CPE cDNA ORF clone, Homo sapiens(human)
Gene Symbol | CPE |
Entrez Gene ID | 1363 |
Full Name | carboxypeptidase E |
Synonyms | CPH |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_001873.2 | NP_001864.1 | carboxypeptidase E preproprotein |
NM_001873.4 | NP_001864.1 | carboxypeptidase E preproprotein |
NM_001873.3 | NP_001864.1 | carboxypeptidase E preproprotein |

Rattus norvegicus (Norway rat) | Cpe | NP_037260.1 |
Xenopus tropicalis (tropical clawed frog) | cpe | NP_001106417.1 |
CPE | XP_001097378.2 | |
Danio rerio (zebrafish) | cpe | NP_999975.1 |
Pan troglodytes (chimpanzee) | CPE | NP_001092029.1 |
Caenorhabditis elegans (roundworm) | egl-21 | NP_501935.1 |
Homo sapiens (human) | CPE | NP_001864.1 |
Bos taurus (cattle) | CPE | NP_776328.2 |
Mus musculus (house mouse) | Cpe | NP_038522.2 |
Canis lupus familiaris (dog) | CPE | XP_005629450.1 |
Gallus gallus (chicken) | CPE | XP_420392.3 |

Related articles in PubMed
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.
Armento A, Ilina EI, Kaoma T, Muller A, Vallar L, Niclou SP, Kr?ger MA, Mittelbronn M, Naumann U
International journal of oncology51(2)702-714(2017 Aug)
A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.
Cong L, Cheng Y, Cawley NX, Murthy SR, Loh YP
PloS one12(1)e0170169(2017)
Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a.
Skalka N, Caspi M, Lahav-Ariel L, Loh YP, Hirschberg K, Rosin-Arbesfeld R
Oncogene35(50)6416-6428(2016 Dec)
A human carboxypeptidase E/NF-?1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
Cheng Y, Cawley NX, Yanik T, Murthy SR, Liu C, Kasikci F, Abebe D, Loh YP
Translational psychiatry6(12)e973(2016 12)
Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma.
Huang SF, Wu HD, Chen YT, Murthy SR, Chiu YT, Chang Y, Chang IC, Yang X, Loh YP
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(7)9745-53(2016 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
we have identified a novel SNP in the CPE gene which results in the loss of its neuroprotective function in cells and may confer neurological disorders in humans
Title: A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.
CPE through its N'-terminal sequence, forms aggregates with Wnt3a and possible endoplasmic reticulum (ER) stress leading to its loss of function.
Title: Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a.
This study has uncovered a human CPE/NF-alpha1 gene mutation that could lead to comorbidity of dementia and depression, emphasizing the importance of this gene in cognitive function.
Title: A human carboxypeptidase E/NF-?1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
High-level CPE [ carboxypeptidase E] expression was associated with a poor prognosis in early-stage cervical cancer. CPE may serve as a biomarker for predicting PLNM [ pelvic lymph node metastasis ] and survival in these patients.
Title: CPE overexpression is correlated with pelvic lymph node metastasis and poor prognosis in patients with early-stage cervical cancer.
Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.
Title: Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma.
The following CPE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu09011![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_001873.2 , NM_001873.4 , NM_001873.3 | |
Accession Version | NM_001873.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-14 | |
Organism | Homo sapiens(Human) | |
Product | carboxypeptidase E preproprotein | |
Comment |
1 | ATGGCCGGGC GAGGGGGCAG CGCGCTGCTG GCTCTGTGCG GGGCACTGGC TGCCTGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001864.1 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGCCGGGC GAGGGGGCAG CGCGCTGCTG GCTCTGTGCG GGGCACTGGC TGCCTGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu09011![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001873.2 , NM_001873.4 , NM_001873.3 | |
Accession Version | NM_001873.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-31 | |
Organism | Homo sapiens(human) | |
Product | carboxypeptidase E preproprotein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X51405.1, AA683379.1, AC012504.7 and AA883804.1. On Nov 23, 2018 this sequence version replaced NM_001873.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.83919.1, SRR3476690.1065405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000402744.9/ ENSP00000386104.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCCGGGC GAGGGGGCAG CGCGCTGCTG GCTCTGTGCG GGGCACTGGC TGCCTGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001864.1 |
CDS | 215..1645 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCCGGGC GAGGGGGCAG CGCGCTGCTG GCTCTGTGCG GGGCACTGGC TGCCTGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu09011![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001873.2 , NM_001873.4 , NM_001873.3 | |
Accession Version | NM_001873.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-10 | |
Organism | Homo sapiens(human) | |
Product | carboxypeptidase E preproprotein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X51405.1, AA683379.1, AC012504.7 and AA883804.1. On Nov 24, 2015 this sequence version replaced NM_001873.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.83919.1, X51405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCGGGC GAGGGGGCAG CGCGCTGCTG GCTCTGTGCG GGGCACTGGC TGCCTGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001864.1 |
CDS | 281..1711 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCCGGGC GAGGGGGCAG CGCGCTGCTG GCTCTGTGCG GGGCACTGGC TGCCTGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors. |
![]() |
A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function. |
![]() |
Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. |
![]() |
A human carboxypeptidase E/NF-?1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice. |
![]() |
Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma. |