Gene Symbol | PHB2 |
Entrez Gene ID | 11331 |
Full Name | prohibitin 2 |
Synonyms | BAP,BCAP37,Bap37,PNAS-141,REA,hBAP,p22 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PHB2 cDNA ORF clone
Gene Symbol | PHB2 |
Entrez Gene ID | 11331 |
Full Name | prohibitin 2 |
Synonyms | BAP,BCAP37,Bap37,PNAS-141,REA,hBAP,p22 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001144831.1 | NP_001138303.1 | prohibitin-2 isoform 1 |
NM_001267700.1 | NP_001254629.1 | prohibitin-2 isoform 3 |
NM_001144831.2 | NP_001138303.1 | prohibitin-2 isoform 1 |
Danio rerio (zebrafish) | phb2b | NP_001002681.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009642 | XP_318676.3 |
Saccharomyces cerevisiae (baker's yeast) | PHB2 | NP_011747.2 |
Kluyveromyces lactis | KLLA0E15731g | XP_454659.1 |
Arabidopsis thaliana (thale cress) | PHB2 | NP_973756.1 |
Eremothecium gossypii | AGOS_ADL141W | NP_983955.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_09886 | XP_003709979.1 |
Arabidopsis thaliana (thale cress) | PHB1 | NP_194580.1 |
Homo sapiens (human) | PHB2 | NP_001138303.1 |
PHB2 | XP_001111957.1 | |
Bos taurus (cattle) | PHB2 | NP_001039663.1 |
Mus musculus (house mouse) | Phb2 | NP_031557.2 |
Rattus norvegicus (Norway rat) | Phb2 | NP_001013053.1 |
Drosophila melanogaster (fruit fly) | l(2)03709 | NP_001097372.1 |
Xenopus tropicalis (tropical clawed frog) | phb2 | NP_001016551.1 |
Canis lupus familiaris (dog) | PHB2 | XP_543843.3 |
Gallus gallus (chicken) | PHB2 | NP_001074354.1 |
Caenorhabditis elegans (roundworm) | phb-2 | NP_495250.2 |
Schizosaccharomyces pombe (fission yeast) | phb2 | NP_588144.2 |
Arabidopsis thaliana (thale cress) | PHB6 | NP_001077924.1 |
Arabidopsis thaliana (thale cress) | PHB7 | NP_199227.1 |
Oryza sativa (rice) | Os03g0841700 | NP_001051853.1 |
Pan troglodytes (chimpanzee) | PHB2 | XP_508977.2 |
Danio rerio (zebrafish) | phb2a | NP_955975.1 |
Neurospora crassa | NCU03310 | XP_964487.1 |
Oryza sativa (rice) | Os07g0262200 | NP_001059325.1 |
Prohibitin-2 is a novel regulator of p21
Taniguchi K, Matsumura K, Kageyama S, Ii H, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S
Biochemical and biophysical research communications496(1)218-224(2018 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
REA modulates cross talk among multiple cell types in the uterine tissue and host background, serving as a brake on the estradiol-ER axis and restraining multiple aspects that contribute to the pathologic progression of endometriosis.
Title: Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis.
analysis of LGALS3, PHB2, MUC1, and GK2 expression with CA15-3 in early-stage breast cancer
Title: Identification of a panel of complex autoantigens (LGALS3, PHB2, MUC1, and GK2) in combination with CA15-3 for the diagnosis of early-stage breast cancer.
Fluorizoline bind to prohibitin, inducing mitochondrial apoptotic pathway through NOXA and BIM upregulation.
Title: A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.
results show that PHB2 binds to the ligand binding domain of ERalpha with a conformational change in the helix 12 of ERalpha
Title: Differential binding of prohibitin-2 to estrogen receptor ? and to drug-resistant ER? mutants.
BIG3 may block the KPNAs (KPNA1, KPNA5, and KPNA6) binding region(s) of PHB2.
Title: BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.
The following PHB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PHB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu17487 | |
Clone ID Related Accession (Same CDS sequence) | NM_001144831.1 , NM_001144831.2 | |
Accession Version | NM_001144831.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-19 | |
Organism | Homo sapiens(human) | |
Product | prohibitin-2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC110322.1. On Jun 12, 2012 this sequence version replaced NM_007273.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110322.1, AF126021.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCCAGA ACTTGAAGGA CTTGGCGGGA CGGCTGCCCG CCGGGCCCCG GGGCATGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001138303.1 |
CDS | 211..1110 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001144831.1 |
1 | ATGGCCCAGA ACTTGAAGGA CTTGGCGGGA CGGCTGCCCG CCGGGCCCCG GGGCATGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu17487 | |
Clone ID Related Accession (Same CDS sequence) | NM_001144831.1 , NM_001144831.2 | |
Accession Version | NM_001144831.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-03 | |
Organism | Homo sapiens(human) | |
Product | prohibitin-2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC110322.1 and U47924.1. On May 17, 2019 this sequence version replaced NM_001144831.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.496782.1, SRR7410570.496788.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000535923.6/ ENSP00000441875.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCCAGA ACTTGAAGGA CTTGGCGGGA CGGCTGCCCG CCGGGCCCCG GGGCATGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001138303.1 |
CDS | 122..1021 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001144831.2 |
1 | ATGGCCCAGA ACTTGAAGGA CTTGGCGGGA CGGCTGCCCG CCGGGCCCCG GGGCATGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu21903 | |
Clone ID Related Accession (Same CDS sequence) | NM_001267700.1 | |
Accession Version | NM_001267700.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Homo sapiens(human) | |
Product | prohibitin-2 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC110322.1, AK298217.1, U47924.1 and AF150962.1. Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.18000.1, SRR1163657.80834.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCCAGA ACTTGAAGGA CTTGGCGGGA CGGCTGCCCG CCGGGCCCCG GGGCATGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001254629.1 |
CDS | 211..996 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001267700.1 |
1 | ATGGCCCAGA ACTTGAAGGA CTTGGCGGGA CGGCTGCCCG CCGGGCCCCG GGGCATGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Prohibitin-2 is a novel regulator of p21 |