mitochondrial dynamics protein MID49 Smith-Magenis syndrome chromosomal region candidate gene 7 protein Smith-Magenis syndrome chromosome region, candidate 7 mitochondrial dynamic protein MID49 mitochondrial dynamic protein of 49 kDa mitochondrial dynamics protein of 49 kDa
This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
The following MIEF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MIEF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK056165.1, AC127537.8 and BC014973.1. On Nov 24, 2018 this sequence version replaced NM_139162.3.
Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803611.216912.1, SRR1803616.190074.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
MANE Ensembl match :: ENST00000323019.9/ ENSP00000323591.4
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: full length.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB183618.1, AK056165.1, AC127537.8 and BC014973.1. On Jan 30, 2009 this sequence version replaced NM_139162.2.
Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DB183618.1, SRR1660803.51880.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB183618.1, AK128310.1, AC127537.8 and BC014973.1. On Jun 1, 2019 this sequence version replaced NM_001144900.1.
Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that causes a translational frameshift, compared to variant 1. The resulting isoform (3) contains a distinct C-terminus and is shorter than isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK128310.1, DA153706.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2152719 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB183618.1, AK128310.1, AC127537.8 and BC014973.1.
Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that causes a translational frameshift, compared to variant 1. The resulting isoform (3) contains a distinct C-terminus and is shorter than isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK128310.1, DA153706.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2152719 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014973.1 and AC127537.8.
Transcript Variant: This variant (2) differs in the 5' UTR and uses a distinct translational start codon, compared to variant 1. The resulting isoform (2) is longer at the N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC014973.1, BG762276.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2148874 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607
Annotation Version :: 109.20190607
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.2
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
Annotation Freeze :: 20190607
##Genome-Annotation-Data-END##