Gene Symbol | STRAP |
Entrez Gene ID | 11171 |
Full Name | serine/threonine kinase receptor associated protein |
Synonyms | MAWD,PT-WD,UNRIP |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » STRAP cDNA ORF clone
Gene Symbol | STRAP |
Entrez Gene ID | 11171 |
Full Name | serine/threonine kinase receptor associated protein |
Synonyms | MAWD,PT-WD,UNRIP |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_005253294.2 | XP_005253351.1 | serine-threonine kinase receptor-associated protein isoform X1 |
NM_007178.3 | NP_009109.3 | serine-threonine kinase receptor-associated protein |
NM_007178.4 | NP_009109.3 | serine-threonine kinase receptor-associated protein |
XM_005253294.1 | XP_005253351.1 | serine-threonine kinase receptor-associated protein isoform X1 |
Canis lupus familiaris (dog) | STRAP | XP_543790.1 |
Mus musculus (house mouse) | Strap | NP_035629.2 |
Danio rerio (zebrafish) | strap | NP_956598.1 |
Pan troglodytes (chimpanzee) | STRAP | XP_001159216.2 |
Rattus norvegicus (Norway rat) | Strap | NP_001011969.1 |
Xenopus tropicalis (tropical clawed frog) | strap | NP_001120495.1 |
Homo sapiens (human) | STRAP | NP_009109.3 |
Bos taurus (cattle) | STRAP | NP_001015567.1 |
Drosophila melanogaster (fruit fly) | wmd | NP_611804.1 |
Arabidopsis thaliana (thale cress) | AT1G15470 | NP_563978.1 |
Gallus gallus (chicken) | STRAP | NP_001006247.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005029 | XP_001688468.1 |
Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.
Wu Q, Yu S, Chen J, Li Y, Gao Y
IUBMB life(2017 Dec)
STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.
Jin L, Vu T, Yuan G, Datta PK
Cancer research77(20)5464-5478(2017 Oct)
Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/?-catenin signaling.
Yuan G, Zhang B, Yang S, Jin L, Datta A, Bae S, Chen X, Datta PK
Oncotarget7(13)16023-37(2016 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer.
Title: STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.
these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling
Title: Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/?-catenin signaling.
MAWD and MAWBP were downregulated and associated with the differentiation grade in GC tissues.
Title: Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer.
Strap augments the apoptotic effects of mitochondrial p53.
Title: Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase.
Title: Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1.
The following STRAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STRAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
CloneID | OHu16654 | |
Clone ID Related Accession (Same CDS sequence) | NM_007178.3 , NM_007178.4 | |
Accession Version | NM_007178.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-10 | |
Organism | Homo sapiens(human) | |
Product | serine-threonine kinase receptor-associated protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA666505.1 and BC062306.1. On Jun 8, 2007 this sequence version replaced NM_007178.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062306.1, SRR1163655.182265.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAATGA GACAGACGCC GCTCACCTGC TCTGGCCACA CGCGACCCGT GGTTGATTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_009109.3 |
CDS | 355..1407 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007178.3 |
1 | ATGGCAATGA GACAGACGCC GCTCACCTGC TCTGGCCACA CGCGACCCGT GGTTGATTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu16654 | |
Clone ID Related Accession (Same CDS sequence) | NM_007178.3 , NM_007178.4 | |
Accession Version | NM_007178.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-29 | |
Organism | Homo sapiens(human) | |
Product | serine-threonine kinase receptor-associated protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC022073.13. On Nov 24, 2018 this sequence version replaced NM_007178.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1099325.1, SRR3476690.102734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000419869.7/ ENSP00000392270.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCAATGA GACAGACGCC GCTCACCTGC TCTGGCCACA CGCGACCCGT GGTTGATTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_009109.3 |
CDS | 322..1374 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007178.4 |
1 | ATGGCAATGA GACAGACGCC GCTCACCTGC TCTGGCCACA CGCGACCCGT GGTTGATTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu46045 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253294.2 , XM_005253294.1 | |
Accession Version | XM_005253294.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | serine-threonine kinase receptor-associated protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005253294.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCCTGG CTCATAAACA CATTGTCAAG ACTGTGGATT TCACGCAGGA TAGTAATTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253351.1 |
CDS | 473..1243 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005253294.2 |
1 | ATGACCCTGG CTCATAAACA CATTGTCAAG ACTGTGGATT TCACGCAGGA TAGTAATTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu46045 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253294.2 , XM_005253294.1 | |
Accession Version | XM_005253294.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | serine-threonine kinase receptor-associated protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCCTGG CTCATAAACA CATTGTCAAG ACTGTGGATT TCACGCAGGA TAGTAATTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253351.1 |
CDS | 499..1269 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005253294.1 |
1 | ATGACCCTGG CTCATAAACA CATTGTCAAG ACTGTGGATT TCACGCAGGA TAGTAATTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. |
STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. |
Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/?-catenin signaling. |