ASB7 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | ASB7 |
| Entrez Gene ID | 140460 |
| Full Name | ankyrin repeat and SOCS box containing 7 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_198243.3 | NP_937886.1 | ankyrin repeat and SOCS box protein 7 isoform 2 |
| NM_024708.3 | NP_078984.2 | ankyrin repeat and SOCS box protein 7 isoform 1 |
| Mus musculus (house mouse) | Asb7 | NP_536691.2 |
| Pan troglodytes (chimpanzee) | ASB7 | XP_523240.3 |
| ASB7 | XP_001083533.1 | |
| Bos taurus (cattle) | ASB7 | NP_001179080.1 |
| Homo sapiens (human) | ASB7 | NP_937886.1 |
| Gallus gallus (chicken) | ASB7 | NP_001012788.1 |
| Xenopus tropicalis (tropical clawed frog) | asb7 | NP_001017154.1 |
| Danio rerio (zebrafish) | asb7 | NP_999895.1 |
| Canis lupus familiaris (dog) | ASB7 | XP_545824.1 |
| Rattus norvegicus (Norway rat) | Asb7 | NP_001102385.1 |
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ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T
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BMC cancer12422(2012 Sep)
ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
Kohroki J, Nishiyama T, Nakamura T, Masuho Y
FEBS letters579(30)6796-802(2005 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these data indicate that ASB7 plays a crucial role in regulating spindle dynamics and genome integrity by controlling the expression of DDA3.
Title: ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
The following ASB7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASB7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu31594 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_024708.3 | |
| Accession Version | NM_024708.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-09 | |
| Organism | Homo sapiens(human) | |
| Product | ankyrin repeat and SOCS box protein 7 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD632230.1, AK026204.1 and BC063581.1. On Feb 28, 2009 this sequence version replaced NM_024708.2. Transcript Variant: This variant (1) encodes the shorter isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC063581.1, SRR1803611.639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_078984.2 |
| CDS | 770..1594 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_024708.3 |
ORF Insert Sequence:
1 | ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu08385 | |
| Clone ID Related Accession (Same CDS sequence) | NM_198243.3 | |
| Accession Version | NM_198243.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-03 | |
| Organism | Homo sapiens(human) | |
| Product | ankyrin repeat and SOCS box protein 7 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD632230.1, AK289860.1, AC090695.14 and AA830153.1. On Jun 2, 2019 this sequence version replaced NM_198243.2. Transcript Variant: This variant (2) differs in the 3' CDS and UTR, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.175659.1, SRR1660803.242666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_937886.1 |
| CDS | 731..1687 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_198243.3 |
ORF Insert Sequence:
1 | ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Architecture of the human interactome defines protein communities and disease networks. |
|
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. |
|
Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. |
|
ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. |