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MAD2L2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAD2L2
Entrez Gene ID 10459
Full Name MAD2 mitotic arrest deficient-like 2 (yeast)
Synonyms MAD2B, POLZ2, REV7
General protein information
Preferred Names
mitotic spindle assembly checkpoint protein MAD2B
Names
mitotic spindle assembly checkpoint protein MAD2B
hREV7
REV7 homolog
MAD2-like protein 2
mitotic arrest deficient homolog-like 2
mitotic arrest deficient 2-like protein 2
polymerase (DNA-directed), zeta 2, accessory subunit
MAD2 (mitotic arrest deficient, yeast, homolog)-like 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36

Summary The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604094


mRNA and Protein(s)

mRNA Protein Name
XM_011540507 XP_011538809 mitotic spindle assembly checkpoint protein MAD2B isoform X1
NM_006341 NP_006332 mitotic spindle assembly checkpoint protein MAD2B
NM_001127325 NP_001120797 mitotic spindle assembly checkpoint protein MAD2B



Homo sapiens (human) MAD2L2 NP_001120797.1
Pan troglodytes (chimpanzee) MAD2L2 XP_001138745.1
Macaca mulatta (Rhesus monkey) MAD2L2 XP_001104002.1
Canis lupus familiaris (dog) MAD2L2 XP_544568.4
Bos taurus (cattle) MAD2L2 NP_001039411.1
Mus musculus (house mouse) Mad2l2 NP_082261.2
Gallus gallus (chicken) MAD2L2 NP_001020749.1
Danio rerio (zebrafish) si:dkey-23c22.2 NP_001017595.1
Danio rerio (zebrafish) LOC557968 XP_685100.1
Arabidopsis thaliana (thale cress) REV7 NP_564002.1
Xenopus (Silurana) tropicalis (western clawed frog) mad2l2 NP_001231770.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAD2L2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAD2L2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17491
XM_011540507 PREDICTED: Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu17491
NM_006341 Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu17491
NM_001127325 Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17491
Clone ID Related Accession (Same CDS sequence) NM_001127325 , NM_006341 , XM_011540507
Accession Version XM_011540507.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 636bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product mitotic spindle assembly checkpoint protein MAD2B isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_032977.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
ATGACCACGC TCACACGACA AGACCTCAAC TTTGGCCAAG TGGTGGCCGA TGTGCTCTGC 
GAGTTCCTGG AGGTGGCTGT GCATCTCATC CTCTACGTGC GCGAGGTCTA CCCCGTGGGC
ATCTTCCAGA AACGCAAGAA GTACAACGTG CCGGTCCAGA TGTCCTGCCA CCCGGAGCTG
AATCAGTATA TCCAGGACAC GCTGCACTGC GTCAAGCCAC TCCTGGAGAA GAATGATGTG
GAGAAAGTGG TGGTGGTGAT TTTGGATAAA GAGCACCGCC CAGTGGAGAA ATTCGTCTTT
GAGATCACCC AGCCTCCACT GCTGTCCATC AGCTCAGACT CGCTGTTGTC TCATGTGGAG
CAGCTGCTCC GGGCCTTCAT CCTGAAGATC AGCGTGTGCG ATGCCGTCCT GGACCACAAC
CCCCCAGGCT GTACCTTCAC AGTCCTGGTG CACACGAGAG AAGCCGCCAC TCGCAACATG
GAGAAGATCC AGGTCATCAA GGATTTCCCC TGGATCCTGG CGGATGAGCA GGATGTCCAC
ATGCATGACC CCCGGCTGAT ACCACTAAAA ACCATGACGT CGGACATTTT AAAGATGCAG
CTTTACGTGG AAGAGCGCGC TCATAAAGGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011538809.1
CDS50..685
Misc Feature(1)86..595(+)
Translation

Target ORF information:

RefSeq Version XM_011540507
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011540507

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGACCACGC TCACACGACA AGACCTCAAC TTTGGCCAAG TGGTGGCCGA TGTGCTCTGC 
GAGTTCCTGG AGGTGGCTGT GCATCTCATC CTCTACGTGC GCGAGGTCTA CCCCGTGGGC
ATCTTCCAGA AACGCAAGAA GTACAACGTG CCGGTCCAGA TGTCCTGCCA CCCGGAGCTG
AATCAGTATA TCCAGGACAC GCTGCACTGC GTCAAGCCAC TCCTGGAGAA GAATGATGTG
GAGAAAGTGG TGGTGGTGAT TTTGGATAAA GAGCACCGCC CAGTGGAGAA ATTCGTCTTT
GAGATCACCC AGCCTCCACT GCTGTCCATC AGCTCAGACT CGCTGTTGTC TCATGTGGAG
CAGCTGCTCC GGGCCTTCAT CCTGAAGATC AGCGTGTGCG ATGCCGTCCT GGACCACAAC
CCCCCAGGCT GTACCTTCAC AGTCCTGGTG CACACGAGAG AAGCCGCCAC TCGCAACATG
GAGAAGATCC AGGTCATCAA GGATTTCCCC TGGATCCTGG CGGATGAGCA GGATGTCCAC
ATGCATGACC CCCGGCTGAT ACCACTAAAA ACCATGACGT CGGACATTTT AAAGATGCAG
CTTTACGTGG AAGAGCGCGC TCATAAAGGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17491
Clone ID Related Accession (Same CDS sequence) NM_001127325 , NM_006341 , XM_011540507
Accession Version NM_006341.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 636bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product mitotic spindle assembly checkpoint protein MAD2B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF157482.1. On May 13, 2008 this sequence version replaced gi:6006019. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF157482.1, AK027327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGACCACGC TCACACGACA AGACCTCAAC TTTGGCCAAG TGGTGGCCGA TGTGCTCTGC 
GAGTTCCTGG AGGTGGCTGT GCATCTCATC CTCTACGTGC GCGAGGTCTA CCCCGTGGGC
ATCTTCCAGA AACGCAAGAA GTACAACGTG CCGGTCCAGA TGTCCTGCCA CCCGGAGCTG
AATCAGTATA TCCAGGACAC GCTGCACTGC GTCAAGCCAC TCCTGGAGAA GAATGATGTG
GAGAAAGTGG TGGTGGTGAT TTTGGATAAA GAGCACCGCC CAGTGGAGAA ATTCGTCTTT
GAGATCACCC AGCCTCCACT GCTGTCCATC AGCTCAGACT CGCTGTTGTC TCATGTGGAG
CAGCTGCTCC GGGCCTTCAT CCTGAAGATC AGCGTGTGCG ATGCCGTCCT GGACCACAAC
CCCCCAGGCT GTACCTTCAC AGTCCTGGTG CACACGAGAG AAGCCGCCAC TCGCAACATG
GAGAAGATCC AGGTCATCAA GGATTTCCCC TGGATCCTGG CGGATGAGCA GGATGTCCAC
ATGCATGACC CCCGGCTGAT ACCACTAAAA ACCATGACGT CGGACATTTT AAAGATGCAG
CTTTACGTGG AAGAGCGCGC TCATAAAGGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006332.3
CDS189..824
Misc Feature(1)39..41(+)
Misc Feature(2)225..734(+)
Misc Feature(3)249..653(+)
Misc Feature(4)636..821(+)
Exon (1)1..176
Gene:MAD2L2
Gene Synonym:
Exon (2)177..228
Gene:MAD2L2
Gene Synonym:
Exon (3)229..347
Gene:MAD2L2
Gene Synonym:
Exon (4)348..419
Gene:MAD2L2
Gene Synonym:
Exon (5)420..520
Gene:MAD2L2
Gene Synonym:
Exon (6)521..615
Gene:MAD2L2
Gene Synonym:
Exon (7)616..689
Gene:MAD2L2
Gene Synonym:
Exon (8)690..782
Gene:MAD2L2
Gene Synonym:
Exon (9)783..1119
Gene:MAD2L2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006341
Organism Homo sapiens (human)
Definition Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006341

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGACCACGC TCACACGACA AGACCTCAAC TTTGGCCAAG TGGTGGCCGA TGTGCTCTGC 
GAGTTCCTGG AGGTGGCTGT GCATCTCATC CTCTACGTGC GCGAGGTCTA CCCCGTGGGC
ATCTTCCAGA AACGCAAGAA GTACAACGTG CCGGTCCAGA TGTCCTGCCA CCCGGAGCTG
AATCAGTATA TCCAGGACAC GCTGCACTGC GTCAAGCCAC TCCTGGAGAA GAATGATGTG
GAGAAAGTGG TGGTGGTGAT TTTGGATAAA GAGCACCGCC CAGTGGAGAA ATTCGTCTTT
GAGATCACCC AGCCTCCACT GCTGTCCATC AGCTCAGACT CGCTGTTGTC TCATGTGGAG
CAGCTGCTCC GGGCCTTCAT CCTGAAGATC AGCGTGTGCG ATGCCGTCCT GGACCACAAC
CCCCCAGGCT GTACCTTCAC AGTCCTGGTG CACACGAGAG AAGCCGCCAC TCGCAACATG
GAGAAGATCC AGGTCATCAA GGATTTCCCC TGGATCCTGG CGGATGAGCA GGATGTCCAC
ATGCATGACC CCCGGCTGAT ACCACTAAAA ACCATGACGT CGGACATTTT AAAGATGCAG
CTTTACGTGG AAGAGCGCGC TCATAAAGGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17491
Clone ID Related Accession (Same CDS sequence) NM_001127325 , NM_006341 , XM_011540507
Accession Version NM_001127325.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 636bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product mitotic spindle assembly checkpoint protein MAD2B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI517654.1 and AF157482.1. Transcript Variant: This variant (1) has the 5'-most first exon. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU175468.1, CN302119.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGACCACGC TCACACGACA AGACCTCAAC TTTGGCCAAG TGGTGGCCGA TGTGCTCTGC 
GAGTTCCTGG AGGTGGCTGT GCATCTCATC CTCTACGTGC GCGAGGTCTA CCCCGTGGGC
ATCTTCCAGA AACGCAAGAA GTACAACGTG CCGGTCCAGA TGTCCTGCCA CCCGGAGCTG
AATCAGTATA TCCAGGACAC GCTGCACTGC GTCAAGCCAC TCCTGGAGAA GAATGATGTG
GAGAAAGTGG TGGTGGTGAT TTTGGATAAA GAGCACCGCC CAGTGGAGAA ATTCGTCTTT
GAGATCACCC AGCCTCCACT GCTGTCCATC AGCTCAGACT CGCTGTTGTC TCATGTGGAG
CAGCTGCTCC GGGCCTTCAT CCTGAAGATC AGCGTGTGCG ATGCCGTCCT GGACCACAAC
CCCCCAGGCT GTACCTTCAC AGTCCTGGTG CACACGAGAG AAGCCGCCAC TCGCAACATG
GAGAAGATCC AGGTCATCAA GGATTTCCCC TGGATCCTGG CGGATGAGCA GGATGTCCAC
ATGCATGACC CCCGGCTGAT ACCACTAAAA ACCATGACGT CGGACATTTT AAAGATGCAG
CTTTACGTGG AAGAGCGCGC TCATAAAGGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001120797.1
CDS222..857
Misc Feature(1)258..767(+)
Misc Feature(2)282..686(+)
Misc Feature(3)669..854(+)
Exon (1)1..209
Gene:MAD2L2
Gene Synonym:
Exon (2)210..261
Gene:MAD2L2
Gene Synonym:
Exon (3)262..380
Gene:MAD2L2
Gene Synonym:
Exon (4)381..452
Gene:MAD2L2
Gene Synonym:
Exon (5)453..553
Gene:MAD2L2
Gene Synonym:
Exon (6)554..648
Gene:MAD2L2
Gene Synonym:
Exon (7)649..722
Gene:MAD2L2
Gene Synonym:
Exon (8)723..815
Gene:MAD2L2
Gene Synonym:
Exon (9)816..1152
Gene:MAD2L2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001127325
Organism Homo sapiens (human)
Definition Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001127325

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGACCACGC TCACACGACA AGACCTCAAC TTTGGCCAAG TGGTGGCCGA TGTGCTCTGC 
GAGTTCCTGG AGGTGGCTGT GCATCTCATC CTCTACGTGC GCGAGGTCTA CCCCGTGGGC
ATCTTCCAGA AACGCAAGAA GTACAACGTG CCGGTCCAGA TGTCCTGCCA CCCGGAGCTG
AATCAGTATA TCCAGGACAC GCTGCACTGC GTCAAGCCAC TCCTGGAGAA GAATGATGTG
GAGAAAGTGG TGGTGGTGAT TTTGGATAAA GAGCACCGCC CAGTGGAGAA ATTCGTCTTT
GAGATCACCC AGCCTCCACT GCTGTCCATC AGCTCAGACT CGCTGTTGTC TCATGTGGAG
CAGCTGCTCC GGGCCTTCAT CCTGAAGATC AGCGTGTGCG ATGCCGTCCT GGACCACAAC
CCCCCAGGCT GTACCTTCAC AGTCCTGGTG CACACGAGAG AAGCCGCCAC TCGCAACATG
GAGAAGATCC AGGTCATCAA GGATTTCCCC TGGATCCTGG CGGATGAGCA GGATGTCCAC
ATGCATGACC CCCGGCTGAT ACCACTAAAA ACCATGACGT CGGACATTTT AAAGATGCAG
CTTTACGTGG AAGAGCGCGC TCATAAAGGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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