DCTN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCTN6
Entrez Gene ID	10671
Full Name	dynactin subunit 6
Synonyms	WS-3,WS3,p27
General protein information	Preferred Names dynactin subunit 6 Names dynactin subunit 6 dynactin 6 dynactin subunit p27 novel RGD-containing protein protein WS-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p12
Summary	The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008].
Disorder MIM:	612963

mRNA and Protein(s)

mRNA	Protein	Name
NM_006571.3	NP_006562.1	dynactin subunit 6
NM_006571.4	NP_006562.1	dynactin subunit 6

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DCTN6	XP_532816.2
Mus musculus (house mouse)	Dctn6	NP_035852.1
Homo sapiens (human)	DCTN6	NP_006562.1
Pan troglodytes (chimpanzee)	DCTN6	XP_528102.2
Gallus gallus (chicken)	DCTN6	NP_001264758.1
Caenorhabditis elegans (roundworm)	dnc-6	NP_491116.2
Bos taurus (cattle)	DCTN6	NP_001069106.1
Rattus norvegicus (Norway rat)	Dctn6	NP_001099555.1
Drosophila melanogaster (fruit fly)	l(2)37Ce	NP_609949.1
	DCTN6	XP_001082975.2
Danio rerio (zebrafish)	zgc:112102	NP_001018487.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006924	XP_001688103.1
Xenopus tropicalis (tropical clawed frog)	dctn6	NP_001039059.1

Gene Ontology
Bibliography

Related articles in PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Gupta GD, Coyaud ?, Gon?alves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B, Pelletier L
Cell163(6)1484-99(2015 Dec)

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
Yeh TY, Kowalska AK, Scipioni BR, Cheong FK, Zheng M, Derewenda U, Derewenda ZS, Schroer TA
The EMBO journal32(7)1023-35(2013 Apr)

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS
The EMBO journal30(8)1520-35(2011 Apr)

Dynactins p25 and p27 are predicted to adopt the LbetaH fold.
Parisi G, Fornasari MS, Echave J
FEBS letters562(1-3)1-4(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
Title: Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.

The following DCTN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCTN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26753	NM_006571.4 Latest version!	Homo sapiens dynactin subunit 6 (DCTN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26753	NM_006571.3	Homo sapiens dynactin subunit 6 (DCTN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCTN6 ( NM_006571.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006562.1 Homo sapiens dynactin subunit 6 (DCTN6), mRNA.

Price & Availability↑

CloneID	OHu26753
Clone ID Related Accession (Same CDS sequence)	NM_006571.3 , NM_006571.4
Accession Version	NM_006571.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	dynactin subunit 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D84145.1, BI562535.1, BC013175.1 and D79389.1. On Jan 7, 2011 this sequence version replaced NM_006571.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.517648.1, SRR1660809.21578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA AGACTCAAAA GAGTGTGAAG ATTGCTCCTG GAGCAGTTGT ATGTGTAGAA 
AGTGAAATCA GAGGAGATGT AACTATCGGA CCTCGGACAG TGATCCACCC TAAAGCAAGA 
ATTATTGCGG AAGCCGGGCC AATAGTGATT GGCGAAGGGA ACCTAATAGA AGAACAGGCC 
CTTATCATAA ATGCTTACCC AGATAATATC ACTCCTGACA CTGAAGATCC AGAACCAAAA 
CCTATGATCA TTGGCACCAA TAATGTGTTT GAAGTTGGCT GTTATTCCCA AGCCATGAAG 
ATGGGAGATA ATAATGTCAT TGAATCAAAA GCATATGTAG GCAGAAATGT AATATTGACA 
AGTGGCTGCA TCATTGGGGC TTGTTGCAAC CTAAATACAT TTGAAGTCAT CCCTGAGAAT 
ACGGTGATCT ATGGTGCAGA CTGCCTTCGT CGGGTGCAGA CTGAGCGACC GCAGCCCCAG 
ACACTACAGC TGGATTTCTT GATGAAAATC TTGCCAAATT ACCACCACCT AAAGAAGACT 
ATGAAAGGAA GCTCAACTCC AGTAAAGAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006562.1
CDS	88..660
Translation	MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN

Target ORF information:

RefSeq Version	NM_006571.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynactin subunit 6 (DCTN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006571.3

ORF Insert Sequence:

ATGGCGGAGA AGACTCAAAA GAGTGTGAAG ATTGCTCCTG GAGCAGTTGT ATGTGTAGAA 
AGTGAAATCA GAGGAGATGT AACTATCGGA CCTCGGACAG TGATCCACCC TAAAGCAAGA 
ATTATTGCGG AAGCCGGGCC AATAGTGATT GGCGAAGGGA ACCTAATAGA AGAACAGGCC 
CTTATCATAA ATGCTTACCC AGATAATATC ACTCCTGACA CTGAAGATCC AGAACCAAAA 
CCTATGATCA TTGGCACCAA TAATGTGTTT GAAGTTGGCT GTTATTCCCA AGCCATGAAG 
ATGGGAGATA ATAATGTCAT TGAATCAAAA GCATATGTAG GCAGAAATGT AATATTGACA 
AGTGGCTGCA TCATTGGGGC TTGTTGCAAC CTAAATACAT TTGAAGTCAT CCCTGAGAAT 
ACGGTGATCT ATGGTGCAGA CTGCCTTCGT CGGGTGCAGA CTGAGCGACC GCAGCCCCAG 
ACACTACAGC TGGATTTCTT GATGAAAATC TTGCCAAATT ACCACCACCT AAAGAAGACT 
ATGAAAGGAA GCTCAACTCC AGTAAAGAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCTN6 ( NM_006571.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006562.1 Homo sapiens dynactin subunit 6 (DCTN6), mRNA.

Price & Availability↑

CloneID	OHu26753
Clone ID Related Accession (Same CDS sequence)	NM_006571.3 , NM_006571.4
Accession Version	NM_006571.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	dynactin subunit 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013175.1 and D79389.1. On Nov 23, 2018 this sequence version replaced NM_006571.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.517648.1, SRR3476690.1104743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221114.8/ ENSP00000221114.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAGA AGACTCAAAA GAGTGTGAAG ATTGCTCCTG GAGCAGTTGT ATGTGTAGAA 
AGTGAAATCA GAGGAGATGT AACTATCGGA CCTCGGACAG TGATCCACCC TAAAGCAAGA 
ATTATTGCGG AAGCCGGGCC AATAGTGATT GGCGAAGGGA ACCTAATAGA AGAACAGGCC 
CTTATCATAA ATGCTTACCC AGATAATATC ACTCCTGACA CTGAAGATCC AGAACCAAAA 
CCTATGATCA TTGGCACCAA TAATGTGTTT GAAGTTGGCT GTTATTCCCA AGCCATGAAG 
ATGGGAGATA ATAATGTCAT TGAATCAAAA GCATATGTAG GCAGAAATGT AATATTGACA 
AGTGGCTGCA TCATTGGGGC TTGTTGCAAC CTAAATACAT TTGAAGTCAT CCCTGAGAAT 
ACGGTGATCT ATGGTGCAGA CTGCCTTCGT CGGGTGCAGA CTGAGCGACC GCAGCCCCAG 
ACACTACAGC TGGATTTCTT GATGAAAATC TTGCCAAATT ACCACCACCT AAAGAAGACT 
ATGAAAGGAA GCTCAACTCC AGTAAAGAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006562.1
CDS	16..588
Translation	MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN

Target ORF information:

RefSeq Version	NM_006571.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dynactin subunit 6 (DCTN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006571.4

ORF Insert Sequence:

ATGGCGGAGA AGACTCAAAA GAGTGTGAAG ATTGCTCCTG GAGCAGTTGT ATGTGTAGAA 
AGTGAAATCA GAGGAGATGT AACTATCGGA CCTCGGACAG TGATCCACCC TAAAGCAAGA 
ATTATTGCGG AAGCCGGGCC AATAGTGATT GGCGAAGGGA ACCTAATAGA AGAACAGGCC 
CTTATCATAA ATGCTTACCC AGATAATATC ACTCCTGACA CTGAAGATCC AGAACCAAAA 
CCTATGATCA TTGGCACCAA TAATGTGTTT GAAGTTGGCT GTTATTCCCA AGCCATGAAG 
ATGGGAGATA ATAATGTCAT TGAATCAAAA GCATATGTAG GCAGAAATGT AATATTGACA 
AGTGGCTGCA TCATTGGGGC TTGTTGCAAC CTAAATACAT TTGAAGTCAT CCCTGAGAAT 
ACGGTGATCT ATGGTGCAGA CTGCCTTCGT CGGGTGCAGA CTGAGCGACC GCAGCCCCAG 
ACACTACAGC TGGATTTCTT GATGAAAATC TTGCCAAATT ACCACCACCT AAAGAAGACT 
ATGAAAGGAA GCTCAACTCC AGTAAAGAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Cell163(6)1484-99(2015 Dec)
Gupta GD,Coyaud ?,Gon?alves J,Mojarad BA,Liu Y,Wu Q,Gheiratmand L,Comartin D,Tkach JM,Cheung SW,Bashkurov M,Hasegan M,Knight JD,Lin ZY,Schueler M,Hildebrandt F,Moffat J,Gingras AC,Raught B,Pelletier L

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
The EMBO journal32(7)1023-35(2013 Apr)
Yeh TY,Kowalska AK,Scipioni BR,Cheong FK,Zheng M,Derewenda U,Derewenda ZS,Schroer TA

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
The EMBO journal30(8)1520-35(2011 Apr)
Jakobsen L,Vanselow K,Skogs M,Toyoda Y,Lundberg E,Poser I,Falkenby LG,Bennetzen M,Westendorf J,Nigg EA,Uhlen M,Hyman AA,Andersen JS

Dynactins p25 and p27 are predicted to adopt the LbetaH fold.
FEBS letters562(1-3)1-4(2004 Mar)
Parisi G,Fornasari MS,Echave J

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DCTN6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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