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HCN4 cDNA ORF clone, Homo sapiens (human)

Gene Symbol HCN4
Entrez Gene ID 10021
Full Name hyperpolarization activated cyclic nucleotide gated potassium channel 4
Synonyms SSS2
General protein information
Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
hyperpolarization activated cyclic nucleotide-gated cation channel 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q24.1

Summary This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

605206

Disorder Html: Sick sinus syndrome 2, 163800 (3); Brugada syndrome 8, 613123 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011521148 XP_011519450 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X1
NM_005477 NP_005468 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4



Homo sapiens (human) HCN4 NP_005468.1
Pan troglodytes (chimpanzee) HCN4 XP_003952750.1
Macaca mulatta (Rhesus monkey) HCN4 XP_002804905.1
Bos taurus (cattle) HCN4 XP_002690539.1
Mus musculus (house mouse) Hcn4 NP_001074661.1
Rattus norvegicus (Norway rat) Hcn4 NP_067690.1
Gallus gallus (chicken) HCN4 XP_425050.3
Danio rerio (zebrafish) hcn4 XP_686078.4
Danio rerio (zebrafish) hcn4l XP_684730.5
Xenopus (Silurana) tropicalis (western clawed frog) hcn4 XP_004916024.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HCN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HCN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu63614 XM_011521148 PREDICTED: Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $391.30
$559.00
OHu18158 NM_005477 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $643.30
$919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu63614
Clone ID Related Accession (Same CDS sequence) XM_011521148
Accession Version XM_011521148.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2394bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010194.18) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGACCTACG ACCTGGCCAG CGCCGTGGTG CGCATCGTGA ACCTCATCGG CATGATGCTC 
CTGCTCTGCC ACTGGGACGG CTGCCTGCAG TTCCTGGTAC CCATGCTACA GGACTTCCCT
GACGACTGCT GGGTGTCCAT CAACAACATG GTGAACAACT CCTGGGGGAA GCAGTACTCC
TACGCGCTCT TCAAGGCCAT GAGCCACATG CTGTGCATCG GCTACGGGCG GCAGGCGCCC
GTGGGCATGT CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTGGGTGC CACCTGCTAC
GCCATGTTCA TTGGCCACGC CACTGCCCTC ATCCAGTCCC TGGACTCCTC CCGGCGCCAG
TACCAGGAAA AGTACAAGCA GGTGGAGCAG TACATGTCCT TTCACAAGCT CCCGCCCGAC
ACCCGGCAGC GCATCCACGA CTACTACGAG CACCGCTACC AGGGCAAGAT GTTCGACGAG
GAGAGCATCC TGGGCGAGCT AAGCGAGCCC CTGCGGGAGG AGATCATCAA CTTTAACTGT
CGGAAGCTGG TGGCCTCCAT GCCACTGTTT GCCAATGCGG ACCCCAACTT CGTGACGTCC
ATGCTGACCA AGCTGCGTTT CGAGGTCTTC CAGCCTGGGG ACTACATCAT CCGGGAAGGC
ACCATTGGCA AGAAGATGTA CTTCATCCAG CATGGCGTGG TCAGCGTGCT CACCAAGGGC
AACAAGGAGA CCAAGCTGGC CGACGGCTCC TACTTTGGAG AGATCTGCCT GCTGACCCGG
GGCCGGCGCA CAGCCAGCGT GAGGGCCGAC ACCTACTGCC GCCTCTACTC GCTGAGCGTG
GACAACTTCA ATGAGGTGCT GGAGGAGTAC CCCATGATGC GAAGGGCCTT CGAGACCGTG
GCGCTGGACC GCCTGGACCG CATTGGCAAG AAGAACTCCA TCCTCCTCCA CAAAGTCCAG
CACGACCTCA ACTCCGGCGT CTTCAACTAC CAGGAGAATG AGATCATCCA GCAGATTGTG
CAGCATGACC GGGAGATGGC CCACTGCGCG CACCGCGTCC AGGCTGCTGC CTCTGCCACC
CCAACCCCCA CGCCCGTCAT CTGGACCCCG CTGATCCAGG CACCACTGCA GGCTGCCGCT
GCCACCACTT CTGTGGCCAT AGCCCTCACC CACCACCCTC GCCTGCCTGC TGCCATCTTC
CGCCCTCCCC CAGGATCTGG GCTGGGCAAC CTCGGTGCCG GGCAGACGCC AAGGCACCTG
AAACGGCTGC AGTCCCTGAT CCCTTCTGCG CTGGGCTCCG CCTCGCCCGC CAGCAGCCCG
TCCCAGGTGG ACACACCGTC TTCATCCTCC TTCCACATCC AACAGCTGGC TGGATTCTCT
GCCCCCGCTG GACTGAGCCC ACTCCTGCCC TCATCCAGCT CCTCCCCACC CCCCGGGGCC
TGTGGCTCCC CCTCGGCTCC CACACCATCA GCTGGCGTAG CCGCCACCAC CATAGCCGGG
TTTGGCCACT TCCACAAGGC GCTGGGTGGC TCCCTGTCCT CCTCCGACTC TCCCCTGCTC
ACCCCGCTGC AGCCAGGCGC CCGCTCCCCG CAGGCTGCCC AGCCATCTCC CGCGCCACCC
GGGGCCCGGG GAGGCCTGGG ACTCCCGGAG CACTTCCTGC CACCCCCACC CTCATCCAGA
TCCCCGTCAT CTAGCCCCGG GCAGCTGGGC CAGCCTCCCG GGGAGTTGTC CCTAGGTCTG
GCCACTGGCC CACTGAGCAC GCCAGAGACA CCCCCACGGC AGCCTGAGCC GCCGTCCCTT
GTGGCAGGGG CCTCTGGGGG GGCTTCCCCT GTAGGCTTTA CTCCCCGAGG AGGTCTCAGC
CCCCCTGGCC ACAGCCCAGG CCCCCCAAGA ACCTTCCCGA GTGCCCCGCC CCGGGCCTCT
GGCTCCCACG GATCCTTGCT CCTGCCACCT GCATCCAGCC CCCCACCACC CCAGGTCCCC
CAGCGCCGGG GCACACCCCC GCTCACCCCC GGCCGCCTCA CCCAGGACCT CAAGCTCATC
TCCGCGTCTC AGCCAGCCCT GCCTCAGGAC GGGGCGCAGA CTCTCCGCAG AGCCTCCCCG
CACTCCTCAG GGGAGTCCAT GGCTGCCTTC CCGCTCTTCC CCAGGGCTGG GGGTGGCAGC
GGGGGCAGTG GGAGCAGCGG GGGCCTCGGT CCCCCTGGGA GGCCCTATGG TGCCATCCCC
GGCCAGCACG TCACTCTGCC TCGGAAGACA TCCTCAGGTT CTTTGCCACC CCCTCTGTCT
TTGTTTGGGG CAAGAGCCAC CTCTTCTGGG GGGCCCCCTC TGACTGCTGG ACCCCAGAGG
GAACCTGGGG CCAGGCCTGA GCCAGTGCGC TCCAAACTGC CATCCAATCT ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011519450.1
CDS61..2454
Misc Feature(1)73..375(+)
Misc Feature(2)607..>1014(+)
Misc Feature(3)625..951(+)
Misc Feature(4)817..855(+)
Misc Feature(5)913..939(+)
Translation

Target ORF information:

RefSeq Version XM_011521148
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011521148

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGACCTACG ACCTGGCCAG CGCCGTGGTG CGCATCGTGA ACCTCATCGG CATGATGCTC 
CTGCTCTGCC ACTGGGACGG CTGCCTGCAG TTCCTGGTAC CCATGCTACA GGACTTCCCT
GACGACTGCT GGGTGTCCAT CAACAACATG GTGAACAACT CCTGGGGGAA GCAGTACTCC
TACGCGCTCT TCAAGGCCAT GAGCCACATG CTGTGCATCG GCTACGGGCG GCAGGCGCCC
GTGGGCATGT CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTGGGTGC CACCTGCTAC
GCCATGTTCA TTGGCCACGC CACTGCCCTC ATCCAGTCCC TGGACTCCTC CCGGCGCCAG
TACCAGGAAA AGTACAAGCA GGTGGAGCAG TACATGTCCT TTCACAAGCT CCCGCCCGAC
ACCCGGCAGC GCATCCACGA CTACTACGAG CACCGCTACC AGGGCAAGAT GTTCGACGAG
GAGAGCATCC TGGGCGAGCT AAGCGAGCCC CTGCGGGAGG AGATCATCAA CTTTAACTGT
CGGAAGCTGG TGGCCTCCAT GCCACTGTTT GCCAATGCGG ACCCCAACTT CGTGACGTCC
ATGCTGACCA AGCTGCGTTT CGAGGTCTTC CAGCCTGGGG ACTACATCAT CCGGGAAGGC
ACCATTGGCA AGAAGATGTA CTTCATCCAG CATGGCGTGG TCAGCGTGCT CACCAAGGGC
AACAAGGAGA CCAAGCTGGC CGACGGCTCC TACTTTGGAG AGATCTGCCT GCTGACCCGG
GGCCGGCGCA CAGCCAGCGT GAGGGCCGAC ACCTACTGCC GCCTCTACTC GCTGAGCGTG
GACAACTTCA ATGAGGTGCT GGAGGAGTAC CCCATGATGC GAAGGGCCTT CGAGACCGTG
GCGCTGGACC GCCTGGACCG CATTGGCAAG AAGAACTCCA TCCTCCTCCA CAAAGTCCAG
CACGACCTCA ACTCCGGCGT CTTCAACTAC CAGGAGAATG AGATCATCCA GCAGATTGTG
CAGCATGACC GGGAGATGGC CCACTGCGCG CACCGCGTCC AGGCTGCTGC CTCTGCCACC
CCAACCCCCA CGCCCGTCAT CTGGACCCCG CTGATCCAGG CACCACTGCA GGCTGCCGCT
GCCACCACTT CTGTGGCCAT AGCCCTCACC CACCACCCTC GCCTGCCTGC TGCCATCTTC
CGCCCTCCCC CAGGATCTGG GCTGGGCAAC CTCGGTGCCG GGCAGACGCC AAGGCACCTG
AAACGGCTGC AGTCCCTGAT CCCTTCTGCG CTGGGCTCCG CCTCGCCCGC CAGCAGCCCG
TCCCAGGTGG ACACACCGTC TTCATCCTCC TTCCACATCC AACAGCTGGC TGGATTCTCT
GCCCCCGCTG GACTGAGCCC ACTCCTGCCC TCATCCAGCT CCTCCCCACC CCCCGGGGCC
TGTGGCTCCC CCTCGGCTCC CACACCATCA GCTGGCGTAG CCGCCACCAC CATAGCCGGG
TTTGGCCACT TCCACAAGGC GCTGGGTGGC TCCCTGTCCT CCTCCGACTC TCCCCTGCTC
ACCCCGCTGC AGCCAGGCGC CCGCTCCCCG CAGGCTGCCC AGCCATCTCC CGCGCCACCC
GGGGCCCGGG GAGGCCTGGG ACTCCCGGAG CACTTCCTGC CACCCCCACC CTCATCCAGA
TCCCCGTCAT CTAGCCCCGG GCAGCTGGGC CAGCCTCCCG GGGAGTTGTC CCTAGGTCTG
GCCACTGGCC CACTGAGCAC GCCAGAGACA CCCCCACGGC AGCCTGAGCC GCCGTCCCTT
GTGGCAGGGG CCTCTGGGGG GGCTTCCCCT GTAGGCTTTA CTCCCCGAGG AGGTCTCAGC
CCCCCTGGCC ACAGCCCAGG CCCCCCAAGA ACCTTCCCGA GTGCCCCGCC CCGGGCCTCT
GGCTCCCACG GATCCTTGCT CCTGCCACCT GCATCCAGCC CCCCACCACC CCAGGTCCCC
CAGCGCCGGG GCACACCCCC GCTCACCCCC GGCCGCCTCA CCCAGGACCT CAAGCTCATC
TCCGCGTCTC AGCCAGCCCT GCCTCAGGAC GGGGCGCAGA CTCTCCGCAG AGCCTCCCCG
CACTCCTCAG GGGAGTCCAT GGCTGCCTTC CCGCTCTTCC CCAGGGCTGG GGGTGGCAGC
GGGGGCAGTG GGAGCAGCGG GGGCCTCGGT CCCCCTGGGA GGCCCTATGG TGCCATCCCC
GGCCAGCACG TCACTCTGCC TCGGAAGACA TCCTCAGGTT CTTTGCCACC CCCTCTGTCT
TTGTTTGGGG CAAGAGCCAC CTCTTCTGGG GGGCCCCCTC TGACTGCTGG ACCCCAGAGG
GAACCTGGGG CCAGGCCTGA GCCAGTGCGC TCCAAACTGC CATCCAATCT ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18158
Clone ID Related Accession (Same CDS sequence) NM_005477
Accession Version NM_005477.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3612bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ238850.1, AJ132429.1, AC068397.6, BP291686.1 and BM979827.1. This sequence is a reference standard in the RefSeqGene project. On Oct 31, 2008 this sequence version replaced gi:4885406. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ238850.1, AJ132429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTCCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GACGCCGAGG AGGAGGGGGC CGGGGGCCGC
CAAGACCCCA GCCGCAGGAG CATCCGGCTG CGGCCACTGC CCTCGCCCTC CCCCTCGGCG
GCCGCGGGTG GCACGGAGTC CCGGAGCTCG GCCCTCGGGG CAGCGGACAG CGAAGGGCCG
GCCCGCGGCG CGGGCAAGTC CAGCACGAAC GGCGACTGCA GGCGCTTCCG CGGGAGCCTG
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGC GGCGGCACGG GGAGCGGCAG CAGTCACGGA
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG AGGGCGACGC GTCCCCCGGC
GAGGACAGGA CGCCCCCAGG CCTGGCGGCC GAGCCCGAGC GCCCCGGCGC CTCGGCGCAG
CCCGCAGCCT CGCCGCCGCC GCCCCAGCAG CCACCGCAGC CGGCCTCCGC CTCCTGCGAG
CAGCCCTCGG TGGACACCGC TATCAAAGTG GAGGGAGGCG CGGCTGCCGG CGACCAGATC
CTCCCGGAGG CCGAGGTGCG CCTGGGCCAG GCCGGCTTCA TGCAGCGCCA GTTCGGGGCC
ATGCTCCAAC CCGGGGTCAA CAAATTCTCC CTAAGGATGT TCGGCAGCCA GAAAGCCGTG
GAGCGCGAAC AGGAGAGGGT CAAGTCGGCC GGATTTTGGA TTATCCACCC CTACAGTGAC
TTCAGATTTT ACTGGGACCT GACCATGCTG CTGCTGATGG TGGGAAACCT GATTATCATT
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACAC CCTGGATTGT CTTCAATGTG
GTGTCAGACA CATTCTTCCT CATCGACTTG GTCCTCAACT TCCGCACAGG GATCGTGGTG
GAGGACAACA CAGAGATCAT CCTGGACCCG CAGCGGATTA AAATGAAGTA CCTGAAAAGC
TGGTTCATGG TAGATTTCAT TTCCTCCATC CCCGTGGACT ACATCTTCCT CATTGTGGAG
ACACGCATCG ACTCGGAGGT CTACAAGACT GCCCGGGCCC TGCGCATTGT CCGCTTCACG
AAGATCCTCA GCCTCTTACG CCTGTTACGC CTCTCCCGCC TCATTCGATA TATTCACCAG
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGCG CCGTGGTGCG CATCGTGAAC
CTCATCGGCA TGATGCTCCT GCTCTGCCAC TGGGACGGCT GCCTGCAGTT CCTGGTACCC
ATGCTACAGG ACTTCCCTGA CGACTGCTGG GTGTCCATCA ACAACATGGT GAACAACTCC
TGGGGGAAGC AGTACTCCTA CGCGCTCTTC AAGGCCATGA GCCACATGCT GTGCATCGGC
TACGGGCGGC AGGCGCCCGT GGGCATGTCC GACGTCTGGC TCACCATGCT CAGCATGATC
GTGGGTGCCA CCTGCTACGC CATGTTCATT GGCCACGCCA CTGCCCTCAT CCAGTCCCTG
GACTCCTCCC GGCGCCAGTA CCAGGAAAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTT
CACAAGCTCC CGCCCGACAC CCGGCAGCGC ATCCACGACT ACTACGAGCA CCGCTACCAG
GGCAAGATGT TCGACGAGGA GAGCATCCTG GGCGAGCTAA GCGAGCCCCT GCGGGAGGAG
ATCATCAACT TTAACTGTCG GAAGCTGGTG GCCTCCATGC CACTGTTTGC CAATGCGGAC
CCCAACTTCG TGACGTCCAT GCTGACCAAG CTGCGTTTCG AGGTCTTCCA GCCTGGGGAC
TACATCATCC GGGAAGGCAC CATTGGCAAG AAGATGTACT TCATCCAGCA TGGCGTGGTC
AGCGTGCTCA CCAAGGGCAA CAAGGAGACC AAGCTGGCCG ACGGCTCCTA CTTTGGAGAG
ATCTGCCTGC TGACCCGGGG CCGGCGCACA GCCAGCGTGA GGGCCGACAC CTACTGCCGC
CTCTACTCGC TGAGCGTGGA CAACTTCAAT GAGGTGCTGG AGGAGTACCC CATGATGCGA
AGGGCCTTCG AGACCGTGGC GCTGGACCGC CTGGACCGCA TTGGCAAGAA GAACTCCATC
CTCCTCCACA AAGTCCAGCA CGACCTCAAC TCCGGCGTCT TCAACTACCA GGAGAATGAG
ATCATCCAGC AGATTGTGCA GCATGACCGG GAGATGGCCC ACTGCGCGCA CCGCGTCCAG
GCTGCTGCCT CTGCCACCCC AACCCCCACG CCCGTCATCT GGACCCCGCT GATCCAGGCA
CCACTGCAGG CTGCCGCTGC CACCACTTCT GTGGCCATAG CCCTCACCCA CCACCCTCGC
CTGCCTGCTG CCATCTTCCG CCCTCCCCCA GGATCTGGGC TGGGCAACCT CGGTGCCGGG
CAGACGCCAA GGCACCTGAA ACGGCTGCAG TCCCTGATCC CTTCTGCGCT GGGCTCCGCC
TCGCCCGCCA GCAGCCCGTC CCAGGTGGAC ACACCGTCTT CATCCTCCTT CCACATCCAA
CAGCTGGCTG GATTCTCTGC CCCCGCTGGA CTGAGCCCAC TCCTGCCCTC ATCCAGCTCC
TCCCCACCCC CCGGGGCCTG TGGCTCCCCC TCGGCTCCCA CACCATCAGC TGGCGTAGCC
GCCACCACCA TAGCCGGGTT TGGCCACTTC CACAAGGCGC TGGGTGGCTC CCTGTCCTCC
TCCGACTCTC CCCTGCTCAC CCCGCTGCAG CCAGGCGCCC GCTCCCCGCA GGCTGCCCAG
CCATCTCCCG CGCCACCCGG GGCCCGGGGA GGCCTGGGAC TCCCGGAGCA CTTCCTGCCA
CCCCCACCCT CATCCAGATC CCCGTCATCT AGCCCCGGGC AGCTGGGCCA GCCTCCCGGG
GAGTTGTCCC TAGGTCTGGC CACTGGCCCA CTGAGCACGC CAGAGACACC CCCACGGCAG
CCTGAGCCGC CGTCCCTTGT GGCAGGGGCC TCTGGGGGGG CTTCCCCTGT AGGCTTTACT
CCCCGAGGAG GTCTCAGCCC CCCTGGCCAC AGCCCAGGCC CCCCAAGAAC CTTCCCGAGT
GCCCCGCCCC GGGCCTCTGG CTCCCACGGA TCCTTGCTCC TGCCACCTGC ATCCAGCCCC
CCACCACCCC AGGTCCCCCA GCGCCGGGGC ACACCCCCGC TCACCCCCGG CCGCCTCACC
CAGGACCTCA AGCTCATCTC CGCGTCTCAG CCAGCCCTGC CTCAGGACGG GGCGCAGACT
CTCCGCAGAG CCTCCCCGCA CTCCTCAGGG GAGTCCATGG CTGCCTTCCC GCTCTTCCCC
AGGGCTGGGG GTGGCAGCGG GGGCAGTGGG AGCAGCGGGG GCCTCGGTCC CCCTGGGAGG
CCCTATGGTG CCATCCCCGG CCAGCACGTC ACTCTGCCTC GGAAGACATC CTCAGGTTCT
TTGCCACCCC CTCTGTCTTT GTTTGGGGCA AGAGCCACCT CTTCTGGGGG GCCCCCTCTG
ACTGCTGGAC CCCAGAGGGA ACCTGGGGCC AGGCCTGAGC CAGTGCGCTC CAAACTGCCA
TCCAATCTAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005468.1
CDS995..4606
Misc Feature(1)866..868(+)
Misc Feature(2)1619..1774(+)
Misc Feature(3)1643..1873(+)
Misc Feature(4)1793..1855(+)
Misc Feature(5)1874..1936(+)
Misc Feature(6)1883..2527(+)
Misc Feature(7)2015..2077(+)
Misc Feature(8)2099..2161(+)
Misc Feature(9)2255..2317(+)
Misc Feature(10)2483..2545(+)
Misc Feature(11)2759..>3166(+)
Misc Feature(12)2777..3103(+)
Misc Feature(13)2969..3007(+)
Misc Feature(14)3065..3091(+)
Exon (1)1..1779
Gene:HCN4
Gene Synonym:
Exon (2)1780..2203
Gene:HCN4
Gene Synonym:
Exon (3)2204..2365
Gene:HCN4
Gene Synonym:
Exon (4)2366..2584
Gene:HCN4
Gene Synonym:
Exon (5)2585..2731
Gene:HCN4
Gene Synonym:
Exon (6)2732..2972
Gene:HCN4
Gene Synonym:
Exon (7)2973..3137
Gene:HCN4
Gene Synonym:
Exon (8)3138..7228
Gene:HCN4
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005477
Organism Homo sapiens (human)
Definition Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005477

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTCCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GACGCCGAGG AGGAGGGGGC CGGGGGCCGC
CAAGACCCCA GCCGCAGGAG CATCCGGCTG CGGCCACTGC CCTCGCCCTC CCCCTCGGCG
GCCGCGGGTG GCACGGAGTC CCGGAGCTCG GCCCTCGGGG CAGCGGACAG CGAAGGGCCG
GCCCGCGGCG CGGGCAAGTC CAGCACGAAC GGCGACTGCA GGCGCTTCCG CGGGAGCCTG
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGC GGCGGCACGG GGAGCGGCAG CAGTCACGGA
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG AGGGCGACGC GTCCCCCGGC
GAGGACAGGA CGCCCCCAGG CCTGGCGGCC GAGCCCGAGC GCCCCGGCGC CTCGGCGCAG
CCCGCAGCCT CGCCGCCGCC GCCCCAGCAG CCACCGCAGC CGGCCTCCGC CTCCTGCGAG
CAGCCCTCGG TGGACACCGC TATCAAAGTG GAGGGAGGCG CGGCTGCCGG CGACCAGATC
CTCCCGGAGG CCGAGGTGCG CCTGGGCCAG GCCGGCTTCA TGCAGCGCCA GTTCGGGGCC
ATGCTCCAAC CCGGGGTCAA CAAATTCTCC CTAAGGATGT TCGGCAGCCA GAAAGCCGTG
GAGCGCGAAC AGGAGAGGGT CAAGTCGGCC GGATTTTGGA TTATCCACCC CTACAGTGAC
TTCAGATTTT ACTGGGACCT GACCATGCTG CTGCTGATGG TGGGAAACCT GATTATCATT
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACAC CCTGGATTGT CTTCAATGTG
GTGTCAGACA CATTCTTCCT CATCGACTTG GTCCTCAACT TCCGCACAGG GATCGTGGTG
GAGGACAACA CAGAGATCAT CCTGGACCCG CAGCGGATTA AAATGAAGTA CCTGAAAAGC
TGGTTCATGG TAGATTTCAT TTCCTCCATC CCCGTGGACT ACATCTTCCT CATTGTGGAG
ACACGCATCG ACTCGGAGGT CTACAAGACT GCCCGGGCCC TGCGCATTGT CCGCTTCACG
AAGATCCTCA GCCTCTTACG CCTGTTACGC CTCTCCCGCC TCATTCGATA TATTCACCAG
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGCG CCGTGGTGCG CATCGTGAAC
CTCATCGGCA TGATGCTCCT GCTCTGCCAC TGGGACGGCT GCCTGCAGTT CCTGGTACCC
ATGCTACAGG ACTTCCCTGA CGACTGCTGG GTGTCCATCA ACAACATGGT GAACAACTCC
TGGGGGAAGC AGTACTCCTA CGCGCTCTTC AAGGCCATGA GCCACATGCT GTGCATCGGC
TACGGGCGGC AGGCGCCCGT GGGCATGTCC GACGTCTGGC TCACCATGCT CAGCATGATC
GTGGGTGCCA CCTGCTACGC CATGTTCATT GGCCACGCCA CTGCCCTCAT CCAGTCCCTG
GACTCCTCCC GGCGCCAGTA CCAGGAAAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTT
CACAAGCTCC CGCCCGACAC CCGGCAGCGC ATCCACGACT ACTACGAGCA CCGCTACCAG
GGCAAGATGT TCGACGAGGA GAGCATCCTG GGCGAGCTAA GCGAGCCCCT GCGGGAGGAG
ATCATCAACT TTAACTGTCG GAAGCTGGTG GCCTCCATGC CACTGTTTGC CAATGCGGAC
CCCAACTTCG TGACGTCCAT GCTGACCAAG CTGCGTTTCG AGGTCTTCCA GCCTGGGGAC
TACATCATCC GGGAAGGCAC CATTGGCAAG AAGATGTACT TCATCCAGCA TGGCGTGGTC
AGCGTGCTCA CCAAGGGCAA CAAGGAGACC AAGCTGGCCG ACGGCTCCTA CTTTGGAGAG
ATCTGCCTGC TGACCCGGGG CCGGCGCACA GCCAGCGTGA GGGCCGACAC CTACTGCCGC
CTCTACTCGC TGAGCGTGGA CAACTTCAAT GAGGTGCTGG AGGAGTACCC CATGATGCGA
AGGGCCTTCG AGACCGTGGC GCTGGACCGC CTGGACCGCA TTGGCAAGAA GAACTCCATC
CTCCTCCACA AAGTCCAGCA CGACCTCAAC TCCGGCGTCT TCAACTACCA GGAGAATGAG
ATCATCCAGC AGATTGTGCA GCATGACCGG GAGATGGCCC ACTGCGCGCA CCGCGTCCAG
GCTGCTGCCT CTGCCACCCC AACCCCCACG CCCGTCATCT GGACCCCGCT GATCCAGGCA
CCACTGCAGG CTGCCGCTGC CACCACTTCT GTGGCCATAG CCCTCACCCA CCACCCTCGC
CTGCCTGCTG CCATCTTCCG CCCTCCCCCA GGATCTGGGC TGGGCAACCT CGGTGCCGGG
CAGACGCCAA GGCACCTGAA ACGGCTGCAG TCCCTGATCC CTTCTGCGCT GGGCTCCGCC
TCGCCCGCCA GCAGCCCGTC CCAGGTGGAC ACACCGTCTT CATCCTCCTT CCACATCCAA
CAGCTGGCTG GATTCTCTGC CCCCGCTGGA CTGAGCCCAC TCCTGCCCTC ATCCAGCTCC
TCCCCACCCC CCGGGGCCTG TGGCTCCCCC TCGGCTCCCA CACCATCAGC TGGCGTAGCC
GCCACCACCA TAGCCGGGTT TGGCCACTTC CACAAGGCGC TGGGTGGCTC CCTGTCCTCC
TCCGACTCTC CCCTGCTCAC CCCGCTGCAG CCAGGCGCCC GCTCCCCGCA GGCTGCCCAG
CCATCTCCCG CGCCACCCGG GGCCCGGGGA GGCCTGGGAC TCCCGGAGCA CTTCCTGCCA
CCCCCACCCT CATCCAGATC CCCGTCATCT AGCCCCGGGC AGCTGGGCCA GCCTCCCGGG
GAGTTGTCCC TAGGTCTGGC CACTGGCCCA CTGAGCACGC CAGAGACACC CCCACGGCAG
CCTGAGCCGC CGTCCCTTGT GGCAGGGGCC TCTGGGGGGG CTTCCCCTGT AGGCTTTACT
CCCCGAGGAG GTCTCAGCCC CCCTGGCCAC AGCCCAGGCC CCCCAAGAAC CTTCCCGAGT
GCCCCGCCCC GGGCCTCTGG CTCCCACGGA TCCTTGCTCC TGCCACCTGC ATCCAGCCCC
CCACCACCCC AGGTCCCCCA GCGCCGGGGC ACACCCCCGC TCACCCCCGG CCGCCTCACC
CAGGACCTCA AGCTCATCTC CGCGTCTCAG CCAGCCCTGC CTCAGGACGG GGCGCAGACT
CTCCGCAGAG CCTCCCCGCA CTCCTCAGGG GAGTCCATGG CTGCCTTCCC GCTCTTCCCC
AGGGCTGGGG GTGGCAGCGG GGGCAGTGGG AGCAGCGGGG GCCTCGGTCC CCCTGGGAGG
CCCTATGGTG CCATCCCCGG CCAGCACGTC ACTCTGCCTC GGAAGACATC CTCAGGTTCT
TTGCCACCCC CTCTGTCTTT GTTTGGGGCA AGAGCCACCT CTTCTGGGGG GCCCCCTCTG
ACTGCTGGAC CCCAGAGGGA ACCTGGGGCC AGGCCTGAGC CAGTGCGCTC CAAACTGCCA
TCCAATCTAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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