SUGT1 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | SUGT1 |
Entrez Gene ID | 10910 |
Full Name | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone |
Synonyms | SGT1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_001130912.1 | NP_001124384.1 | protein SGT1 homolog isoform SGT1B |
XM_017020366.1 | XP_016875855.1 | protein SGT1 homolog isoform X2 |
NM_001130912.3 | NP_001124384.1 | protein SGT1 homolog isoform B |
NM_006704.5 | NP_006695.1 | protein SGT1 homolog isoform A |
XM_017020367.1 | XP_016875856.1 | protein SGT1 homolog isoform X2 |
NM_001130912.2 | NP_001124384.1 | protein SGT1 homolog isoform B |
XM_011534893.2 | XP_011533195.1 | protein SGT1 homolog isoform X5 |
NM_006704.3 | NP_006695.1 | protein SGT1 homolog isoform SGT1A |
NM_001320831.1 | NP_001307760.1 | protein SGT1 homolog isoform C |
NM_001320831.2 | NP_001307760.1 | protein SGT1 homolog isoform C |
XM_017020368.1 | XP_016875857.1 | protein SGT1 homolog isoform X4 |
NM_006704.4 | NP_006695.1 | protein SGT1 homolog isoform A |
XM_017020366.2 | XP_016875855.1 | protein SGT1 homolog isoform X2 |
XM_017020365.1 | XP_016875854.1 | protein SGT1 homolog isoform X1 |
XM_011534891.2 | XP_011533193.1 | protein SGT1 homolog isoform X3 |
XM_011534893.3 | XP_011533195.1 | protein SGT1 homolog isoform X5 |

Pan troglodytes (chimpanzee) | SUGT1 | XP_003952448.1 |
Arabidopsis thaliana (thale cress) | SGT1A | NP_849429.1 |
Oryza sativa (rice) | Os01g0624500 | NP_001043620.1 |
Canis lupus familiaris (dog) | SUGT1 | XP_005633996.1 |
Mus musculus (house mouse) | Sugt1 | NP_080750.1 |
Rattus norvegicus (Norway rat) | Sugt1 | NP_001013069.1 |
Arabidopsis thaliana (thale cress) | SGT1B | NP_192865.1 |
Bos taurus (cattle) | SUGT1 | NP_001039668.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006161 | XP_316219.4 |
Xenopus tropicalis (tropical clawed frog) | sugt1 | NP_001016156.1 |
Homo sapiens (human) | SUGT1 | NP_001124384.1 |
SUGT1 | XP_001084394.1 | |
Gallus gallus (chicken) | SUGT1 | NP_001025994.2 |
Danio rerio (zebrafish) | sgut1 | NP_001007362.1 |
Drosophila melanogaster (fruit fly) | Sgt1 | NP_649783.2 |
Caenorhabditis elegans (roundworm) | CELE_D1054.3 | NP_505751.1 |

Related articles in PubMed
SGT1-HSP90 complex is required for CENP-A deposition at centromeres.
Niikura Y, Kitagawa R, Ogi H, Kitagawa K
Cell cycle (Georgetown, Tex.)16(18)1683-1694(2017 Sep)
Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.
Gangula NR, Maddika S
The Journal of biological chemistry292(34)13947-13958(2017 08)
Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E.?coli.
Hong TJ, Hahn JS
Biochemical and biophysical research communications478(4)1647-52(2016 09)
Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
Novosylna O, Jurewicz E, Pydiura N, Goral A, Filipek A, Negrutskii B, El'skaya A
Biochimie119137-45(2015 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1)
Title: Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.
Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha.
Title: Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E.?coli.
Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A.
Title: Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
our data revealed a previously uncovered role of SGT1 in gastric cancer development, and suggested that SGT1 could be a promising anti-cancer target to against gastric cancer
Title: SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.
Data suggest that SspH2 (ubiquitin ligase effector from Salmonella typhimurium) ubiquitination activity and protein stability is enhanced by SGT1.
Title: The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.
The following SUGT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SUGT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu09232![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006704.5 , NM_006704.3 , NM_006704.4 | |
Accession Version | NM_006704.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-26 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform A | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139089.13. On Jun 2, 2019 this sequence version replaced NM_006704.4. Transcript Variant: This variant (2, also known as A) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (A) is shorter than isoform B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.91720.1, SRR1803614.129272.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006695.1 |
CDS | 86..1087 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu09232![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006704.5 , NM_006704.3 , NM_006704.4 | |
Accession Version | NM_006704.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-08-08 | |
Organism | Homo sapiens(Human) | |
Product | protein SGT1 homolog isoform SGT1A | |
Comment |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006695.1 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu09232![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_006704.5 , NM_006704.3 , NM_006704.4 | |
Accession Version | NM_006704.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-02 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform A | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN345940.1, BC000911.1 and AK292128.1. On Mar 9, 2016 this sequence version replaced NM_006704.3. Transcript Variant: This variant (2, also known as A) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (A) is shorter than isoform B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292128.1, SRR1660803.100103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006695.1 |
CDS | 231..1232 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu19340![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001130912.1 , NM_001130912.3 , NM_001130912.2 | |
Accession Version | NM_001130912.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-08-08 | |
Organism | Homo sapiens(Human) | |
Product | protein SGT1 homolog isoform SGT1B | |
Comment |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001124384.1 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu19340![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001130912.1 , NM_001130912.3 , NM_001130912.2 | |
Accession Version | NM_001130912.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-26 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform B | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139089.13. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001130912.2. Transcript Variant: This variant (1, also known as B or SGT1.2) encodes the longest isoform (B). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.31332.1, SRR1803614.94755.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001124384.1 |
CDS | 86..1183 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu19340![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001130912.1 , NM_001130912.3 , NM_001130912.2 | |
Accession Version | NM_001130912.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform B | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN345940.1, AY321358.1, BC000911.1 and AK292128.1. This sequence is a reference standard in the RefSeqGene project. On Mar 9, 2016 this sequence version replaced NM_001130912.1. Transcript Variant: This variant (1, also known as B or SGT1.2) encodes the longest isoform (B). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.31332.1, SRR1803615.3090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001124384.1 |
CDS | 231..1328 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu64514 | |
Clone ID Related Accession (Same CDS sequence) | XM_011534893.2 , XM_011534893.3 | |
Accession Version | XM_011534893.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011534893.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011533195.1 |
CDS | 383..1141 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu64514 | |
Clone ID Related Accession (Same CDS sequence) | XM_011534893.2 , XM_011534893.3 | |
Accession Version | XM_011534893.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011534893.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011533195.1 |
CDS | 565..1323 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu64513 | |
Clone ID Related Accession (Same CDS sequence) | NM_001320831.1 , NM_001320831.2 | |
Accession Version | NM_001320831.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-02 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform C | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN345940.1, AK302363.1, BC000911.1 and AK292128.1. On Mar 9, 2016 this sequence version replaced XM_011534892.1. Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001307760.1 |
CDS | 527..1360 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu64513 | |
Clone ID Related Accession (Same CDS sequence) | NM_001320831.1 , NM_001320831.2 | |
Accession Version | NM_001320831.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-26 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform C | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139089.13. On Jun 2, 2019 this sequence version replaced NM_001320831.1. Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.481669.1, AK302363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001307760.1 |
CDS | 382..1215 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu64512 | |
Clone ID Related Accession (Same CDS sequence) | XM_011534891.2 | |
Accession Version | XM_011534891.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011534891.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011533193.1 |
CDS | 569..1423 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84409 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020365.1 | |
Accession Version | XM_017020365.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875854.1 |
CDS | 219..1313 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGGCGG CTGCAGCAGG AACTGCAACA TCCCAGAGGT TTTTCCAGAG CTTCTCGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84410 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020366.1 , XM_017020367.1 , XM_017020366.2 | |
Accession Version | XM_017020366.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875855.1 |
CDS | 259..1188 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84410 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020366.1 , XM_017020367.1 , XM_017020366.2 | |
Accession Version | XM_017020367.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875856.1 |
CDS | 293..1222 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84410 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020366.1 , XM_017020367.1 , XM_017020366.2 | |
Accession Version | XM_017020366.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017020366.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875855.1 |
CDS | 374..1303 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTTAAGCC AAAAGGAAGT TGCTGTTGCT GATGCAAAGA AGTCTCTAGA ACTCAATCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84411 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020368.1 | |
Accession Version | XM_017020368.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein SGT1 homolog isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875857.1 |
CDS | 383..1234 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCTGAGAA AAGGAATATG TGAATACCAT GAAAAAAACT ATGCTGCTGC CCTAGAAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
SGT1-HSP90 complex is required for CENP-A deposition at centromeres. |
![]() |
Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1. |
![]() |
Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E.?coli. |
![]() |
Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1. |