×

HOXB13 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol HOXB13
Entrez Gene ID 10481
Full Name homeobox B13
Synonyms PSGD
General protein information
Preferred Names

homeobox B13

Names

homeobox protein Hox-B13

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

17

17q21.32

Summary This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008].
Disorder MIM:

604607


mRNA and Protein(s)

mRNA Protein Name
NM_006361.5 NP_006352.2 homeobox protein Hox-B13



Homo sapiens (human) HOXB13 NP_006352.2
Rattus norvegicus (Norway rat) Hoxb13 NP_001100511.1
Bos taurus (cattle) HOXB13 XP_003587468.1
Danio rerio (zebrafish) hoxb13a NP_001038377.1
Mus musculus (house mouse) Hoxb13 NP_032293.1
Gallus gallus (chicken) HOXB13 XP_001234927.1
Pan troglodytes (chimpanzee) HOXB13 XP_523822.1
Canis lupus familiaris (dog) HOXB13 XP_548180.2
Macaca mulatta (rhesus monkey) HOXB13 XP_001089620.1


Related articles in PubMed

Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness.
Storebjerg TM, Høyer S, Kirkegaard P, Bro F, , Ørntoft TF, Borre M, Sørensen KD
BJU international118(4)646-53(2016 Oct)

Tumor-associated macrophage-derived CXCL8 could induce ERα suppression via HOXB13 in endometrial cancer.
Tong H, Ke JQ, Jiang FZ, Wang XJ, Wang FY, Li YR, Lu W, Wan XP
Cancer letters376(1)127-36(2016 06)

HOXB13 protein expression in metastatic lesions is a promising marker for prostate origin.
Varinot J, Furudoï A, Drouin S, Phe V, Penna RR, Roupret M, Bitker MO, Cussenot O, Compérat E
Virchows Archiv : an international journal of pathology468(5)619-22(2016 May)

Regulating NKX3.1 stability and function: Post-translational modifications and structural determinants.
Padmanabhan A, Rao V, De Marzo AM, Bieberich CJ
The Prostate76(6)523-33(2016 May)

HOXB13-mediated suppression of p21WAF1/CIP1 regulates JNK/c-Jun signaling in prostate cancer cells.
Kim YR, Kang TW, To PK, Xuan Nguyen NT, Cho YS, Jung C, Kim MS
Oncology reports35(4)2011-6(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study presents in silico prediction approaches of the deleterious ns single nucleotide polymorphisms (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer.
Title: In silico analysis of the deleterious nsSNPs (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer.

CCAT1 regulates HOXB13 as a molecular decoy for miR-7, a microRNA that targets both CCAT1 and HOXB13, thus facilitating cell growth and migration in esophageal squamous cell carcinoma
Title: H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma.

Tumor-associated macrophage-secreted CXCL8 downregulated the ERalpha expression of endometrial cancer cells via HOXB13, which may be associated with cancer invasion, metastasis and poor prognosis.
Title: Tumor-associated macrophage-derived CXCL8 could induce ERα suppression via HOXB13 in endometrial cancer.

HOXB13 is a useful marker for prostate origin when doubt exists regarding the site of the primary of a metastatic lesion
Title: HOXB13 protein expression in metastatic lesions is a promising marker for prostate origin.

Recent studies have shown that HOXB13 is a strong candidate for familial Prostate cancer gene.
Title: Regulating NKX3.1 stability and function: Post-translational modifications and structural determinants.

The following HOXB13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

Free DYK Tag Antibody

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20252
NM_006361.5
Latest version!
Homo sapiens homeobox B13 (HOXB13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20252
Clone ID Related Accession (Same CDS sequence) NM_006361.5
Accession Version NM_006361.5 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 855bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product homeobox protein Hox-B13
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY937237.1 and BC070233.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2005 this sequence version replaced NM_006361.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY937237.1, BC070233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAGCCCG GCAATTATGC CACCTTGGAT GGAGCCAAGG ATATCGAAGG CTTGCTGGGA 
GCGGGAGGGG GGCGGAATCT GGTCGCCCAC TCCCCTCTGA CCAGCCACCC AGCGGCGCCT
ACGCTGATGC CTGCTGTCAA CTATGCCCCC TTGGATCTGC CAGGCTCGGC GGAGCCGCCA
AAGCAATGCC ACCCATGCCC TGGGGTGCCC CAGGGGACGT CCCCAGCTCC CGTGCCTTAT
GGTTACTTTG GAGGCGGGTA CTACTCCTGC CGAGTGTCCC GGAGCTCGCT GAAACCCTGT
GCCCAGGCAG CCACCCTGGC CGCGTACCCC GCGGAGACTC CCACGGCCGG GGAAGAGTAC
CCCAGCCGCC CCACTGAGTT TGCCTTCTAT CCGGGATATC CGGGAACCTA CCAGCCTATG
GCCAGTTACC TGGACGTGTC TGTGGTGCAG ACTCTGGGTG CTCCTGGAGA ACCGCGACAT
GACTCCCTGT TGCCTGTGGA CAGTTACCAG TCTTGGGCTC TCGCTGGTGG CTGGAACAGC
CAGATGTGTT GCCAGGGAGA ACAGAACCCA CCAGGTCCCT TTTGGAAGGC AGCATTTGCA
GACTCCAGCG GGCAGCACCC TCCTGACGCC TGCGCCTTTC GTCGCGGCCG CAAGAAACGC
ATTCCGTACA GCAAGGGGCA GTTGCGGGAG CTGGAGCGGG AGTATGCGGC TAACAAGTTC
ATCACCAAGG ACAAGAGGCG CAAGATCTCG GCAGCCACCA GCCTCTCGGA GCGCCAGATT
ACCATCTGGT TTCAGAACCG CCGGGTCAAA GAGAAGAAGG TTCTCGCCAA GGTGAAGAAC
AGCGCTACCC CTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006352.2
CDS157..1011
Misc Feature(1)190..519
Misc Feature(2)802..972
Misc Feature(3)order(805..819,823..825,874..876,892..894,931..933,937..942,949..954,958..966,970..975)
Misc Feature(4)order(811..813,820..822,940..942,949..954,961..963)
Exon (1)1..757
Exon (2)758..3038
Translation

Target ORF information:

RefSeq Version NM_006361.5
Organism Homo sapiens(Human)
Definition Homo sapiens homeobox B13 (HOXB13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006361.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAGCCCG GCAATTATGC CACCTTGGAT GGAGCCAAGG ATATCGAAGG CTTGCTGGGA 
GCGGGAGGGG GGCGGAATCT GGTCGCCCAC TCCCCTCTGA CCAGCCACCC AGCGGCGCCT
ACGCTGATGC CTGCTGTCAA CTATGCCCCC TTGGATCTGC CAGGCTCGGC GGAGCCGCCA
AAGCAATGCC ACCCATGCCC TGGGGTGCCC CAGGGGACGT CCCCAGCTCC CGTGCCTTAT
GGTTACTTTG GAGGCGGGTA CTACTCCTGC CGAGTGTCCC GGAGCTCGCT GAAACCCTGT
GCCCAGGCAG CCACCCTGGC CGCGTACCCC GCGGAGACTC CCACGGCCGG GGAAGAGTAC
CCCAGCCGCC CCACTGAGTT TGCCTTCTAT CCGGGATATC CGGGAACCTA CCAGCCTATG
GCCAGTTACC TGGACGTGTC TGTGGTGCAG ACTCTGGGTG CTCCTGGAGA ACCGCGACAT
GACTCCCTGT TGCCTGTGGA CAGTTACCAG TCTTGGGCTC TCGCTGGTGG CTGGAACAGC
CAGATGTGTT GCCAGGGAGA ACAGAACCCA CCAGGTCCCT TTTGGAAGGC AGCATTTGCA
GACTCCAGCG GGCAGCACCC TCCTGACGCC TGCGCCTTTC GTCGCGGCCG CAAGAAACGC
ATTCCGTACA GCAAGGGGCA GTTGCGGGAG CTGGAGCGGG AGTATGCGGC TAACAAGTTC
ATCACCAAGG ACAAGAGGCG CAAGATCTCG GCAGCCACCA GCCTCTCGGA GCGCCAGATT
ACCATCTGGT TTCAGAACCG CCGGGTCAAA GAGAAGAAGG TTCTCGCCAA GGTGAAGAAC
AGCGCTACCC CTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness.
BJU international118(4)646-53(2016 Oct)
Storebjerg TM,Høyer S,Kirkegaard P,Bro F,,Ørntoft TF,Borre M,Sørensen KD


book

Tumor-associated macrophage-derived CXCL8 could induce ERα suppression via HOXB13 in endometrial cancer.
Cancer letters376(1)127-36(2016 06)
Tong H,Ke JQ,Jiang FZ,Wang XJ,Wang FY,Li YR,Lu W,Wan XP


book

HOXB13 protein expression in metastatic lesions is a promising marker for prostate origin.
Virchows Archiv : an international journal of pathology468(5)619-22(2016 May)
Varinot J,Furudoï A,Drouin S,Phe V,Penna RR,Roupret M,Bitker MO,Cussenot O,Compérat E


book

Regulating NKX3.1 stability and function: Post-translational modifications and structural determinants.
The Prostate76(6)523-33(2016 May)
Padmanabhan A,Rao V,De Marzo AM,Bieberich CJ


book

HOXB13-mediated suppression of p21WAF1/CIP1 regulates JNK/c-Jun signaling in prostate cancer cells.
Oncology reports35(4)2011-6(2016 Apr)
Kim YR,Kang TW,To PK,Xuan Nguyen NT,Cho YS,Jung C,Kim MS


 
*
*
*
*