SRSF1 cDNA ORF clone, Gallus gallus(chicken)
| Gene Symbol | SRSF1 |
| Entrez Gene ID | 772264 |
| Full Name | serine and arginine rich splicing factor 1 |
| Synonyms | SFRS1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Gallus gallus(chicken) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001113741.1 | NP_001107213.1 | serine/arginine-rich splicing factor 1 |
| Pan troglodytes (chimpanzee) | SRSF1 | NP_001182476.1 |
| Gallus gallus (chicken) | SRSF1 | NP_001107213.1 |
| Xenopus tropicalis (tropical clawed frog) | srsf1 | NP_001006919.1 |
| Homo sapiens (human) | SRSF1 | NP_008855.1 |
| Danio rerio (zebrafish) | srsf1a | NP_998180.1 |
| Drosophila melanogaster (fruit fly) | SF2 | NP_652611.1 |
| Mus musculus (house mouse) | Srsf1 | NP_775550.2 |
| Arabidopsis thaliana (thale cress) | SR1 | NP_850934.1 |
| Canis lupus familiaris (dog) | SRSF1 | XP_005624772.1 |
| Bos taurus (cattle) | SRSF1 | NP_001069862.1 |
| SRSF1 | XP_001103473.2 | |
| Rattus norvegicus (Norway rat) | Srsf1 | NP_001103022.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010496 | XP_314469.4 |
| Caenorhabditis elegans (roundworm) | rsp-3 | NP_499649.2 |
| Arabidopsis thaliana (thale cress) | AT4G02430 | NP_567235.3 |
Related articles in PubMed
SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus.
Kawaguchi Y, Nariki H, Kawamoto N, Kanehiro Y, Miyazaki S, Suzuki M, Magari M, Tokumitsu H, Kanayama N
Biochemical and biophysical research communications485(2)261-266(2017 04)
Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1.
Kanehiro Y, Todo K, Negishi M, Fukuoka J, Gan W, Hikasa T, Kaga Y, Takemoto M, Magari M, Li X, Manley JL, Ohmori H, Kanayama N
Proceedings of the National Academy of Sciences of the United States of America109(4)1216-21(2012 Jan)
Proteomic analysis of the Gallus gallus embryo at stage-29 of development.
Agudo D, Agudo Garcill?n D, G?mez-Esquer F, D?az-Gil G, Mart?nez-Arribas F, Delc?n J, Schneider J, Palomar MA, Linares R
Proteomics5(18)4946-57(2005 Dec)
Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)
A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that SRSF1-3 (a splicing isoform of SRSF1)promotes nuclear localization of AID probably by forming a nuclear protein complex, which might stabilize nuclear AID and induce immunoglobulin variable region diversification in an AID C-terminus-dependent manner.
Title: SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus.
SRSF1-3 binds preferentially to the IgV gene and inhibits processing of the Ig transcript, providing a mechanism by which SRSF1-3 makes the IgV gene available for AID-dependent somatic hypermutation.
Title: Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1.
The following SRSF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRSF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OGa28129 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001113741.1 | |
| Accession Version | NM_001113741.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-19 | |
| Organism | Gallus gallus(chicken) | |
| Product | serine/arginine-rich splicing factor 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ719371.1, BU143051.1 and CR386959.1. On Jan 26, 2008 this sequence version replaced XR_026804.1. | |
1 | ATGTCCGGAG GGGGCGTGAT CCGCGGCCCA GCCGGCAATA ACGACTGCCG CATCTACGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001107213.1 |
| CDS | 137..883 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001113741.1 |
ORF Insert Sequence:
1 | ATGTCCGGAG GGGGCGTGAT CCGCGGCCCA GCCGGCAATA ACGACTGCCG CATCTACGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus. |
|
Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1. |
|
Proteomic analysis of the Gallus gallus embryo at stage-29 of development. |
|
Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. |
|
A comprehensive collection of chicken cDNAs. |