MLLT11 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | MLLT11 |
| Entrez Gene ID | 10962 |
| Full Name | MLLT11, transcription factor 7 cofactor |
| Synonyms | AF1Q |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_006818.4 | NP_006809.1 | protein AF1q |
| NM_006818.3 | NP_006809.1 | protein AF1q |
| Pan troglodytes (chimpanzee) | MLLT11 | XP_513785.1 |
| MLLT11 | XP_001103655.1 | |
| Canis lupus familiaris (dog) | MLLT11 | XP_003432297.1 |
| Homo sapiens (human) | MLLT11 | NP_006809.1 |
| Bos taurus (cattle) | MLLT11 | NP_001069637.1 |
| Mus musculus (house mouse) | Mllt11 | NP_064298.1 |
| Rattus norvegicus (Norway rat) | Mllt11 | NP_001013934.1 |
Related articles in PubMed
The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.
Su Y, Ding W, Xing M, Qi D, Li Z, Cui D
Molecular neurobiology54(6)4806-4812(2017 Aug)
AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling.
Hu J, Li G, Liu L, Wang Y, Li X, Gong J
International journal of molecular sciences18(5)(2017 May)
Involvement of AF1q/MLLT11 in the progression of ovarian cancer.
Tiberio P, Lozneanu L, Angeloni V, Cavadini E, Pinciroli P, Callari M, Carcangiu ML, Lorusso D, Raspagliesi F, Pala V, Daidone MG, Appierto V
Oncotarget8(14)23246-23264(2017 Apr)
Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.
Tse CO, Kim S, Park J
Biochemical and biophysical research communications484(4)884-889(2017 03)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression.
Title: Involvement of AF1q/MLLT11 in the progression of ovarian cancer.
These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway.
Title: Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.
Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation.
Title: MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling.
Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter.
Title: RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription.
Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
Title: AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.
The following MLLT11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLLT11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu16243 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_006818.4 , NM_006818.3 | |
| Accession Version | NM_006818.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-11-19 | |
| Organism | Homo sapiens(human) | |
| Product | protein AF1q | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590133.32. On Jul 27, 2019 this sequence version replaced NM_006818.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.137394.1, BC022448.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_006809.1 |
| CDS | 164..436 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_006818.4 |
ORF Insert Sequence:
1 | ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu16243 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_006818.4 , NM_006818.3 | |
| Accession Version | NM_006818.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-30 | |
| Organism | Homo sapiens(human) | |
| Product | protein AF1q | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC022448.1 and BC006471.2. On Nov 16, 2004 this sequence version replaced NM_006818.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.266213.1, BC022448.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_006809.1 |
| CDS | 886..1158 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_006818.3 |
ORF Insert Sequence:
1 | ATGAGGGACC CTGTGAGTAG CCAGTACAGT TCCTTTCTTT TCTGGAGGAT GCCCATCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia. |
|
AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling. |
|
Involvement of AF1q/MLLT11 in the progression of ovarian cancer. |
|
Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells. |