Gene Symbol | SPRY2 |
Entrez Gene ID | 395584 |
Full Name | sprouty RTK signaling antagonist 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
ORF » Species Summary » Gallus gallus » SPRY2 cDNA ORF clone
gRNAs
Gene Symbol | SPRY2 |
Entrez Gene ID | 395584 |
Full Name | sprouty RTK signaling antagonist 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
mRNA | Protein | Name |
---|---|---|
XM_015275115.1 | XP_015130601.1 | protein sprouty homolog 2 isoform X1 |
XM_015275115.2 | XP_015130601.1 | protein sprouty homolog 2 isoform X1 |
XM_015275119.1 | XP_015130605.1 | protein sprouty homolog 2 isoform X1 |
XM_015275119.2 | XP_015130605.1 | protein sprouty homolog 2 isoform X1 |
XM_015275123.2 | XP_015130609.1 | protein sprouty homolog 2 isoform X1 |
XM_015275123.1 | XP_015130609.1 | protein sprouty homolog 2 isoform X1 |
NM_204800.1 | NP_990131.1 | protein sprouty homolog 2 |
Pan troglodytes (chimpanzee) | SPRY2 | XP_003952460.1 |
Bos taurus (cattle) | SPRY2 | NP_001069615.1 |
SPRY2 | XP_001090386.2 | |
Canis lupus familiaris (dog) | SPRY2 | XP_005634066.1 |
Rattus norvegicus (Norway rat) | Spry2 | NP_001012046.1 |
Mus musculus (house mouse) | Spry2 | NP_036027.1 |
Danio rerio (zebrafish) | spry2 | NP_001003842.2 |
Xenopus tropicalis (tropical clawed frog) | spry2 | NP_001006932.2 |
Homo sapiens (human) | SPRY2 | NP_005833.1 |
Gallus gallus (chicken) | SPRY2 | NP_990131.1 |
Sprouty2 mediated tuning of signalling is essential for somite myogenesis.
Abu-Elmagd M, Goljanek Whysall K, Wheeler G, M?nsterberg A
BMC medical genomics8 Suppl 1S8(2015)
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity.
Suzuki-Hirano A, Harada H, Sato T, Nakamura H
Developmental biology337(2)284-93(2010 Jan)
Stage-dependent craniofacial defects resulting from Sprouty2 overexpression.
Goodnough LH, Brugmann SA, Hu D, Helms JA
Developmental dynamics : an official publication of the American Association of Anatomists236(7)1918-28(2007 Jul)
Regulation of isthmic Fgf8 signal by sprouty2.
Suzuki-Hirano A, Sato T, Nakamura H
Development (Cambridge, England)132(2)257-65(2005 Jan)
Differential display of genes expressed at the midbrain - hindbrain junction identifies sprouty2: an FGF8-inducible member of a family of intracellular FGF antagonists.
Chambers D, Medhurst AD, Walsh FS, Price J, Mason I
Molecular and cellular neurosciences15(1)22-35(2000 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Spry2 function during chick somite myogenesis
Title: Sprouty2 mediated tuning of signalling is essential for somite myogenesis.
'Prolonged' activation of ERK by misexpression of Fgf8b and dominant-negative Sprouty2 (dnSprouty2) did not change the fate of the mesencephalic alar plate.
Title: Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity.
Sprouty2 plays a role in the outgrowth of facial prominences independent of canonical fibroblast growth factor signaling.
Title: Stage-dependent craniofacial defects resulting from Sprouty2 overexpression.
Sprouty2 may regulate the Fgf8-Ras-ERK signaling pathway for the proper regionalization of the metencephalon and mesencephalon
Title: Regulation of isthmic Fgf8 signal by sprouty2.
The following SPRY2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPRY2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OGa27020 | |
Clone ID Related Accession (Same CDS sequence) | NM_204800.1 | |
Accession Version | NM_204800.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-15 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF176904.1. ##Evidence-Data-START## Transcript exon combination :: AF176904.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_990131.1 |
CDS | 156..1097 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa30792 | |
Clone ID Related Accession (Same CDS sequence) | XM_015275115.1 , XM_015275115.2 , XM_015275119.1 , XM_015275119.2 , XM_015275123.2 , XM_015275123.1 | |
Accession Version | XM_015275115.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-03 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455757.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015130601.1 |
CDS | 175..1116 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa30792 | |
Clone ID Related Accession (Same CDS sequence) | XM_015275115.1 , XM_015275115.2 , XM_015275119.1 , XM_015275119.2 , XM_015275123.2 , XM_015275123.1 | |
Accession Version | XM_015275115.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-16 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006088.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015275115.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015130601.1 |
CDS | 186..1127 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa30792 | |
Clone ID Related Accession (Same CDS sequence) | XM_015275115.1 , XM_015275115.2 , XM_015275119.1 , XM_015275119.2 , XM_015275123.2 , XM_015275123.1 | |
Accession Version | XM_015275119.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-03 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455757.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015130605.1 |
CDS | 180..1121 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa30792 | |
Clone ID Related Accession (Same CDS sequence) | XM_015275115.1 , XM_015275115.2 , XM_015275119.1 , XM_015275119.2 , XM_015275123.2 , XM_015275123.1 | |
Accession Version | XM_015275119.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-16 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006088.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015275119.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015130605.1 |
CDS | 196..1137 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa30792 | |
Clone ID Related Accession (Same CDS sequence) | XM_015275115.1 , XM_015275115.2 , XM_015275119.1 , XM_015275119.2 , XM_015275123.2 , XM_015275123.1 | |
Accession Version | XM_015275123.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-16 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006088.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015275123.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015130609.1 |
CDS | 146..1087 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa30792 | |
Clone ID Related Accession (Same CDS sequence) | XM_015275115.1 , XM_015275115.2 , XM_015275119.1 , XM_015275119.2 , XM_015275123.2 , XM_015275123.1 | |
Accession Version | XM_015275123.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-03 | |
Organism | Gallus gallus(chicken) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455757.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015130609.1 |
CDS | 136..1077 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GAGTTCAGCA CGGCAGCGGG TCACAGGCCT TGCTACAGGC TCGGCGTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Sprouty2 mediated tuning of signalling is essential for somite myogenesis. |
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity. |
Stage-dependent craniofacial defects resulting from Sprouty2 overexpression. |
Regulation of isthmic Fgf8 signal by sprouty2. |
Differential display of genes expressed at the midbrain - hindbrain junction identifies sprouty2: an FGF8-inducible member of a family of intracellular FGF antagonists. |