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APOA5 cDNA ORF clone, Homo sapiens (human)

Gene Symbol APOA5
Entrez Gene ID 116519
Full Name apolipoprotein A-V
Synonyms APOAV, RAP3
General protein information
Preferred Names
apolipoprotein A-V
Names
apolipoprotein A-V
apo-AV
apolipoprotein A5
regeneration-associated protein 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23

Summary The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

606368

Disorder Html: {Hypertriglyceridemia, susceptibility to}, 145750 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_052968 NP_443200 apolipoprotein A-V precursor
NM_001166598 NP_001160070 apolipoprotein A-V precursor



Homo sapiens (human) APOA5 NP_443200.2
Pan troglodytes (chimpanzee) APOA5 XP_003313361.1
Macaca mulatta (Rhesus monkey) APOA5 XP_002799851.1
Canis lupus familiaris (dog) APOA5 XP_546511.1
Bos taurus (cattle) APOA5 NP_001076961.1
Mus musculus (house mouse) Apoa5 NP_536682.2
Rattus norvegicus (Norway rat) Apoa5 NP_542143.1
Gallus gallus (chicken) APOA5 XP_004948132.1
Xenopus (Silurana) tropicalis (western clawed frog) apoa5 NP_001116904.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APOA5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOA5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu15824 NM_052968 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00
OHu15824 NM_001166598 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu15824
Clone ID Related Accession (Same CDS sequence) NM_001166598 , NM_052968
Accession Version NM_052968.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 04-AUG-2015
Organism Homo sapiens (human)
Product apolipoprotein A-V precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA641693.1, DB184692.1, BC101787.1, AF202889.1 and AP006216.1. This sequence is a reference standard in the RefSeqGene project. On Oct 30, 2009 this sequence version replaced gi:63079708. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB123028.1, DB184692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAAGCA TGGCTGCCGT GCTCACCTGG GCTCTGGCTC TTCTTTCAGC GTTTTCGGCC 
ACCCAGGCAC GGAAAGGCTT CTGGGACTAC TTCAGCCAGA CCAGCGGGGA CAAAGGCAGG
GTGGAGCAGA TCCATCAGCA GAAGATGGCT CGCGAGCCCG CGACCCTGAA AGACAGCCTT
GAGCAAGACC TCAACAATAT GAACAAGTTC CTGGAAAAGC TGAGGCCTCT GAGTGGGAGC
GAGGCTCCTC GGCTCCCACA GGACCCGGTG GGCATGCGGC GGCAGCTGCA GGAGGAGTTG
GAGGAGGTGA AGGCTCGCCT CCAGCCCTAC ATGGCAGAGG CGCACGAGCT GGTGGGCTGG
AATTTGGAGG GCTTGCGGCA GCAACTGAAG CCCTACACGA TGGATCTGAT GGAGCAGGTG
GCCCTGCGCG TGCAGGAGCT GCAGGAGCAG TTGCGCGTGG TGGGGGAAGA CACCAAGGCC
CAGTTGCTGG GGGGCGTGGA CGAGGCTTGG GCTTTGCTGC AGGGACTGCA GAGCCGCGTG
GTGCACCACA CCGGCCGCTT CAAAGAGCTC TTCCACCCAT ACGCCGAGAG CCTGGTGAGC
GGCATCGGGC GCCACGTGCA GGAGCTGCAC CGCAGTGTGG CTCCGCACGC CCCCGCCAGC
CCCGCGCGCC TCAGTCGCTG CGTGCAGGTG CTCTCCCGGA AGCTCACGCT CAAGGCCAAG
GCCCTGCACG CACGCATCCA GCAGAACCTG GACCAGCTGC GCGAAGAGCT CAGCAGAGCC
TTTGCAGGCA CTGGGACTGA GGAAGGGGCC GGCCCGGACC CCCAGATGCT CTCCGAGGAG
GTGCGCCAGC GACTTCAGGC TTTCCGCCAG GACACCTACC TGCAGATAGC TGCCTTCACT
CGCGCCATCG ACCAGGAGAC TGAGGAGGTC CAGCAGCAGC TGGCGCCACC TCCACCAGGC
CACAGTGCCT TCGCCCCAGA GTTTCAACAA ACAGACAGTG GCAAGGTTCT GAGCAAGCTG
CAGGCCCGTC TGGATGACCT GTGGGAAGAC ATCACTCACA GCCTTCATGA CCAGGGCCAC
AGCCATCTGG GGGACCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_443200.2
CDS74..1174
Misc Feature(1)35..37(+)
Misc Feature(2)248..250(+)
Misc Feature(3)305..844(+)
Exon (1)1..41
Gene:APOA5
Gene Synonym:
Exon (2)42..122
Gene:APOA5
Gene Synonym:
Exon (3)123..234
Gene:APOA5
Gene Synonym:
Exon (4)235..1932
Gene:APOA5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_052968
Organism Homo sapiens (human)
Definition Homo sapiens apolipoprotein A-V (APOA5), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_052968

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAAGCA TGGCTGCCGT GCTCACCTGG GCTCTGGCTC TTCTTTCAGC GTTTTCGGCC 
ACCCAGGCAC GGAAAGGCTT CTGGGACTAC TTCAGCCAGA CCAGCGGGGA CAAAGGCAGG
GTGGAGCAGA TCCATCAGCA GAAGATGGCT CGCGAGCCCG CGACCCTGAA AGACAGCCTT
GAGCAAGACC TCAACAATAT GAACAAGTTC CTGGAAAAGC TGAGGCCTCT GAGTGGGAGC
GAGGCTCCTC GGCTCCCACA GGACCCGGTG GGCATGCGGC GGCAGCTGCA GGAGGAGTTG
GAGGAGGTGA AGGCTCGCCT CCAGCCCTAC ATGGCAGAGG CGCACGAGCT GGTGGGCTGG
AATTTGGAGG GCTTGCGGCA GCAACTGAAG CCCTACACGA TGGATCTGAT GGAGCAGGTG
GCCCTGCGCG TGCAGGAGCT GCAGGAGCAG TTGCGCGTGG TGGGGGAAGA CACCAAGGCC
CAGTTGCTGG GGGGCGTGGA CGAGGCTTGG GCTTTGCTGC AGGGACTGCA GAGCCGCGTG
GTGCACCACA CCGGCCGCTT CAAAGAGCTC TTCCACCCAT ACGCCGAGAG CCTGGTGAGC
GGCATCGGGC GCCACGTGCA GGAGCTGCAC CGCAGTGTGG CTCCGCACGC CCCCGCCAGC
CCCGCGCGCC TCAGTCGCTG CGTGCAGGTG CTCTCCCGGA AGCTCACGCT CAAGGCCAAG
GCCCTGCACG CACGCATCCA GCAGAACCTG GACCAGCTGC GCGAAGAGCT CAGCAGAGCC
TTTGCAGGCA CTGGGACTGA GGAAGGGGCC GGCCCGGACC CCCAGATGCT CTCCGAGGAG
GTGCGCCAGC GACTTCAGGC TTTCCGCCAG GACACCTACC TGCAGATAGC TGCCTTCACT
CGCGCCATCG ACCAGGAGAC TGAGGAGGTC CAGCAGCAGC TGGCGCCACC TCCACCAGGC
CACAGTGCCT TCGCCCCAGA GTTTCAACAA ACAGACAGTG GCAAGGTTCT GAGCAAGCTG
CAGGCCCGTC TGGATGACCT GTGGGAAGAC ATCACTCACA GCCTTCATGA CCAGGGCCAC
AGCCATCTGG GGGACCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15824
Clone ID Related Accession (Same CDS sequence) NM_001166598 , NM_052968
Accession Version NM_001166598.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 04-AUG-2015
Organism Homo sapiens (human)
Product apolipoprotein A-V precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA641693.1, AF202889.1 and AP006216.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA641318.1, AK292739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAAGCA TGGCTGCCGT GCTCACCTGG GCTCTGGCTC TTCTTTCAGC GTTTTCGGCC 
ACCCAGGCAC GGAAAGGCTT CTGGGACTAC TTCAGCCAGA CCAGCGGGGA CAAAGGCAGG
GTGGAGCAGA TCCATCAGCA GAAGATGGCT CGCGAGCCCG CGACCCTGAA AGACAGCCTT
GAGCAAGACC TCAACAATAT GAACAAGTTC CTGGAAAAGC TGAGGCCTCT GAGTGGGAGC
GAGGCTCCTC GGCTCCCACA GGACCCGGTG GGCATGCGGC GGCAGCTGCA GGAGGAGTTG
GAGGAGGTGA AGGCTCGCCT CCAGCCCTAC ATGGCAGAGG CGCACGAGCT GGTGGGCTGG
AATTTGGAGG GCTTGCGGCA GCAACTGAAG CCCTACACGA TGGATCTGAT GGAGCAGGTG
GCCCTGCGCG TGCAGGAGCT GCAGGAGCAG TTGCGCGTGG TGGGGGAAGA CACCAAGGCC
CAGTTGCTGG GGGGCGTGGA CGAGGCTTGG GCTTTGCTGC AGGGACTGCA GAGCCGCGTG
GTGCACCACA CCGGCCGCTT CAAAGAGCTC TTCCACCCAT ACGCCGAGAG CCTGGTGAGC
GGCATCGGGC GCCACGTGCA GGAGCTGCAC CGCAGTGTGG CTCCGCACGC CCCCGCCAGC
CCCGCGCGCC TCAGTCGCTG CGTGCAGGTG CTCTCCCGGA AGCTCACGCT CAAGGCCAAG
GCCCTGCACG CACGCATCCA GCAGAACCTG GACCAGCTGC GCGAAGAGCT CAGCAGAGCC
TTTGCAGGCA CTGGGACTGA GGAAGGGGCC GGCCCGGACC CCCAGATGCT CTCCGAGGAG
GTGCGCCAGC GACTTCAGGC TTTCCGCCAG GACACCTACC TGCAGATAGC TGCCTTCACT
CGCGCCATCG ACCAGGAGAC TGAGGAGGTC CAGCAGCAGC TGGCGCCACC TCCACCAGGC
CACAGTGCCT TCGCCCCAGA GTTTCAACAA ACAGACAGTG GCAAGGTTCT GAGCAAGCTG
CAGGCCCGTC TGGATGACCT GTGGGAAGAC ATCACTCACA GCCTTCATGA CCAGGGCCAC
AGCCATCTGG GGGACCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001160070.1
CDS50..1150
Misc Feature(1)35..37(+)
Misc Feature(2)224..226(+)
Misc Feature(3)281..820(+)
Exon (1)1..41
Gene:APOA5
Gene Synonym:
Exon (2)42..98
Gene:APOA5
Gene Synonym:
Exon (3)99..210
Gene:APOA5
Gene Synonym:
Exon (4)211..1908
Gene:APOA5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001166598
Organism Homo sapiens (human)
Definition Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001166598

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCAAGCA TGGCTGCCGT GCTCACCTGG GCTCTGGCTC TTCTTTCAGC GTTTTCGGCC 
ACCCAGGCAC GGAAAGGCTT CTGGGACTAC TTCAGCCAGA CCAGCGGGGA CAAAGGCAGG
GTGGAGCAGA TCCATCAGCA GAAGATGGCT CGCGAGCCCG CGACCCTGAA AGACAGCCTT
GAGCAAGACC TCAACAATAT GAACAAGTTC CTGGAAAAGC TGAGGCCTCT GAGTGGGAGC
GAGGCTCCTC GGCTCCCACA GGACCCGGTG GGCATGCGGC GGCAGCTGCA GGAGGAGTTG
GAGGAGGTGA AGGCTCGCCT CCAGCCCTAC ATGGCAGAGG CGCACGAGCT GGTGGGCTGG
AATTTGGAGG GCTTGCGGCA GCAACTGAAG CCCTACACGA TGGATCTGAT GGAGCAGGTG
GCCCTGCGCG TGCAGGAGCT GCAGGAGCAG TTGCGCGTGG TGGGGGAAGA CACCAAGGCC
CAGTTGCTGG GGGGCGTGGA CGAGGCTTGG GCTTTGCTGC AGGGACTGCA GAGCCGCGTG
GTGCACCACA CCGGCCGCTT CAAAGAGCTC TTCCACCCAT ACGCCGAGAG CCTGGTGAGC
GGCATCGGGC GCCACGTGCA GGAGCTGCAC CGCAGTGTGG CTCCGCACGC CCCCGCCAGC
CCCGCGCGCC TCAGTCGCTG CGTGCAGGTG CTCTCCCGGA AGCTCACGCT CAAGGCCAAG
GCCCTGCACG CACGCATCCA GCAGAACCTG GACCAGCTGC GCGAAGAGCT CAGCAGAGCC
TTTGCAGGCA CTGGGACTGA GGAAGGGGCC GGCCCGGACC CCCAGATGCT CTCCGAGGAG
GTGCGCCAGC GACTTCAGGC TTTCCGCCAG GACACCTACC TGCAGATAGC TGCCTTCACT
CGCGCCATCG ACCAGGAGAC TGAGGAGGTC CAGCAGCAGC TGGCGCCACC TCCACCAGGC
CACAGTGCCT TCGCCCCAGA GTTTCAACAA ACAGACAGTG GCAAGGTTCT GAGCAAGCTG
CAGGCCCGTC TGGATGACCT GTGGGAAGAC ATCACTCACA GCCTTCATGA CCAGGGCCAC
AGCCATCTGG GGGACCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Apolipoprotein polymorphism is associated with pro-thrombotic profile in non-demented dyslipidemic subjects
Exp. Biol. Med. (Maywood) 240 (1), 79-86 (2015)
Ferreira CN, Carvalho MG, Gomes KB, Reis HJ, Fernandes AP, Palotas A and Sousa MO.


book

Increased risk of obesity related to total energy intake with the APOA5-1131T > C polymorphism in Korean premenopausal women
Nutr Res 34 (10), 827-836 (2014)
Lim HH, Choi M, Kim JY, Lee JH and Kim OY.


book

Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291)
Arterioscler. Thromb. Vasc. Biol. 34 (10), 2254-2260 (2014)
Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM and Ryan RO.


book

A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency
J. Am. Coll. Cardiol. 64 (3), 267-277 (2014)
Cui G, Li Z, Li R, Huang J, Wang H, Zhang L, Ding H and Wang DW.


book

Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study
Lipids Health Dis 13, 162 (2014)
Hishida A, Wakai K, Naito M, Suma S, Sasakabe T, Hamajima N, Hosono S, Horita M, Turin TC, Suzuki S, Kairupan TS, Mikami H, Ohnaka K, Watanabe I, Uemura H, Kubo M and Tanaka H.


book

Definitive N-terminal protein sequence and further characterization of the novel apolipoprotein A5 in human serum
Clin. Chem. 52 (3), 514-517 (2006)
Alborn WE, Johnson MG, Prince MJ and Konrad RJ.


book

The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese
Atherosclerosis 165 (2), 201-204 (2002)
Nabika T, Nasreen S, Kobayashi S and Masuda J.


book

Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
Hum. Mol. Genet. 11 (24), 3031-3038 (2002)
Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM and Cohen JC.


book

Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration
J. Biol. Chem. 276 (48), 44512-44520 (2001)
van der Vliet HN, Sammels MG, Leegwater AC, Levels JH, Reitsma PH, Boers W and Chamuleau RA.


book

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
Science 294 (5540), 169-173 (2001)
Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM and Rubin EM.


 
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