×

ADCYAP1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ADCYAP1
Entrez Gene ID 116
Full Name adenylate cyclase activating polypeptide 1 (pituitary)
Synonyms PACAP
General protein information
Preferred Names
pituitary adenylate cyclase-activating polypeptide
Names
pituitary adenylate cyclase-activating polypeptide
prepro-PACAP
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18p11

Summary This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. lac of sum
Disorder MIM:

102980


mRNA and Protein(s)

mRNA Protein Name
XM_005258081 XP_005258138 pituitary adenylate cyclase-activating polypeptide isoform X1
NM_001099733 NP_001093203 pituitary adenylate cyclase-activating polypeptide preproprotein
NM_001117 NP_001108 pituitary adenylate cyclase-activating polypeptide preproprotein



Homo sapiens (human) ADCYAP1 NP_001093203.1
Pan troglodytes (chimpanzee) ADCYAP1 NP_001181872.1
Canis lupus familiaris (dog) ADCYAP1 XP_849191.2
Bos taurus (cattle) ADCYAP1 NP_001040020.1
Mus musculus (house mouse) Adcyap1 NP_033755.1
Rattus norvegicus (Norway rat) Adcyap1 NP_058685.1
Gallus gallus (chicken) ADCYAP1 NP_001001291.2
Xenopus (Silurana) tropicalis (western clawed frog) adcyap1 NP_001096425.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADCYAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADCYAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu50973 XM_005258081 PREDICTED: Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
OHu16639 NM_001099733 Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu16639 NM_001117 Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu50973
Clone ID Related Accession (Same CDS sequence) XM_005258081
Accession Version XM_005258081.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1014bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product pituitary adenylate cyclase-activating polypeptide isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010859.15) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530424798. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAATAAAA ATCGGAGCGC AACAGTGCAA CAAAATATTC TGTACTTAAA GGCAACAGGC 
AGGCAGATGT TGACAAAGAG GGCTCTCCAA AAACCATGTT CGGATAGATT TTTGCGAACT
GCACAGATAA ATAGGAGCAG AAGGCCGGTC ACCTCTGTAA CCAGCGGTAG CAGCAGCAGA
AGCCGCGCTT CACCTCATCG CCCCCTCTTT CTTTCTTCTG CCTCTCTCTC TGCGCCCCCT
TCTCTCCGTG TCACGCTCCC TCCTGGTTCT GCGCGTCTAC AAACTTTTGA GCAGAACACG
AGCCTCGGCA AACGAGTCCC GCAGCTCCTC CTGCTGCTCC CGCTGGTTCC TGCGGCTTCT
GCTCAGACAC CAACGCCAGA CGGCGATGCC TCTCGGGTGG TGACTCCAGC GCAGGAACTT
GAAGAAGCGC TTTGCCCGCC GTCCTACCTG GCAGCTCTCC TGGCAGCGGG AGGAGTTGAA
GGAATGACCA TGTGTAGCGG AGCGAGGCTG GCCCTGCTGG TCTATGGGAT AATCATGCAC
AGCAGCGTCT ACAGCTCACC TGCCGCCGCC GGACTCCGGT TCCCCGGGAT CAGGCCAGAG
GAAGAGGCGT ACGGCGAGGA CGGAAACCCG CTGCCAGACT TCGATGGCTC GGAGCCGCCG
GGCGCAGGGA GCCCCGCCTC CGCGCCGCGC GCCGCCGCCG CCTGGTACCG CCCGGCCGGG
AGAAGAGATG TCGCCCACGG GATCCTTAAC GAGGCCTACC GCAAAGTGCT GGACCAGCTG
TCCGCCGGGA AGCACCTGCA GTCGCTCGTG GCCCGGGGCG TGGGTGGGAG CCTCGGCGGC
GGCGCGGGGG ACGACGCGGA GCCGCTCTCC AAGCGCCACT CGGACGGGAT CTTCACGGAC
AGCTACAGCC GCTACCGGAA ACAAATGGCT GTCAAGAAAT ACTTGGCGGC CGTCCTAGGG
AAGAGGTATA AACAAAGGGT TAAAAACAAA GGACGCCGAA TAGCTTATTT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005258138.1
CDS33..1046
Misc Feature(1)762..842(+)
Misc Feature(2)909..989(+)
Translation

Target ORF information:

RefSeq Version XM_005258081
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005258081

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAATAAAA ATCGGAGCGC AACAGTGCAA CAAAATATTC TGTACTTAAA GGCAACAGGC 
AGGCAGATGT TGACAAAGAG GGCTCTCCAA AAACCATGTT CGGATAGATT TTTGCGAACT
GCACAGATAA ATAGGAGCAG AAGGCCGGTC ACCTCTGTAA CCAGCGGTAG CAGCAGCAGA
AGCCGCGCTT CACCTCATCG CCCCCTCTTT CTTTCTTCTG CCTCTCTCTC TGCGCCCCCT
TCTCTCCGTG TCACGCTCCC TCCTGGTTCT GCGCGTCTAC AAACTTTTGA GCAGAACACG
AGCCTCGGCA AACGAGTCCC GCAGCTCCTC CTGCTGCTCC CGCTGGTTCC TGCGGCTTCT
GCTCAGACAC CAACGCCAGA CGGCGATGCC TCTCGGGTGG TGACTCCAGC GCAGGAACTT
GAAGAAGCGC TTTGCCCGCC GTCCTACCTG GCAGCTCTCC TGGCAGCGGG AGGAGTTGAA
GGAATGACCA TGTGTAGCGG AGCGAGGCTG GCCCTGCTGG TCTATGGGAT AATCATGCAC
AGCAGCGTCT ACAGCTCACC TGCCGCCGCC GGACTCCGGT TCCCCGGGAT CAGGCCAGAG
GAAGAGGCGT ACGGCGAGGA CGGAAACCCG CTGCCAGACT TCGATGGCTC GGAGCCGCCG
GGCGCAGGGA GCCCCGCCTC CGCGCCGCGC GCCGCCGCCG CCTGGTACCG CCCGGCCGGG
AGAAGAGATG TCGCCCACGG GATCCTTAAC GAGGCCTACC GCAAAGTGCT GGACCAGCTG
TCCGCCGGGA AGCACCTGCA GTCGCTCGTG GCCCGGGGCG TGGGTGGGAG CCTCGGCGGC
GGCGCGGGGG ACGACGCGGA GCCGCTCTCC AAGCGCCACT CGGACGGGAT CTTCACGGAC
AGCTACAGCC GCTACCGGAA ACAAATGGCT GTCAAGAAAT ACTTGGCGGC CGTCCTAGGG
AAGAGGTATA AACAAAGGGT TAAAAACAAA GGACGCCGAA TAGCTTATTT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16639
Clone ID Related Accession (Same CDS sequence) NM_001099733 , NM_001117
Accession Version NM_001099733.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product pituitary adenylate cyclase-activating polypeptide preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC320719.1, BC093837.1 and AP000894.6. Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313050.1, BX333515.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGACCATGT GTAGCGGAGC GAGGCTGGCC CTGCTGGTCT ATGGGATAAT CATGCACAGC 
AGCGTCTACA GCTCACCTGC CGCCGCCGGA CTCCGGTTCC CCGGGATCAG GCCAGAGGAA
GAGGCGTACG GCGAGGACGG AAACCCGCTG CCAGACTTCG ATGGCTCGGA GCCGCCGGGC
GCAGGGAGCC CCGCCTCCGC GCCGCGCGCC GCCGCCGCCT GGTACCGCCC GGCCGGGAGA
AGAGATGTCG CCCACGGGAT CCTTAACGAG GCCTACCGCA AAGTGCTGGA CCAGCTGTCC
GCCGGGAAGC ACCTGCAGTC GCTCGTGGCC CGGGGCGTGG GTGGGAGCCT CGGCGGCGGC
GCGGGGGACG ACGCGGAGCC GCTCTCCAAG CGCCACTCGG ACGGGATCTT CACGGACAGC
TACAGCCGCT ACCGGAAACA AATGGCTGTC AAGAAATACT TGGCGGCCGT CCTAGGGAAG
AGGTATAAAC AAAGGGTTAA AAACAAAGGA CGCCGAATAG CTTATTTGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001093203.1
CDS120..650
Misc Feature(1)366..446(+)
Misc Feature(2)513..593(+)
Exon (1)1..118
Gene:ADCYAP1
Gene Synonym:
Exon (2)119..229
Gene:ADCYAP1
Gene Synonym:
Exon (3)230..361
Gene:ADCYAP1
Gene Synonym:
Exon (4)362..460
Gene:ADCYAP1
Gene Synonym:
Exon (5)461..3187
Gene:ADCYAP1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001099733
Organism Homo sapiens (human)
Definition Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001099733

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGACCATGT GTAGCGGAGC GAGGCTGGCC CTGCTGGTCT ATGGGATAAT CATGCACAGC 
AGCGTCTACA GCTCACCTGC CGCCGCCGGA CTCCGGTTCC CCGGGATCAG GCCAGAGGAA
GAGGCGTACG GCGAGGACGG AAACCCGCTG CCAGACTTCG ATGGCTCGGA GCCGCCGGGC
GCAGGGAGCC CCGCCTCCGC GCCGCGCGCC GCCGCCGCCT GGTACCGCCC GGCCGGGAGA
AGAGATGTCG CCCACGGGAT CCTTAACGAG GCCTACCGCA AAGTGCTGGA CCAGCTGTCC
GCCGGGAAGC ACCTGCAGTC GCTCGTGGCC CGGGGCGTGG GTGGGAGCCT CGGCGGCGGC
GCGGGGGACG ACGCGGAGCC GCTCTCCAAG CGCCACTCGG ACGGGATCTT CACGGACAGC
TACAGCCGCT ACCGGAAACA AATGGCTGTC AAGAAATACT TGGCGGCCGT CCTAGGGAAG
AGGTATAAAC AAAGGGTTAA AAACAAAGGA CGCCGAATAG CTTATTTGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16639
Clone ID Related Accession (Same CDS sequence) NM_001099733 , NM_001117
Accession Version NM_001117.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product pituitary adenylate cyclase-activating polypeptide preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA145895.1, BC093837.1 and AP000894.6. On Feb 22, 2013 this sequence version replaced gi:153266794. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S83513.1, DN991692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGACCATGT GTAGCGGAGC GAGGCTGGCC CTGCTGGTCT ATGGGATAAT CATGCACAGC 
AGCGTCTACA GCTCACCTGC CGCCGCCGGA CTCCGGTTCC CCGGGATCAG GCCAGAGGAA
GAGGCGTACG GCGAGGACGG AAACCCGCTG CCAGACTTCG ATGGCTCGGA GCCGCCGGGC
GCAGGGAGCC CCGCCTCCGC GCCGCGCGCC GCCGCCGCCT GGTACCGCCC GGCCGGGAGA
AGAGATGTCG CCCACGGGAT CCTTAACGAG GCCTACCGCA AAGTGCTGGA CCAGCTGTCC
GCCGGGAAGC ACCTGCAGTC GCTCGTGGCC CGGGGCGTGG GTGGGAGCCT CGGCGGCGGC
GCGGGGGACG ACGCGGAGCC GCTCTCCAAG CGCCACTCGG ACGGGATCTT CACGGACAGC
TACAGCCGCT ACCGGAAACA AATGGCTGTC AAGAAATACT TGGCGGCCGT CCTAGGGAAG
AGGTATAAAC AAAGGGTTAA AAACAAAGGA CGCCGAATAG CTTATTTGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001108.2
CDS192..722
Misc Feature(1)438..518(+)
Misc Feature(2)585..665(+)
Exon (1)1..301
Gene:ADCYAP1
Gene Synonym:
Exon (2)302..433
Gene:ADCYAP1
Gene Synonym:
Exon (3)434..532
Gene:ADCYAP1
Gene Synonym:
Exon (4)533..3259
Gene:ADCYAP1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001117
Organism Homo sapiens (human)
Definition Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001117

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGACCATGT GTAGCGGAGC GAGGCTGGCC CTGCTGGTCT ATGGGATAAT CATGCACAGC 
AGCGTCTACA GCTCACCTGC CGCCGCCGGA CTCCGGTTCC CCGGGATCAG GCCAGAGGAA
GAGGCGTACG GCGAGGACGG AAACCCGCTG CCAGACTTCG ATGGCTCGGA GCCGCCGGGC
GCAGGGAGCC CCGCCTCCGC GCCGCGCGCC GCCGCCGCCT GGTACCGCCC GGCCGGGAGA
AGAGATGTCG CCCACGGGAT CCTTAACGAG GCCTACCGCA AAGTGCTGGA CCAGCTGTCC
GCCGGGAAGC ACCTGCAGTC GCTCGTGGCC CGGGGCGTGG GTGGGAGCCT CGGCGGCGGC
GCGGGGGACG ACGCGGAGCC GCTCTCCAAG CGCCACTCGG ACGGGATCTT CACGGACAGC
TACAGCCGCT ACCGGAAACA AATGGCTGTC AAGAAATACT TGGCGGCCGT CCTAGGGAAG
AGGTATAAAC AAAGGGTTAA AAACAAAGGA CGCCGAATAG CTTATTTGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
*
*
*
*