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TOMM40 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol TOMM40
Entrez Gene ID 10452
Full Name translocase of outer mitochondrial membrane 40
Synonyms C19orf1,D19S1177E,PER-EC1,PEREC1,TOM40
General protein information
Preferred Names

translocase of outer mitochondrial membrane 40

Names

mitochondrial import receptor subunit TOM40 homolog
mitochondrial outer membrane protein
p38.5
protein Haymaker
translocase of outer membrane 40 kDa subunit homolog
translocase of outer mitochondrial membrane 40 homolog

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

19

19q13.32

Summary The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015].
Disorder MIM:

608061


mRNA and Protein(s)

mRNA Protein Name
NM_001128917.1 NP_001122389.1 mitochondrial import receptor subunit TOM40 homolog
XM_005258411.3 XP_005258468.1 mitochondrial import receptor subunit TOM40 homolog isoform X1
NM_001128916.1 NP_001122388.1 mitochondrial import receptor subunit TOM40 homolog
NM_006114.2 NP_006105.1 mitochondrial import receptor subunit TOM40 homolog



Drosophila melanogaster (fruit fly) tomboy40 NP_610213.1
Saccharomyces cerevisiae (baker's yeast) TOM40 NP_013930.1
Drosophila melanogaster (fruit fly) Tom40 NP_001259313.1
Caenorhabditis elegans (roundworm) tomm-40 NP_495912.1
Kluyveromyces lactis KLLA0F06292g XP_455365.1
Eremothecium gossypii AGOS_AFL183C NP_985367.1
Xenopus tropicalis (tropical clawed frog) tomm40 NP_989125.1
Macaca mulatta (rhesus monkey) TOMM40 XP_001109661.1
Homo sapiens (human) TOMM40 NP_006105.1
Bos taurus (cattle) TOMM40 NP_001068906.1
Rattus norvegicus (Norway rat) Tomm40 NP_997685.1
Danio rerio (zebrafish) tomm40 NP_955908.1
Schizosaccharomyces pombe (fission yeast) tom40 NP_595546.2
Arabidopsis thaliana (thale cress) AT1G50400 NP_175457.1
Canis lupus familiaris (dog) TOMM40 XP_852633.1
Magnaporthe oryzae (rice blast fungus) MGG_08637 XP_003711067.1
Neurospora crassa NCU01179 XP_961545.1
Mus musculus (house mouse) Tomm40 NP_001103218.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP007871 XP_317621.2


Related articles in PubMed

Genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein E.
Lien E, Andersen G, Bao Y, Gordish-Dressman H, Skranes JS, Blackman JA, Vik T
Acta paediatrica (Oslo, Norway : 1992)104(7)701-6(2015 Jul)

The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.
Laczó J, Andel R, Vyhnalek M, Matoska V, Kaplan V, Nedelska Z, Lerch O, Gazova I, Moffat SD, Hort J
Neurobiology of aging36(6)2024-33(2015 Jun)

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis.
Gang Q, Bettencourt C, Machado PM, Fox Z, Brady S, Healy E, Parton M, Holton JL, Hilton-Jones D, Shieh PB, Zanoteli E, De Paepe B, De Bleecker J, Shaibani A, Ripolone M, Violano R, Moggio M, Barohn RJ, Dimachkie MM, Mora M, Mantegazza R, Zanotti S, Hanna MG, Houlden H,
Neurobiology of aging36(4)1766.e1-1766.e3(2015 Apr)

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris SE, Hill WD, Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Assareh AA, Au R, Becker JT, Beiser A, Berr C, Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, De Jager PL, Dufouil C, Eriksson JG, Espeseth T, Faul JD, Ford I, , Gottesman RF, Griswold ME, Gudnason V, Harris TB, Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SL, Kochan N, Knopman DS, Kwok JB, Lambert JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS, Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P, Reppermund S, Rotter JI, Schmidt H, Schuur M, Schofield PW, Scott RJ, Steen VM, Stott DJ, van Swieten JC, Taylor KD, Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF, Wright MJ, Yang Q, Amieva H, Attia JR, Bennett DA, Brodaty H, de Craen AJ, Hayward C, Ikram MA, Lindenberger U, Nilsson LG, Porteous DJ, Räikkönen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R, Schofield PR, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, van Duijn C, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH Jr, Deary IJ
Molecular psychiatry20(2)183-92(2015 Feb)

[TOMM40 gene polymorphism association with lipid profile].
Salakhov RR, Goncharova IA, Makeeva OA, Golubenko MV, Kulish EV, Kashtalap VV, Barbarash OL, Puzyrev VP
Genetika50(2)222-9(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results reveal an association of APOE epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.

meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations
Title: The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer's disease in Caucasian, and Asian populations.

These findings indicated that variants in TOMM40/APOE/APOC1 region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.
Title: Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.

investigate the influence of the TOMM40 intron 6 poly-T variant (rs10524523) on TOMM40 gene expression and cognitive abilities and decline in a cohort of 1613 community-dwelling elderly volunteers
Title: A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging.

Our results do not support the notion that TOMM40 poly-T repeat variants have independent effects on Parkinson's disease with dementia and Dementia with Lewy bodies pathology
Title: Associations between TOMM40 Poly-T Repeat Variants and Dementia in Cases with Parkinsonism.

The following TOMM40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOMM40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu16384 NM_001128916.1
Latest version!
Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$149.50-$209.30
$299.00
OHu16384 NM_006114.2
Latest version!
Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$149.50-$209.30
$299.00
OHu16384 NM_001128917.1
Latest version!
Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$149.50-$209.30
$299.00
OHu51947 XM_005258411.3
Latest version!
Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16384
Clone ID Related Accession (Same CDS sequence) NM_001128917.1 , NM_001128916.1 , NM_006114.2
Accession Version NM_001128917.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1086bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-04
Organism Homo sapiens(Human)
Product mitochondrial import receptor subunit TOM40 homolog
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP265648.1, BC001779.1 and BC017224.2. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017224.2, SRR1163658.312031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGCTC TGTGGATAGC
AACTGGATCG TGGGTGCCAC GCTGGAGAAG AAGCTCCCAC CCCTGCCCCT GACACTGGCC
CTTGGGGCCT TCCTGAATCA CCGCAAGAAC AAGTTTCAGT GTGGCTTTGG CCTCACCATC
GGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001122389.1
CDS197..1282
Misc Feature(1)185..187
Misc Feature(2)425..1279
Exon (1)1..470
Exon (2)471..538
Exon (3)539..631
Exon (4)632..733
Exon (5)734..839
Exon (6)840..962
Exon (7)963..1039
Exon (8)1040..1142
Exon (9)1143..1802
Translation

Target ORF information:

RefSeq Version NM_001128917.1
Organism Homo sapiens(Human)
Definition Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001128917.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGCTC TGTGGATAGC
AACTGGATCG TGGGTGCCAC GCTGGAGAAG AAGCTCCCAC CCCTGCCCCT GACACTGGCC
CTTGGGGCCT TCCTGAATCA CCGCAAGAAC AAGTTTCAGT GTGGCTTTGG CCTCACCATC
GGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16384
Clone ID Related Accession (Same CDS sequence) NM_001128917.1 , NM_001128916.1 , NM_006114.2
Accession Version NM_001128916.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1086bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-04
Organism Homo sapiens(Human)
Product mitochondrial import receptor subunit TOM40 homolog
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP265648.1, BC012134.1 and BC017224.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.244274.1, SRR1163657.139642.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGCTC TGTGGATAGC
AACTGGATCG TGGGTGCCAC GCTGGAGAAG AAGCTCCCAC CCCTGCCCCT GACACTGGCC
CTTGGGGCCT TCCTGAATCA CCGCAAGAAC AAGTTTCAGT GTGGCTTTGG CCTCACCATC
GGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001122388.1
CDS105..1190
Misc Feature(1)333..1187
Exon (1)1..95
Exon (2)96..378
Exon (3)379..446
Exon (4)447..539
Exon (5)540..641
Exon (6)642..747
Exon (7)748..870
Exon (8)871..947
Exon (9)948..1050
Exon (10)1051..1710
Translation

Target ORF information:

RefSeq Version NM_001128916.1
Organism Homo sapiens(Human)
Definition Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001128916.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGCTC TGTGGATAGC
AACTGGATCG TGGGTGCCAC GCTGGAGAAG AAGCTCCCAC CCCTGCCCCT GACACTGGCC
CTTGGGGCCT TCCTGAATCA CCGCAAGAAC AAGTTTCAGT GTGGCTTTGG CCTCACCATC
GGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16384
Clone ID Related Accession (Same CDS sequence) NM_001128917.1 , NM_001128916.1 , NM_006114.2
Accession Version NM_006114.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1086bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-04
Organism Homo sapiens(Human)
Product mitochondrial import receptor subunit TOM40 homolog
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP265648.1, AF043250.1 and BC017224.2. On Jun 27, 2008 this sequence version replaced NM_006114.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF043250.1, SRR1163655.412049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGCTC TGTGGATAGC
AACTGGATCG TGGGTGCCAC GCTGGAGAAG AAGCTCCCAC CCCTGCCCCT GACACTGGCC
CTTGGGGCCT TCCTGAATCA CCGCAAGAAC AAGTTTCAGT GTGGCTTTGG CCTCACCATC
GGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006105.1
CDS102..1187
Misc Feature(1)330..1184
Exon (1)1..95
Exon (2)96..375
Exon (3)376..443
Exon (4)444..536
Exon (5)537..638
Exon (6)639..744
Exon (7)745..867
Exon (8)868..944
Exon (9)945..1047
Exon (10)1048..1707
Translation

Target ORF information:

RefSeq Version NM_006114.2
Organism Homo sapiens(Human)
Definition Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006114.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGCTC TGTGGATAGC
AACTGGATCG TGGGTGCCAC GCTGGAGAAG AAGCTCCCAC CCCTGCCCCT GACACTGGCC
CTTGGGGCCT TCCTGAATCA CCGCAAGAAC AAGTTTCAGT GTGGCTTTGG CCTCACCATC
GGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu51947
Clone ID Related Accession (Same CDS sequence) XM_005258411.3
Accession Version XM_005258411.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1008bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product mitochondrial import receptor subunit TOM40 homolog isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005258411.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGTGC TGGAGGACAG
TGTGCTGCCA CCCTGTGGGC CTCCACATTA CCAGGGAACA CTTGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005258468.1
CDS99..1106
Misc Feature(1)327..1046
Translation

Target ORF information:

RefSeq Version XM_005258411.3
Organism Homo sapiens(Human)
Definition Homo sapiens translocase of outer mitochondrial membrane 40 (TOMM40), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005258411.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGGGAACG TGTTGGCTGC CAGCTCGCCG CCCGCAGGGC CGCCACCGCC GCCTGCGCCG 
GCCCTCGTGG GGCTGCCGCC ACCTCCGCCC TCGCCGCCGG GCTTCACGCT GCCGCCGCTG
GGAGGCAGCC TGGGCGCCGG CACCAGTACG AGTCGAAGTT CGGAACGGAC CCCCGGGGCT
GCAACCGCCA GCGCCTCAGG GGCCGCCGAG GATGGGGCCT GCGGCTGCCT GCCCAACCCG
GGCACATTCG AGGAGTGCCA CCGGAAGTGC AAGGAGCTGT TTCCCATTCA GATGGAGGGT
GTCAAGCTCA CAGTCAACAA AGGGTTGAGT AACCATTTTC AGGTCAACCA CACAGTAGCC
CTCAGCACAA TCGGGGAGTC CAACTACCAC TTCGGGGTCA CATATGTGGG GACAAAGCAG
CTGAGTCCCA CAGAGGCGTT CCCTGTACTG GTGGGTGACA TGGACAACAG TGGCAGTCTC
AACGCTCAGG TCATTCACCA GCTGGGCCCC GGTCTCAGGT CCAAGATGGC CATCCAGACC
CAGCAGTCGA AGTTTGTGAA CTGGCAGGTG GACGGGGAGT ATCGGGGCTC TGACTTCACA
GCAGCCGTCA CCCTGGGGAA CCCAGACGTC CTCGTGGGTT CAGGAATCCT CGTAGCCCAC
TACCTCCAGA GCATCACGCC TTGCCTGGCC CTGGGTGGAG AGCTGGTCTA CCACCGGCGG
CCTGGAGAGG AGGGCACTGT CATGTCTCTA GCTGGGAAAT ACACATTGAA CAACTGGTTG
GCAACGGTAA CGTTGGGCCA GGCGGGCATG CACGCAACAT ACTACCACAA AGCCAGTGAC
CAGCTGCAGG TGGGTGTGGA GTTTGAGGCC AGCACAAGGA TGCAGGACAC CAGCGTCTCC
TTCGGGTACC AGCTGGACCT GCCCAAGGCC AACCTCCTCT TCAAAGGTGC TGGAGGACAG
TGTGCTGCCA CCCTGTGGGC CTCCACATTA CCAGGGAACA CTTGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein E.
Acta paediatrica (Oslo, Norway : 1992)104(7)701-6(2015 Jul)
Lien E,Andersen G,Bao Y,Gordish-Dressman H,Skranes JS,Blackman JA,Vik T


book

The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.
Neurobiology of aging36(6)2024-33(2015 Jun)
Laczó J,Andel R,Vyhnalek M,Matoska V,Kaplan V,Nedelska Z,Lerch O,Gazova I,Moffat SD,Hort J


book

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis.
Neurobiology of aging36(4)1766.e1-1766.e3(2015 Apr)
Gang Q,Bettencourt C,Machado PM,Fox Z,Brady S,Healy E,Parton M,Holton JL,Hilton-Jones D,Shieh PB,Zanoteli E,De Paepe B,De Bleecker J,Shaibani A,Ripolone M,Violano R,Moggio M,Barohn RJ,Dimachkie MM,Mora M,Mantegazza R,Zanotti S,Hanna MG,Houlden H,


book

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
Molecular psychiatry20(2)183-92(2015 Feb)
Davies G,Armstrong N,Bis JC,Bressler J,Chouraki V,Giddaluru S,Hofer E,Ibrahim-Verbaas CA,Kirin M,Lahti J,van der Lee SJ,Le Hellard S,Liu T,Marioni RE,Oldmeadow C,Postmus I,Smith AV,Smith JA,Thalamuthu A,Thomson R,Vitart V,Wang J,Yu L,Zgaga L,Zhao W,Boxall R,Harris SE,Hill WD,Liewald DC,Luciano M,Adams H,Ames D,Amin N,Amouyel P,Assareh AA,Au R,Becker JT,Beiser A,Berr C,Bertram L,Boerwinkle E,Buckley BM,Campbell H,Corley J,De Jager PL,Dufouil C,Eriksson JG,Espeseth T,Faul JD,Ford I,,Gottesman RF,Griswold ME,Gudnason V,Harris TB,Heiss G,Hofman A,Holliday EG,Huffman J,Kardia SL,Kochan N,Knopman DS,Kwok JB,Lambert JC,Lee T,Li G,Li SC,Loitfelder M,Lopez OL,Lundervold AJ,Lundqvist A,Mather KA,Mirza SS,Nyberg L,Oostra BA,Palotie A,Papenberg G,Pattie A,Petrovic K,Polasek O,Psaty BM,Redmond P,Reppermund S,Rotter JI,Schmidt H,Schuur M,Schofield PW,Scott RJ,Steen VM,Stott DJ,van Swieten JC,Taylor KD,Trollor J,Trompet S,Uitterlinden AG,Weinstein G,Widen E,Windham BG,Jukema JW,Wright AF,Wright MJ,Yang Q,Amieva H,Attia JR,Bennett DA,Brodaty H,de Craen AJ,Hayward C,Ikram MA,Lindenberger U,Nilsson LG,Porteous DJ,Räikkönen K,Reinvang I,Rudan I,Sachdev PS,Schmidt R,Schofield PR,Srikanth V,Starr JM,Turner ST,Weir DR,Wilson JF,van Duijn C,Launer L,Fitzpatrick AL,Seshadri S,Mosley TH Jr,Deary IJ


book

[TOMM40 gene polymorphism association with lipid profile].
Genetika50(2)222-9(2014 Feb)
Salakhov RR,Goncharova IA,Makeeva OA,Golubenko MV,Kulish EV,Kashtalap VV,Barbarash OL,Puzyrev VP


 
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