This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE PLoS genetics7(4)e1002033(2011 Apr)
Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
The following SCAMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCAMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
secretory carrier-associated membrane protein 2 isoform 2
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091230.23, BC004385.1 and R59393.1. On Mar 5, 2016 this sequence version replaced NM_005697.3.
Transcript Variant: This variant (2) lacks a exon in the central coding region compared to variant 1. The encoded isoform (2) is sorter than isoform 2.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163655.250030.1, SRR1163655.385152.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
secretory carrier-associated membrane protein 2 isoform 2
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091230.23, BC004385.1 and R59393.1. On Nov 23, 2018 this sequence version replaced NM_005697.4.
Transcript Variant: This variant (2) lacks a exon in the central coding region compared to variant 1. The encoded isoform (2) is sorter than isoform 2.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR3476690.8622.1, SRR3476690.142249.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000268099.13/ ENSP00000268099.9
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: full length.
secretory carrier-associated membrane protein 2 isoform 1
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091230.23, CD300387.1, AK291884.1 and R59393.1. On Mar 5, 2016 this sequence version replaced XM_006720369.1.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803615.169456.1, ERR279834.1951.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
secretory carrier-associated membrane protein 2 isoform 1
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091230.23, CD300387.1, AK291884.1 and R59393.1. On May 31, 2019 this sequence version replaced NM_001320778.1.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803615.169456.1, SRR1803615.349257.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
secretory carrier-associated membrane protein 2 isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
User Manual
NM_005697.4
