Gene Symbol | SLC38A3 |
Entrez Gene ID | 10991 |
Full Name | solute carrier family 38 member 3 |
Synonyms | G17,NAT1,SN1,SNAT3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SLC38A3 cDNA ORF clone
Gene Symbol | SLC38A3 |
Entrez Gene ID | 10991 |
Full Name | solute carrier family 38 member 3 |
Synonyms | G17,NAT1,SN1,SNAT3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_006841.6 | NP_006832.1 | sodium-coupled neutral amino acid transporter 3 |
NM_006841.5 | NP_006832.1 | sodium-coupled neutral amino acid transporter 3 |
XM_006712954.2 | XP_006713017.1 | sodium-coupled neutral amino acid transporter 3 isoform X1 |
XM_006712954.3 | XP_006713017.1 | sodium-coupled neutral amino acid transporter 3 isoform X1 |
Homo sapiens (human) | SLC38A3 | NP_006832.1 |
Rattus norvegicus (Norway rat) | Slc38a3 | NP_665719.1 |
Oryza sativa (rice) | Os02g0191300 | NP_001046156.1 |
Xenopus tropicalis (tropical clawed frog) | slc38a3 | NP_001025548.1 |
Danio rerio (zebrafish) | slc38a5b | NP_001002648.1 |
Canis lupus familiaris (dog) | SLC38A3 | XP_005632572.1 |
Arabidopsis thaliana (thale cress) | AT3G30390 | NP_566854.1 |
Oryza sativa (rice) | Os06g0275800 | NP_001057382.1 |
Oryza sativa (rice) | Os02g0727100 | NP_001047994.1 |
Pan troglodytes (chimpanzee) | SLC38A3 | NP_001233290.1 |
Mus musculus (house mouse) | Slc38a3 | NP_076294.2 |
Arabidopsis thaliana (thale cress) | AT5G38820 | NP_198698.1 |
Oryza sativa (rice) | Os06g0633800 | NP_001058132.1 |
SLC38A3 | XP_001102960.1 | |
Bos taurus (cattle) | SLC38A3 | NP_001035576.1 |
Gallus gallus (chicken) | SLC38A3 | XP_426756.3 |
Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1.
Wang Y, Fu L, Cui M, Wang Y, Xu Y, Li M, Mi J
Cancer letters3938-15(2017 May)
Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.
Balkrishna S, Br?er A, Welford SM, Hatzoglou M, Br?er S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology33(5)1591-606(2014)
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.
Schi?th HB, Roshanbin S, H?gglund MG, Fredriksson R
Molecular aspects of medicine34(2-3)571-85(2013 Apr-Jun)
Expression and role of SNAT3 in the placenta.
Yoshioka C, Yasuda S, Kimura F, Kobayashi M, Itagaki S, Hirano T, Iseki K
Placenta30(12)1071-7(2009 Dec)
Amino acid transport across mammalian intestinal and renal epithelia.
Br?er S
Physiological reviews88(1)249-86(2008 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SLC38A3 activated PDK1/AKT signaling and promoted metastasis of non-small cell lung cancer cells through regulating glutamine and histidine transport.
Title: Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1.
The regulation of SNAT3 gene expression by extracellular pH involves post-transcriptional and transcriptional mechanisms, the latter being distinct from the mechanisms that control the tissue-specific expression of the gene.
Title: Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.
SNAT3 is expressed in the placenta in the early stage of pregnancy.
Title: Expression and role of SNAT3 in the placenta.
Transcription of the SLC38A3 gene was impaired in all 5 RCC cell lines analyzed. Our data indicate this gene as a putative tumour suppressor gene.
Title: Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice.
SNAT3 mRNA showed a 3-5 times stronger expression in gliomas than in metastases or control tissue, and was virtually absent from glioma cultures. Native glioblastoma immunostained positively with anti-SNAT3 antibody.
Title: Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas.
The following SLC38A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC38A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu01769 | |
Clone ID Related Accession (Same CDS sequence) | NM_006841.6 , NM_006841.5 , XM_006712954.2 , XM_006712954.3 | |
Accession Version | NM_006841.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | sodium-coupled neutral amino acid transporter 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP362985.1, BX537382.1, BM662099.1 and AC002077.1. On Nov 23, 2018 this sequence version replaced NM_006841.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.25344.1, BX537382.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000614032.5/ ENSP00000481301.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006832.1 |
CDS | 130..1644 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006841.6 |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01769 | |
Clone ID Related Accession (Same CDS sequence) | NM_006841.6 , NM_006841.5 , XM_006712954.2 , XM_006712954.3 | |
Accession Version | NM_006841.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | sodium-coupled neutral amino acid transporter 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP362985.1, BX537382.1 and BM662099.1. On Feb 20, 2014 this sequence version replaced NM_006841.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX537382.1, BC042875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006832.1 |
CDS | 155..1669 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006841.5 |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01769 | |
Clone ID Related Accession (Same CDS sequence) | NM_006841.6 , NM_006841.5 , XM_006712954.2 , XM_006712954.3 | |
Accession Version | XM_006712954.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | sodium-coupled neutral amino acid transporter 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006712954.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006713017.1 |
CDS | 189..1703 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006712954.2 |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01769 | |
Clone ID Related Accession (Same CDS sequence) | NM_006841.6 , NM_006841.5 , XM_006712954.2 , XM_006712954.3 | |
Accession Version | XM_006712954.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | sodium-coupled neutral amino acid transporter 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006712954.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006713017.1 |
CDS | 189..1703 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006712954.3 |
1 | ATGGAGGCGC CTTTGCAGAC AGAGATGGTG GAGCTGGTGC CCAATGGCAA ACACTCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1. |
Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression. |
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. |
Expression and role of SNAT3 in the placenta. |
Amino acid transport across mammalian intestinal and renal epithelia. |