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MESP2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MESP2
Entrez Gene ID 145873
Full Name mesoderm posterior bHLH transcription factor 2
Synonyms SCDO2,bHLHc6
General protein information
Preferred Names

mesoderm posterior bHLH transcription factor 2

Names

mesoderm posterior protein 2
class C basic helix-loop-helix protein 6
mesoderm posterior 2 homolog
mesoderm posterior basic helix-loop-helix transcription factor 2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

15

15q26.1

Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008].
Disorder MIM:

605195

Disorder Html: Spondylocostal dysostosis, autosomal recessive 2, 608681 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001039958.1 NP_001035047.1 mesoderm posterior protein 2



Macaca mulatta (rhesus monkey) MESP2 XP_001093605.1
Mus musculus (house mouse) Mesp2 NP_032615.2
Rattus norvegicus (Norway rat) Mesp2 NP_001099743.1
Homo sapiens (human) MESP2 NP_001035047.1
Canis lupus familiaris (dog) MESP2 XP_003434391.1
Pan troglodytes (chimpanzee) MESP2 XP_523152.2
Bos taurus (cattle) MESP2 XP_002696623.1


Related articles in PubMed

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P, Moll S
Journal of proteomics82193-229(2013 Apr)

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
Qiu XS, Zhou S, Jiang H, Ji ML, Ding Q, Lv F, Liu Z, Tang N, Cheng JC, Qiu Y
Studies in health technology and informatics17652-5(2012)

Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.
Cornier AS, Staehling-Hampton K, Delventhal KM, Saga Y, Caubet JF, Sasaki N, Ellard S, Young E, Ramirez N, Carlo SE, Torres J, Emans JB, Turnpenny PD, Pourquié O
American journal of human genetics82(6)1334-41(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Title: Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.

findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
Title: Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.

Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
Title: Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis.

Mutated MESP2 causes spondylocostal dysostosis
Title: Mutated MESP2 causes spondylocostal dysostosis in humans.

The following MESP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MESP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu28715 NM_001039958.1
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Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu28715
Clone ID Related Accession (Same CDS sequence) NM_001039958.1
Accession Version NM_001039958.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-28
Organism Homo sapiens(Human)
Product mesoderm posterior protein 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK000142.1 and AC079075.6. This sequence is a reference standard in the RefSeqGene project. On or before Mar 25, 2006 this sequence version replaced XM_085261.4, XM_938609.1. ##Evidence-Data-START## Transcript exon combination :: BC111413.1, SRR1803613.386327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
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841
901
961
1021
1081
1141
ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001035047.1
CDS1..1194
Translation

Target ORF information:

RefSeq Version NM_001039958.1
Organism Homo sapiens(Human)
Definition Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001039958.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
Journal of proteomics82193-229(2013 Apr)
Prunotto M,Farina A,Lane L,Pernin A,Schifferli J,Hochstrasser DF,Lescuyer P,Moll S


book

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
Studies in health technology and informatics17652-5(2012)
Qiu XS,Zhou S,Jiang H,Ji ML,Ding Q,Lv F,Liu Z,Tang N,Cheng JC,Qiu Y


book

Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.
American journal of human genetics82(6)1334-41(2008 Jun)
Cornier AS,Staehling-Hampton K,Delventhal KM,Saga Y,Caubet JF,Sasaki N,Ellard S,Young E,Ramirez N,Carlo SE,Torres J,Emans JB,Turnpenny PD,Pourquié O


 
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