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CRY1 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CRY1
Entrez Gene ID 1407
Full Name cryptochrome circadian regulator 1
Synonyms DSPD,PHLL1
General protein information
Preferred Names

cryptochrome circadian regulator 1

Names

cryptochrome-1
cryptochrome 1 (photolyase-like)
cryptochrome circadian clock 1
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

12

12q23.3
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014].
Disorder MIM:

601933

Disorder Html: {Delayed sleep phase disorder, susceptibility to}, 614163 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017018832.1 XP_016874321.1 cryptochrome-1 isoform X1
XM_024448844.1 XP_024304612.1 cryptochrome-1 isoform X1
XM_024448845.1 XP_024304613.1 cryptochrome-1 isoform X2
NM_004075.4 NP_004066.1 cryptochrome-1
NM_004075.5 NP_004066.1 cryptochrome-1
XM_017018832.2 XP_016874321.1 cryptochrome-1 isoform X3

Pathways from BioSystems


Homologies


Bos taurus (cattle) CRY1 NP_001098885.1
Mus musculus (house mouse) Cry1 NP_031797.1
Gallus gallus (chicken) CRY1 NP_989576.1
Xenopus tropicalis (tropical clawed frog) cry1 NP_001017311.2
Danio rerio (zebrafish) cry1a NP_001070765.2
CRY1 XP_001100653.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP004261 XP_313179.4
Rattus norvegicus (Norway rat) Cry1 NP_942045.2
Homo sapiens (human) CRY1 NP_004066.1
Pan troglodytes (chimpanzee) CRY1 XP_509339.2
Canis lupus familiaris (dog) CRY1 XP_005625994.1
Danio rerio (zebrafish) cry1b NP_571865.4

Gene Ontology


Bibliography

Related articles in PubMed

Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.
Ode KL, Ukai H, Susaki EA, Narumi R, Matsumoto K, Hara J, Koide N, Abe T, Kanemaki MT, Kiyonari H, Ueda HR
Molecular cell65(1)176-190(2017 Jan)

PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Kovanen L, Donner K, Kaunisto M, Partonen T
Journal of affective disorders207136-140(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockout-rescue embryonic stem cell-derived mouse reveals that CRY1 determines circadian period through both its degradation-dependent and -independent pathways.
Title: Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.

CRY1 variants were not associated with major depressive disorder.
Title: PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.

CRY1 SNP rs714359 showed nominally significant association with the problematicity of seasonal variations (problematic vs. no variation) of mood disorder. The set-based analysis did not support these associations. However, the CRY1 haplotype TAG including rs714359 showed nominally significant association with the problematicity of seasonal variations in mood disorder.
Title: CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study.

Given the distinct characteristics of the C-terminal tails of the CRY1 and CRY2 proteins, our study addresses a long-standing hypothesis that the ratio of these two CRY molecules affects the clock period.
Title: The ratio of intracellular CRY proteins determines the clock period length.

The present study identified USP7 and TDP-43 as the regulators of CRY1 and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork.
Title: USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.

The following CRY1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRY1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu15210 NM_004075.5
Latest version!		 Homo sapiens cryptochrome circadian regulator 1 (CRY1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $219.50-$307.30
$439.00
OHu57085 XM_017018832.2
Latest version!		 Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu103684 XM_024448844.1
Latest version!		 Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 14-16 $307.30
$439.00
OHu103685 XM_024448845.1
Latest version!		 Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 14-16 $307.30
$439.00
View Old Accession Versions >>
OHu15210 NM_004075.4 Homo sapiens cryptochrome circadian regulator 1 (CRY1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $219.50-$307.30
$439.00
OHu57085 XM_017018832.1 Homo sapiens cryptochrome circadian clock 1 (CRY1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu15210
Clone ID Related Accession (Same CDS sequence) NM_004075.4 , NM_004075.5
Accession Version NM_004075.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1761bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-27
Organism Homo sapiens(human)
Product cryptochrome-1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454192.1, BJ993835.1, AK290552.1 and BC017466.1. On Aug 15, 2012 this sequence version replaced NM_004075.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83702.1, SRR1660809.240236.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

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ATGGGGGTGA ACGCCGTGCA CTGGTTCCGA AAGGGGCTCC GGCTCCACGA CAACCCCGCC 
CTGAAGGAGT GCATTCAGGG CGCCGACACC ATCCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAATGT GGGCATCAAC AGGTGGCGAT TTTTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG AAAATTAAAC TCCCGTCTGT TTGTGATTCG TGGACAACCA 
GCAGATGTGT TTCCCAGGCT TTTCAAGGAA TGGAACATTA CTAAACTTTC AATTGAGTAT 
GATTCTGAGC CCTTTGGAAA GGAACGAGAC GCAGCTATTA AGAAACTGGC AACTGAAGCT 
GGAGTAGAAG TCATTGTAAG AATTTCACAT ACATTATATG ACCTAGACAA GATCATAGAA 
CTCAATGGTG GACAACCGCC TCTAACTTAT AAAAGATTCC AGACTCTCAT CAGCAAAATG 
GAACCACTAG AGATACCAGT AGAGACAATT ACTTCAGAAG TGATAGAAAA GTGCACAACT 
CCTCTGTCTG ATGACCATGA TGAGAAATAT GGAGTCCCTT CACTGGAAGA GCTAGGTTTT 
GATACAGATG GCTTATCCTC TGCAGTGTGG CCAGGTGGAG AAACTGAAGC ACTTACTCGT 
TTGGAAAGGC ATTTGGAAAG AAAAGCTTGG GTGGCAAATT TTGAAAGACC TCGAATGAAT 
GCGAATTCTC TGCTTGCAAG CCCTACTGGA CTTAGTCCTT ATCTCCGATT TGGTTGTTTG 
TCATGTCGAC TGTTTTACTT CAAACTAACA GATCTCTACA AAAAGGTAAA GAAGAACAGT 
TCCCCTCCCC TTTCCCTTTA TGGGCAACTG TTATGGCGTG AATTTTTCTA TACAGCAGCA 
ACAAATAATC CACGCTTTGA TAAAATGGAA GGAAACCCTA TCTGTGTTCA GATTCCTTGG 
GATAAAAATC CTGAGGCTTT AGCCAAATGG GCGGAAGGCC GGACAGGCTT TCCATGGATT 
GATGCCATCA TGACACAGCT TCGTCAGGAG GGTTGGATTC ATCATCTAGC CAGGCATGCA 
GTTGCTTGCT TCCTGACACG AGGGGACCTG TGGATTAGTT GGGAAGAAGG AATGAAGGTA 
TTTGAAGAAT TATTGCTTGA TGCAGATTGG AGCATAAATG CTGGAAGTTG GATGTGGCTG 
TCTTGTAGTT CCTTTTTTCA ACAGTTTTTT CACTGCTATT GCCCTGTTGG TTTTGGTAGG 
AGAACAGATC CCAATGGAGA CTATATCAGG CGTTATTTGC CTGTCCTAAG AGGCTTCCCT 
GCAAAATATA TCTATGATCC CTGGAATGCA CCAGAAGGTA TCCAAAAGGT AGCCAAATGT 
TTGATAGGAG TTAATTATCC TAAACCAATG GTGAACCATG CTGAGGCAAG CCGTTTGAAT 
ATCGAAAGGA TGAAACAGAT CTATCAGCAG CTTTCACGAT ATAGAGGACT AGGTCTTCTG 
GCATCAGTAC CTTCTAATCC TAATGGGAAT GGAGGCTTCA TGGGATATTC TGCAGAAAAT 
ATCCCAGGTT GTAGCAGCAG TGGAAGTTGC TCTCAAGGGA GTGGTATTTT ACACTATGCT 
CATGGCGACA GTCAGCAAAC TCACCTGTTG AAGCAAGGAA GAAGCTCCAT GGGCACTGGT 
CTCAGTGGTG GGAAACGTCC TAGTCAGGAA GAGGACACAC AGAGTATTGG TCCTAAAGTC 
CAGAGACAGA GCACTAATTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004066.1
CDS897..2657
Translation

Target ORF information:

RefSeq Version NM_004075.4
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 1 (CRY1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004075.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGGGGTGA ACGCCGTGCA CTGGTTCCGA AAGGGGCTCC GGCTCCACGA CAACCCCGCC 
CTGAAGGAGT GCATTCAGGG CGCCGACACC ATCCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAATGT GGGCATCAAC AGGTGGCGAT TTTTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG AAAATTAAAC TCCCGTCTGT TTGTGATTCG TGGACAACCA 
GCAGATGTGT TTCCCAGGCT TTTCAAGGAA TGGAACATTA CTAAACTTTC AATTGAGTAT 
GATTCTGAGC CCTTTGGAAA GGAACGAGAC GCAGCTATTA AGAAACTGGC AACTGAAGCT 
GGAGTAGAAG TCATTGTAAG AATTTCACAT ACATTATATG ACCTAGACAA GATCATAGAA 
CTCAATGGTG GACAACCGCC TCTAACTTAT AAAAGATTCC AGACTCTCAT CAGCAAAATG 
GAACCACTAG AGATACCAGT AGAGACAATT ACTTCAGAAG TGATAGAAAA GTGCACAACT 
CCTCTGTCTG ATGACCATGA TGAGAAATAT GGAGTCCCTT CACTGGAAGA GCTAGGTTTT 
GATACAGATG GCTTATCCTC TGCAGTGTGG CCAGGTGGAG AAACTGAAGC ACTTACTCGT 
TTGGAAAGGC ATTTGGAAAG AAAAGCTTGG GTGGCAAATT TTGAAAGACC TCGAATGAAT 
GCGAATTCTC TGCTTGCAAG CCCTACTGGA CTTAGTCCTT ATCTCCGATT TGGTTGTTTG 
TCATGTCGAC TGTTTTACTT CAAACTAACA GATCTCTACA AAAAGGTAAA GAAGAACAGT 
TCCCCTCCCC TTTCCCTTTA TGGGCAACTG TTATGGCGTG AATTTTTCTA TACAGCAGCA 
ACAAATAATC CACGCTTTGA TAAAATGGAA GGAAACCCTA TCTGTGTTCA GATTCCTTGG 
GATAAAAATC CTGAGGCTTT AGCCAAATGG GCGGAAGGCC GGACAGGCTT TCCATGGATT 
GATGCCATCA TGACACAGCT TCGTCAGGAG GGTTGGATTC ATCATCTAGC CAGGCATGCA 
GTTGCTTGCT TCCTGACACG AGGGGACCTG TGGATTAGTT GGGAAGAAGG AATGAAGGTA 
TTTGAAGAAT TATTGCTTGA TGCAGATTGG AGCATAAATG CTGGAAGTTG GATGTGGCTG 
TCTTGTAGTT CCTTTTTTCA ACAGTTTTTT CACTGCTATT GCCCTGTTGG TTTTGGTAGG 
AGAACAGATC CCAATGGAGA CTATATCAGG CGTTATTTGC CTGTCCTAAG AGGCTTCCCT 
GCAAAATATA TCTATGATCC CTGGAATGCA CCAGAAGGTA TCCAAAAGGT AGCCAAATGT 
TTGATAGGAG TTAATTATCC TAAACCAATG GTGAACCATG CTGAGGCAAG CCGTTTGAAT 
ATCGAAAGGA TGAAACAGAT CTATCAGCAG CTTTCACGAT ATAGAGGACT AGGTCTTCTG 
GCATCAGTAC CTTCTAATCC TAATGGGAAT GGAGGCTTCA TGGGATATTC TGCAGAAAAT 
ATCCCAGGTT GTAGCAGCAG TGGAAGTTGC TCTCAAGGGA GTGGTATTTT ACACTATGCT 
CATGGCGACA GTCAGCAAAC TCACCTGTTG AAGCAAGGAA GAAGCTCCAT GGGCACTGGT 
CTCAGTGGTG GGAAACGTCC TAGTCAGGAA GAGGACACAC AGAGTATTGG TCCTAAAGTC 
CAGAGACAGA GCACTAATTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15210
Clone ID Related Accession (Same CDS sequence) NM_004075.4 , NM_004075.5
Accession Version NM_004075.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1761bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-26
Organism Homo sapiens(human)
Product cryptochrome-1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454192.1, BJ993835.1, AK290552.1 and BC017466.1. On Nov 24, 2018 this sequence version replaced NM_004075.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83702.1, SRR3476690.36215.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000008527.10/ ENSP00000008527.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. 

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1561
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ATGGGGGTGA ACGCCGTGCA CTGGTTCCGA AAGGGGCTCC GGCTCCACGA CAACCCCGCC 
CTGAAGGAGT GCATTCAGGG CGCCGACACC ATCCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAATGT GGGCATCAAC AGGTGGCGAT TTTTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG AAAATTAAAC TCCCGTCTGT TTGTGATTCG TGGACAACCA 
GCAGATGTGT TTCCCAGGCT TTTCAAGGAA TGGAACATTA CTAAACTTTC AATTGAGTAT 
GATTCTGAGC CCTTTGGAAA GGAACGAGAC GCAGCTATTA AGAAACTGGC AACTGAAGCT 
GGAGTAGAAG TCATTGTAAG AATTTCACAT ACATTATATG ACCTAGACAA GATCATAGAA 
CTCAATGGTG GACAACCGCC TCTAACTTAT AAAAGATTCC AGACTCTCAT CAGCAAAATG 
GAACCACTAG AGATACCAGT AGAGACAATT ACTTCAGAAG TGATAGAAAA GTGCACAACT 
CCTCTGTCTG ATGACCATGA TGAGAAATAT GGAGTCCCTT CACTGGAAGA GCTAGGTTTT 
GATACAGATG GCTTATCCTC TGCAGTGTGG CCAGGTGGAG AAACTGAAGC ACTTACTCGT 
TTGGAAAGGC ATTTGGAAAG AAAAGCTTGG GTGGCAAATT TTGAAAGACC TCGAATGAAT 
GCGAATTCTC TGCTTGCAAG CCCTACTGGA CTTAGTCCTT ATCTCCGATT TGGTTGTTTG 
TCATGTCGAC TGTTTTACTT CAAACTAACA GATCTCTACA AAAAGGTAAA GAAGAACAGT 
TCCCCTCCCC TTTCCCTTTA TGGGCAACTG TTATGGCGTG AATTTTTCTA TACAGCAGCA 
ACAAATAATC CACGCTTTGA TAAAATGGAA GGAAACCCTA TCTGTGTTCA GATTCCTTGG 
GATAAAAATC CTGAGGCTTT AGCCAAATGG GCGGAAGGCC GGACAGGCTT TCCATGGATT 
GATGCCATCA TGACACAGCT TCGTCAGGAG GGTTGGATTC ATCATCTAGC CAGGCATGCA 
GTTGCTTGCT TCCTGACACG AGGGGACCTG TGGATTAGTT GGGAAGAAGG AATGAAGGTA 
TTTGAAGAAT TATTGCTTGA TGCAGATTGG AGCATAAATG CTGGAAGTTG GATGTGGCTG 
TCTTGTAGTT CCTTTTTTCA ACAGTTTTTT CACTGCTATT GCCCTGTTGG TTTTGGTAGG 
AGAACAGATC CCAATGGAGA CTATATCAGG CGTTATTTGC CTGTCCTAAG AGGCTTCCCT 
GCAAAATATA TCTATGATCC CTGGAATGCA CCAGAAGGTA TCCAAAAGGT AGCCAAATGT 
TTGATAGGAG TTAATTATCC TAAACCAATG GTGAACCATG CTGAGGCAAG CCGTTTGAAT 
ATCGAAAGGA TGAAACAGAT CTATCAGCAG CTTTCACGAT ATAGAGGACT AGGTCTTCTG 
GCATCAGTAC CTTCTAATCC TAATGGGAAT GGAGGCTTCA TGGGATATTC TGCAGAAAAT 
ATCCCAGGTT GTAGCAGCAG TGGAAGTTGC TCTCAAGGGA GTGGTATTTT ACACTATGCT 
CATGGCGACA GTCAGCAAAC TCACCTGTTG AAGCAAGGAA GAAGCTCCAT GGGCACTGGT 
CTCAGTGGTG GGAAACGTCC TAGTCAGGAA GAGGACACAC AGAGTATTGG TCCTAAAGTC 
CAGAGACAGA GCACTAATTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004066.1
CDS589..2349
Translation

Target ORF information:

RefSeq Version NM_004075.5
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 1 (CRY1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004075.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGGGGTGA ACGCCGTGCA CTGGTTCCGA AAGGGGCTCC GGCTCCACGA CAACCCCGCC 
CTGAAGGAGT GCATTCAGGG CGCCGACACC ATCCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAATGT GGGCATCAAC AGGTGGCGAT TTTTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG AAAATTAAAC TCCCGTCTGT TTGTGATTCG TGGACAACCA 
GCAGATGTGT TTCCCAGGCT TTTCAAGGAA TGGAACATTA CTAAACTTTC AATTGAGTAT 
GATTCTGAGC CCTTTGGAAA GGAACGAGAC GCAGCTATTA AGAAACTGGC AACTGAAGCT 
GGAGTAGAAG TCATTGTAAG AATTTCACAT ACATTATATG ACCTAGACAA GATCATAGAA 
CTCAATGGTG GACAACCGCC TCTAACTTAT AAAAGATTCC AGACTCTCAT CAGCAAAATG 
GAACCACTAG AGATACCAGT AGAGACAATT ACTTCAGAAG TGATAGAAAA GTGCACAACT 
CCTCTGTCTG ATGACCATGA TGAGAAATAT GGAGTCCCTT CACTGGAAGA GCTAGGTTTT 
GATACAGATG GCTTATCCTC TGCAGTGTGG CCAGGTGGAG AAACTGAAGC ACTTACTCGT 
TTGGAAAGGC ATTTGGAAAG AAAAGCTTGG GTGGCAAATT TTGAAAGACC TCGAATGAAT 
GCGAATTCTC TGCTTGCAAG CCCTACTGGA CTTAGTCCTT ATCTCCGATT TGGTTGTTTG 
TCATGTCGAC TGTTTTACTT CAAACTAACA GATCTCTACA AAAAGGTAAA GAAGAACAGT 
TCCCCTCCCC TTTCCCTTTA TGGGCAACTG TTATGGCGTG AATTTTTCTA TACAGCAGCA 
ACAAATAATC CACGCTTTGA TAAAATGGAA GGAAACCCTA TCTGTGTTCA GATTCCTTGG 
GATAAAAATC CTGAGGCTTT AGCCAAATGG GCGGAAGGCC GGACAGGCTT TCCATGGATT 
GATGCCATCA TGACACAGCT TCGTCAGGAG GGTTGGATTC ATCATCTAGC CAGGCATGCA 
GTTGCTTGCT TCCTGACACG AGGGGACCTG TGGATTAGTT GGGAAGAAGG AATGAAGGTA 
TTTGAAGAAT TATTGCTTGA TGCAGATTGG AGCATAAATG CTGGAAGTTG GATGTGGCTG 
TCTTGTAGTT CCTTTTTTCA ACAGTTTTTT CACTGCTATT GCCCTGTTGG TTTTGGTAGG 
AGAACAGATC CCAATGGAGA CTATATCAGG CGTTATTTGC CTGTCCTAAG AGGCTTCCCT 
GCAAAATATA TCTATGATCC CTGGAATGCA CCAGAAGGTA TCCAAAAGGT AGCCAAATGT 
TTGATAGGAG TTAATTATCC TAAACCAATG GTGAACCATG CTGAGGCAAG CCGTTTGAAT 
ATCGAAAGGA TGAAACAGAT CTATCAGCAG CTTTCACGAT ATAGAGGACT AGGTCTTCTG 
GCATCAGTAC CTTCTAATCC TAATGGGAAT GGAGGCTTCA TGGGATATTC TGCAGAAAAT 
ATCCCAGGTT GTAGCAGCAG TGGAAGTTGC TCTCAAGGGA GTGGTATTTT ACACTATGCT 
CATGGCGACA GTCAGCAAAC TCACCTGTTG AAGCAAGGAA GAAGCTCCAT GGGCACTGGT 
CTCAGTGGTG GGAAACGTCC TAGTCAGGAA GAGGACACAC AGAGTATTGG TCCTAAAGTC 
CAGAGACAGA GCACTAATTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57085
Clone ID Related Accession (Same CDS sequence) XM_017018832.1 , XM_017018832.2
Accession Version XM_017018832.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1677bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product cryptochrome-1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
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121
181
241
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361
421
481
541
601
661
721
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841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGATGATCA TTTTCCACAA AATGATGGCC AGTTATTCCA ACACTACTTA TTGGATCATT 
TCCAATTCAG TGAGATTTTT GCTTCAGTGT CTTGAGGATC TTGATGCCAA TCTACGAAAA 
TTAAACTCCC GTCTGTTTGT GATTCGTGGA CAACCAGCAG ATGTGTTTCC CAGGCTTTTC 
AAGGAATGGA ACATTACTAA ACTTTCAATT GAGTATGATT CTGAGCCCTT TGGAAAGGAA 
CGAGACGCAG CTATTAAGAA ACTGGCAACT GAAGCTGGAG TAGAAGTCAT TGTAAGAATT 
TCACATACAT TATATGACCT AGACAAGATC ATAGAACTCA ATGGTGGACA ACCGCCTCTA 
ACTTATAAAA GATTCCAGAC TCTCATCAGC AAAATGGAAC CACTAGAGAT ACCAGTAGAG 
ACAATTACTT CAGAAGTGAT AGAAAAGTGC ACAACTCCTC TGTCTGATGA CCATGATGAG 
AAATATGGAG TCCCTTCACT GGAAGAGCTA GGTTTTGATA CAGATGGCTT ATCCTCTGCA 
GTGTGGCCAG GTGGAGAAAC TGAAGCACTT ACTCGTTTGG AAAGGCATTT GGAAAGAAAA 
GCTTGGGTGG CAAATTTTGA AAGACCTCGA ATGAATGCGA ATTCTCTGCT TGCAAGCCCT 
ACTGGACTTA GTCCTTATCT CCGATTTGGT TGTTTGTCAT GTCGACTGTT TTACTTCAAA 
CTAACAGATC TCTACAAAAA GGTAAAGAAG AACAGTTCCC CTCCCCTTTC CCTTTATGGG 
CAACTGTTAT GGCGTGAATT TTTCTATACA GCAGCAACAA ATAATCCACG CTTTGATAAA 
ATGGAAGGAA ACCCTATCTG TGTTCAGATT CCTTGGGATA AAAATCCTGA GGCTTTAGCC 
AAATGGGCGG AAGGCCGGAC AGGCTTTCCA TGGATTGATG CCATCATGAC ACAGCTTCGT 
CAGGAGGGTT GGATTCATCA TCTAGCCAGG CATGCAGTTG CTTGCTTCCT GACACGAGGG 
GACCTGTGGA TTAGTTGGGA AGAAGGAATG AAGGTATTTG AAGAATTATT GCTTGATGCA 
GATTGGAGCA TAAATGCTGG AAGTTGGATG TGGCTGTCTT GTAGTTCCTT TTTTCAACAG 
TTTTTTCACT GCTATTGCCC TGTTGGTTTT GGTAGGAGAA CAGATCCCAA TGGAGACTAT 
ATCAGGCGTT ATTTGCCTGT CCTAAGAGGC TTCCCTGCAA AATATATCTA TGATCCCTGG 
AATGCACCAG AAGGTATCCA AAAGGTAGCC AAATGTTTGA TAGGAGTTAA TTATCCTAAA 
CCAATGGTGA ACCATGCTGA GGCAAGCCGT TTGAATATCG AAAGGATGAA ACAGATCTAT 
CAGCAGCTTT CACGATATAG AGGACTAGGT CTTCTGGCAT CAGTACCTTC TAATCCTAAT 
GGGAATGGAG GCTTCATGGG ATATTCTGCA GAAAATATCC CAGGTTGTAG CAGCAGTGGA 
AGTTGCTCTC AAGGGAGTGG TATTTTACAC TATGCTCATG GCGACAGTCA GCAAACTCAC 
CTGTTGAAGC AAGGAAGAAG CTCCATGGGC ACTGGTCTCA GTGGTGGGAA ACGTCCTAGT 
CAGGAAGAGG ACACACAGAG TATTGGTCCT AAAGTCCAGA GACAGAGCAC TAATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016874321.1
CDS1116..2792
Translation

Target ORF information:

RefSeq Version XM_017018832.1
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian clock 1 (CRY1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017018832.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGATGATCA TTTTCCACAA AATGATGGCC AGTTATTCCA ACACTACTTA TTGGATCATT 
TCCAATTCAG TGAGATTTTT GCTTCAGTGT CTTGAGGATC TTGATGCCAA TCTACGAAAA 
TTAAACTCCC GTCTGTTTGT GATTCGTGGA CAACCAGCAG ATGTGTTTCC CAGGCTTTTC 
AAGGAATGGA ACATTACTAA ACTTTCAATT GAGTATGATT CTGAGCCCTT TGGAAAGGAA 
CGAGACGCAG CTATTAAGAA ACTGGCAACT GAAGCTGGAG TAGAAGTCAT TGTAAGAATT 
TCACATACAT TATATGACCT AGACAAGATC ATAGAACTCA ATGGTGGACA ACCGCCTCTA 
ACTTATAAAA GATTCCAGAC TCTCATCAGC AAAATGGAAC CACTAGAGAT ACCAGTAGAG 
ACAATTACTT CAGAAGTGAT AGAAAAGTGC ACAACTCCTC TGTCTGATGA CCATGATGAG 
AAATATGGAG TCCCTTCACT GGAAGAGCTA GGTTTTGATA CAGATGGCTT ATCCTCTGCA 
GTGTGGCCAG GTGGAGAAAC TGAAGCACTT ACTCGTTTGG AAAGGCATTT GGAAAGAAAA 
GCTTGGGTGG CAAATTTTGA AAGACCTCGA ATGAATGCGA ATTCTCTGCT TGCAAGCCCT 
ACTGGACTTA GTCCTTATCT CCGATTTGGT TGTTTGTCAT GTCGACTGTT TTACTTCAAA 
CTAACAGATC TCTACAAAAA GGTAAAGAAG AACAGTTCCC CTCCCCTTTC CCTTTATGGG 
CAACTGTTAT GGCGTGAATT TTTCTATACA GCAGCAACAA ATAATCCACG CTTTGATAAA 
ATGGAAGGAA ACCCTATCTG TGTTCAGATT CCTTGGGATA AAAATCCTGA GGCTTTAGCC 
AAATGGGCGG AAGGCCGGAC AGGCTTTCCA TGGATTGATG CCATCATGAC ACAGCTTCGT 
CAGGAGGGTT GGATTCATCA TCTAGCCAGG CATGCAGTTG CTTGCTTCCT GACACGAGGG 
GACCTGTGGA TTAGTTGGGA AGAAGGAATG AAGGTATTTG AAGAATTATT GCTTGATGCA 
GATTGGAGCA TAAATGCTGG AAGTTGGATG TGGCTGTCTT GTAGTTCCTT TTTTCAACAG 
TTTTTTCACT GCTATTGCCC TGTTGGTTTT GGTAGGAGAA CAGATCCCAA TGGAGACTAT 
ATCAGGCGTT ATTTGCCTGT CCTAAGAGGC TTCCCTGCAA AATATATCTA TGATCCCTGG 
AATGCACCAG AAGGTATCCA AAAGGTAGCC AAATGTTTGA TAGGAGTTAA TTATCCTAAA 
CCAATGGTGA ACCATGCTGA GGCAAGCCGT TTGAATATCG AAAGGATGAA ACAGATCTAT 
CAGCAGCTTT CACGATATAG AGGACTAGGT CTTCTGGCAT CAGTACCTTC TAATCCTAAT 
GGGAATGGAG GCTTCATGGG ATATTCTGCA GAAAATATCC CAGGTTGTAG CAGCAGTGGA 
AGTTGCTCTC AAGGGAGTGG TATTTTACAC TATGCTCATG GCGACAGTCA GCAAACTCAC 
CTGTTGAAGC AAGGAAGAAG CTCCATGGGC ACTGGTCTCA GTGGTGGGAA ACGTCCTAGT 
CAGGAAGAGG ACACACAGAG TATTGGTCCT AAAGTCCAGA GACAGAGCAC TAATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57085
Clone ID Related Accession (Same CDS sequence) XM_017018832.1 , XM_017018832.2
Accession Version XM_017018832.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1677bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product cryptochrome-1 isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017018832.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGATGATCA TTTTCCACAA AATGATGGCC AGTTATTCCA ACACTACTTA TTGGATCATT 
TCCAATTCAG TGAGATTTTT GCTTCAGTGT CTTGAGGATC TTGATGCCAA TCTACGAAAA 
TTAAACTCCC GTCTGTTTGT GATTCGTGGA CAACCAGCAG ATGTGTTTCC CAGGCTTTTC 
AAGGAATGGA ACATTACTAA ACTTTCAATT GAGTATGATT CTGAGCCCTT TGGAAAGGAA 
CGAGACGCAG CTATTAAGAA ACTGGCAACT GAAGCTGGAG TAGAAGTCAT TGTAAGAATT 
TCACATACAT TATATGACCT AGACAAGATC ATAGAACTCA ATGGTGGACA ACCGCCTCTA 
ACTTATAAAA GATTCCAGAC TCTCATCAGC AAAATGGAAC CACTAGAGAT ACCAGTAGAG 
ACAATTACTT CAGAAGTGAT AGAAAAGTGC ACAACTCCTC TGTCTGATGA CCATGATGAG 
AAATATGGAG TCCCTTCACT GGAAGAGCTA GGTTTTGATA CAGATGGCTT ATCCTCTGCA 
GTGTGGCCAG GTGGAGAAAC TGAAGCACTT ACTCGTTTGG AAAGGCATTT GGAAAGAAAA 
GCTTGGGTGG CAAATTTTGA AAGACCTCGA ATGAATGCGA ATTCTCTGCT TGCAAGCCCT 
ACTGGACTTA GTCCTTATCT CCGATTTGGT TGTTTGTCAT GTCGACTGTT TTACTTCAAA 
CTAACAGATC TCTACAAAAA GGTAAAGAAG AACAGTTCCC CTCCCCTTTC CCTTTATGGG 
CAACTGTTAT GGCGTGAATT TTTCTATACA GCAGCAACAA ATAATCCACG CTTTGATAAA 
ATGGAAGGAA ACCCTATCTG TGTTCAGATT CCTTGGGATA AAAATCCTGA GGCTTTAGCC 
AAATGGGCGG AAGGCCGGAC AGGCTTTCCA TGGATTGATG CCATCATGAC ACAGCTTCGT 
CAGGAGGGTT GGATTCATCA TCTAGCCAGG CATGCAGTTG CTTGCTTCCT GACACGAGGG 
GACCTGTGGA TTAGTTGGGA AGAAGGAATG AAGGTATTTG AAGAATTATT GCTTGATGCA 
GATTGGAGCA TAAATGCTGG AAGTTGGATG TGGCTGTCTT GTAGTTCCTT TTTTCAACAG 
TTTTTTCACT GCTATTGCCC TGTTGGTTTT GGTAGGAGAA CAGATCCCAA TGGAGACTAT 
ATCAGGCGTT ATTTGCCTGT CCTAAGAGGC TTCCCTGCAA AATATATCTA TGATCCCTGG 
AATGCACCAG AAGGTATCCA AAAGGTAGCC AAATGTTTGA TAGGAGTTAA TTATCCTAAA 
CCAATGGTGA ACCATGCTGA GGCAAGCCGT TTGAATATCG AAAGGATGAA ACAGATCTAT 
CAGCAGCTTT CACGATATAG AGGACTAGGT CTTCTGGCAT CAGTACCTTC TAATCCTAAT 
GGGAATGGAG GCTTCATGGG ATATTCTGCA GAAAATATCC CAGGTTGTAG CAGCAGTGGA 
AGTTGCTCTC AAGGGAGTGG TATTTTACAC TATGCTCATG GCGACAGTCA GCAAACTCAC 
CTGTTGAAGC AAGGAAGAAG CTCCATGGGC ACTGGTCTCA GTGGTGGGAA ACGTCCTAGT 
CAGGAAGAGG ACACACAGAG TATTGGTCCT AAAGTCCAGA GACAGAGCAC TAATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016874321.1
CDS518..2194
Translation

Target ORF information:

RefSeq Version XM_017018832.2
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017018832.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGATGATCA TTTTCCACAA AATGATGGCC AGTTATTCCA ACACTACTTA TTGGATCATT 
TCCAATTCAG TGAGATTTTT GCTTCAGTGT CTTGAGGATC TTGATGCCAA TCTACGAAAA 
TTAAACTCCC GTCTGTTTGT GATTCGTGGA CAACCAGCAG ATGTGTTTCC CAGGCTTTTC 
AAGGAATGGA ACATTACTAA ACTTTCAATT GAGTATGATT CTGAGCCCTT TGGAAAGGAA 
CGAGACGCAG CTATTAAGAA ACTGGCAACT GAAGCTGGAG TAGAAGTCAT TGTAAGAATT 
TCACATACAT TATATGACCT AGACAAGATC ATAGAACTCA ATGGTGGACA ACCGCCTCTA 
ACTTATAAAA GATTCCAGAC TCTCATCAGC AAAATGGAAC CACTAGAGAT ACCAGTAGAG 
ACAATTACTT CAGAAGTGAT AGAAAAGTGC ACAACTCCTC TGTCTGATGA CCATGATGAG 
AAATATGGAG TCCCTTCACT GGAAGAGCTA GGTTTTGATA CAGATGGCTT ATCCTCTGCA 
GTGTGGCCAG GTGGAGAAAC TGAAGCACTT ACTCGTTTGG AAAGGCATTT GGAAAGAAAA 
GCTTGGGTGG CAAATTTTGA AAGACCTCGA ATGAATGCGA ATTCTCTGCT TGCAAGCCCT 
ACTGGACTTA GTCCTTATCT CCGATTTGGT TGTTTGTCAT GTCGACTGTT TTACTTCAAA 
CTAACAGATC TCTACAAAAA GGTAAAGAAG AACAGTTCCC CTCCCCTTTC CCTTTATGGG 
CAACTGTTAT GGCGTGAATT TTTCTATACA GCAGCAACAA ATAATCCACG CTTTGATAAA 
ATGGAAGGAA ACCCTATCTG TGTTCAGATT CCTTGGGATA AAAATCCTGA GGCTTTAGCC 
AAATGGGCGG AAGGCCGGAC AGGCTTTCCA TGGATTGATG CCATCATGAC ACAGCTTCGT 
CAGGAGGGTT GGATTCATCA TCTAGCCAGG CATGCAGTTG CTTGCTTCCT GACACGAGGG 
GACCTGTGGA TTAGTTGGGA AGAAGGAATG AAGGTATTTG AAGAATTATT GCTTGATGCA 
GATTGGAGCA TAAATGCTGG AAGTTGGATG TGGCTGTCTT GTAGTTCCTT TTTTCAACAG 
TTTTTTCACT GCTATTGCCC TGTTGGTTTT GGTAGGAGAA CAGATCCCAA TGGAGACTAT 
ATCAGGCGTT ATTTGCCTGT CCTAAGAGGC TTCCCTGCAA AATATATCTA TGATCCCTGG 
AATGCACCAG AAGGTATCCA AAAGGTAGCC AAATGTTTGA TAGGAGTTAA TTATCCTAAA 
CCAATGGTGA ACCATGCTGA GGCAAGCCGT TTGAATATCG AAAGGATGAA ACAGATCTAT 
CAGCAGCTTT CACGATATAG AGGACTAGGT CTTCTGGCAT CAGTACCTTC TAATCCTAAT 
GGGAATGGAG GCTTCATGGG ATATTCTGCA GAAAATATCC CAGGTTGTAG CAGCAGTGGA 
AGTTGCTCTC AAGGGAGTGG TATTTTACAC TATGCTCATG GCGACAGTCA GCAAACTCAC 
CTGTTGAAGC AAGGAAGAAG CTCCATGGGC ACTGGTCTCA GTGGTGGGAA ACGTCCTAGT 
CAGGAAGAGG ACACACAGAG TATTGGTCCT AAAGTCCAGA GACAGAGCAC TAATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu103684
Clone ID Related Accession (Same CDS sequence) XM_024448844.1
Accession Version XM_024448844.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1899bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product cryptochrome-1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGGGGTGA ACGCCGTGCA CTGGTTCCGA AAGGGGCTCC GGCTCCACGA CAACCCCGCC 
CTGAAGGAGT GCATTCAGGG CGCCGACACC ATCCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAATGT GGGCATCAAC AGGTGGCGAT TTTTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG AAAATTAAAC TCCCGTCTGT TTGTGATTCG TGGACAACCA 
GCAGATGTGT TTCCCAGGCT TTTCAAGGAA TGGAACATTA CTAAACTTTC AATTGAGTAT 
GATTCTGAGC CCTTTGGAAA GGAACGAGAC GCAGCTATTA AGAAACTGGC AACTGAAGCT 
GGAGTAGAAG TCATTGTAAG AATTTCACAT ACATTATATG ACCTAGACAA GATCATAGAA 
CTCAATGGTG GACAACCGCC TCTAACTTAT AAAAGATTCC AGACTCTCAT CAGCAAAATG 
GAACCACTAG AGATACCAGT AGAGACAATT ACTTCAGAAG TGATAGAAAA GTGCACAACT 
CCTCTGTCTG ATGACCATGA TGAGAAATAT GGAGTCCCTT CACTGGAAGA GCTAGGTTTT 
GATACAGATG GCTTATCCTC TGCAGTGTGG CCAGGTGGAG AAACTGAAGC ACTTACTCGT 
TTGGAAAGGC ATTTGGAAAG AAAAGCTTGG GTGGCAAATT TTGAAAGACC TCGAATGAAT 
GCGAATTCTC TGCTTGCAAG CCCTACTGGA CTTAGTCCTT ATCTCCGATT TGGTTGTTTG 
TCATGTCGAC TGTTTTACTT CAAACTAACA GATCTCTACA AAAAGGTAAA GAAGAACAGT 
TCCCCTCCCC TTTCCCTTTA TGGGCAACTG TTATGGCGTG AATTTTTCTA TACAGCAGCA 
ACAAATAATC CACGCTTTGA TAAAATGGAA GGAAACCCTA TCTGTGTTCA GATTCCTTGG 
GATAAAAATC CTGAGGCTTT AGCCAAATGG GCGGAAGGCC GGACAGGCTT TCCATGGATT 
GATGCCATCA TGACACAGCT TCGTCAGGAG GGTTGGATTC ATCATCTAGC CAGGCATGCA 
GTTGCTTGCT TCCTGACACG AGGGGACCTG TGGATTAGTT GGGAAGAAGG AATGAAGGTA 
TTTGAAGAAT TATTGCTTGA TGCAGATTGG AGCATAAATG CTGGAAGTTG GATGTGGCTG 
TCTTGTAGTT CCTTTTTTCA ACAGTTTTTT CACTGCTATT GCCCTGTTGG TTTTGGTAGG 
AGAACAGATC CCAATGGAGA CTATATCAGG CGTTATTTGC CTGTCCTAAG AGGCTTCCCT 
GCAAAATATA TCTATGATCC CTGGAATGCA CCAGAAGGTA TCCAAAAGGT AGCCAAATGT 
TTGATAGGAG TTAATTATCC TAAACCAATG GTGAACCATG CTGAGGCAAG CCGTTTGAAT 
ATCGAAAGGA TGAAACAGAT CTATCAGCAG CTTTCACGAT ATAGAGGACT AGGTCTTCTG 
GCATCAGTAC CTTCTAATCC TAATGGGAAT GGAGGCTTCA TGGGATATTC TGCAGAAAAT 
ATCCCAGGTT GTAGCAGCAG TGGAAGTTGC TCTCAAGGGA GTGGTATTTT ACACTATGCT 
CATGGCGACA GTCAGCAAAC TCACCTGTTG AAGCAAGGTA AGAATGAAGC ATTGGAGCAT 
ACTGTTCTTT TTCCTTTTCC TATCTTAAAC ATACATTTTT TAAATGTGCA GGAAGAAGCT 
CCATGGGCAC TGGTCTCAGT GGTGGGAAAC GTCCTAGTCA GGAAGAGGAC ACACAGAGTA 
TTGGTCCTAA AGTCCAGAGA CAGAGCACTA ATTAGAAAAC ATTCAGGAGG AATACTGTTG 
CAGCTGAAAT TGGTGGGGAG TTCAATACTT TTCAATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_024304612.1
CDS314..2212
Translation

Target ORF information:

RefSeq Version XM_024448844.1
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_024448844.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGGGGTGA ACGCCGTGCA CTGGTTCCGA AAGGGGCTCC GGCTCCACGA CAACCCCGCC 
CTGAAGGAGT GCATTCAGGG CGCCGACACC ATCCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAATGT GGGCATCAAC AGGTGGCGAT TTTTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG AAAATTAAAC TCCCGTCTGT TTGTGATTCG TGGACAACCA 
GCAGATGTGT TTCCCAGGCT TTTCAAGGAA TGGAACATTA CTAAACTTTC AATTGAGTAT 
GATTCTGAGC CCTTTGGAAA GGAACGAGAC GCAGCTATTA AGAAACTGGC AACTGAAGCT 
GGAGTAGAAG TCATTGTAAG AATTTCACAT ACATTATATG ACCTAGACAA GATCATAGAA 
CTCAATGGTG GACAACCGCC TCTAACTTAT AAAAGATTCC AGACTCTCAT CAGCAAAATG 
GAACCACTAG AGATACCAGT AGAGACAATT ACTTCAGAAG TGATAGAAAA GTGCACAACT 
CCTCTGTCTG ATGACCATGA TGAGAAATAT GGAGTCCCTT CACTGGAAGA GCTAGGTTTT 
GATACAGATG GCTTATCCTC TGCAGTGTGG CCAGGTGGAG AAACTGAAGC ACTTACTCGT 
TTGGAAAGGC ATTTGGAAAG AAAAGCTTGG GTGGCAAATT TTGAAAGACC TCGAATGAAT 
GCGAATTCTC TGCTTGCAAG CCCTACTGGA CTTAGTCCTT ATCTCCGATT TGGTTGTTTG 
TCATGTCGAC TGTTTTACTT CAAACTAACA GATCTCTACA AAAAGGTAAA GAAGAACAGT 
TCCCCTCCCC TTTCCCTTTA TGGGCAACTG TTATGGCGTG AATTTTTCTA TACAGCAGCA 
ACAAATAATC CACGCTTTGA TAAAATGGAA GGAAACCCTA TCTGTGTTCA GATTCCTTGG 
GATAAAAATC CTGAGGCTTT AGCCAAATGG GCGGAAGGCC GGACAGGCTT TCCATGGATT 
GATGCCATCA TGACACAGCT TCGTCAGGAG GGTTGGATTC ATCATCTAGC CAGGCATGCA 
GTTGCTTGCT TCCTGACACG AGGGGACCTG TGGATTAGTT GGGAAGAAGG AATGAAGGTA 
TTTGAAGAAT TATTGCTTGA TGCAGATTGG AGCATAAATG CTGGAAGTTG GATGTGGCTG 
TCTTGTAGTT CCTTTTTTCA ACAGTTTTTT CACTGCTATT GCCCTGTTGG TTTTGGTAGG 
AGAACAGATC CCAATGGAGA CTATATCAGG CGTTATTTGC CTGTCCTAAG AGGCTTCCCT 
GCAAAATATA TCTATGATCC CTGGAATGCA CCAGAAGGTA TCCAAAAGGT AGCCAAATGT 
TTGATAGGAG TTAATTATCC TAAACCAATG GTGAACCATG CTGAGGCAAG CCGTTTGAAT 
ATCGAAAGGA TGAAACAGAT CTATCAGCAG CTTTCACGAT ATAGAGGACT AGGTCTTCTG 
GCATCAGTAC CTTCTAATCC TAATGGGAAT GGAGGCTTCA TGGGATATTC TGCAGAAAAT 
ATCCCAGGTT GTAGCAGCAG TGGAAGTTGC TCTCAAGGGA GTGGTATTTT ACACTATGCT 
CATGGCGACA GTCAGCAAAC TCACCTGTTG AAGCAAGGTA AGAATGAAGC ATTGGAGCAT 
ACTGTTCTTT TTCCTTTTCC TATCTTAAAC ATACATTTTT TAAATGTGCA GGAAGAAGCT 
CCATGGGCAC TGGTCTCAGT GGTGGGAAAC GTCCTAGTCA GGAAGAGGAC ACACAGAGTA 
TTGGTCCTAA AGTCCAGAGA CAGAGCACTA ATTAGAAAAC ATTCAGGAGG AATACTGTTG 
CAGCTGAAAT TGGTGGGGAG TTCAATACTT TTCAATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu103685
Clone ID Related Accession (Same CDS sequence) XM_024448845.1
Accession Version XM_024448845.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1815bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product cryptochrome-1 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGATGATCA TTTTCCACAA AATGATGGCC AGTTATTCCA ACACTACTTA TTGGATCATT 
TCCAATTCAG TGAGATTTTT GCTTCAGTGT CTTGAGGATC TTGATGCCAA TCTACGAAAA 
TTAAACTCCC GTCTGTTTGT GATTCGTGGA CAACCAGCAG ATGTGTTTCC CAGGCTTTTC 
AAGGAATGGA ACATTACTAA ACTTTCAATT GAGTATGATT CTGAGCCCTT TGGAAAGGAA 
CGAGACGCAG CTATTAAGAA ACTGGCAACT GAAGCTGGAG TAGAAGTCAT TGTAAGAATT 
TCACATACAT TATATGACCT AGACAAGATC ATAGAACTCA ATGGTGGACA ACCGCCTCTA 
ACTTATAAAA GATTCCAGAC TCTCATCAGC AAAATGGAAC CACTAGAGAT ACCAGTAGAG 
ACAATTACTT CAGAAGTGAT AGAAAAGTGC ACAACTCCTC TGTCTGATGA CCATGATGAG 
AAATATGGAG TCCCTTCACT GGAAGAGCTA GGTTTTGATA CAGATGGCTT ATCCTCTGCA 
GTGTGGCCAG GTGGAGAAAC TGAAGCACTT ACTCGTTTGG AAAGGCATTT GGAAAGAAAA 
GCTTGGGTGG CAAATTTTGA AAGACCTCGA ATGAATGCGA ATTCTCTGCT TGCAAGCCCT 
ACTGGACTTA GTCCTTATCT CCGATTTGGT TGTTTGTCAT GTCGACTGTT TTACTTCAAA 
CTAACAGATC TCTACAAAAA GGTAAAGAAG AACAGTTCCC CTCCCCTTTC CCTTTATGGG 
CAACTGTTAT GGCGTGAATT TTTCTATACA GCAGCAACAA ATAATCCACG CTTTGATAAA 
ATGGAAGGAA ACCCTATCTG TGTTCAGATT CCTTGGGATA AAAATCCTGA GGCTTTAGCC 
AAATGGGCGG AAGGCCGGAC AGGCTTTCCA TGGATTGATG CCATCATGAC ACAGCTTCGT 
CAGGAGGGTT GGATTCATCA TCTAGCCAGG CATGCAGTTG CTTGCTTCCT GACACGAGGG 
GACCTGTGGA TTAGTTGGGA AGAAGGAATG AAGGTATTTG AAGAATTATT GCTTGATGCA 
GATTGGAGCA TAAATGCTGG AAGTTGGATG TGGCTGTCTT GTAGTTCCTT TTTTCAACAG 
TTTTTTCACT GCTATTGCCC TGTTGGTTTT GGTAGGAGAA CAGATCCCAA TGGAGACTAT 
ATCAGGCGTT ATTTGCCTGT CCTAAGAGGC TTCCCTGCAA AATATATCTA TGATCCCTGG 
AATGCACCAG AAGGTATCCA AAAGGTAGCC AAATGTTTGA TAGGAGTTAA TTATCCTAAA 
CCAATGGTGA ACCATGCTGA GGCAAGCCGT TTGAATATCG AAAGGATGAA ACAGATCTAT 
CAGCAGCTTT CACGATATAG AGGACTAGGT CTTCTGGCAT CAGTACCTTC TAATCCTAAT 
GGGAATGGAG GCTTCATGGG ATATTCTGCA GAAAATATCC CAGGTTGTAG CAGCAGTGGA 
AGTTGCTCTC AAGGGAGTGG TATTTTACAC TATGCTCATG GCGACAGTCA GCAAACTCAC 
CTGTTGAAGC AAGGTAAGAA TGAAGCATTG GAGCATACTG TTCTTTTTCC TTTTCCTATC 
TTAAACATAC ATTTTTTAAA TGTGCAGGAA GAAGCTCCAT GGGCACTGGT CTCAGTGGTG 
GGAAACGTCC TAGTCAGGAA GAGGACACAC AGAGTATTGG TCCTAAAGTC CAGAGACAGA 
GCACTAATTA GAAAACATTC AGGAGGAATA CTGTTGCAGC TGAAATTGGT GGGGAGTTCA 
ATACTTTTCA ATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_024304613.1
CDS1116..2930
Translation

Target ORF information:

RefSeq Version XM_024448845.1
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_024448845.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGATGATCA TTTTCCACAA AATGATGGCC AGTTATTCCA ACACTACTTA TTGGATCATT 
TCCAATTCAG TGAGATTTTT GCTTCAGTGT CTTGAGGATC TTGATGCCAA TCTACGAAAA 
TTAAACTCCC GTCTGTTTGT GATTCGTGGA CAACCAGCAG ATGTGTTTCC CAGGCTTTTC 
AAGGAATGGA ACATTACTAA ACTTTCAATT GAGTATGATT CTGAGCCCTT TGGAAAGGAA 
CGAGACGCAG CTATTAAGAA ACTGGCAACT GAAGCTGGAG TAGAAGTCAT TGTAAGAATT 
TCACATACAT TATATGACCT AGACAAGATC ATAGAACTCA ATGGTGGACA ACCGCCTCTA 
ACTTATAAAA GATTCCAGAC TCTCATCAGC AAAATGGAAC CACTAGAGAT ACCAGTAGAG 
ACAATTACTT CAGAAGTGAT AGAAAAGTGC ACAACTCCTC TGTCTGATGA CCATGATGAG 
AAATATGGAG TCCCTTCACT GGAAGAGCTA GGTTTTGATA CAGATGGCTT ATCCTCTGCA 
GTGTGGCCAG GTGGAGAAAC TGAAGCACTT ACTCGTTTGG AAAGGCATTT GGAAAGAAAA 
GCTTGGGTGG CAAATTTTGA AAGACCTCGA ATGAATGCGA ATTCTCTGCT TGCAAGCCCT 
ACTGGACTTA GTCCTTATCT CCGATTTGGT TGTTTGTCAT GTCGACTGTT TTACTTCAAA 
CTAACAGATC TCTACAAAAA GGTAAAGAAG AACAGTTCCC CTCCCCTTTC CCTTTATGGG 
CAACTGTTAT GGCGTGAATT TTTCTATACA GCAGCAACAA ATAATCCACG CTTTGATAAA 
ATGGAAGGAA ACCCTATCTG TGTTCAGATT CCTTGGGATA AAAATCCTGA GGCTTTAGCC 
AAATGGGCGG AAGGCCGGAC AGGCTTTCCA TGGATTGATG CCATCATGAC ACAGCTTCGT 
CAGGAGGGTT GGATTCATCA TCTAGCCAGG CATGCAGTTG CTTGCTTCCT GACACGAGGG 
GACCTGTGGA TTAGTTGGGA AGAAGGAATG AAGGTATTTG AAGAATTATT GCTTGATGCA 
GATTGGAGCA TAAATGCTGG AAGTTGGATG TGGCTGTCTT GTAGTTCCTT TTTTCAACAG 
TTTTTTCACT GCTATTGCCC TGTTGGTTTT GGTAGGAGAA CAGATCCCAA TGGAGACTAT 
ATCAGGCGTT ATTTGCCTGT CCTAAGAGGC TTCCCTGCAA AATATATCTA TGATCCCTGG 
AATGCACCAG AAGGTATCCA AAAGGTAGCC AAATGTTTGA TAGGAGTTAA TTATCCTAAA 
CCAATGGTGA ACCATGCTGA GGCAAGCCGT TTGAATATCG AAAGGATGAA ACAGATCTAT 
CAGCAGCTTT CACGATATAG AGGACTAGGT CTTCTGGCAT CAGTACCTTC TAATCCTAAT 
GGGAATGGAG GCTTCATGGG ATATTCTGCA GAAAATATCC CAGGTTGTAG CAGCAGTGGA 
AGTTGCTCTC AAGGGAGTGG TATTTTACAC TATGCTCATG GCGACAGTCA GCAAACTCAC 
CTGTTGAAGC AAGGTAAGAA TGAAGCATTG GAGCATACTG TTCTTTTTCC TTTTCCTATC 
TTAAACATAC ATTTTTTAAA TGTGCAGGAA GAAGCTCCAT GGGCACTGGT CTCAGTGGTG 
GGAAACGTCC TAGTCAGGAA GAGGACACAC AGAGTATTGG TCCTAAAGTC CAGAGACAGA 
GCACTAATTA GAAAACATTC AGGAGGAATA CTGTTGCAGC TGAAATTGGT GGGGAGTTCA 
ATACTTTTCA ATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.
Molecular cell65(1)176-190(2017 Jan)
Ode KL,Ukai H,Susaki EA,Narumi R,Matsumoto K,Hara J,Koide N,Abe T,Kanemaki MT,Kiyonari H,Ueda HR


book

PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Journal of affective disorders207136-140(2017 Jan)
Kovanen L,Donner K,Kaunisto M,Partonen T