GBX2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	GBX2
Entrez Gene ID	395950
Full Name	gastrulation brain homeobox 2
General protein information	Preferred Names gastrulation brain homeobox 2 Names homeobox protein GBX-2 gastrulation and brain-specific homeobox protein 2 gastrulation brain homeo box 2 gastrulation brain homeobox 2 protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_205068.1	NP_990399.1	homeobox protein GBX-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gbx2	NP_694496.1
Xenopus tropicalis (tropical clawed frog)	gbx2	XP_002932046.1
Homo sapiens (human)	GBX2	NP_001476.2
Mus musculus (house mouse)	Gbx2	NP_034392.1
Rattus norvegicus (Norway rat)	Gbx2	NP_446160.1
Xenopus tropicalis (tropical clawed frog)	gbx2.2	NP_001011472.1
Pan troglodytes (chimpanzee)	GBX2	XP_526072.2
	GBX2	XP_001082998.1
Canis lupus familiaris (dog)	GBX2	XP_543300.1
Bos taurus (cattle)	GBX2	NP_001179074.1
Gallus gallus (chicken)	GBX2	NP_990399.1

Gene Ontology
Bibliography

Related articles in PubMed

The epigenetic modifier DNMT3A is necessary for proper otic placode formation.
Roellig D, Bronner ME
Developmental biology411(2)294-300(2016 Mar)

Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.
Steventon B, Mayor R, Streit A
Developmental biology367(1)55-65(2012 Jul)

Comparison of Pretectal Genoarchitectonic Pattern between Quail and Chicken Embryos.
Merch?n P, Bardet SM, Puelles L, Ferran JL
Frontiers in neuroanatomy523(2011)

Role of Gbx2 and Otx2 in the formation of cochlear ganglion and endolymphatic duct.
Miyazaki H, Kobayashi T, Nakamura H, Funahashi J
Development, growth & differentiation48(7)429-38(2006 Sep)

Otx2, Gbx2, and Fgf8 expression patterns in the chick developing inner ear and their possible roles in otic specification and early innervation.
S?nchez-Calder?n H, Mart?n-Partido G, Hidalgo-S?nchez M
Gene expression patterns : GEP4(6)659-69(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNMT3A is important for enabling the activation of Gbx2 expression, necessary for normal development of the inner ear
Title: The epigenetic modifier DNMT3A is necessary for proper otic placode formation.

Otx2 and Gbx2 provide a global mechanism for patterning of the embryonic ectoderm and ensure the coordinated development of the central and peripheral nervous system in the head.
Title: Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.

Results suggest that the interaction between Gbx2 and Otx2 in developing inner ear defines Fgf10 expression domain to induce the cochlear ganglion and that Gbx2 expression is important for the formation of the endolymphatic duct.
Title: Role of Gbx2 and Otx2 in the formation of cochlear ganglion and endolymphatic duct.

Otx2, Gbx2, and Fgf8 are expressed in the chick developing inner ear
Title: Otx2, Gbx2, and Fgf8 expression patterns in the chick developing inner ear and their possible roles in otic specification and early innervation.

The following GBX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GBX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa27202	NM_205068.1 Latest version!	Gallus gallus gastrulation brain homeobox 2 (GBX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GBX2 ( NM_205068.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990399.1 Gallus gallus gastrulation brain homeobox 2 (GBX2), mRNA.

Price & Availability↑

CloneID	OGa27202
Clone ID Related Accession (Same CDS sequence)	NM_205068.1
Accession Version	NM_205068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Gallus gallus(chicken)
Product	homeobox protein GBX-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF022151.1. ##Evidence-Data-START## Transcript exon combination :: AF022151.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGCGCGG CTTTCCAGCC CTCGCTGATG ATGATGCAGC GCCCGCTGGG AAGCAGCACG 
GCCTTCAGCA TCGATTCGCT CATCGGCAGC CCCCCGCCGC CCGCCCCCGG CCACTTCGTC 
TACACCGGCT ACCCCATGTT CATGCCGTAC CGGCCCGTCG TGCTGCCCCC CCCGCCGCCC 
GCCCTGCCGC AGGCCGCCCT GCAGCCGCCG CTGCCCCCCG CGCCGCCCCC GCCGCTGCCC 
GCGTTGCCCG GAGCCTTCTG CCCCGGGCTG GCGCAGGGCA TGGCCCTCAC CTCCACGCTG 
ATGGCCGCGC TGCCCGGCTC CTTCCCCGCC TCCCCGCCGC GCCCCGAGGC CGCCAGGAAG 
TTCGCCCCCC CGGGGAACTT CGACAAGGCC GACGGACTGC CTCCCCCGGA CGGCGGCGGC 
GGCGGCGGAG ACGACGGCAA AACCGGGGGG GGGCTGCTAC CCTTCCCCGC TGCCGACGCC 
GTGCACGCAT CGCTGGCCGG GGCCCTCCGC GGCGGCCCCA AAGACGATCC CAAAGCGGAG 
GAGGAGGCGA AGGGCCGCGA GGAGAACTTC TCCATGGACA GCGACCTCGA CTACAGCTCC 
GACGAGAACG GCCCCGCGCC GGCGGCCCCG CGGGAGGAGG ACTGTGGCAC CGCGTTGGAG 
GAGAACCCCC CCAGCGCCGC CAACGCCGCC GCCAACGCCG CGGCCACGGG GAAGAACCGA 
CGGCGGCGGA CGGCGTTCAC CAGCGAGCAG CTGCTGGAGC TGGAGAAGGA GTTCCACTGC 
AAGAAGTACC TCTCGCTGAC GGAGCGCTCG CAGATCGCGC ACGCCCTGAA GCTGAGCGAG 
GTGCAGGTGA AGATCTGGTT CCAGAACAGG CGAGCCAAAT GGAAGCGGGT GAAGGCGGGC 
AACGCCAGCT CCAAGGCGGG GGAACCGTCG CGGAACCCCA AGATCGTCGT GCCCATCCCC 
GTGCACGTCA GCCGCTTCGC CATCAGGAGT CAGCACCAGC AGCTGGAGCA GGCGCGGCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990399.1
CDS	55..1077
Translation	MSAAFQPSLMMMQRPLGSSTAFSIDSLIGSPPPPAPGHFVYTGYPMFMPYRPVVLPPPPPALPQAALQPPLPPAPPPPLPALPGAFCPGLAQGMALTSTLMAALPGSFPASPPRPEAARKFAPPGNFDKADGLPPPDGGGGGGDDGKTGGGLLPFPAADAVHASLAGALRGGPKDDPKAEEEAKGREENFSMDSDLDYSSDENGPAPAAPREEDCGTALEENPPSAANAAANAAATGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNASSKAGEPSRNPKIVVPIPVHVSRFAIRSQHQQLEQARP

Target ORF information:

RefSeq Version	NM_205068.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus gastrulation brain homeobox 2 (GBX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205068.1

ORF Insert Sequence:

ATGAGCGCGG CTTTCCAGCC CTCGCTGATG ATGATGCAGC GCCCGCTGGG AAGCAGCACG 
GCCTTCAGCA TCGATTCGCT CATCGGCAGC CCCCCGCCGC CCGCCCCCGG CCACTTCGTC 
TACACCGGCT ACCCCATGTT CATGCCGTAC CGGCCCGTCG TGCTGCCCCC CCCGCCGCCC 
GCCCTGCCGC AGGCCGCCCT GCAGCCGCCG CTGCCCCCCG CGCCGCCCCC GCCGCTGCCC 
GCGTTGCCCG GAGCCTTCTG CCCCGGGCTG GCGCAGGGCA TGGCCCTCAC CTCCACGCTG 
ATGGCCGCGC TGCCCGGCTC CTTCCCCGCC TCCCCGCCGC GCCCCGAGGC CGCCAGGAAG 
TTCGCCCCCC CGGGGAACTT CGACAAGGCC GACGGACTGC CTCCCCCGGA CGGCGGCGGC 
GGCGGCGGAG ACGACGGCAA AACCGGGGGG GGGCTGCTAC CCTTCCCCGC TGCCGACGCC 
GTGCACGCAT CGCTGGCCGG GGCCCTCCGC GGCGGCCCCA AAGACGATCC CAAAGCGGAG 
GAGGAGGCGA AGGGCCGCGA GGAGAACTTC TCCATGGACA GCGACCTCGA CTACAGCTCC 
GACGAGAACG GCCCCGCGCC GGCGGCCCCG CGGGAGGAGG ACTGTGGCAC CGCGTTGGAG 
GAGAACCCCC CCAGCGCCGC CAACGCCGCC GCCAACGCCG CGGCCACGGG GAAGAACCGA 
CGGCGGCGGA CGGCGTTCAC CAGCGAGCAG CTGCTGGAGC TGGAGAAGGA GTTCCACTGC 
AAGAAGTACC TCTCGCTGAC GGAGCGCTCG CAGATCGCGC ACGCCCTGAA GCTGAGCGAG 
GTGCAGGTGA AGATCTGGTT CCAGAACAGG CGAGCCAAAT GGAAGCGGGT GAAGGCGGGC 
AACGCCAGCT CCAAGGCGGG GGAACCGTCG CGGAACCCCA AGATCGTCGT GCCCATCCCC 
GTGCACGTCA GCCGCTTCGC CATCAGGAGT CAGCACCAGC AGCTGGAGCA GGCGCGGCCC 
TGA