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CRY2 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CRY2
Entrez Gene ID 1408
Full Name cryptochrome circadian regulator 2
Synonyms HCRY2,PHLL2
General protein information
Preferred Names

cryptochrome circadian regulator 2

Names

cryptochrome-2
cryptochrome 2 (photolyase-like)
cryptochrome circadian clock 2
growth-inhibiting protein 37
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

11

11p11.2
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Disorder MIM:

603732


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_021117.4 NP_066940.3 cryptochrome-2 isoform 1
NM_021117.3 NP_066940.2 cryptochrome-2 isoform 1
NM_001127457.2 NP_001120929.1 cryptochrome-2 isoform 2
NM_021117.5 NP_066940.3 cryptochrome-2 isoform 1

Pathways from BioSystems


Homologies


Bos taurus (cattle) LOC509058 XP_002693610.3
Homo sapiens (human) CRY2 NP_066940.2
Pan troglodytes (chimpanzee) CRY2 XP_001160595.2
Danio rerio (zebrafish) cry3 NP_571861.2
Canis lupus familiaris (dog) CRY2 XP_540761.2
Mus musculus (house mouse) Cry2 NP_034093.1
Rattus norvegicus (Norway rat) Cry2 NP_596896.1
Gallus gallus (chicken) CRY2 NP_989575.1
Xenopus tropicalis (tropical clawed frog) cry2 XP_002934138.2
CRY2 XP_001113162.1

Gene Ontology

The following CRY2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRY2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu27506 NM_021117.3
Latest version!		 Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$259.50-$363.30
$519.00
OHu27583 NM_001127457.2
Latest version!		 Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $314.30
$449.00
OHu107137 NM_021117.5
Latest version!		 Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 14-16 $307.30
$439.00
View Old Accession Versions >>
OHu107137 NM_021117.4 Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 14-16 $307.30
$439.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu27506
Clone ID Related Accession (Same CDS sequence) NM_021117.3
Accession Version NM_021117.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1845bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-26
Organism Homo sapiens(human)
Product cryptochrome-2 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302865.1, BC041814.1, AC068385.9 and AI375851.1. On May 20, 2008 this sequence version replaced NM_021117.2. Transcript Variant: This variant (1) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.218023.1, SRR1803617.263223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGGCGGGG TCCACGTCGC CTACCGGGGC GGAGCGGGGG TGGCTGGAGC AGTCTGGACA 
GTCATGGCGG CGACTGTGGC GACGGCGGCA GCTGTGGCCC CGGCGCCAGC GCCCGGCACG 
GACAGCGCCT CTTCGGTGCA CTGGTTCCGC AAAGGGCTGC GACTCCACGA CAACCCGGCG 
TTGCTGGCGG CCGTGCGCGG GGCGCGCTGC GTGCGCTGCG TTTACATTCT CGACCCGTGG 
TTCGCGGCCT CCTCCTCAGT CGGGATCAAC CGATGGAGGT TCCTACTTCA GTCTCTGGAA 
GATTTGGACA CAAGTTTAAG GAAACTGAAC TCCCGCCTGT TTGTAGTCCG GGGACAGCCA 
GCCGACGTGT TCCCAAGGCT GTTCAAGGAA TGGGGAGTGA CCCGCTTGAC CTTTGAATAT 
GACTCTGAAC CCTTTGGGAA AGAACGGGAT GCAGCCATCA TGAAGATGGC CAAGGAGGCT 
GGTGTGGAAG TAGTGACGGA GAATTCTCAT ACCCTCTATG ACCTGGACAG GATCATTGAG 
CTGAATGGGC AGAAGCCACC CCTTACATAC AAGCGCTTTC AGGCCATCAT CAGCCGCATG 
GAGCTGCCCA AGAAGCCAGT GGGCTTGGTG ACCAGCCAGC AGATGGAGAG CTGCAGGGCC 
GAGATCCAGG AGAACCACGA CGAGACCTAC GGCGTGCCCT CCCTGGAGGA GCTGGGGTTC 
CCCACTGAAG GACTTGGTCC AGCTGTCTGG CAGGGAGGAG AGACAGAAGC TCTGGCCCGC 
CTGGATAAGC ACTTGGAACG GAAGGCCTGG GTTGCCAACT ATGAGAGACC CCGAATGAAC 
GCCAACTCCC TCCTGGCCAG CCCCACAGGC CTCAGCCCCT ACCTGCGCTT TGGTTGTCTC 
TCCTGCCGCC TCTTCTACTA CCGCCTGTGG GACCTGTATA AAAAGGTGAA GCGGAACAGC 
ACACCTCCCC TCTCCCTATT TGGGCAACTC CTATGGCGAG AGTTCTTCTA CACGGCAGCT 
ACCAACAACC CCAGGTTTGA CCGCATGGAG GGGAACCCCA TCTGCATCCA GATCCCCTGG 
GACCGCAATC CTGAGGCCCT GGCCAAGTGG GCTGAGGGCA AGACAGGCTT CCCTTGGATT 
GATGCCATCA TGACCCAACT GAGGCAGGAG GGCTGGATCC ACCACCTGGC CCGGCATGCC 
GTGGCCTGCT TCCTGACCCG CGGGGACCTC TGGGTCAGCT GGGAGAGCGG GGTCCGGGTA 
TTTGATGAGC TGCTCCTGGA TGCAGATTTC AGCGTGAACG CAGGCAGCTG GATGTGGCTG 
TCCTGCAGTG CTTTCTTCCA GCAGTTCTTC CACTGCTACT GCCCTGTGGG CTTTGGCCGT 
CGCACGGACC CCAGTGGGGA CTACATCAGG CGATACCTGC CCAAATTGAA AGCGTTCCCC 
TCTCGATACA TCTATGAGCC CTGGAATGCC CCAGAGTCAA TTCAGAAGGC AGCCAAGTGC 
ATCATTGGTG TGGACTACCC ACGGCCCATC GTCAACCATG CCGAGACCAG CCGGCTTAAC 
ATTGAACGAA TGAAGCAGAT TTACCAGCAG CTTTCGCGCT ACCGGGGACT CTGTCTACTG 
GCATCTGTCC CTTCCTGTGT GGAAGACCTC AGTCACCCTG TGGCAGAGCC CAGCTCGAGC 
CAGGCTGGCA GCATGAGCAG TGCAGGCCCA AGACCACTAC CCAGTGGCCC AGCATCCCCC 
AAACGCAAGC TGGAAGCAGC CGAGGAACCA CCTGGTGAAG AACTCAGCAA ACGGGCCCGG 
GTGGCAGAGT TGCCAACCCC AGAGCTGCCG AGCAAGGATG CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_066940.2
CDS23..1867
Translation

Target ORF information:

RefSeq Version NM_021117.3
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_021117.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGGCGGGG TCCACGTCGC CTACCGGGGC GGAGCGGGGG TGGCTGGAGC AGTCTGGACA 
GTCATGGCGG CGACTGTGGC GACGGCGGCA GCTGTGGCCC CGGCGCCAGC GCCCGGCACG 
GACAGCGCCT CTTCGGTGCA CTGGTTCCGC AAAGGGCTGC GACTCCACGA CAACCCGGCG 
TTGCTGGCGG CCGTGCGCGG GGCGCGCTGC GTGCGCTGCG TTTACATTCT CGACCCGTGG 
TTCGCGGCCT CCTCCTCAGT CGGGATCAAC CGATGGAGGT TCCTACTTCA GTCTCTGGAA 
GATTTGGACA CAAGTTTAAG GAAACTGAAC TCCCGCCTGT TTGTAGTCCG GGGACAGCCA 
GCCGACGTGT TCCCAAGGCT GTTCAAGGAA TGGGGAGTGA CCCGCTTGAC CTTTGAATAT 
GACTCTGAAC CCTTTGGGAA AGAACGGGAT GCAGCCATCA TGAAGATGGC CAAGGAGGCT 
GGTGTGGAAG TAGTGACGGA GAATTCTCAT ACCCTCTATG ACCTGGACAG GATCATTGAG 
CTGAATGGGC AGAAGCCACC CCTTACATAC AAGCGCTTTC AGGCCATCAT CAGCCGCATG 
GAGCTGCCCA AGAAGCCAGT GGGCTTGGTG ACCAGCCAGC AGATGGAGAG CTGCAGGGCC 
GAGATCCAGG AGAACCACGA CGAGACCTAC GGCGTGCCCT CCCTGGAGGA GCTGGGGTTC 
CCCACTGAAG GACTTGGTCC AGCTGTCTGG CAGGGAGGAG AGACAGAAGC TCTGGCCCGC 
CTGGATAAGC ACTTGGAACG GAAGGCCTGG GTTGCCAACT ATGAGAGACC CCGAATGAAC 
GCCAACTCCC TCCTGGCCAG CCCCACAGGC CTCAGCCCCT ACCTGCGCTT TGGTTGTCTC 
TCCTGCCGCC TCTTCTACTA CCGCCTGTGG GACCTGTATA AAAAGGTGAA GCGGAACAGC 
ACACCTCCCC TCTCCCTATT TGGGCAACTC CTATGGCGAG AGTTCTTCTA CACGGCAGCT 
ACCAACAACC CCAGGTTTGA CCGCATGGAG GGGAACCCCA TCTGCATCCA GATCCCCTGG 
GACCGCAATC CTGAGGCCCT GGCCAAGTGG GCTGAGGGCA AGACAGGCTT CCCTTGGATT 
GATGCCATCA TGACCCAACT GAGGCAGGAG GGCTGGATCC ACCACCTGGC CCGGCATGCC 
GTGGCCTGCT TCCTGACCCG CGGGGACCTC TGGGTCAGCT GGGAGAGCGG GGTCCGGGTA 
TTTGATGAGC TGCTCCTGGA TGCAGATTTC AGCGTGAACG CAGGCAGCTG GATGTGGCTG 
TCCTGCAGTG CTTTCTTCCA GCAGTTCTTC CACTGCTACT GCCCTGTGGG CTTTGGCCGT 
CGCACGGACC CCAGTGGGGA CTACATCAGG CGATACCTGC CCAAATTGAA AGCGTTCCCC 
TCTCGATACA TCTATGAGCC CTGGAATGCC CCAGAGTCAA TTCAGAAGGC AGCCAAGTGC 
ATCATTGGTG TGGACTACCC ACGGCCCATC GTCAACCATG CCGAGACCAG CCGGCTTAAC 
ATTGAACGAA TGAAGCAGAT TTACCAGCAG CTTTCGCGCT ACCGGGGACT CTGTCTACTG 
GCATCTGTCC CTTCCTGTGT GGAAGACCTC AGTCACCCTG TGGCAGAGCC CAGCTCGAGC 
CAGGCTGGCA GCATGAGCAG TGCAGGCCCA AGACCACTAC CCAGTGGCCC AGCATCCCCC 
AAACGCAAGC TGGAAGCAGC CGAGGAACCA CCTGGTGAAG AACTCAGCAA ACGGGCCCGG 
GTGGCAGAGT TGCCAACCCC AGAGCTGCCG AGCAAGGATG CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27583
Clone ID Related Accession (Same CDS sequence) NM_001127457.2
Accession Version NM_001127457.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1599bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-23
Organism Homo sapiens(human)
Product cryptochrome-2 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC330290.1, BC041814.1, AC068385.9 and AI375851.1. On Feb 7, 2014 this sequence version replaced NM_001127457.1. Transcript Variant: This variant (2) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.250942.1, AK294904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGCCAGCTC CACCCGGGCG GACCCACACA TGGTTCCTAC TTCAGTCTCT GGAAGATTTG 
GACACAAGTT TAAGGAAACT GAACTCCCGC CTGTTTGTAG TCCGGGGACA GCCAGCCGAC 
GTGTTCCCAA GGCTGTTCAA GGAATGGGGA GTGACCCGCT TGACCTTTGA ATATGACTCT 
GAACCCTTTG GGAAAGAACG GGATGCAGCC ATCATGAAGA TGGCCAAGGA GGCTGGTGTG 
GAAGTAGTGA CGGAGAATTC TCATACCCTC TATGACCTGG ACAGGATCAT TGAGCTGAAT 
GGGCAGAAGC CACCCCTTAC ATACAAGCGC TTTCAGGCCA TCATCAGCCG CATGGAGCTG 
CCCAAGAAGC CAGTGGGCTT GGTGACCAGC CAGCAGATGG AGAGCTGCAG GGCCGAGATC 
CAGGAGAACC ACGACGAGAC CTACGGCGTG CCCTCCCTGG AGGAGCTGGG GTTCCCCACT 
GAAGGACTTG GTCCAGCTGT CTGGCAGGGA GGAGAGACAG AAGCTCTGGC CCGCCTGGAT 
AAGCACTTGG AACGGAAGGC CTGGGTTGCC AACTATGAGA GACCCCGAAT GAACGCCAAC 
TCCCTCCTGG CCAGCCCCAC AGGCCTCAGC CCCTACCTGC GCTTTGGTTG TCTCTCCTGC 
CGCCTCTTCT ACTACCGCCT GTGGGACCTG TATAAAAAGG TGAAGCGGAA CAGCACACCT 
CCCCTCTCCC TATTTGGGCA ACTCCTATGG CGAGAGTTCT TCTACACGGC AGCTACCAAC 
AACCCCAGGT TTGACCGCAT GGAGGGGAAC CCCATCTGCA TCCAGATCCC CTGGGACCGC 
AATCCTGAGG CCCTGGCCAA GTGGGCTGAG GGCAAGACAG GCTTCCCTTG GATTGATGCC 
ATCATGACCC AACTGAGGCA GGAGGGCTGG ATCCACCACC TGGCCCGGCA TGCCGTGGCC 
TGCTTCCTGA CCCGCGGGGA CCTCTGGGTC AGCTGGGAGA GCGGGGTCCG GGTATTTGAT 
GAGCTGCTCC TGGATGCAGA TTTCAGCGTG AACGCAGGCA GCTGGATGTG GCTGTCCTGC 
AGTGCTTTCT TCCAGCAGTT CTTCCACTGC TACTGCCCTG TGGGCTTTGG CCGTCGCACG 
GACCCCAGTG GGGACTACAT CAGGCGATAC CTGCCCAAAT TGAAAGCGTT CCCCTCTCGA 
TACATCTATG AGCCCTGGAA TGCCCCAGAG TCAATTCAGA AGGCAGCCAA GTGCATCATT 
GGTGTGGACT ACCCACGGCC CATCGTCAAC CATGCCGAGA CCAGCCGGCT TAACATTGAA 
CGAATGAAGC AGATTTACCA GCAGCTTTCG CGCTACCGGG GACTCTGTCT ACTGGCATCT 
GTCCCTTCCT GTGTGGAAGA CCTCAGTCAC CCTGTGGCAG AGCCCAGCTC GAGCCAGGCT 
GGCAGCATGA GCAGTGCAGG CCCAAGACCA CTACCCAGTG GCCCAGCATC CCCCAAACGC 
AAGCTGGAAG CAGCCGAGGA ACCACCTGGT GAAGAACTCA GCAAACGGGC CCGGGTGGCA 
GAGTTGCCAA CCCCAGAGCT GCCGAGCAAG GATGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001120929.1
CDS133..1731
Translation

Target ORF information:

RefSeq Version NM_001127457.2
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001127457.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGCCAGCTC CACCCGGGCG GACCCACACA TGGTTCCTAC TTCAGTCTCT GGAAGATTTG 
GACACAAGTT TAAGGAAACT GAACTCCCGC CTGTTTGTAG TCCGGGGACA GCCAGCCGAC 
GTGTTCCCAA GGCTGTTCAA GGAATGGGGA GTGACCCGCT TGACCTTTGA ATATGACTCT 
GAACCCTTTG GGAAAGAACG GGATGCAGCC ATCATGAAGA TGGCCAAGGA GGCTGGTGTG 
GAAGTAGTGA CGGAGAATTC TCATACCCTC TATGACCTGG ACAGGATCAT TGAGCTGAAT 
GGGCAGAAGC CACCCCTTAC ATACAAGCGC TTTCAGGCCA TCATCAGCCG CATGGAGCTG 
CCCAAGAAGC CAGTGGGCTT GGTGACCAGC CAGCAGATGG AGAGCTGCAG GGCCGAGATC 
CAGGAGAACC ACGACGAGAC CTACGGCGTG CCCTCCCTGG AGGAGCTGGG GTTCCCCACT 
GAAGGACTTG GTCCAGCTGT CTGGCAGGGA GGAGAGACAG AAGCTCTGGC CCGCCTGGAT 
AAGCACTTGG AACGGAAGGC CTGGGTTGCC AACTATGAGA GACCCCGAAT GAACGCCAAC 
TCCCTCCTGG CCAGCCCCAC AGGCCTCAGC CCCTACCTGC GCTTTGGTTG TCTCTCCTGC 
CGCCTCTTCT ACTACCGCCT GTGGGACCTG TATAAAAAGG TGAAGCGGAA CAGCACACCT 
CCCCTCTCCC TATTTGGGCA ACTCCTATGG CGAGAGTTCT TCTACACGGC AGCTACCAAC 
AACCCCAGGT TTGACCGCAT GGAGGGGAAC CCCATCTGCA TCCAGATCCC CTGGGACCGC 
AATCCTGAGG CCCTGGCCAA GTGGGCTGAG GGCAAGACAG GCTTCCCTTG GATTGATGCC 
ATCATGACCC AACTGAGGCA GGAGGGCTGG ATCCACCACC TGGCCCGGCA TGCCGTGGCC 
TGCTTCCTGA CCCGCGGGGA CCTCTGGGTC AGCTGGGAGA GCGGGGTCCG GGTATTTGAT 
GAGCTGCTCC TGGATGCAGA TTTCAGCGTG AACGCAGGCA GCTGGATGTG GCTGTCCTGC 
AGTGCTTTCT TCCAGCAGTT CTTCCACTGC TACTGCCCTG TGGGCTTTGG CCGTCGCACG 
GACCCCAGTG GGGACTACAT CAGGCGATAC CTGCCCAAAT TGAAAGCGTT CCCCTCTCGA 
TACATCTATG AGCCCTGGAA TGCCCCAGAG TCAATTCAGA AGGCAGCCAA GTGCATCATT 
GGTGTGGACT ACCCACGGCC CATCGTCAAC CATGCCGAGA CCAGCCGGCT TAACATTGAA 
CGAATGAAGC AGATTTACCA GCAGCTTTCG CGCTACCGGG GACTCTGTCT ACTGGCATCT 
GTCCCTTCCT GTGTGGAAGA CCTCAGTCAC CCTGTGGCAG AGCCCAGCTC GAGCCAGGCT 
GGCAGCATGA GCAGTGCAGG CCCAAGACCA CTACCCAGTG GCCCAGCATC CCCCAAACGC 
AAGCTGGAAG CAGCCGAGGA ACCACCTGGT GAAGAACTCA GCAAACGGGC CCGGGTGGCA 
GAGTTGCCAA CCCCAGAGCT GCCGAGCAAG GATGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu107137
Clone ID Related Accession (Same CDS sequence) NM_021117.4 , NM_021117.5
Accession Version NM_021117.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1782bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-03-03
Organism Homo sapiens(human)
Product cryptochrome-2 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302865.1, BC041814.1, AC068385.9 and AI375851.1. On Jul 28, 2018 this sequence version replaced NM_021117.3. Transcript Variant: This variant (1) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.218023.1, BC041814.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGCGA CTGTGGCGAC GGCGGCAGCT GTGGCCCCGG CGCCAGCGCC CGGCACGGAC 
AGCGCCTCTT CGGTGCACTG GTTCCGCAAA GGGCTGCGAC TCCACGACAA CCCGGCGTTG 
CTGGCGGCCG TGCGCGGGGC GCGCTGCGTG CGCTGCGTTT ACATTCTCGA CCCGTGGTTC 
GCGGCCTCCT CCTCAGTCGG GATCAACCGA TGGAGGTTCC TACTTCAGTC TCTGGAAGAT 
TTGGACACAA GTTTAAGGAA ACTGAACTCC CGCCTGTTTG TAGTCCGGGG ACAGCCAGCC 
GACGTGTTCC CAAGGCTGTT CAAGGAATGG GGAGTGACCC GCTTGACCTT TGAATATGAC 
TCTGAACCCT TTGGGAAAGA ACGGGATGCA GCCATCATGA AGATGGCCAA GGAGGCTGGT 
GTGGAAGTAG TGACGGAGAA TTCTCATACC CTCTATGACC TGGACAGGAT CATTGAGCTG 
AATGGGCAGA AGCCACCCCT TACATACAAG CGCTTTCAGG CCATCATCAG CCGCATGGAG 
CTGCCCAAGA AGCCAGTGGG CTTGGTGACC AGCCAGCAGA TGGAGAGCTG CAGGGCCGAG 
ATCCAGGAGA ACCACGACGA GACCTACGGC GTGCCCTCCC TGGAGGAGCT GGGGTTCCCC 
ACTGAAGGAC TTGGTCCAGC TGTCTGGCAG GGAGGAGAGA CAGAAGCTCT GGCCCGCCTG 
GATAAGCACT TGGAACGGAA GGCCTGGGTT GCCAACTATG AGAGACCCCG AATGAACGCC 
AACTCCCTCC TGGCCAGCCC CACAGGCCTC AGCCCCTACC TGCGCTTTGG TTGTCTCTCC 
TGCCGCCTCT TCTACTACCG CCTGTGGGAC CTGTATAAAA AGGTGAAGCG GAACAGCACA 
CCTCCCCTCT CCCTATTTGG GCAACTCCTA TGGCGAGAGT TCTTCTACAC GGCAGCTACC 
AACAACCCCA GGTTTGACCG CATGGAGGGG AACCCCATCT GCATCCAGAT CCCCTGGGAC 
CGCAATCCTG AGGCCCTGGC CAAGTGGGCT GAGGGCAAGA CAGGCTTCCC TTGGATTGAT 
GCCATCATGA CCCAACTGAG GCAGGAGGGC TGGATCCACC ACCTGGCCCG GCATGCCGTG 
GCCTGCTTCC TGACCCGCGG GGACCTCTGG GTCAGCTGGG AGAGCGGGGT CCGGGTATTT 
GATGAGCTGC TCCTGGATGC AGATTTCAGC GTGAACGCAG GCAGCTGGAT GTGGCTGTCC 
TGCAGTGCTT TCTTCCAGCA GTTCTTCCAC TGCTACTGCC CTGTGGGCTT TGGCCGTCGC 
ACGGACCCCA GTGGGGACTA CATCAGGCGA TACCTGCCCA AATTGAAAGC GTTCCCCTCT 
CGATACATCT ATGAGCCCTG GAATGCCCCA GAGTCAATTC AGAAGGCAGC CAAGTGCATC 
ATTGGTGTGG ACTACCCACG GCCCATCGTC AACCATGCCG AGACCAGCCG GCTTAACATT 
GAACGAATGA AGCAGATTTA CCAGCAGCTT TCGCGCTACC GGGGACTCTG TCTACTGGCA 
TCTGTCCCTT CCTGTGTGGA AGACCTCAGT CACCCTGTGG CAGAGCCCAG CTCGAGCCAG 
GCTGGCAGCA TGAGCAGTGC AGGCCCAAGA CCACTACCCA GTGGCCCAGC ATCCCCCAAA 
CGCAAGCTGG AAGCAGCCGA GGAACCACCT GGTGAAGAAC TCAGCAAACG GGCCCGGGTG 
GCAGAGTTGC CAACCCCAGA GCTGCCGAGC AAGGATGCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_066940.3
CDS17..1798
Translation

Target ORF information:

RefSeq Version NM_021117.4
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_021117.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGCGA CTGTGGCGAC GGCGGCAGCT GTGGCCCCGG CGCCAGCGCC CGGCACGGAC 
AGCGCCTCTT CGGTGCACTG GTTCCGCAAA GGGCTGCGAC TCCACGACAA CCCGGCGTTG 
CTGGCGGCCG TGCGCGGGGC GCGCTGCGTG CGCTGCGTTT ACATTCTCGA CCCGTGGTTC 
GCGGCCTCCT CCTCAGTCGG GATCAACCGA TGGAGGTTCC TACTTCAGTC TCTGGAAGAT 
TTGGACACAA GTTTAAGGAA ACTGAACTCC CGCCTGTTTG TAGTCCGGGG ACAGCCAGCC 
GACGTGTTCC CAAGGCTGTT CAAGGAATGG GGAGTGACCC GCTTGACCTT TGAATATGAC 
TCTGAACCCT TTGGGAAAGA ACGGGATGCA GCCATCATGA AGATGGCCAA GGAGGCTGGT 
GTGGAAGTAG TGACGGAGAA TTCTCATACC CTCTATGACC TGGACAGGAT CATTGAGCTG 
AATGGGCAGA AGCCACCCCT TACATACAAG CGCTTTCAGG CCATCATCAG CCGCATGGAG 
CTGCCCAAGA AGCCAGTGGG CTTGGTGACC AGCCAGCAGA TGGAGAGCTG CAGGGCCGAG 
ATCCAGGAGA ACCACGACGA GACCTACGGC GTGCCCTCCC TGGAGGAGCT GGGGTTCCCC 
ACTGAAGGAC TTGGTCCAGC TGTCTGGCAG GGAGGAGAGA CAGAAGCTCT GGCCCGCCTG 
GATAAGCACT TGGAACGGAA GGCCTGGGTT GCCAACTATG AGAGACCCCG AATGAACGCC 
AACTCCCTCC TGGCCAGCCC CACAGGCCTC AGCCCCTACC TGCGCTTTGG TTGTCTCTCC 
TGCCGCCTCT TCTACTACCG CCTGTGGGAC CTGTATAAAA AGGTGAAGCG GAACAGCACA 
CCTCCCCTCT CCCTATTTGG GCAACTCCTA TGGCGAGAGT TCTTCTACAC GGCAGCTACC 
AACAACCCCA GGTTTGACCG CATGGAGGGG AACCCCATCT GCATCCAGAT CCCCTGGGAC 
CGCAATCCTG AGGCCCTGGC CAAGTGGGCT GAGGGCAAGA CAGGCTTCCC TTGGATTGAT 
GCCATCATGA CCCAACTGAG GCAGGAGGGC TGGATCCACC ACCTGGCCCG GCATGCCGTG 
GCCTGCTTCC TGACCCGCGG GGACCTCTGG GTCAGCTGGG AGAGCGGGGT CCGGGTATTT 
GATGAGCTGC TCCTGGATGC AGATTTCAGC GTGAACGCAG GCAGCTGGAT GTGGCTGTCC 
TGCAGTGCTT TCTTCCAGCA GTTCTTCCAC TGCTACTGCC CTGTGGGCTT TGGCCGTCGC 
ACGGACCCCA GTGGGGACTA CATCAGGCGA TACCTGCCCA AATTGAAAGC GTTCCCCTCT 
CGATACATCT ATGAGCCCTG GAATGCCCCA GAGTCAATTC AGAAGGCAGC CAAGTGCATC 
ATTGGTGTGG ACTACCCACG GCCCATCGTC AACCATGCCG AGACCAGCCG GCTTAACATT 
GAACGAATGA AGCAGATTTA CCAGCAGCTT TCGCGCTACC GGGGACTCTG TCTACTGGCA 
TCTGTCCCTT CCTGTGTGGA AGACCTCAGT CACCCTGTGG CAGAGCCCAG CTCGAGCCAG 
GCTGGCAGCA TGAGCAGTGC AGGCCCAAGA CCACTACCCA GTGGCCCAGC ATCCCCCAAA 
CGCAAGCTGG AAGCAGCCGA GGAACCACCT GGTGAAGAAC TCAGCAAACG GGCCCGGGTG 
GCAGAGTTGC CAACCCCAGA GCTGCCGAGC AAGGATGCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu107137
Clone ID Related Accession (Same CDS sequence) NM_021117.4 , NM_021117.5
Accession Version NM_021117.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1782bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-25
Organism Homo sapiens(human)
Product cryptochrome-2 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302865.1, BC041814.1 and AC068385.9. On May 17, 2019 this sequence version replaced NM_021117.4. Transcript Variant: This variant (1) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1817366.1, SRR7346977.1410335.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000616080.2/ ENSP00000484684.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGCGA CTGTGGCGAC GGCGGCAGCT GTGGCCCCGG CGCCAGCGCC CGGCACGGAC 
AGCGCCTCTT CGGTGCACTG GTTCCGCAAA GGGCTGCGAC TCCACGACAA CCCGGCGTTG 
CTGGCGGCCG TGCGCGGGGC GCGCTGCGTG CGCTGCGTTT ACATTCTCGA CCCGTGGTTC 
GCGGCCTCCT CCTCAGTCGG GATCAACCGA TGGAGGTTCC TACTTCAGTC TCTGGAAGAT 
TTGGACACAA GTTTAAGGAA ACTGAACTCC CGCCTGTTTG TAGTCCGGGG ACAGCCAGCC 
GACGTGTTCC CAAGGCTGTT CAAGGAATGG GGAGTGACCC GCTTGACCTT TGAATATGAC 
TCTGAACCCT TTGGGAAAGA ACGGGATGCA GCCATCATGA AGATGGCCAA GGAGGCTGGT 
GTGGAAGTAG TGACGGAGAA TTCTCATACC CTCTATGACC TGGACAGGAT CATTGAGCTG 
AATGGGCAGA AGCCACCCCT TACATACAAG CGCTTTCAGG CCATCATCAG CCGCATGGAG 
CTGCCCAAGA AGCCAGTGGG CTTGGTGACC AGCCAGCAGA TGGAGAGCTG CAGGGCCGAG 
ATCCAGGAGA ACCACGACGA GACCTACGGC GTGCCCTCCC TGGAGGAGCT GGGGTTCCCC 
ACTGAAGGAC TTGGTCCAGC TGTCTGGCAG GGAGGAGAGA CAGAAGCTCT GGCCCGCCTG 
GATAAGCACT TGGAACGGAA GGCCTGGGTT GCCAACTATG AGAGACCCCG AATGAACGCC 
AACTCCCTCC TGGCCAGCCC CACAGGCCTC AGCCCCTACC TGCGCTTTGG TTGTCTCTCC 
TGCCGCCTCT TCTACTACCG CCTGTGGGAC CTGTATAAAA AGGTGAAGCG GAACAGCACA 
CCTCCCCTCT CCCTATTTGG GCAACTCCTA TGGCGAGAGT TCTTCTACAC GGCAGCTACC 
AACAACCCCA GGTTTGACCG CATGGAGGGG AACCCCATCT GCATCCAGAT CCCCTGGGAC 
CGCAATCCTG AGGCCCTGGC CAAGTGGGCT GAGGGCAAGA CAGGCTTCCC TTGGATTGAT 
GCCATCATGA CCCAACTGAG GCAGGAGGGC TGGATCCACC ACCTGGCCCG GCATGCCGTG 
GCCTGCTTCC TGACCCGCGG GGACCTCTGG GTCAGCTGGG AGAGCGGGGT CCGGGTATTT 
GATGAGCTGC TCCTGGATGC AGATTTCAGC GTGAACGCAG GCAGCTGGAT GTGGCTGTCC 
TGCAGTGCTT TCTTCCAGCA GTTCTTCCAC TGCTACTGCC CTGTGGGCTT TGGCCGTCGC 
ACGGACCCCA GTGGGGACTA CATCAGGCGA TACCTGCCCA AATTGAAAGC GTTCCCCTCT 
CGATACATCT ATGAGCCCTG GAATGCCCCA GAGTCAATTC AGAAGGCAGC CAAGTGCATC 
ATTGGTGTGG ACTACCCACG GCCCATCGTC AACCATGCCG AGACCAGCCG GCTTAACATT 
GAACGAATGA AGCAGATTTA CCAGCAGCTT TCGCGCTACC GGGGACTCTG TCTACTGGCA 
TCTGTCCCTT CCTGTGTGGA AGACCTCAGT CACCCTGTGG CAGAGCCCAG CTCGAGCCAG 
GCTGGCAGCA TGAGCAGTGC AGGCCCAAGA CCACTACCCA GTGGCCCAGC ATCCCCCAAA 
CGCAAGCTGG AAGCAGCCGA GGAACCACCT GGTGAAGAAC TCAGCAAACG GGCCCGGGTG 
GCAGAGTTGC CAACCCCAGA GCTGCCGAGC AAGGATGCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_066940.3
CDS17..1798
Translation

Target ORF information:

RefSeq Version NM_021117.5
Organism Homo sapiens(human)
Definition Homo sapiens cryptochrome circadian regulator 2 (CRY2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_021117.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGCGA CTGTGGCGAC GGCGGCAGCT GTGGCCCCGG CGCCAGCGCC CGGCACGGAC 
AGCGCCTCTT CGGTGCACTG GTTCCGCAAA GGGCTGCGAC TCCACGACAA CCCGGCGTTG 
CTGGCGGCCG TGCGCGGGGC GCGCTGCGTG CGCTGCGTTT ACATTCTCGA CCCGTGGTTC 
GCGGCCTCCT CCTCAGTCGG GATCAACCGA TGGAGGTTCC TACTTCAGTC TCTGGAAGAT 
TTGGACACAA GTTTAAGGAA ACTGAACTCC CGCCTGTTTG TAGTCCGGGG ACAGCCAGCC 
GACGTGTTCC CAAGGCTGTT CAAGGAATGG GGAGTGACCC GCTTGACCTT TGAATATGAC 
TCTGAACCCT TTGGGAAAGA ACGGGATGCA GCCATCATGA AGATGGCCAA GGAGGCTGGT 
GTGGAAGTAG TGACGGAGAA TTCTCATACC CTCTATGACC TGGACAGGAT CATTGAGCTG 
AATGGGCAGA AGCCACCCCT TACATACAAG CGCTTTCAGG CCATCATCAG CCGCATGGAG 
CTGCCCAAGA AGCCAGTGGG CTTGGTGACC AGCCAGCAGA TGGAGAGCTG CAGGGCCGAG 
ATCCAGGAGA ACCACGACGA GACCTACGGC GTGCCCTCCC TGGAGGAGCT GGGGTTCCCC 
ACTGAAGGAC TTGGTCCAGC TGTCTGGCAG GGAGGAGAGA CAGAAGCTCT GGCCCGCCTG 
GATAAGCACT TGGAACGGAA GGCCTGGGTT GCCAACTATG AGAGACCCCG AATGAACGCC 
AACTCCCTCC TGGCCAGCCC CACAGGCCTC AGCCCCTACC TGCGCTTTGG TTGTCTCTCC 
TGCCGCCTCT TCTACTACCG CCTGTGGGAC CTGTATAAAA AGGTGAAGCG GAACAGCACA 
CCTCCCCTCT CCCTATTTGG GCAACTCCTA TGGCGAGAGT TCTTCTACAC GGCAGCTACC 
AACAACCCCA GGTTTGACCG CATGGAGGGG AACCCCATCT GCATCCAGAT CCCCTGGGAC 
CGCAATCCTG AGGCCCTGGC CAAGTGGGCT GAGGGCAAGA CAGGCTTCCC TTGGATTGAT 
GCCATCATGA CCCAACTGAG GCAGGAGGGC TGGATCCACC ACCTGGCCCG GCATGCCGTG 
GCCTGCTTCC TGACCCGCGG GGACCTCTGG GTCAGCTGGG AGAGCGGGGT CCGGGTATTT 
GATGAGCTGC TCCTGGATGC AGATTTCAGC GTGAACGCAG GCAGCTGGAT GTGGCTGTCC 
TGCAGTGCTT TCTTCCAGCA GTTCTTCCAC TGCTACTGCC CTGTGGGCTT TGGCCGTCGC 
ACGGACCCCA GTGGGGACTA CATCAGGCGA TACCTGCCCA AATTGAAAGC GTTCCCCTCT 
CGATACATCT ATGAGCCCTG GAATGCCCCA GAGTCAATTC AGAAGGCAGC CAAGTGCATC 
ATTGGTGTGG ACTACCCACG GCCCATCGTC AACCATGCCG AGACCAGCCG GCTTAACATT 
GAACGAATGA AGCAGATTTA CCAGCAGCTT TCGCGCTACC GGGGACTCTG TCTACTGGCA 
TCTGTCCCTT CCTGTGTGGA AGACCTCAGT CACCCTGTGG CAGAGCCCAG CTCGAGCCAG 
GCTGGCAGCA TGAGCAGTGC AGGCCCAAGA CCACTACCCA GTGGCCCAGC ATCCCCCAAA 
CGCAAGCTGG AAGCAGCCGA GGAACCACCT GGTGAAGAAC TCAGCAAACG GGCCCGGGTG 
GCAGAGTTGC CAACCCCAGA GCTGCCGAGC AAGGATGCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed