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TMC1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TMC1
Entrez Gene ID 117531
Full Name transmembrane channel-like 1
Synonyms DFNA36, DFNB11, DFNB7
General protein information
Preferred Names
transmembrane channel-like protein 1
Names
transmembrane channel-like protein 1
transmembrane, cochlear expressed, 1
transmembrane cochlear-expressed protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q21.12

Summary This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

606706

Disorder Html: Deafness, autosomal recessive 7, 600974 (3); Deafness, autosomal

mRNA and Protein(s)

mRNA Protein Name
NM_138691 NP_619636 transmembrane channel-like protein 1
XM_011518213 XP_011516515 transmembrane channel-like protein 1 isoform X1


Homo sapiens (human) TMC1 NP_619636.2
Pan troglodytes (chimpanzee) TMC1 XP_528322.2
Macaca mulatta (Rhesus monkey) TMC1 XP_001093188.2
Canis lupus familiaris (dog) TMC1 XP_005616877.1
Bos taurus (cattle) TMC1 XP_002689695.2
Mus musculus (house mouse) Tmc1 NP_083229.1
Rattus norvegicus (Norway rat) Tmc1 NP_001101991.1
Gallus gallus (chicken) TMC1 NP_001006580.1
Danio rerio (zebrafish) tmc1 XP_695621.4
Xenopus (Silurana) tropicalis (western clawed frog) tmc1 XP_002935639.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TMC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25940
NM_138691 Homo sapiens transmembrane channel-like 1 (TMC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$384.50-$538.30
$769.00
OHu75047 XM_011518213 PREDICTED: Homo sapiens transmembrane channel-like 1 (TMC1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $475.30
$679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25940
Clone ID Related Accession (Same CDS sequence) NM_138691
Accession Version NM_138691.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2283bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 24-MAY-2014
Organism Homo sapiens (human)
Product transmembrane channel-like protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF417578.1. This sequence is a reference standard in the RefSeqGene project. On May 22, 2002 this sequence version replaced gi:20162551. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF417578.1 [ECO:0000332] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGTCACCCA AAAAAGTACA AATCAAAGTG GAGGAAAAAG AAGACGAGAC TGAGGAAAGC 
TCAAGTGAAG AGGAAGAGGA GGTGGAAGAT AAGCTACCTC GAAGAGAGAG CTTGAGACCA
AAGAGGAAAC GGACCAGAGA TGTTATCAAT GAGGATGACC CAGAACCTGA ACCAGAGGAT
GAAGAAACAA GGAAGGCAAG AGAAAAAGAG AGGAGGAGGA GGCTAAAGAG AGGAGCAGAA
GAAGAAGAAA TTGATGAAGA GGAATTGGAA AGATTGAAGG CAGAGTTAGA TGAGAAAAGA
CAAATAATTG CTACTGTCAA ATGCAAACCA TGGAAGATGG AGAAGAAAAT TGAAGTTCTC
AAGGAGGCAA AAAAATTTGT GAGTGAAAAT GAAGGGGCTC TTGGGAAAGG AAAAGGAAAA
CGGTGGTTTG CATTTAAGAT GATGATGGCC AAGAAATGGG CAAAATTCCT CCGTGATTTT
GAGAACTTCA AAGCTGCGTG TGTCCCATGG GAAAATAAAA TCAAGGCTAT TGAAAGTCAG
TTTGGCTCCT CAGTGGCCTC ATACTTCCTC TTCTTGAGAT GGATGTATGG AGTCAATATG
GTTCTCTTTA TCCTGACATT TAGCCTCATC ATGTTGCCAG AGTACCTCTG GGGTTTGCCA
TATGGCAGTT TACCTAGGAA AACCGTTCCC AGAGCCGAAG AGGCATCGGC AGCAAACTTT
GGTGTGTTGT ACGACTTCAA TGGTTTGGCA CAATATTCCG TTCTCTTTTA TGGCTATTAT
GACAATAAAC GAACAATTGG ATGGATGAAT TTCAGGTTGC CGCTCTCCTA TTTTCTAGTG
GGGATTATGT GCATTGGATA CAGCTTTCTG GTTGTCCTCA AAGCAATGAC CAAAAACATT
GGTGATGATG GAGGTGGAGA TGACAACACT TTCAATTTCA GCTGGAAGGT CTTTACCAGC
TGGGACTACC TGATCGGCAA TCCTGAAACA GCAGACAACA AATTTAATTC TATCACAATG
AACTTTAAGG AAGCTATCAC AGAAGAAAAA GCAGCCCAAG TAGAAGAAAA CGTCCACTTG
ATCAGATTCC TGAGGTTTCT GGCTAACTTC TTCGTGTTTC TAACACTTGG AGGGAGTGGA
TACCTCATCT TTTGGGCTGT GAAGCGATCC CAGGAATTTG CACAGCAAGA TCCTGACACC
CTTGGGTGGT GGGAAAAAAA TGAAATGAAC ATGGTTATGT CCCTCCTAGG GATGTTCTGT
CCAACATTGT TTGACTTATT TGCTGAATTA GAAGACTACC ATCCTCTCAT CGCTTTGAAA
TGGCTACTGG GACGCATTTT TGCTCTTCTT TTAGGCAATT TATACGTATT TATTCTTGCA
TTAATGGATG AGATTAACAA CAAGATTGAA GAGGAGAAGC TAGTAAAGGC CAATATTACC
CTTTGGGAAG CCAATATGAT CAAGGCCTAC AATGCATCAT TCTCTGAAAA TAGCACTGGA
CCACCCTTTT TTGTTCACCC TGCAGATGTA CCTCGAGGAC CTTGCTGGGA AACAATGGTG
GGACAGGAGT TTGTGAGGCT GACAGTCTCT GATGTTCTGA CCACCTACGT CACAATCCTC
ATTGGGGACT TTCTAAGGGC ATGTTTTGTG AGGTTTTGCA ATTATTGCTG GTGCTGGGAC
TTGGAGTATG GATATCCTTC ATACACCGAA TTCGACATCA GTGGCAACGT CCTCGCTCTG
ATCTTCAACC AAGGCATGAT CTGGATGGGC TCCTTCTTTG CTCCCAGCCT CCCAGGCATC
AATATCCTTC GACTCCATAC ATCCATGTAC TTCCAGTGCT GGGCCGTTAT GTGCTGCAAT
GTTCCTGAGG CCAGGGTCTT CAAAGCTTCC AGATCAAATA ACTTCTACCT GGGCATGCTA
CTGCTCATCC TCTTCCTGTC CACAATGCCT GTCTTGTACA TGATCGTGTC CCTCCCACCA
TCTTTTGATT GTGGTCCATT CAGTGGCAAA AATAGAATGT TTGAAGTCAT TGGAGAGACC
CTGGAGCACG ATTTCCCAAG CTGGATGGCG AAGATCTTGA GACAGCTTTC AAACCCTGGG
CTGGTCATTG CTGTCATTTT GGTGATGGTT TTGGCCATCT ATTATCTCAA TGCTACTGCC
AAGGGCCAGA AGGCAGCGAA TCTGGATCTC AAAAAGAAGA TGAAAATGCA AGCTTTGGAG
AACAAAATGC GAAACAAGAA AATGGCAGCT GCACGAGCAG CTGCAGCTGC TGGTCGCCAG
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_619636.2
CDS541..2823
Misc Feature(1)523..525(+)
Misc Feature(2)1138..1200(+)
Misc Feature(3)1357..1419(+)
Misc Feature(4)1636..1698(+)
Misc Feature(5)1861..1923(+)
Misc Feature(6)2083..2430(+)
Misc Feature(7)2443..2505(+)
Misc Feature(8)2638..2700(+)
Exon (1)1..113
Gene:TMC1
Gene Synonym:
Exon (2)114..235
Gene:TMC1
Gene Synonym:
Exon (3)236..345
Gene:TMC1
Gene Synonym:
Exon (4)346..488
Gene:TMC1
Gene Synonym:
Exon (5)489..556
Gene:TMC1
Gene Synonym:
Exon (6)557..604
Gene:TMC1
Gene Synonym:
Exon (7)605..776
Gene:TMC1
Gene Synonym:
Exon (8)777..902
Gene:TMC1
Gene Synonym:
Exon (9)903..993
Gene:TMC1
Gene Synonym:
Exon (10)994..1075
Gene:TMC1
Gene Synonym:
Exon (11)1076..1182
Gene:TMC1
Gene Synonym:
Exon (12)1183..1281
Gene:TMC1
Gene Synonym:
Exon (13)1282..1424
Gene:TMC1
Gene Synonym:
Exon (14)1425..1569
Gene:TMC1
Gene Synonym:
Exon (15)1570..1764
Gene:TMC1
Gene Synonym:
Exon (16)1765..1944
Gene:TMC1
Gene Synonym:
Exon (17)1945..2106
Gene:TMC1
Gene Synonym:
Exon (18)2107..2235
Gene:TMC1
Gene Synonym:
Exon (19)2236..2303
Gene:TMC1
Gene Synonym:
Exon (20)2304..2543
Gene:TMC1
Gene Synonym:
Exon (21)2544..2669
Gene:TMC1
Gene Synonym:
Exon (22)2670..2748
Gene:TMC1
Gene Synonym:
Exon (23)2749..2800
Gene:TMC1
Gene Synonym:
Exon (24)2801..3201
Gene:TMC1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_138691
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane channel-like 1 (TMC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_138691

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGTCACCCA AAAAAGTACA AATCAAAGTG GAGGAAAAAG AAGACGAGAC TGAGGAAAGC 
TCAAGTGAAG AGGAAGAGGA GGTGGAAGAT AAGCTACCTC GAAGAGAGAG CTTGAGACCA
AAGAGGAAAC GGACCAGAGA TGTTATCAAT GAGGATGACC CAGAACCTGA ACCAGAGGAT
GAAGAAACAA GGAAGGCAAG AGAAAAAGAG AGGAGGAGGA GGCTAAAGAG AGGAGCAGAA
GAAGAAGAAA TTGATGAAGA GGAATTGGAA AGATTGAAGG CAGAGTTAGA TGAGAAAAGA
CAAATAATTG CTACTGTCAA ATGCAAACCA TGGAAGATGG AGAAGAAAAT TGAAGTTCTC
AAGGAGGCAA AAAAATTTGT GAGTGAAAAT GAAGGGGCTC TTGGGAAAGG AAAAGGAAAA
CGGTGGTTTG CATTTAAGAT GATGATGGCC AAGAAATGGG CAAAATTCCT CCGTGATTTT
GAGAACTTCA AAGCTGCGTG TGTCCCATGG GAAAATAAAA TCAAGGCTAT TGAAAGTCAG
TTTGGCTCCT CAGTGGCCTC ATACTTCCTC TTCTTGAGAT GGATGTATGG AGTCAATATG
GTTCTCTTTA TCCTGACATT TAGCCTCATC ATGTTGCCAG AGTACCTCTG GGGTTTGCCA
TATGGCAGTT TACCTAGGAA AACCGTTCCC AGAGCCGAAG AGGCATCGGC AGCAAACTTT
GGTGTGTTGT ACGACTTCAA TGGTTTGGCA CAATATTCCG TTCTCTTTTA TGGCTATTAT
GACAATAAAC GAACAATTGG ATGGATGAAT TTCAGGTTGC CGCTCTCCTA TTTTCTAGTG
GGGATTATGT GCATTGGATA CAGCTTTCTG GTTGTCCTCA AAGCAATGAC CAAAAACATT
GGTGATGATG GAGGTGGAGA TGACAACACT TTCAATTTCA GCTGGAAGGT CTTTACCAGC
TGGGACTACC TGATCGGCAA TCCTGAAACA GCAGACAACA AATTTAATTC TATCACAATG
AACTTTAAGG AAGCTATCAC AGAAGAAAAA GCAGCCCAAG TAGAAGAAAA CGTCCACTTG
ATCAGATTCC TGAGGTTTCT GGCTAACTTC TTCGTGTTTC TAACACTTGG AGGGAGTGGA
TACCTCATCT TTTGGGCTGT GAAGCGATCC CAGGAATTTG CACAGCAAGA TCCTGACACC
CTTGGGTGGT GGGAAAAAAA TGAAATGAAC ATGGTTATGT CCCTCCTAGG GATGTTCTGT
CCAACATTGT TTGACTTATT TGCTGAATTA GAAGACTACC ATCCTCTCAT CGCTTTGAAA
TGGCTACTGG GACGCATTTT TGCTCTTCTT TTAGGCAATT TATACGTATT TATTCTTGCA
TTAATGGATG AGATTAACAA CAAGATTGAA GAGGAGAAGC TAGTAAAGGC CAATATTACC
CTTTGGGAAG CCAATATGAT CAAGGCCTAC AATGCATCAT TCTCTGAAAA TAGCACTGGA
CCACCCTTTT TTGTTCACCC TGCAGATGTA CCTCGAGGAC CTTGCTGGGA AACAATGGTG
GGACAGGAGT TTGTGAGGCT GACAGTCTCT GATGTTCTGA CCACCTACGT CACAATCCTC
ATTGGGGACT TTCTAAGGGC ATGTTTTGTG AGGTTTTGCA ATTATTGCTG GTGCTGGGAC
TTGGAGTATG GATATCCTTC ATACACCGAA TTCGACATCA GTGGCAACGT CCTCGCTCTG
ATCTTCAACC AAGGCATGAT CTGGATGGGC TCCTTCTTTG CTCCCAGCCT CCCAGGCATC
AATATCCTTC GACTCCATAC ATCCATGTAC TTCCAGTGCT GGGCCGTTAT GTGCTGCAAT
GTTCCTGAGG CCAGGGTCTT CAAAGCTTCC AGATCAAATA ACTTCTACCT GGGCATGCTA
CTGCTCATCC TCTTCCTGTC CACAATGCCT GTCTTGTACA TGATCGTGTC CCTCCCACCA
TCTTTTGATT GTGGTCCATT CAGTGGCAAA AATAGAATGT TTGAAGTCAT TGGAGAGACC
CTGGAGCACG ATTTCCCAAG CTGGATGGCG AAGATCTTGA GACAGCTTTC AAACCCTGGG
CTGGTCATTG CTGTCATTTT GGTGATGGTT TTGGCCATCT ATTATCTCAA TGCTACTGCC
AAGGGCCAGA AGGCAGCGAA TCTGGATCTC AAAAAGAAGA TGAAAATGCA AGCTTTGGAG
AACAAAATGC GAAACAAGAA AATGGCAGCT GCACGAGCAG CTGCAGCTGC TGGTCGCCAG
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu75047
Clone ID Related Accession (Same CDS sequence) XM_011518213
Accession Version XM_011518213.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2871bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transmembrane channel-like protein 1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_008470.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##RefSeq-Attributes-START## ab initio :: 19% of CDS bases ##RefSeq-Attributes-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGCCCTTGC CAAGCAGGTC AGCGGGGCAC AGGGACTGCG CTCCTCATGA TAGTGCAGAT 
TGGCTCGGAA GTACTCAATT CTGTGGAGTC ACAGCGCCCT CTGACAGATT TCAGTTTCTG
GAAAAGGAAG GGCCCCCTTC AGGGCAGATG TGGAAGAAGA TGGAAGCGAT GAAAACCTTC
TTGCCAAAAT CTCCCAAAAG ACCTGGCCAG TGGAGCTTAC TGACTATACT CAAGCAACAA
AATGCACACT TGGAAATCCT GTGTCACGTG CCTATACTAG CTTTGTCGCT GATTCAGCAT
ATACACATCC TCCAGTGTGA CAGGATTGTG TATGGAAACA GTTTCATAAT AGATCTCTTG
GAATATGGTC GTTTGGTGTT AAGCATTCTA TCTGGCAAAA TGAAAAATAA GATGGTAGCA
GTTGTGGGAG CTTCTGTGGA ACAGATTCAG GTGGTACAGC TGCTCAAACT CATAACTCAC
CTGCAATGTG TTCTGAAAAT GTGTGGCTTA ACTGCATCTA CCCTAAAAGA ACAAGTTGCC
TGTGGGGAAG GAACTGTCCA CGTGGAGTGG TCTGGTGAAT GCTTAAGGAG CTGCAGAAGG
GAAGTACAAA TCAAAGTGGA GGAAAAAGAA GACGAGACTG AGGAAAGCTC AAGTGAAGAG
GAAGAGGAGG TGGAAGATAA GCTACCTCGA AGAGAGAGCT TGAGACCAAA GAGGAAACGG
ACCAGAGATG TTATCAATGA GGATGACCCA GAACCTGAAC CAGAGGATGA AGAAACAAGG
AAGGCAAGAG AAAAAGAGAG GAGGAGGAGG CTAAAGAGAG GAGCAGAAGA AGAAGAAATT
GATGAAGAGG AATTGGAAAG ATTGAAGGCA GAGTTAGATG AGAAAAGACA AATAATTGCT
ACTGTCAAAT GCAAACCATG GAAGATGGAG AAGAAAATTG AAGTTCTCAA GGAGGCAAAA
AAATTTGTGA GTGAAAATGA AGGGGCTCTT GGGAAAGGAA AAGGAAAACG GTGGTTTGCA
TTTAAGATGA TGATGGCCAA GAAATGGGCA AAATTCCTCC GTGATTTTGA GAACTTCAAA
GCTGCGTGTG TCCCATGGGA AAATAAAATC AAGGCTATTG AAAGTCAGTT TGGCTCCTCA
GTGGCCTCAT ACTTCCTCTT CTTGAGATGG ATGTATGGAG TCAATATGGT TCTCTTTATC
CTGACATTTA GCCTCATCAT GTTGCCAGAG TACCTCTGGG GTTTGCCATA TGGCAGTTTA
CCTAGGAAAA CCGTTCCCAG AGCCGAAGAG GCATCGGCAG CAAACTTTGG TGTGTTGTAC
GACTTCAATG GTTTGGCACA ATATTCCGTT CTCTTTTATG GCTATTATGA CAATAAACGA
ACAATTGGAT GGATGAATTT CAGGTTGCCG CTCTCCTATT TTCTAGTGGG GATTATGTGC
ATTGGATACA GCTTTCTGGT TGTCCTCAAA GCAATGACCA AAAACATTGG TGATGATGGA
GGTGGAGATG ACAACACTTT CAATTTCAGC TGGAAGGTCT TTACCAGCTG GGACTACCTG
ATCGGCAATC CTGAAACAGC AGACAACAAA TTTAATTCTA TCACAATGAA CTTTAAGGAA
GCTATCACAG AAGAAAAAGC AGCCCAAGTA GAAGAAAACG TCCACTTGAT CAGATTCCTG
AGGTTTCTGG CTAACTTCTT CGTGTTTCTA ACACTTGGAG GGAGTGGATA CCTCATCTTT
TGGGCTGTGA AGCGATCCCA GGAATTTGCA CAGCAAGATC CTGACACCCT TGGGTGGTGG
GAAAAAAATG AAATGAACAT GGTTATGTCC CTCCTAGGGA TGTTCTGTCC AACATTGTTT
GACTTATTTG CTGAATTAGA AGACTACCAT CCTCTCATCG CTTTGAAATG GCTACTGGGA
CGCATTTTTG CTCTTCTTTT AGGCAATTTA TACGTATTTA TTCTTGCATT AATGGATGAG
ATTAACAACA AGATTGAAGA GGAGAAGCTA GTAAAGGCCA ATATTACCCT TTGGGAAGCC
AATATGATCA AGGCCTACAA TGCATCATTC TCTGAAAATA GCACTGGACC ACCCTTTTTT
GTTCACCCTG CAGATGTACC TCGAGGACCT TGCTGGGAAA CAATGGTGGG ACAGGAGTTT
GTGAGGCTGA CAGTCTCTGA TGTTCTGACC ACCTACGTCA CAATCCTCAT TGGGGACTTT
CTAAGGGCAT GTTTTGTGAG GTTTTGCAAT TATTGCTGGT GCTGGGACTT GGAGTATGGA
TATCCTTCAT ACACCGAATT CGACATCAGT GGCAACGTCC TCGCTCTGAT CTTCAACCAA
GGCATGATCT GGATGGGCTC CTTCTTTGCT CCCAGCCTCC CAGGCATCAA TATCCTTCGA
CTCCATACAT CCATGTACTT CCAGTGCTGG GCCGTTATGT GCTGCAATGT TCCTGAGGCC
AGGGTCTTCA AAGCTTCCAG ATCAAATAAC TTCTACCTGG GCATGCTACT GCTCATCCTC
TTCCTGTCCA CAATGCCTGT CTTGTACATG ATCGTGTCCC TCCCACCATC TTTTGATTGT
GGTCCATTCA GTGGCAAAAA TAGAATGTTT GAAGTCATTG GAGAGACCCT GGAGCACGAT
TTCCCAAGCT GGATGGCGAA GATCTTGAGA CAGCTTTCAA ACCCTGGGCT GGTCATTGCT
GTCATTTTGG TGATGGTTTT GGCCATCTAT TATCTCAATG CTACTGCCAA GGGCCAGAAG
GCAGCGAATC TGGATCTCAA AAAGAAGATG AAAATGCAAG CTTTGGAGAA CAAAATGCGA
AACAAGAAAA TGGCAGCTGC ACGAGCAGCT GCAGCTGCTG GTCGCCAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011516515.1
CDS1..2871
Misc Feature(1)2131..2478(+)
Translation

Target ORF information:

RefSeq Version XM_011518213
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens transmembrane channel-like 1 (TMC1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011518213

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGCCCTTGC CAAGCAGGTC AGCGGGGCAC AGGGACTGCG CTCCTCATGA TAGTGCAGAT 
TGGCTCGGAA GTACTCAATT CTGTGGAGTC ACAGCGCCCT CTGACAGATT TCAGTTTCTG
GAAAAGGAAG GGCCCCCTTC AGGGCAGATG TGGAAGAAGA TGGAAGCGAT GAAAACCTTC
TTGCCAAAAT CTCCCAAAAG ACCTGGCCAG TGGAGCTTAC TGACTATACT CAAGCAACAA
AATGCACACT TGGAAATCCT GTGTCACGTG CCTATACTAG CTTTGTCGCT GATTCAGCAT
ATACACATCC TCCAGTGTGA CAGGATTGTG TATGGAAACA GTTTCATAAT AGATCTCTTG
GAATATGGTC GTTTGGTGTT AAGCATTCTA TCTGGCAAAA TGAAAAATAA GATGGTAGCA
GTTGTGGGAG CTTCTGTGGA ACAGATTCAG GTGGTACAGC TGCTCAAACT CATAACTCAC
CTGCAATGTG TTCTGAAAAT GTGTGGCTTA ACTGCATCTA CCCTAAAAGA ACAAGTTGCC
TGTGGGGAAG GAACTGTCCA CGTGGAGTGG TCTGGTGAAT GCTTAAGGAG CTGCAGAAGG
GAAGTACAAA TCAAAGTGGA GGAAAAAGAA GACGAGACTG AGGAAAGCTC AAGTGAAGAG
GAAGAGGAGG TGGAAGATAA GCTACCTCGA AGAGAGAGCT TGAGACCAAA GAGGAAACGG
ACCAGAGATG TTATCAATGA GGATGACCCA GAACCTGAAC CAGAGGATGA AGAAACAAGG
AAGGCAAGAG AAAAAGAGAG GAGGAGGAGG CTAAAGAGAG GAGCAGAAGA AGAAGAAATT
GATGAAGAGG AATTGGAAAG ATTGAAGGCA GAGTTAGATG AGAAAAGACA AATAATTGCT
ACTGTCAAAT GCAAACCATG GAAGATGGAG AAGAAAATTG AAGTTCTCAA GGAGGCAAAA
AAATTTGTGA GTGAAAATGA AGGGGCTCTT GGGAAAGGAA AAGGAAAACG GTGGTTTGCA
TTTAAGATGA TGATGGCCAA GAAATGGGCA AAATTCCTCC GTGATTTTGA GAACTTCAAA
GCTGCGTGTG TCCCATGGGA AAATAAAATC AAGGCTATTG AAAGTCAGTT TGGCTCCTCA
GTGGCCTCAT ACTTCCTCTT CTTGAGATGG ATGTATGGAG TCAATATGGT TCTCTTTATC
CTGACATTTA GCCTCATCAT GTTGCCAGAG TACCTCTGGG GTTTGCCATA TGGCAGTTTA
CCTAGGAAAA CCGTTCCCAG AGCCGAAGAG GCATCGGCAG CAAACTTTGG TGTGTTGTAC
GACTTCAATG GTTTGGCACA ATATTCCGTT CTCTTTTATG GCTATTATGA CAATAAACGA
ACAATTGGAT GGATGAATTT CAGGTTGCCG CTCTCCTATT TTCTAGTGGG GATTATGTGC
ATTGGATACA GCTTTCTGGT TGTCCTCAAA GCAATGACCA AAAACATTGG TGATGATGGA
GGTGGAGATG ACAACACTTT CAATTTCAGC TGGAAGGTCT TTACCAGCTG GGACTACCTG
ATCGGCAATC CTGAAACAGC AGACAACAAA TTTAATTCTA TCACAATGAA CTTTAAGGAA
GCTATCACAG AAGAAAAAGC AGCCCAAGTA GAAGAAAACG TCCACTTGAT CAGATTCCTG
AGGTTTCTGG CTAACTTCTT CGTGTTTCTA ACACTTGGAG GGAGTGGATA CCTCATCTTT
TGGGCTGTGA AGCGATCCCA GGAATTTGCA CAGCAAGATC CTGACACCCT TGGGTGGTGG
GAAAAAAATG AAATGAACAT GGTTATGTCC CTCCTAGGGA TGTTCTGTCC AACATTGTTT
GACTTATTTG CTGAATTAGA AGACTACCAT CCTCTCATCG CTTTGAAATG GCTACTGGGA
CGCATTTTTG CTCTTCTTTT AGGCAATTTA TACGTATTTA TTCTTGCATT AATGGATGAG
ATTAACAACA AGATTGAAGA GGAGAAGCTA GTAAAGGCCA ATATTACCCT TTGGGAAGCC
AATATGATCA AGGCCTACAA TGCATCATTC TCTGAAAATA GCACTGGACC ACCCTTTTTT
GTTCACCCTG CAGATGTACC TCGAGGACCT TGCTGGGAAA CAATGGTGGG ACAGGAGTTT
GTGAGGCTGA CAGTCTCTGA TGTTCTGACC ACCTACGTCA CAATCCTCAT TGGGGACTTT
CTAAGGGCAT GTTTTGTGAG GTTTTGCAAT TATTGCTGGT GCTGGGACTT GGAGTATGGA
TATCCTTCAT ACACCGAATT CGACATCAGT GGCAACGTCC TCGCTCTGAT CTTCAACCAA
GGCATGATCT GGATGGGCTC CTTCTTTGCT CCCAGCCTCC CAGGCATCAA TATCCTTCGA
CTCCATACAT CCATGTACTT CCAGTGCTGG GCCGTTATGT GCTGCAATGT TCCTGAGGCC
AGGGTCTTCA AAGCTTCCAG ATCAAATAAC TTCTACCTGG GCATGCTACT GCTCATCCTC
TTCCTGTCCA CAATGCCTGT CTTGTACATG ATCGTGTCCC TCCCACCATC TTTTGATTGT
GGTCCATTCA GTGGCAAAAA TAGAATGTTT GAAGTCATTG GAGAGACCCT GGAGCACGAT
TTCCCAAGCT GGATGGCGAA GATCTTGAGA CAGCTTTCAA ACCCTGGGCT GGTCATTGCT
GTCATTTTGG TGATGGTTTT GGCCATCTAT TATCTCAATG CTACTGCCAA GGGCCAGAAG
GCAGCGAATC TGGATCTCAA AAAGAAGATG AAAATGCAAG CTTTGGAGAA CAAAATGCGA
AACAAGAAAA TGGCAGCTGC ACGAGCAGCT GCAGCTGCTG GTCGCCAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Novel compound heterozygous TMC1 mutations associated with autosomal recessive hearing loss in a Chinese family
PLoS ONE 8 (5), E63026 (2013)
Gao X, Su Y, Guan LP, Yuan YY, Huang SS, Lu Y, Wang GJ, Han MY, Yu F, Song YS, Zhu QY, Wu J and Dai P.


book

A transversion mutation in non-coding exon 3 of the TMC1 gene in two ethnically related Iranian deaf families from different geographical regions; evidence for founder effect
Int. J. Pediatr. Otorhinolaryngol. 77 (5), 821-826 (2013)
Davoudi-Dehaghani E, Zeinali S, Mahdieh N, Shirkavand A, Bagherian H and Tabatabaiefar MA.


book

The common TMC1 mutation c.100C>T (p.Arg34X) is not a significant cause of deafness in British Asians
Genet Test Mol Biomarkers 16 (5), 453-455 (2012)
Searle C, Mavrogiannis LA, Bennett CP and Charlton RS.


book

Progressive sensorineural hearing loss and normal vestibular function in a Dutch DFNB7/11 family with a novel mutation in TMC1
Audiol. Neurootol. 16 (2), 93-105 (2011)
de Heer AM, Collin RW, Huygen PL, Schraders M, Oostrik J, Rouwette M, Kunst HP, Kremer H and Cremers CW.


book

Mutations in TMC1 are a common cause of DFNB7/11 hearing loss in the Iranian population
Ann. Otol. Rhinol. Laryngol. 119 (12), 830-835 (2010)
Hildebrand MS, Kahrizi K, Bromhead CJ, Shearer AE, Webster JA, Khodaei H, Abtahi R, Bazazzadegan N, Babanejad M, Nikzat N, Kimberling WJ, Stephan D, Huygen PL, Bahlo M, Smith RJ and Najmabadi H.


book

Novel TMC1 structural and splice variants associated with congenital nonsyndromic deafness in a Sudanese pedigree
Hum. Mutat. 25 (1), 100 (2005)
Meyer CG, Gasmelseed NM, Mergani A, Magzoub MM, Muntau B, Thye T and Horstmann RD.


book

TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins
BMC Genomics 4 (1), 24 (2003)
Keresztes G, Mutai H and Heller S.


book

Beethoven, a mouse model for dominant, progressive hearing loss DFNA36
Nat. Genet. 30 (3), 257-258 (2002)
Vreugde S, Erven A, Kros CJ, Marcotti W, Fuchs H, Kurima K, Wilcox ER, Friedman TB, Griffith AJ, Balling R, Hrabe De Angelis M, Avraham KB and Steel KP.


book

Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function
Nat. Genet. 30 (3), 277-284 (2002)
Kurima K, Peters LM, Yang Y, Riazuddin S, Ahmed ZM, Naz S, Arnaud D, Drury S, Mo J, Makishima T, Ghosh M, Menon PS, Deshmukh D, Oddoux C, Ostrer H, Khan S, Riazuddin S, Deininger PL, Hampton LL, Sullivan SL, Battey JF Jr, Keats BJ, Wilcox ER, Friedman TB and Griffith AJ.


book

Deafness and Hereditary Hearing Loss Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Shearer,A.E., Hildebrand,M.S. and Van Camp,G.


 
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