ANGPTL7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANGPTL7
Entrez Gene ID	10218
Full Name	angiopoietin like 7
Synonyms	AngX,CDT6,dJ647M16.1
General protein information	Preferred Names angiopoietin like 7 Names angiopoietin-related protein 7 angiopoietin-like factor (CDT6) angiopoietin-like protein 7 cornea-derived transcript 6 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.22

mRNA and Protein(s)

mRNA	Protein	Name
NM_021146.3	NP_066969.1	angiopoietin-related protein 7 precursor
XM_017000004.1	XP_016855493.1	angiopoietin-related protein 7 isoform X1
NM_021146.4	NP_066969.1	angiopoietin-related protein 7 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANGPTL7	NP_066969.1
	ANGPTL7	XP_001103825.1
Bos taurus (cattle)	ANGPTL7	NP_001014909.1
Gallus gallus (chicken)	ANGPTL7	XP_004947524.1
Xenopus tropicalis (tropical clawed frog)	angptl7	NP_001096248.1
Canis lupus familiaris (dog)	ANGPTL7	XP_852356.1
Mus musculus (house mouse)	Angptl7	NP_001034643.1
Pan troglodytes (chimpanzee)	ANGPTL7	XP_001137075.1
Rattus norvegicus (Norway rat)	LOC102552055	XP_006239486.1
Danio rerio (zebrafish)	angptl7	NP_001006073.1

Gene Ontology
Bibliography

Related articles in PubMed

Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise.
Abu-Farha M, Cherian P, Al-Khairi I, Madhu D, Tiss A, Warsam S, Alhubail A, Sriraman D, Al-Refaei F, Abubaker J
PloS one12(3)e0173024(2017)

Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells.
Lim SY, Gordon-Weeks A, Allen D, Kersemans V, Beech J, Smart S, Muschel RJ
Hepatology (Baltimore, Md.)62(2)521-33(2015 Aug)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea.
Toyono T, Usui T, Yokoo S, Taketani Y, Nakagawa S, Kuroda M, Yamagami S, Amano S
PloS one10(1)e0116838(2015)

Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer.
Parri M, Pietrovito L, Grandi A, Campagnoli S, De Camilli E, Bianchini F, Marchi? S, Bussolino F, Jin B, Sarmientos P, Grandi G, Viale G, Pileri P, Chiarugi P, Grifantini R
Angiogenesis17(4)881-96(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

obesity increases the level of ANGPTL7 in both plasma and adipose tissue. Increased expression of ANGPTL7 might play a minor role in the regulation of TG level in obese subjects either directly or through interaction with other ANGPTL protein members. Physical exercise reduced the level of ANGPTL7 highlighting the potential for targeting this protein as a therapeutic target for regulating dyslipidemia.
Title: Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise.

ANGPTL7 is markedly down regulated in metastatic liver cancer.
Title: Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells.

ANGPTL7, which is abundantly expressed in keratocytes, plays a major role in maintaining corneal avascularity and transparency.
Title: Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea.

Angiopoietin-like 7 is a novel pro-angiogenetic factor over-expressed in cancer
Title: Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer.

Together with previous findings, these properties strengthen ANGPTL7's candidacy for the regulation of intraocular pressure and glaucoma.
Title: Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma.

The following ANGPTL7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANGPTL7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14364	NM_021146.4 Latest version!	Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu82981	XM_017000004.1 Latest version!	Homo sapiens angiopoietin like 7 (ANGPTL7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu14364	NM_021146.3	Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANGPTL7 ( NM_021146.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066969.1 Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.

Price & Availability↑

CloneID	OHu14364
Clone ID Related Accession (Same CDS sequence)	NM_021146.3 , NM_021146.4
Accession Version	NM_021146.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	angiopoietin-related protein 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA391009.1 and BC001881.1. On May 14, 2013 this sequence version replaced NM_021146.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001881.1, AB593027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAAAA AGCCTCTCTC AGCTGTGACC TGGCTCTGCA TTTTCATCGT GGCCTTTGTC 
AGCCACCCAG CGTGGCTGCA GAAGCTCTCT AAGCACAAGA CACCAGCACA GCCACAGCTC 
AAAGCGGCCA ACTGCTGTGA GGAGGTGAAG GAGCTCAAGG CCCAAGTTGC CAACCTTAGC 
AGCCTGCTGA GTGAACTGAA CAAGAAGCAG GAGAGGGACT GGGTCAGCGT GGTCATGCAG 
GTGATGGAGC TGGAGAGCAA CAGCAAGCGC ATGGAGTCGC GGCTCACAGA TGCTGAGAGC 
AAGTACTCCG AGATGAACAA CCAAATTGAC ATCATGCAGC TGCAGGCAGC ACAGACGGTC 
ACTCAGACCT CCGCAGATGC CATCTACGAC TGCTCTTCCC TCTACCAGAA GAACTACCGC 
ATCTCTGGAG TGTATAAGCT TCCTCCTGAT GACTTCCTGG GCAGCCCTGA ACTGGAGGTG 
TTCTGTGACA TGGAGACTTC AGGCGGAGGC TGGACCATCA TCCAGAGACG AAAAAGTGGC 
CTTGTCTCCT TCTACCGGGA CTGGAAGCAG TACAAGCAGG GCTTTGGCAG CATCCGTGGG 
GACTTCTGGC TGGGGAACGA ACACATCCAC CGGCTCTCCA GACAGCCAAC CCGGCTGCGT 
GTAGAGATGG AGGACTGGGA GGGCAACCTG CGCTACGCTG AGTATAGCCA CTTTGTTTTG 
GGCAATGAAC TCAACAGCTA TCGCCTCTTC CTGGGGAACT ACACTGGCAA TGTGGGGAAC 
GACGCCCTCC AGTATCATAA CAACACAGCC TTCAGCACCA AGGACAAGGA CAATGACAAC 
TGCTTGGACA AGTGTGCACA GCTCCGCAAA GGTGGCTACT GGTACAACTG CTGCACAGAC 
TCCAACCTCA ATGGAGTGTA CTACCGCCTG GGTGAGCACA ATAAGCACCT GGATGGCATC 
ACCTGGTATG GCTGGCATGG ATCTACCTAC TCCCTCAAAC GGGTGGAGAT GAAAATCCGC 
CCAGAAGACT TCAAGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066969.1
CDS	292..1332
Translation	MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKP

Target ORF information:

RefSeq Version	NM_021146.3
Organism	Homo sapiens(human)
Definition	Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021146.3

ORF Insert Sequence:

ATGCTGAAAA AGCCTCTCTC AGCTGTGACC TGGCTCTGCA TTTTCATCGT GGCCTTTGTC 
AGCCACCCAG CGTGGCTGCA GAAGCTCTCT AAGCACAAGA CACCAGCACA GCCACAGCTC 
AAAGCGGCCA ACTGCTGTGA GGAGGTGAAG GAGCTCAAGG CCCAAGTTGC CAACCTTAGC 
AGCCTGCTGA GTGAACTGAA CAAGAAGCAG GAGAGGGACT GGGTCAGCGT GGTCATGCAG 
GTGATGGAGC TGGAGAGCAA CAGCAAGCGC ATGGAGTCGC GGCTCACAGA TGCTGAGAGC 
AAGTACTCCG AGATGAACAA CCAAATTGAC ATCATGCAGC TGCAGGCAGC ACAGACGGTC 
ACTCAGACCT CCGCAGATGC CATCTACGAC TGCTCTTCCC TCTACCAGAA GAACTACCGC 
ATCTCTGGAG TGTATAAGCT TCCTCCTGAT GACTTCCTGG GCAGCCCTGA ACTGGAGGTG 
TTCTGTGACA TGGAGACTTC AGGCGGAGGC TGGACCATCA TCCAGAGACG AAAAAGTGGC 
CTTGTCTCCT TCTACCGGGA CTGGAAGCAG TACAAGCAGG GCTTTGGCAG CATCCGTGGG 
GACTTCTGGC TGGGGAACGA ACACATCCAC CGGCTCTCCA GACAGCCAAC CCGGCTGCGT 
GTAGAGATGG AGGACTGGGA GGGCAACCTG CGCTACGCTG AGTATAGCCA CTTTGTTTTG 
GGCAATGAAC TCAACAGCTA TCGCCTCTTC CTGGGGAACT ACACTGGCAA TGTGGGGAAC 
GACGCCCTCC AGTATCATAA CAACACAGCC TTCAGCACCA AGGACAAGGA CAATGACAAC 
TGCTTGGACA AGTGTGCACA GCTCCGCAAA GGTGGCTACT GGTACAACTG CTGCACAGAC 
TCCAACCTCA ATGGAGTGTA CTACCGCCTG GGTGAGCACA ATAAGCACCT GGATGGCATC 
ACCTGGTATG GCTGGCATGG ATCTACCTAC TCCCTCAAAC GGGTGGAGAT GAAAATCCGC 
CCAGAAGACT TCAAGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANGPTL7 ( NM_021146.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066969.1 Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.

Price & Availability↑

CloneID	OHu14364
Clone ID Related Accession (Same CDS sequence)	NM_021146.3 , NM_021146.4
Accession Version	NM_021146.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	angiopoietin-related protein 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC001881.1. On Nov 23, 2018 this sequence version replaced NM_021146.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001881.1, AY358301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376819.4/ ENSP00000366015.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAAAA AGCCTCTCTC AGCTGTGACC TGGCTCTGCA TTTTCATCGT GGCCTTTGTC 
AGCCACCCAG CGTGGCTGCA GAAGCTCTCT AAGCACAAGA CACCAGCACA GCCACAGCTC 
AAAGCGGCCA ACTGCTGTGA GGAGGTGAAG GAGCTCAAGG CCCAAGTTGC CAACCTTAGC 
AGCCTGCTGA GTGAACTGAA CAAGAAGCAG GAGAGGGACT GGGTCAGCGT GGTCATGCAG 
GTGATGGAGC TGGAGAGCAA CAGCAAGCGC ATGGAGTCGC GGCTCACAGA TGCTGAGAGC 
AAGTACTCCG AGATGAACAA CCAAATTGAC ATCATGCAGC TGCAGGCAGC ACAGACGGTC 
ACTCAGACCT CCGCAGATGC CATCTACGAC TGCTCTTCCC TCTACCAGAA GAACTACCGC 
ATCTCTGGAG TGTATAAGCT TCCTCCTGAT GACTTCCTGG GCAGCCCTGA ACTGGAGGTG 
TTCTGTGACA TGGAGACTTC AGGCGGAGGC TGGACCATCA TCCAGAGACG AAAAAGTGGC 
CTTGTCTCCT TCTACCGGGA CTGGAAGCAG TACAAGCAGG GCTTTGGCAG CATCCGTGGG 
GACTTCTGGC TGGGGAACGA ACACATCCAC CGGCTCTCCA GACAGCCAAC CCGGCTGCGT 
GTAGAGATGG AGGACTGGGA GGGCAACCTG CGCTACGCTG AGTATAGCCA CTTTGTTTTG 
GGCAATGAAC TCAACAGCTA TCGCCTCTTC CTGGGGAACT ACACTGGCAA TGTGGGGAAC 
GACGCCCTCC AGTATCATAA CAACACAGCC TTCAGCACCA AGGACAAGGA CAATGACAAC 
TGCTTGGACA AGTGTGCACA GCTCCGCAAA GGTGGCTACT GGTACAACTG CTGCACAGAC 
TCCAACCTCA ATGGAGTGTA CTACCGCCTG GGTGAGCACA ATAAGCACCT GGATGGCATC 
ACCTGGTATG GCTGGCATGG ATCTACCTAC TCCCTCAAAC GGGTGGAGAT GAAAATCCGC 
CCAGAAGACT TCAAGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066969.1
CDS	226..1266
Translation	MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKP

Target ORF information:

RefSeq Version	NM_021146.4
Organism	Homo sapiens(human)
Definition	Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021146.4

ORF Insert Sequence:

ATGCTGAAAA AGCCTCTCTC AGCTGTGACC TGGCTCTGCA TTTTCATCGT GGCCTTTGTC 
AGCCACCCAG CGTGGCTGCA GAAGCTCTCT AAGCACAAGA CACCAGCACA GCCACAGCTC 
AAAGCGGCCA ACTGCTGTGA GGAGGTGAAG GAGCTCAAGG CCCAAGTTGC CAACCTTAGC 
AGCCTGCTGA GTGAACTGAA CAAGAAGCAG GAGAGGGACT GGGTCAGCGT GGTCATGCAG 
GTGATGGAGC TGGAGAGCAA CAGCAAGCGC ATGGAGTCGC GGCTCACAGA TGCTGAGAGC 
AAGTACTCCG AGATGAACAA CCAAATTGAC ATCATGCAGC TGCAGGCAGC ACAGACGGTC 
ACTCAGACCT CCGCAGATGC CATCTACGAC TGCTCTTCCC TCTACCAGAA GAACTACCGC 
ATCTCTGGAG TGTATAAGCT TCCTCCTGAT GACTTCCTGG GCAGCCCTGA ACTGGAGGTG 
TTCTGTGACA TGGAGACTTC AGGCGGAGGC TGGACCATCA TCCAGAGACG AAAAAGTGGC 
CTTGTCTCCT TCTACCGGGA CTGGAAGCAG TACAAGCAGG GCTTTGGCAG CATCCGTGGG 
GACTTCTGGC TGGGGAACGA ACACATCCAC CGGCTCTCCA GACAGCCAAC CCGGCTGCGT 
GTAGAGATGG AGGACTGGGA GGGCAACCTG CGCTACGCTG AGTATAGCCA CTTTGTTTTG 
GGCAATGAAC TCAACAGCTA TCGCCTCTTC CTGGGGAACT ACACTGGCAA TGTGGGGAAC 
GACGCCCTCC AGTATCATAA CAACACAGCC TTCAGCACCA AGGACAAGGA CAATGACAAC 
TGCTTGGACA AGTGTGCACA GCTCCGCAAA GGTGGCTACT GGTACAACTG CTGCACAGAC 
TCCAACCTCA ATGGAGTGTA CTACCGCCTG GGTGAGCACA ATAAGCACCT GGATGGCATC 
ACCTGGTATG GCTGGCATGG ATCTACCTAC TCCCTCAAAC GGGTGGAGAT GAAAATCCGC 
CCAGAAGACT TCAAGCCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANGPTL7 ( XM_017000004.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855493.1 Homo sapiens angiopoietin like 7 (ANGPTL7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu82981
Clone ID Related Accession (Same CDS sequence)	XM_017000004.1
Accession Version	XM_017000004.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	angiopoietin-related protein 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAAAA AGCCTCTCTC AGCTGTGACC TGGCTCTGCA TTTTCATCGT GGCCTTTGTC 
AGCCACCCAG CGTGGCTGCA GAAGCTCTCT AAGCACAAGA CACCAGCACA GCCACAGCTC 
AAAGCGGCCA ACTGCTGTGA GGAGGTGAAG GAGCTCAAGG CCCAAGTTGC CAACCTTAGC 
AGCCTGCTGA GTGAACTGAA CAAGAAGCAG GAGAGGGACT GGGTCAGCGT GGTCATGCAG 
GTGATGGAGC TGGAGAGCAA CAGCAAGCGC ATGGAGTCGC GGCTCACAGA TGCTGAGAGC 
AAGTACTCCG AGATGAACAA CCAAATTGAC ATCATGCAGC TGCAGGCAGC ACAGACGGTC 
ACTCAGACCT CCGCAGATGC CATCTACGAC TGCTCTTCCC TCTACCAGAA GAACTACCGC 
ATCTCTGGAG TGTATAAGCT TCCTCCTGAT GACTTCCTGG GCAGCCCTGA ACTGGAGGTG 
TTCTGTGACA TGGAGACTTC AGGCGGAGGC TGGACCATCA TCCAGAGACG AAAAAGTGGC 
CTTGTCTCCT TCTACCGGGA CTGGAAGCAG TACAAGCAGG GCTTTGGCAG CATCCGTGGG 
GACTTCTGGC TGGGGAACGA ACACATCCAC CGGCTCTCCA GACAGCCAAC CCGGCTGCGT 
GTAGAGATGG AGCAGCTCTG TGTGGGATTC AGCAAAAACA TAGCTGCACC TTATAAGCAG 
GAAAGTGAGG AATATAGAAA GAGAGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855493.1
CDS	257..1006
Translation	MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEQLCVGFSKNIAAPYKQESEEYRKRD

Target ORF information:

RefSeq Version	XM_017000004.1
Organism	Homo sapiens(human)
Definition	Homo sapiens angiopoietin like 7 (ANGPTL7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000004.1

ORF Insert Sequence:

ATGCTGAAAA AGCCTCTCTC AGCTGTGACC TGGCTCTGCA TTTTCATCGT GGCCTTTGTC 
AGCCACCCAG CGTGGCTGCA GAAGCTCTCT AAGCACAAGA CACCAGCACA GCCACAGCTC 
AAAGCGGCCA ACTGCTGTGA GGAGGTGAAG GAGCTCAAGG CCCAAGTTGC CAACCTTAGC 
AGCCTGCTGA GTGAACTGAA CAAGAAGCAG GAGAGGGACT GGGTCAGCGT GGTCATGCAG 
GTGATGGAGC TGGAGAGCAA CAGCAAGCGC ATGGAGTCGC GGCTCACAGA TGCTGAGAGC 
AAGTACTCCG AGATGAACAA CCAAATTGAC ATCATGCAGC TGCAGGCAGC ACAGACGGTC 
ACTCAGACCT CCGCAGATGC CATCTACGAC TGCTCTTCCC TCTACCAGAA GAACTACCGC 
ATCTCTGGAG TGTATAAGCT TCCTCCTGAT GACTTCCTGG GCAGCCCTGA ACTGGAGGTG 
TTCTGTGACA TGGAGACTTC AGGCGGAGGC TGGACCATCA TCCAGAGACG AAAAAGTGGC 
CTTGTCTCCT TCTACCGGGA CTGGAAGCAG TACAAGCAGG GCTTTGGCAG CATCCGTGGG 
GACTTCTGGC TGGGGAACGA ACACATCCAC CGGCTCTCCA GACAGCCAAC CCGGCTGCGT 
GTAGAGATGG AGCAGCTCTG TGTGGGATTC AGCAAAAACA TAGCTGCACC TTATAAGCAG 
GAAAGTGAGG AATATAGAAA GAGAGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise.
PloS one12(3)e0173024(2017)
Abu-Farha M,Cherian P,Al-Khairi I,Madhu D,Tiss A,Warsam S,Alhubail A,Sriraman D,Al-Refaei F,Abubaker J

Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells.
Hepatology (Baltimore, Md.)62(2)521-33(2015 Aug)
Lim SY,Gordon-Weeks A,Allen D,Kersemans V,Beech J,Smart S,Muschel RJ

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea.
PloS one10(1)e0116838(2015)
Toyono T,Usui T,Yokoo S,Taketani Y,Nakagawa S,Kuroda M,Yamagami S,Amano S

Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer.
Angiogenesis17(4)881-96(2014 Oct)
Parri M,Pietrovito L,Grandi A,Campagnoli S,De Camilli E,Bianchini F,Marchi? S,Bussolino F,Jin B,Sarmientos P,Grandi G,Viale G,Pileri P,Chiarugi P,Grifantini R

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ANGPTL7 cDNA ORF clone, Homo sapiens(human)

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