ZNHIT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	ZNHIT1
Entrez Gene ID	10467
Full Name	zinc finger HIT-type containing 1
Synonyms	CG1I,ZNFN4A1
General protein information	Preferred Names zinc finger HIT-type containing 1 Names zinc finger HIT domain-containing protein 1 H_DJ0747G18.14 cyclin-G1-binding protein 1 p18 Hamlet p18Hamlet putative cyclin G1 interacting protein zinc finger protein subfamily 4A member 1 zinc finger protein, subfamily 4A (HIT domain containing), member 1 zinc finger, HIT domain containing 1 zinc finger, HIT type 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_006349.3	NP_006340.1	zinc finger HIT domain-containing protein 1
NM_006349.2	NP_006340.1	zinc finger HIT domain-containing protein 1
XM_011515739.2	XP_011514041.1	zinc finger HIT domain-containing protein 1 isoform X1

Pathways from BioSystems

Homologies

	ZNHIT1	XP_001107951.1
Rattus norvegicus (Norway rat)	Znhit1	NP_001258279.1
Danio rerio (zebrafish)	znhit1	NP_001017401.1
Caenorhabditis elegans (roundworm)	zhit-1	NP_001122894.1
Xenopus tropicalis (tropical clawed frog)	znhit1	NP_001017056.2
Canis lupus familiaris (dog)	ZNHIT1	XP_536855.2
Drosophila melanogaster (fruit fly)	CG31917	NP_608895.1
Pan troglodytes (chimpanzee)	ZNHIT1	XP_527843.2
Mus musculus (house mouse)	Znhit1	NP_081594.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007853	XP_317641.2
Homo sapiens (human)	ZNHIT1	NP_006340.1
Bos taurus (cattle)	ZNHIT1	NP_001039650.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A
Nature505(7485)648-53(2014 Jan)

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Mu?oz-Canoves P, Nebreda AR
The EMBO journal29(12)2014-25(2010 Jun)

Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
Journal of proteome research7(9)3879-89(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study reports that p18(Hamlet) can also mediate the cell cycle arrest induced in response to gamma-irradiation, by participating in the p53-dependent upregulation of the cell cycle inhibitor p21(Cip1) (CDKN1A).
Title: p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents.

p18(Hamlet) is a new cell-fate regulator that links the p38 MAPK and p53 pathways and contributes to the establishment of p53-regulated stress responses.
Title: A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.

The following ZNHIT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZNHIT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30321	NM_006349.3 Latest version!	Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu64043	XM_011515739.2 Latest version!	Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30321	NM_006349.2	Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZNHIT1 ( NM_006349.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006340.1 Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.

Price & Availability↑

CloneID	OHu30321
Clone ID Related Accession (Same CDS sequence)	NM_006349.3 , NM_006349.2
Accession Version	NM_006349.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC017333.2 and BC001877.1. On Nov 22, 2018 this sequence version replaced NM_006349.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001877.1, BC017333.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305105.3/ ENSP00000304593.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGAGA AGAAAACTTC GGTTCGCTCC CAGGACCCCG GGCAGCGGCG GGTGCTGGAC 
CGGGCTGCCC GGCAGCGTCG CATCAACCGG CAGCTGGAGG CCCTGGAGAA TGACAACTTC 
CAGGATGACC CCCACGCGGG ACTCCCTCAG CTCGGCAAGA GACTGCCTCA GTTTGATGAC 
GATGCGGACA CTGGAAAGAA AAAGAAGAAA ACCCGAGGTG ATCATTTTAA ACTTCGCTTC 
CGAAAAAACT TTCAGGCCCT GTTGGAGGAG CAGAACTTGA GTGTGGCCGA GGGCCCTAAC 
TACCTGACGG CCTGTGCGGG ACCCCCATCG CGGCCCCAGC GCCCCTTCTG TGCTGTCTGT 
GGCTTCCCAT CCCCCTACAC CTGTGTCAGC TGCGGTGCCC GGTACTGCAC TGTGCGCTGT 
CTGGGGACCC ACCAGGAGAC CAGGTGTCTG AAGTGGACTG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006340.1
CDS	32..496
Translation	MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

Target ORF information:

RefSeq Version	NM_006349.3
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006349.3

ORF Insert Sequence:

ATGGTGGAGA AGAAAACTTC GGTTCGCTCC CAGGACCCCG GGCAGCGGCG GGTGCTGGAC 
CGGGCTGCCC GGCAGCGTCG CATCAACCGG CAGCTGGAGG CCCTGGAGAA TGACAACTTC 
CAGGATGACC CCCACGCGGG ACTCCCTCAG CTCGGCAAGA GACTGCCTCA GTTTGATGAC 
GATGCGGACA CTGGAAAGAA AAAGAAGAAA ACCCGAGGTG ATCATTTTAA ACTTCGCTTC 
CGAAAAAACT TTCAGGCCCT GTTGGAGGAG CAGAACTTGA GTGTGGCCGA GGGCCCTAAC 
TACCTGACGG CCTGTGCGGG ACCCCCATCG CGGCCCCAGC GCCCCTTCTG TGCTGTCTGT 
GGCTTCCCAT CCCCCTACAC CTGTGTCAGC TGCGGTGCCC GGTACTGCAC TGTGCGCTGT 
CTGGGGACCC ACCAGGAGAC CAGGTGTCTG AAGTGGACTG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT1 ( NM_006349.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006340.1 Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.

Price & Availability↑

CloneID	OHu30321
Clone ID Related Accession (Same CDS sequence)	NM_006349.3 , NM_006349.2
Accession Version	NM_006349.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC017333.2 and BC001877.1. On Oct 9, 2003 this sequence version replaced NM_006349.1. ##Evidence-Data-START## Transcript exon combination :: BC017333.2, ERR279867.3017.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGAGA AGAAAACTTC GGTTCGCTCC CAGGACCCCG GGCAGCGGCG GGTGCTGGAC 
CGGGCTGCCC GGCAGCGTCG CATCAACCGG CAGCTGGAGG CCCTGGAGAA TGACAACTTC 
CAGGATGACC CCCACGCGGG ACTCCCTCAG CTCGGCAAGA GACTGCCTCA GTTTGATGAC 
GATGCGGACA CTGGAAAGAA AAAGAAGAAA ACCCGAGGTG ATCATTTTAA ACTTCGCTTC 
CGAAAAAACT TTCAGGCCCT GTTGGAGGAG CAGAACTTGA GTGTGGCCGA GGGCCCTAAC 
TACCTGACGG CCTGTGCGGG ACCCCCATCG CGGCCCCAGC GCCCCTTCTG TGCTGTCTGT 
GGCTTCCCAT CCCCCTACAC CTGTGTCAGC TGCGGTGCCC GGTACTGCAC TGTGCGCTGT 
CTGGGGACCC ACCAGGAGAC CAGGTGTCTG AAGTGGACTG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006340.1
CDS	493..957
Translation	MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

Target ORF information:

RefSeq Version	NM_006349.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006349.2

ORF Insert Sequence:

ATGGTGGAGA AGAAAACTTC GGTTCGCTCC CAGGACCCCG GGCAGCGGCG GGTGCTGGAC 
CGGGCTGCCC GGCAGCGTCG CATCAACCGG CAGCTGGAGG CCCTGGAGAA TGACAACTTC 
CAGGATGACC CCCACGCGGG ACTCCCTCAG CTCGGCAAGA GACTGCCTCA GTTTGATGAC 
GATGCGGACA CTGGAAAGAA AAAGAAGAAA ACCCGAGGTG ATCATTTTAA ACTTCGCTTC 
CGAAAAAACT TTCAGGCCCT GTTGGAGGAG CAGAACTTGA GTGTGGCCGA GGGCCCTAAC 
TACCTGACGG CCTGTGCGGG ACCCCCATCG CGGCCCCAGC GCCCCTTCTG TGCTGTCTGT 
GGCTTCCCAT CCCCCTACAC CTGTGTCAGC TGCGGTGCCC GGTACTGCAC TGTGCGCTGT 
CTGGGGACCC ACCAGGAGAC CAGGTGTCTG AAGTGGACTG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT1 ( XM_011515739.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514041.1 Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64043
Clone ID Related Accession (Same CDS sequence)	XM_011515739.2
Accession Version	XM_011515739.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011515739.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCCCC ACGCCTGGTT AATTTTTAAT TTGTTATGTG GTGACGGGCT CTCGCTATGT 
TGCCCAGTTC GCTCCCAGGA CCCCGGGCAG CGGCGGGTGC TGGACCGGGC TGCCCGGCAG 
CGTCGCATCA ACCGGCAGCT GGAGGCCCTG GAGAATGACA ACTTCCAGGA TGACCCCCAC 
GCGGGACTCC CTCAGCTCGG CAAGAGACTG CCTCAGTTTG ATGACGATGC GGACACTGGA 
AAGAAAAAGA AGAAAACCCG AGGTGATCAT TTTAAACTTC GCTTCCGAAA AAACTTTCAG 
GCCCTGTTGG AGGAGCAGAA CTTGAGTGTG GCCGAGGGCC CTAACTACCT GACGGCCTGT 
GCGGGACCCC CATCGCGGCC CCAGCGCCCC TTCTGTGCTG TCTGTGGCTT CCCATCCCCC 
TACACCTGTG TCAGCTGCGG TGCCCGGTAC TGCACTGTGC GCTGTCTGGG GACCCACCAG 
GAGACCAGGT GTCTGAAGTG GACTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514041.1
CDS	179..688
Translation	MRPHAWLIFNLLCGDGLSLCCPVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

Target ORF information:

RefSeq Version	XM_011515739.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011515739.2

ORF Insert Sequence:

ATGAGGCCCC ACGCCTGGTT AATTTTTAAT TTGTTATGTG GTGACGGGCT CTCGCTATGT 
TGCCCAGTTC GCTCCCAGGA CCCCGGGCAG CGGCGGGTGC TGGACCGGGC TGCCCGGCAG 
CGTCGCATCA ACCGGCAGCT GGAGGCCCTG GAGAATGACA ACTTCCAGGA TGACCCCCAC 
GCGGGACTCC CTCAGCTCGG CAAGAGACTG CCTCAGTTTG ATGACGATGC GGACACTGGA 
AAGAAAAAGA AGAAAACCCG AGGTGATCAT TTTAAACTTC GCTTCCGAAA AAACTTTCAG 
GCCCTGTTGG AGGAGCAGAA CTTGAGTGTG GCCGAGGGCC CTAACTACCT GACGGCCTGT 
GCGGGACCCC CATCGCGGCC CCAGCGCCCC TTCTGTGCTG TCTGTGGCTT CCCATCCCCC 
TACACCTGTG TCAGCTGCGG TGCCCGGTAC TGCACTGTGC GCTGTCTGGG GACCCACCAG 
GAGACCAGGT GTCTGAAGTG GACTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Nature505(7485)648-53(2014 Jan)
Obri A,Ouararhni K,Papin C,Diebold ML,Padmanabhan K,Marek M,Stoll I,Roy L,Reilly PT,Mak TW,Dimitrov S,Romier C,Hamiche A

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
The EMBO journal29(12)2014-25(2010 Jun)
Cuadrado A,Corrado N,Perdiguero E,Lafarga V,Mu?oz-Canoves P,Nebreda AR

Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Journal of proteome research7(9)3879-89(2008 Sep)
Wang J,Yuan Y,Zhou Y,Guo L,Zhang L,Kuai X,Deng B,Pan Z,Li D,He F

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ZNHIT1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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Target ORF information:

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