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HOXB13 cDNA ORF clone, Homo sapiens (human)

Gene Symbol HOXB13
Entrez Gene ID 10481
Full Name homeobox B13
Synonyms PSGD
General protein information
Preferred Names
homeobox protein Hox-B13
Names
homeobox protein Hox-B13
homeo box B13
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.2

Summary This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604607


mRNA and Protein(s)

mRNA Protein Name
NM_006361 NP_006352 homeobox protein Hox-B13



Homo sapiens (human) HOXB13 NP_006352.2
Pan troglodytes (chimpanzee) HOXB13 XP_523822.1
Macaca mulatta (Rhesus monkey) HOXB13 XP_001089620.1
Canis lupus familiaris (dog) HOXB13 XP_548180.2
Bos taurus (cattle) HOXB13 XP_003587468.1
Mus musculus (house mouse) Hoxb13 NP_032293.1
Rattus norvegicus (Norway rat) Hoxb13 NP_001100511.1
Gallus gallus (chicken) HOXB13 XP_001234927.1
Danio rerio (zebrafish) hoxb13a NP_001038377.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HOXB13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20252
NM_006361 Homo sapiens homeobox B13 (HOXB13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20252
Clone ID Related Accession (Same CDS sequence) NM_006361
Accession Version NM_006361.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 855bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein Hox-B13
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY937237.1 and BC070233.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2005 this sequence version replaced gi:70167332. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY937237.1, BC070233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAGCCCG GCAATTATGC CACCTTGGAT GGAGCCAAGG ATATCGAAGG CTTGCTGGGA 
GCGGGAGGGG GGCGGAATCT GGTCGCCCAC TCCCCTCTGA CCAGCCACCC AGCGGCGCCT
ACGCTGATGC CTGCTGTCAA CTATGCCCCC TTGGATCTGC CAGGCTCGGC GGAGCCGCCA
AAGCAATGCC ACCCATGCCC TGGGGTGCCC CAGGGGACGT CCCCAGCTCC CGTGCCTTAT
GGTTACTTTG GAGGCGGGTA CTACTCCTGC CGAGTGTCCC GGAGCTCGCT GAAACCCTGT
GCCCAGGCAG CCACCCTGGC CGCGTACCCC GCGGAGACTC CCACGGCCGG GGAAGAGTAC
CCCAGCCGCC CCACTGAGTT TGCCTTCTAT CCGGGATATC CGGGAACCTA CCAGCCTATG
GCCAGTTACC TGGACGTGTC TGTGGTGCAG ACTCTGGGTG CTCCTGGAGA ACCGCGACAT
GACTCCCTGT TGCCTGTGGA CAGTTACCAG TCTTGGGCTC TCGCTGGTGG CTGGAACAGC
CAGATGTGTT GCCAGGGAGA ACAGAACCCA CCAGGTCCCT TTTGGAAGGC AGCATTTGCA
GACTCCAGCG GGCAGCACCC TCCTGACGCC TGCGCCTTTC GTCGCGGCCG CAAGAAACGC
ATTCCGTACA GCAAGGGGCA GTTGCGGGAG CTGGAGCGGG AGTATGCGGC TAACAAGTTC
ATCACCAAGG ACAAGAGGCG CAAGATCTCG GCAGCCACCA GCCTCTCGGA GCGCCAGATT
ACCATCTGGT TTCAGAACCG CCGGGTCAAA GAGAAGAAGG TTCTCGCCAA GGTGAAGAAC
AGCGCTACCC CTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006352.2
CDS157..1011
Misc Feature(1)184..525(+)
Misc Feature(2)805..975(+)
Misc Feature(3)805..975(+)
Misc Feature(4)811..963(+)
Exon (1)1..757
Gene:HOXB13
Gene Synonym:
Exon (2)758..3038
Gene:HOXB13
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006361
Organism Homo sapiens (human)
Definition Homo sapiens homeobox B13 (HOXB13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006361

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAGCCCG GCAATTATGC CACCTTGGAT GGAGCCAAGG ATATCGAAGG CTTGCTGGGA 
GCGGGAGGGG GGCGGAATCT GGTCGCCCAC TCCCCTCTGA CCAGCCACCC AGCGGCGCCT
ACGCTGATGC CTGCTGTCAA CTATGCCCCC TTGGATCTGC CAGGCTCGGC GGAGCCGCCA
AAGCAATGCC ACCCATGCCC TGGGGTGCCC CAGGGGACGT CCCCAGCTCC CGTGCCTTAT
GGTTACTTTG GAGGCGGGTA CTACTCCTGC CGAGTGTCCC GGAGCTCGCT GAAACCCTGT
GCCCAGGCAG CCACCCTGGC CGCGTACCCC GCGGAGACTC CCACGGCCGG GGAAGAGTAC
CCCAGCCGCC CCACTGAGTT TGCCTTCTAT CCGGGATATC CGGGAACCTA CCAGCCTATG
GCCAGTTACC TGGACGTGTC TGTGGTGCAG ACTCTGGGTG CTCCTGGAGA ACCGCGACAT
GACTCCCTGT TGCCTGTGGA CAGTTACCAG TCTTGGGCTC TCGCTGGTGG CTGGAACAGC
CAGATGTGTT GCCAGGGAGA ACAGAACCCA CCAGGTCCCT TTTGGAAGGC AGCATTTGCA
GACTCCAGCG GGCAGCACCC TCCTGACGCC TGCGCCTTTC GTCGCGGCCG CAAGAAACGC
ATTCCGTACA GCAAGGGGCA GTTGCGGGAG CTGGAGCGGG AGTATGCGGC TAACAAGTTC
ATCACCAAGG ACAAGAGGCG CAAGATCTCG GCAGCCACCA GCCTCTCGGA GCGCCAGATT
ACCATCTGGT TTCAGAACCG CCGGGTCAAA GAGAAGAAGG TTCTCGCCAA GGTGAAGAAC
AGCGCTACCC CTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding
Nat. Genet. 46 (2), 126-135 (2014)
Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Vaisanen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J and Wei GH.


book

G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis
Tumour Biol. 35 (2), 1177-1182 (2014)
Huang H and Cai B.


book

HOXB13 is a sensitive and specific marker of prostate cells, useful in distinguishing between carcinomas of prostatic and urothelial origin
Virchows Arch. 463 (6), 803-809 (2013)
Varinot J, Cussenot O, Roupret M, Conort P, Bitker MO, Chartier-Kastler E, Cheng L and Comperat E.


book

HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression
Cancer Res. 73 (17), 5449-5458 (2013)
Shah N, Jin K, Cruz LA, Park S, Sadik H, Cho S, Goswami CP, Nakshatri H, Gupta R, Chang HY, Zhang Z, Cimino-Mathews A, Cope L, Umbricht C and Sukumar S.


book

Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker
J. Natl. Cancer Inst. 105 (14), 1036-1042 (2013)
Sgroi DC, Carney E, Zarrella E, Steffel L, Binns SN, Finkelstein DM, Szymonifka J, Bhan AK, Shepherd LE, Zhang Y, Schnabel CA, Erlander MG, Ingle JN, Porter P, Muss HB, Pritchard KI, Tu D, Rimm DL and Goss PE.


book

HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development
Dev. Dyn. 227 (2), 192-202 (2003)
Komuves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y and Largman C.


book

Complete mutation analysis panel of the 39 human HOX genes
Teratology 65 (2), 50-62 (2002)
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W and Matsuo N.


book

Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds
J. Invest. Dermatol. 111 (1), 57-63 (1998)
Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M and Largman C.


book

AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
Mol. Cell. Biol. 17 (11), 6448-6458 (1997)
Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM and Largman C.


book

Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity
Development 122 (8), 2475-2484 (1996)
Zeltser L, Desplan C and Heintz N.


 
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