AP1S3 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | AP1S3 |
| Entrez Gene ID | 130340 |
| Full Name | adaptor related protein complex 1 sigma 3 subunit |
| Synonyms | PSORS15 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: | |
| Disorder Html: | {Psoriasis 15, pustular, susceptibility to}, 616106 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001039569.1 | NP_001034658.1 | AP-1 complex subunit sigma-3 |
| XM_011510600.2 | XP_011508902.1 | AP-1 complex subunit sigma-3 isoform X1 |
| Pan troglodytes (chimpanzee) | AP1S3 | XP_516121.2 |
| Bos taurus (cattle) | AP1S3 | NP_001096766.1 |
| LOC710257 | XP_001098858.2 | |
| Canis lupus familiaris (dog) | AP1S3 | XP_536088.3 |
| Danio rerio (zebrafish) | ap1s3a | NP_001017720.1 |
| Mus musculus (house mouse) | Ap1s3 | NP_898848.1 |
| Gallus gallus (chicken) | AP1S3 | NP_001025179.1 |
| Oryza sativa (rice) | Os03g0811300 | NP_001051670.1 |
| Homo sapiens (human) | AP1S3 | NP_001034658.1 |
| Rattus norvegicus (Norway rat) | Ap1s3 | NP_001165621.1 |
| Xenopus tropicalis (tropical clawed frog) | ap1s3 | NP_001016579.1 |
| Danio rerio (zebrafish) | ap1s3b | NP_001004635.1 |
Related articles in PubMed
AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.
Li X, Niu Y, Cheng M, Chi X, Liu X, Yang W
Antiviral research13126-34(2016 Jul)
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F
American journal of human genetics94(5)790-7(2014 May)
Replication of Caucasian loci associated with bone mineral density in Koreans.
Kim YA, Choi HJ, Lee JY, Han BG, Shin CS, Cho NH
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA24(10)2603-10(2013 Oct)
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail.
Roeth JF, Williams M, Kasper MR, Filzen TM, Collins KL
The Journal of cell biology167(5)903-13(2004 Dec)
GGAs: roles of the different domains and comparison with AP-1 and clathrin.
Hirst J, Lindsay MR, Robinson MS
Molecular biology of the cell12(11)3573-88(2001 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
study demonstrated that AP1S3 interacts with hepatitis C virus E2 and protects it from proteasome-dependent degradation
Title: AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.
AP1S3 silencing disrupted the endosomal translocation of the innate pattern-recognition receptor TLR-3 (Toll-like receptor 3) and resulted in a marked inhibition of downstream signaling.
Title: AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The following AP1S3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AP1S3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu23247 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001039569.1 | |
| Accession Version | NM_001039569.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-13 | |
| Organism | Homo sapiens(human) | |
| Product | AP-1 complex subunit sigma-3 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG177582.1, BG340480.1, AC093884.4 and BE856458.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.8576.1, SRR1163657.27300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156266 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001034658.1 |
| CDS | 153..617 |
| Misc Feature(1) | 153..578 |
| Exon (1) | 1..155 |
| Exon (2) | 156..334 |
| Exon (3) | 335..443 |
| Exon (4) | 444..581 |
| Exon (5) | 582..4002 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001039569.1 |
ORF Insert Sequence:
1 | ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu75598 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011510600.2 | |
| Accession Version | XM_011510600.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-06 | |
| Organism | Homo sapiens(human) | |
| Product | AP-1 complex subunit sigma-3 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510600.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011508902.1 |
| CDS | 133..459 |
| Misc Feature(1) | 133..>432 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011510600.2 |
ORF Insert Sequence:
1 | ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein. |
|
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. |
|
Replication of Caucasian loci associated with bone mineral density in Koreans. |
|
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail. |
|
GGAs: roles of the different domains and comparison with AP-1 and clathrin. |