Wei Y, Zhu SK, Zhang S, Han RL, Tian YD, Sun GR, Kang XT
Genetics and molecular research : GMR11(4)4765-74(2012 Sep)
Telomeric DNA quantity, DNA damage, and heat shock protein gene expression as physiological stress markers in chickens.
Sohn SH, Subramani VK, Moon YS, Jang IS
Poultry science91(4)829-36(2012 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
It was concluded that specific variants of the HMGCR gene are associated with chicken egg production, and haplotypes with higher and lower plasma VLDL concentrations showed lower egg production than other haplotypes.
Title: Three novel single nucleotide polymorphisms of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with egg-production in chicken.
Data suggest that liver HMGCR can be induced by dietary factors (here, supplementation with bacteriocin albusin B from Ruminococcus albus).
Title: Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach.
HMGCR polymorphisms in chickens have significant effects on growth, carcass, meat quality, and lipid concentration.
Title: Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken.
Stress conditions had a significant effect on the expression of HMGCR and HSP90alpha in lymphocytes. Telomere length, especially telomere-shortening rates, and expression levels of these two genes can be used as sensitive physiological stress markers.
Title: Telomeric DNA quantity, DNA damage, and heat shock protein gene expression as physiological stress markers in chickens.
The 3-hydroxyl-3-methylglutaryl Coenzyme A reductase (HMGCR) gene was examined for polymorphisms in Beijing-you chickens.
Title: The effect of a mutation in the 3-UTR region of the HMGCR gene on cholesterol in Beijing-you chickens.
The following HMGCR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMGCR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OGa28331 | |
Clone ID Related Accession (Same CDS sequence) | XM_015277227.2 , XM_015277227.1 , NM_204485.2 | |
Accession Version | NM_204485.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2649bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Gallus gallus(chicken) | |
Product | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC190414.3. On Dec 31, 2014 this sequence version replaced NM_204485.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: ERR2286007.63845.1, ERR2368565.110092.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2201357, SAMEA2201358 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTTGTCCA GGCTTTTTCG AATGCATGGC CTTTTTGTGG CCTCTCATCC ATGGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_989816.2 |
CDS | 144..2792 |
Translation |
Target ORF information:
Target ORF information:
|
NM_204485.2 |
1 | ATGTTGTCCA GGCTTTTTCG AATGCATGGC CTTTTTGTGG CCTCTCATCC ATGGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa28331 | |
Clone ID Related Accession (Same CDS sequence) | XM_015277227.2 , XM_015277227.1 , NM_204485.2 | |
Accession Version | XM_015277227.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2649bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-16 | |
Organism | Gallus gallus(chicken) | |
Product | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006127.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015277227.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGTCCA GGCTTTTTCG AATGCATGGC CTTTTTGTGG CCTCTCATCC ATGGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015132713.1 |
CDS | 56..2704 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015277227.2 |
1 | ATGTTGTCCA GGCTTTTTCG AATGCATGGC CTTTTTGTGG CCTCTCATCC ATGGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa28331 | |
Clone ID Related Accession (Same CDS sequence) | XM_015277227.2 , XM_015277227.1 , NM_204485.2 | |
Accession Version | XM_015277227.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2649bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-03 | |
Organism | Gallus gallus(chicken) | |
Product | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_001488830.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGTCCA GGCTTTTTCG AATGCATGGC CTTTTTGTGG CCTCTCATCC ATGGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015132713.1 |
CDS | 56..2704 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015277227.1 |
1 | ATGTTGTCCA GGCTTTTTCG AATGCATGGC CTTTTTGTGG CCTCTCATCC ATGGGAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa47671 | |
Clone ID Related Accession (Same CDS sequence) | XM_015277226.1 | |
Accession Version | XM_015277226.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-03 | |
Organism | Gallus gallus(chicken) | |
Product | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_001488830.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGTGG CCGCCGCGTC GTGCCCCGGG TGTCCTTGTC CGGGGAGGAG CGGCCGCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015132712.1 |
CDS | 8..2800 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015277226.1 |
1 | ATGGCGGTGG CCGCCGCGTC GTGCCCCGGG TGTCCTTGTC CGGGGAGGAG CGGCCGCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Three novel single nucleotide polymorphisms of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with egg-production in chicken. |
Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach. |
Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken. |
Telomeric DNA quantity, DNA damage, and heat shock protein gene expression as physiological stress markers in chickens. |