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CORT cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CORT
Entrez Gene ID 1325
Full Name cortistatin
Synonyms CST-14,CST-17,CST-29
General protein information
Preferred Names

cortistatin

Names

cortistatin
cortistatin-14
cortistatin-17
cortistatin-29
prepro-cortistatin
preprocortistatin

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p36.22

Summary This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010].
Disorder MIM:

602784


mRNA and Protein(s)

mRNA Protein Name
NM_001302.4 NP_001293.3 cortistatin preproprotein



Homo sapiens (human) CORT NP_001293.3
Pan troglodytes (chimpanzee) CORT NP_001191822.1
Bos taurus (cattle) CORT NP_001191825.1
Mus musculus (house mouse) Cort NP_031771.1
Rattus norvegicus (Norway rat) Cort NP_036967.1


Related articles in PubMed

Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.
Duran-Prado M, Morell M, Delgado-Maroto V, Castaño JP, Aneiros-Fernandez J, de Lecea L, Culler MD, Hernandez-Cortes P, O'Valle F, Delgado M
Circulation research112(11)1444-55(2013 May)

Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X
Journal of psychiatric research44(14)971-8(2010 Oct)

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.
Gahete MD, Rubio A, Durán-Prado M, Avila J, Luque RM, Castaño JP
Journal of Alzheimer's disease : JAD20(2)465-75(2010)

Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation.
Carrasco E, Hernández C, de Torres I, Farrés J, Simó R
Molecular vision141496-502(2008 Aug)

The role of cortistatin in the human immune system.
van Hagen PM, Dalm VA, Staal F, Hofland LJ
Molecular and cellular endocrinology286(1-2)141-7(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation.
Title: Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.

The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed.
Title: Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

A lower expression of CST exists in diabetic retinas and it is associated with retinal neurodegeneration.
Title: Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation.

The following CORT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CORT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu08513 NM_001302.4
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Homo sapiens cortistatin (CORT), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu08513
Clone ID Related Accession (Same CDS sequence) NM_001302.4
Accession Version NM_001302.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 318bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product cortistatin preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358561.1, BC119724.1, BC040034.1, BF590359.1 and AL354956.13. On Nov 11, 2010 this sequence version replaced NM_001302.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358561.1, AF013252.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11011067) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001293.3
CDS506..823
Misc Feature(1)254..256
Misc Feature(2)764..817
Exon (1)1..604
Exon (2)605..1231
Translation

Target ORF information:

RefSeq Version NM_001302.4
Organism Homo sapiens(Human)
Definition Homo sapiens cortistatin (CORT), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001302.4

ORF Insert Sequence:

1
61
121
181
241
301
ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.
Circulation research112(11)1444-55(2013 May)
Duran-Prado M,Morell M,Delgado-Maroto V,Castaño JP,Aneiros-Fernandez J,de Lecea L,Culler MD,Hernandez-Cortes P,O'Valle F,Delgado M


book

Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Journal of psychiatric research44(14)971-8(2010 Oct)
Saus E,Brunet A,Armengol L,Alonso P,Crespo JM,Fernández-Aranda F,Guitart M,Martín-Santos R,Menchón JM,Navinés R,Soria V,Torrens M,Urretavizcaya M,Vallès V,Gratacòs M,Estivill X


book

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.
Journal of Alzheimer's disease : JAD20(2)465-75(2010)
Gahete MD,Rubio A,Durán-Prado M,Avila J,Luque RM,Castaño JP


book

Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation.
Molecular vision141496-502(2008 Aug)
Carrasco E,Hernández C,de Torres I,Farrés J,Simó R


book

The role of cortistatin in the human immune system.
Molecular and cellular endocrinology286(1-2)141-7(2008 May)
van Hagen PM,Dalm VA,Staal F,Hofland LJ


 
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