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AP1S3 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol AP1S3
Entrez Gene ID 130340
Full Name adaptor related protein complex 1 sigma 3 subunit
Synonyms PSORS15
General protein information
Preferred Names

adaptor related protein complex 1 sigma 3 subunit

Names

AP-1 complex subunit sigma-3
adapter-related protein complex 1 subunit sigma-1C
adaptor protein complex AP-1 sigma-1C subunit
adaptor-related protein complex 1 subunit sigma-1C
clathrin assembly protein complex 1 sigma-1C small chain
golgi adaptor HA1/AP1 adaptin sigma-1C subunit
sigma 1C subunit of AP-1 clathrin
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

2

2q36.1
Disorder MIM:

615781

Disorder Html: {Psoriasis 15, pustular, susceptibility to}, 616106 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001039569.1 NP_001034658.1 AP-1 complex subunit sigma-3
NM_001039569.2 NP_001034658.1 AP-1 complex subunit sigma-3
XM_011510600.3 XP_011508902.1 AP-1 complex subunit sigma-3 isoform X1
XM_011510600.2 XP_011508902.1 AP-1 complex subunit sigma-3 isoform X1

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) AP1S3 XP_516121.2
Bos taurus (cattle) AP1S3 NP_001096766.1
LOC710257 XP_001098858.2
Canis lupus familiaris (dog) AP1S3 XP_536088.3
Danio rerio (zebrafish) ap1s3a NP_001017720.1
Mus musculus (house mouse) Ap1s3 NP_898848.1
Gallus gallus (chicken) AP1S3 NP_001025179.1
Oryza sativa (rice) Os03g0811300 NP_001051670.1
Homo sapiens (human) AP1S3 NP_001034658.1
Rattus norvegicus (Norway rat) Ap1s3 NP_001165621.1
Xenopus tropicalis (tropical clawed frog) ap1s3 NP_001016579.1
Danio rerio (zebrafish) ap1s3b NP_001004635.1

Gene Ontology


Bibliography

Related articles in PubMed

AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.
Li X, Niu Y, Cheng M, Chi X, Liu X, Yang W
Antiviral research13126-34(2016 Jul)

AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F
American journal of human genetics94(5)790-7(2014 May)

Replication of Caucasian loci associated with bone mineral density in Koreans.
Kim YA, Choi HJ, Lee JY, Han BG, Shin CS, Cho NH
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA24(10)2603-10(2013 Oct)

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail.
Roeth JF, Williams M, Kasper MR, Filzen TM, Collins KL
The Journal of cell biology167(5)903-13(2004 Dec)

GGAs: roles of the different domains and comparison with AP-1 and clathrin.
Hirst J, Lindsay MR, Robinson MS
Molecular biology of the cell12(11)3573-88(2001 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study demonstrated that AP1S3 interacts with hepatitis C virus E2 and protects it from proteasome-dependent degradation
Title: AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.

AP1S3 silencing disrupted the endosomal translocation of the innate pattern-recognition receptor TLR-3 (Toll-like receptor 3) and resulted in a marked inhibition of downstream signaling.
Title: AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following AP1S3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AP1S3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu23247 NM_001039569.2
Latest version!		 Homo sapiens adaptor related protein complex 1 subunit sigma 3 (AP1S3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu75598 XM_011510600.3
Latest version!		 Homo sapiens adaptor related protein complex 1 subunit sigma 3 (AP1S3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu23247 NM_001039569.1 Homo sapiens adaptor related protein complex 1 sigma 3 subunit (AP1S3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu75598 XM_011510600.2 Homo sapiens adaptor related protein complex 1 sigma 3 subunit (AP1S3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu23247
Clone ID Related Accession (Same CDS sequence) NM_001039569.1 , NM_001039569.2
Accession Version NM_001039569.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 465bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-11-12
Organism Homo sapiens(human)
Product AP-1 complex subunit sigma-3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG177582.1, BG340480.1, AC093884.4 and BE856458.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.8576.1, SRR1163657.27300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156266 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TGTCTGTGAG 
CTGGATATTA TCTTTAATTT TGAAAAGGCT TATTTCATCC TGGACGAGTT TATAATAGGT 
GGGGAAATTC AGGAAACATC CAAGAAAATT GCTGTCAAAG CCATTGAAGA CTCTGATATG 
TTACAGGAGA CAATGGAAGA ATACATGAAC AAGCCTACAT TTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001034658.1
CDS153..617
Translation

Target ORF information:

RefSeq Version NM_001039569.1
Organism Homo sapiens(human)
Definition Homo sapiens adaptor related protein complex 1 sigma 3 subunit (AP1S3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001039569.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TGTCTGTGAG 
CTGGATATTA TCTTTAATTT TGAAAAGGCT TATTTCATCC TGGACGAGTT TATAATAGGT 
GGGGAAATTC AGGAAACATC CAAGAAAATT GCTGTCAAAG CCATTGAAGA CTCTGATATG 
TTACAGGAGA CAATGGAAGA ATACATGAAC AAGCCTACAT TTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23247
Clone ID Related Accession (Same CDS sequence) NM_001039569.1 , NM_001039569.2
Accession Version NM_001039569.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 465bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-05-03
Organism Homo sapiens(human)
Product AP-1 complex subunit sigma-3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG177582.1, BG340480.1, AC093884.4 and BE856458.1. On Nov 23, 2018 this sequence version replaced NM_001039569.1. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK299026.1, SRR1163657.8576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156266 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396654.7/ ENSP00000379891.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TGTCTGTGAG 
CTGGATATTA TCTTTAATTT TGAAAAGGCT TATTTCATCC TGGACGAGTT TATAATAGGT 
GGGGAAATTC AGGAAACATC CAAGAAAATT GCTGTCAAAG CCATTGAAGA CTCTGATATG 
TTACAGGAGA CAATGGAAGA ATACATGAAC AAGCCTACAT TTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001034658.1
CDS133..597
Translation

Target ORF information:

RefSeq Version NM_001039569.2
Organism Homo sapiens(human)
Definition Homo sapiens adaptor related protein complex 1 subunit sigma 3 (AP1S3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001039569.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TGTCTGTGAG 
CTGGATATTA TCTTTAATTT TGAAAAGGCT TATTTCATCC TGGACGAGTT TATAATAGGT 
GGGGAAATTC AGGAAACATC CAAGAAAATT GCTGTCAAAG CCATTGAAGA CTCTGATATG 
TTACAGGAGA CAATGGAAGA ATACATGAAC AAGCCTACAT TTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu75598
Clone ID Related Accession (Same CDS sequence) XM_011510600.3 , XM_011510600.2
Accession Version XM_011510600.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 327bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-06-12
Organism Homo sapiens(human)
Product AP-1 complex subunit sigma-3 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011510600.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TACAATGGAA 
GAATACATGA ACAAGCCTAC ATTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011508902.1
CDS133..459
Translation

Target ORF information:

RefSeq Version XM_011510600.3
Organism Homo sapiens(human)
Definition Homo sapiens adaptor related protein complex 1 subunit sigma 3 (AP1S3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011510600.3

ORF Insert Sequence:

1
61
121
181
241
301
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TACAATGGAA 
GAATACATGA ACAAGCCTAC ATTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu75598
Clone ID Related Accession (Same CDS sequence) XM_011510600.3 , XM_011510600.2
Accession Version XM_011510600.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 327bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product AP-1 complex subunit sigma-3 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510600.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TACAATGGAA 
GAATACATGA ACAAGCCTAC ATTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011508902.1
CDS133..459
Translation

Target ORF information:

RefSeq Version XM_011510600.2
Organism Homo sapiens(human)
Definition Homo sapiens adaptor related protein complex 1 sigma 3 subunit (AP1S3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011510600.2

ORF Insert Sequence:

1
61
121
181
241
301
ATGATACATT TCATATTGCT CTTCAGTCGA CAAGGGAAAT TACGGCTACA GAAATGGTAC 
ATCACTCTCC CTGATAAAGA GAGGAAGAAG ATCACCCGGG AAATTGTTCA GATTATTCTC 
TCCCGTGGTC ACAGGACAAG CAGTTTTGTT GACTGGAAGG AGCTAAAACT TGTTTATAAA 
AGGTATGCTA GTTTATATTT TTGCTGTGCA ATAGAAAATC AGGACAATGA GCTCTTGACG 
CTAGAGATTG TGCATCGTTA CGTGGAGCTG CTGGACAAAT ATTTTGGAAA TACAATGGAA 
GAATACATGA ACAAGCCTAC ATTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.
Antiviral research13126-34(2016 Jul)
Li X,Niu Y,Cheng M,Chi X,Liu X,Yang W


book

AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
American journal of human genetics94(5)790-7(2014 May)
Setta-Kaffetzi N,Simpson MA,Navarini AA,Patel VM,Lu HC,Allen MH,Duckworth M,Bachelez H,Burden AD,Choon SE,Griffiths CE,Kirby B,Kolios A,Seyger MM,Prins C,Smahi A,Trembath RC,Fraternali F,Smith CH,Barker JN,Capon F


book

Replication of Caucasian loci associated with bone mineral density in Koreans.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA24(10)2603-10(2013 Oct)
Kim YA,Choi HJ,Lee JY,Han BG,Shin CS,Cho NH


book

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail.
The Journal of cell biology167(5)903-13(2004 Dec)
Roeth JF,Williams M,Kasper MR,Filzen TM,Collins KL


book

GGAs: roles of the different domains and comparison with AP-1 and clathrin.
Molecular biology of the cell12(11)3573-88(2001 Nov)
Hirst J,Lindsay MR,Robinson MS