SIVA1 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | SIVA1 |
Entrez Gene ID | 10572 |
Full Name | SIVA1 apoptosis inducing factor |
Synonyms | CD27BP,SIVA,Siva-1,Siva-2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_006427.3 | NP_006418.2 | apoptosis regulatory protein Siva isoform 1 |
NM_021709.3 | NP_068355.1 | apoptosis regulatory protein Siva isoform 2 |
XM_011536360.2 | XP_011534662.1 | apoptosis regulatory protein Siva isoform X1 |
NM_021709.2 | NP_068355.1 | apoptosis regulatory protein Siva isoform 2 |
NM_006427.4 | NP_006418.2 | apoptosis regulatory protein Siva isoform 1 |

Mus musculus (house mouse) | Siva1 | NP_038957.2 |
Gallus gallus (chicken) | SIVA1 | NP_001264464.1 |
Bos taurus (cattle) | SIVA1 | NP_001180107.1 |
Rattus norvegicus (Norway rat) | Siva1 | NP_001094452.1 |
Danio rerio (zebrafish) | siva1 | XP_700568.6 |
Canis lupus familiaris (dog) | SIVA1 | XP_855513.1 |
Homo sapiens (human) | SIVA1 | NP_006418.2 |
Pan troglodytes (chimpanzee) | SIVA1 | XP_510197.3 |
SIVA1 | XP_001095069.2 | |
Xenopus tropicalis (tropical clawed frog) | siva1 | NP_001039138.1 |

Related articles in PubMed
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.
Park IK, Blum W, Baker SD, Caligiuri MA
Leukemia31(2)502-505(2017 02)
Overexpression and Characterization of The C-Terminal Domain of Human Siva1, A Proapoptotic Factor and Cytoskeleton Binding Protein.
Dantas LE, Saad ST, Ramos CH, B?nichou S
Protein and peptide letters23(1)43-50(2016)
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Van Nostrand JL, Brisac A, Mello SS, Jacobs SB, Luong R, Attardi LD
Cancer discovery5(6)622-35(2015 Jun)
Anticancer activity of recombinant Siva1 protein in human nasopharyngeal carcinoma cell line CNE-2.
Chen GH, Xue QQ, Li J, Gao TL, Sun QS, Bai GP
Cancer biomarkers : section A of Disease markers15(6)833-41(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
electrical stimulation -inducible SIVA1 modulates p53 activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization
Title: Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.
Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.
Title: Anticancer activity of recombinant Siva1 protein in human nasopharyngeal carcinoma cell line CNE-2.
SIVA1 interacts with RAD18 and serves as a molecular bridge between RAD18 and PCNA, thus targeting the E3 ligase activity of RAD18 onto PCNA.
Title: SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.
Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
Title: Preliminary research on the expression, purification and function of the apoptotic fusion protein, Sival.
The following SIVA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIVA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu03722![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_021709.3 , NM_021709.2 | |
Accession Version | NM_021709.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | apoptosis regulatory protein Siva isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU195069.1 and BC034562.1. On May 31, 2019 this sequence version replaced NM_021709.2. Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. It appears to lack the apoptotic properties of Siva. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BE047027.1, DRR138523.27114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_068355.1 |
CDS | 56..388 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu03722![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_021709.3 , NM_021709.2 | |
Accession Version | NM_021709.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Homo sapiens(human) | |
Product | apoptosis regulatory protein Siva isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU195069.1 and BC034562.1. On Dec 14, 2006 this sequence version replaced NM_021709.1. Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. It appears to lack the apoptotic properties of Siva. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034562.1, HX784790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_068355.1 |
CDS | 70..402 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu18390![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006427.3 , NM_006427.4 | |
Accession Version | NM_006427.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | apoptosis regulatory protein Siva isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU195069.1, CK001877.1 and BC034562.1. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2006 this sequence version replaced NM_006427.2. Transcript Variant: This variant (1) is the predominant and longer transcript. It encodes isoform 1 and includes the apoptotic properties of Siva. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.136925.1, SRR1163655.139255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006418.2 |
CDS | 70..597 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu18390![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006427.3 , NM_006427.4 | |
Accession Version | NM_006427.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-26 | |
Organism | Homo sapiens(human) | |
Product | apoptosis regulatory protein Siva isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU195069.1, CK001877.1 and BC034562.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006427.3. Transcript Variant: This variant (1) is the predominant and longer transcript. It encodes isoform 1 and includes the apoptotic properties of Siva. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223332.1, BQ943607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329967.11/ ENSP00000329213.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006418.2 |
CDS | 56..583 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu64122 | |
Clone ID Related Accession (Same CDS sequence) | XM_011536360.2 | |
Accession Version | XM_011536360.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | apoptosis regulatory protein Siva isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011536360.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011534662.1 |
CDS | 783..1283 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC CTTCGCGGAC GTGGCCCCGC TACAGCTCAA GGTCCGCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia. |
![]() |
Overexpression and Characterization of The C-Terminal Domain of Human Siva1, A Proapoptotic Factor and Cytoskeleton Binding Protein. |
![]() |
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development. |
![]() |
Anticancer activity of recombinant Siva1 protein in human nasopharyngeal carcinoma cell line CNE-2. |