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SPC24 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol SPC24
Entrez Gene ID 147841
Full Name SPC24, NDC80 kinetochore complex component
Synonyms SPBC24
General protein information
Preferred Names

SPC24, NDC80 kinetochore complex component

Names

kinetochore protein Spc24
SPC24, NDC80 kinetochore complex component, homolog
hSpc24
spindle pole body component 24 homolog
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

19

19p13.2
Disorder MIM:

609394


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_182513.3 NP_872319.1 kinetochore protein Spc24 isoform 1
NM_001317033.2 NP_001303962.1 kinetochore protein Spc24 isoform 4
NM_001317032.1 NP_001303961.1 kinetochore protein Spc24 isoform 3
XM_011527702.1 XP_011526004.1 kinetochore protein Spc24 isoform X2
NM_001317033.1 NP_001303962.1 kinetochore protein Spc24 isoform 4
NM_182513.2 NP_872319.1 kinetochore protein Spc24
XM_005259753.3 XP_005259810.1 kinetochore protein Spc24 isoform X1
NM_001317031.1 NP_001303960.1 kinetochore protein Spc24 isoform 2

Pathways from BioSystems


Homologies


Homo sapiens (human) SPC24 NP_872319.1
Pan troglodytes (chimpanzee) SPC24 XP_001167473.1
Xenopus tropicalis (tropical clawed frog) spc24 NP_989057.1
SPC24 XP_001104117.1
Danio rerio (zebrafish) spc24 NP_001019611.1
Mus musculus (house mouse) Spc24 NP_080558.1
Rattus norvegicus (Norway rat) Spc24 XP_003750496.2
Canis lupus familiaris (dog) SPC24 XP_853911.1
Bos taurus (cattle) SPC24 NP_001068859.1

Gene Ontology


Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

SPC24 is critical for anaplastic thyroid cancer progression.
Yin H, Meng T, Zhou L, Chen H, Song D
Oncotarget8(13)21884-21891(2017 Mar)

A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.
Zhu P, Jin J, Liao Y, Li J, Yu XZ, Liao W, He S
Oncotarget6(38)41383-97(2015 Dec)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells
Title: SPC24 is critical for anaplastic thyroid cancer progression.

Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy.
Title: A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.

the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex
Title: Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.

hSPC24 is a component of the human NDC80 kinetochore complex
Title: Identification of two novel components of the human NDC80 kinetochore complex.

The following SPC24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPC24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu25892 NM_182513.3
Latest version!		 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu100151 NM_001317033.2
Latest version!		 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu76356 NM_001317031.1
Latest version!		 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu51445 XM_005259753.3
Latest version!		 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu76357 XM_011527702.1
Latest version!		 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu100150 NM_001317032.1
Latest version!		 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OHu100151 NM_001317033.1 Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu25892 NM_182513.2 Homo sapiens SPC24, NDC80 kinetochore complex component (SPC24), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu25892
Clone ID Related Accession (Same CDS sequence) NM_182513.3 , NM_182513.2
Accession Version NM_182513.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 594bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY082333.1, BC105037.1, AC011485.6 and AK075287.1. On Nov 7, 2015 this sequence version replaced NM_182513.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075287.1, BM551899.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAAGTTAG TAAAATTGAG TGGGATTATG AGTGTGAGCC AGGGATGGTC 
AAAGGCATCC ATCATGGCCC CAGTGTGGCC CAGCCCATCC ACCTGGACAG CACCCAGCTC 
TCCAGGAAAT TCATCAGCGA CTACCTCTGG AGTCTGGTGG ACACCGAGTG GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_872319.1
CDS37..630
Translation

Target ORF information:

RefSeq Version NM_182513.3
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_182513.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAAGTTAG TAAAATTGAG TGGGATTATG AGTGTGAGCC AGGGATGGTC 
AAAGGCATCC ATCATGGCCC CAGTGTGGCC CAGCCCATCC ACCTGGACAG CACCCAGCTC 
TCCAGGAAAT TCATCAGCGA CTACCTCTGG AGTCTGGTGG ACACCGAGTG GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25892
Clone ID Related Accession (Same CDS sequence) NM_182513.3 , NM_182513.2
Accession Version NM_182513.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 594bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-14
Organism Homo sapiens(Human)
Product kinetochore protein Spc24
Comment 

1
61
121
181
241
301
361
421
481
541
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAAGTTAG TAAAATTGAG TGGGATTATG AGTGTGAGCC AGGGATGGTC 
AAAGGCATCC ATCATGGCCC CAGTGTGGCC CAGCCCATCC ACCTGGACAG CACCCAGCTC 
TCCAGGAAAT TCATCAGCGA CTACCTCTGG AGTCTGGTGG ACACCGAGTG GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_872319.1
Translation

Target ORF information:

RefSeq Version NM_182513.2
Organism Homo sapiens(Human)
Definition Homo sapiens SPC24, NDC80 kinetochore complex component (SPC24), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_182513.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAAGTTAG TAAAATTGAG TGGGATTATG AGTGTGAGCC AGGGATGGTC 
AAAGGCATCC ATCATGGCCC CAGTGTGGCC CAGCCCATCC ACCTGGACAG CACCCAGCTC 
TCCAGGAAAT TCATCAGCGA CTACCTCTGG AGTCTGGTGG ACACCGAGTG GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu100151
Clone ID Related Accession (Same CDS sequence) NM_001317033.2 , NM_001317033.1
Accession Version NM_001317033.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 423bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-09
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform 4
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK303266.1, AC011485.6 and AK075287.1. On Jun 2, 2019 this sequence version replaced NM_001317033.1. Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303266.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
ATGGAGAAGG AAGTGGCCCA GAGCCTTCTC AATGCGAAGG AGCAGGTGCA CCAGGGAGGC 
GTGGAGCTGC AGCAGCTGGA AGCTGGGCTT CAGGAGGCTG GGGAGGAGGA CACCCGTCTG 
AAGGCCAGCC TCCTTCAGCT CACCAGAGAG CTGGAAGAGC TCAAGGAGAT TGAGGCGGAT 
CTGGAGCGAC AGGAGAAGGA GGTCGACGAG GACACGACAG TCACAATCCC CTCGGCCGTG 
TACGTGGCTC AACTTTACCA CCAAGTTAGT AAAATTGAGT GGGATTATGA GTGTGAGCCA 
GGGATGGTCA AAGGCATCCA TCATGGCCCC AGTGTGGCCC AGCCCATCCA CCTGGACAGC 
ACCCAGCTCT CCAGGAAATT CATCAGCGAC TACCTCTGGA GTCTGGTGGA CACCGAGTGG 
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001303962.1
CDS291..713
Translation

Target ORF information:

RefSeq Version NM_001317033.2
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001317033.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGAGAAGG AAGTGGCCCA GAGCCTTCTC AATGCGAAGG AGCAGGTGCA CCAGGGAGGC 
GTGGAGCTGC AGCAGCTGGA AGCTGGGCTT CAGGAGGCTG GGGAGGAGGA CACCCGTCTG 
AAGGCCAGCC TCCTTCAGCT CACCAGAGAG CTGGAAGAGC TCAAGGAGAT TGAGGCGGAT 
CTGGAGCGAC AGGAGAAGGA GGTCGACGAG GACACGACAG TCACAATCCC CTCGGCCGTG 
TACGTGGCTC AACTTTACCA CCAAGTTAGT AAAATTGAGT GGGATTATGA GTGTGAGCCA 
GGGATGGTCA AAGGCATCCA TCATGGCCCC AGTGTGGCCC AGCCCATCCA CCTGGACAGC 
ACCCAGCTCT CCAGGAAATT CATCAGCGAC TACCTCTGGA GTCTGGTGGA CACCGAGTGG 
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu100151
Clone ID Related Accession (Same CDS sequence) NM_001317033.2 , NM_001317033.1
Accession Version NM_001317033.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 423bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-01-27
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform 4
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY082333.1, AK303266.1, AC011485.6 and AK075287.1. Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303266.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
ATGGAGAAGG AAGTGGCCCA GAGCCTTCTC AATGCGAAGG AGCAGGTGCA CCAGGGAGGC 
GTGGAGCTGC AGCAGCTGGA AGCTGGGCTT CAGGAGGCTG GGGAGGAGGA CACCCGTCTG 
AAGGCCAGCC TCCTTCAGCT CACCAGAGAG CTGGAAGAGC TCAAGGAGAT TGAGGCGGAT 
CTGGAGCGAC AGGAGAAGGA GGTCGACGAG GACACGACAG TCACAATCCC CTCGGCCGTG 
TACGTGGCTC AACTTTACCA CCAAGTTAGT AAAATTGAGT GGGATTATGA GTGTGAGCCA 
GGGATGGTCA AAGGCATCCA TCATGGCCCC AGTGTGGCCC AGCCCATCCA CCTGGACAGC 
ACCCAGCTCT CCAGGAAATT CATCAGCGAC TACCTCTGGA GTCTGGTGGA CACCGAGTGG 
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001303962.1
CDS321..743
Translation

Target ORF information:

RefSeq Version NM_001317033.1
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001317033.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGAGAAGG AAGTGGCCCA GAGCCTTCTC AATGCGAAGG AGCAGGTGCA CCAGGGAGGC 
GTGGAGCTGC AGCAGCTGGA AGCTGGGCTT CAGGAGGCTG GGGAGGAGGA CACCCGTCTG 
AAGGCCAGCC TCCTTCAGCT CACCAGAGAG CTGGAAGAGC TCAAGGAGAT TGAGGCGGAT 
CTGGAGCGAC AGGAGAAGGA GGTCGACGAG GACACGACAG TCACAATCCC CTCGGCCGTG 
TACGTGGCTC AACTTTACCA CCAAGTTAGT AAAATTGAGT GGGATTATGA GTGTGAGCCA 
GGGATGGTCA AAGGCATCCA TCATGGCCCC AGTGTGGCCC AGCCCATCCA CCTGGACAGC 
ACCCAGCTCT CCAGGAAATT CATCAGCGAC TACCTCTGGA GTCTGGTGGA CACCGAGTGG 
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu76356
Clone ID Related Accession (Same CDS sequence) NM_001317031.1
Accession Version NM_001317031.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 528bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-09
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY082333.1, BQ216591.1, AK075287.1 and AC011485.6. On Nov 7, 2015 this sequence version replaced XM_011527701.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.491925.1, BQ216591.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAACTCCT AGAGTGGCCT CAGCTAGGTA ACCAACGGGA GTCGACTTAT 
CTATGCCAGG CCTGCAGTTT CACATCTGTG ACGGGATGGG ACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001303960.1
CDS37..564
Translation

Target ORF information:

RefSeq Version NM_001317031.1
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001317031.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAACTCCT AGAGTGGCCT CAGCTAGGTA ACCAACGGGA GTCGACTTAT 
CTATGCCAGG CCTGCAGTTT CACATCTGTG ACGGGATGGG ACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu51445
Clone ID Related Accession (Same CDS sequence) XM_005259753.3
Accession Version XM_005259753.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 456bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259753.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCTGGAGC GACAGGAGAA GGAGGTCGAC 
GAGGACACGA CAGTCACAAT CCCCTCGGCC GTGTACGTGG CTCAACTTTA CCACCAAGTT 
AGTAAAATTG AGTGGGATTA TGAGTGTGAG CCAGGGATGG TCAAAGGCAT CCATCATGGC 
CCCAGTGTGG CCCAGCCCAT CCACCTGGAC AGCACCCAGC TCTCCAGGAA ATTCATCAGC 
GACTACCTCT GGAGTCTGGT GGACACCGAG TGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005259810.1
CDS222..677
Translation

Target ORF information:

RefSeq Version XM_005259753.3
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005259753.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCTGGAGC GACAGGAGAA GGAGGTCGAC 
GAGGACACGA CAGTCACAAT CCCCTCGGCC GTGTACGTGG CTCAACTTTA CCACCAAGTT 
AGTAAAATTG AGTGGGATTA TGAGTGTGAG CCAGGGATGG TCAAAGGCAT CCATCATGGC 
CCCAGTGTGG CCCAGCCCAT CCACCTGGAC AGCACCCAGC TCTCCAGGAA ATTCATCAGC 
GACTACCTCT GGAGTCTGGT GGACACCGAG TGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu76357
Clone ID Related Accession (Same CDS sequence) XM_011527702.1
Accession Version XM_011527702.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 417bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT CTCCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011526004.1
CDS7..423
Translation

Target ORF information:

RefSeq Version XM_011527702.1
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011527702.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT CTCCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu100150
Clone ID Related Accession (Same CDS sequence) NM_001317032.1
Accession Version NM_001317032.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-09
Organism Homo sapiens(human)
Product kinetochore protein Spc24 isoform 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY082333.1 and BQ061822.1. Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ061822.1, SRR1163657.298228.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267751 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAAGTTAG TAAAATTGAG TGGGATTATG AGTGTGAGCC AGGGATGGTC 
AAAGGCAGTA TCCTTTTTGG GGAGCCATTT TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001303961.1
CDS37..549
Translation

Target ORF information:

RefSeq Version NM_001317032.1
Organism Homo sapiens(human)
Definition Homo sapiens SPC24 component of NDC80 kinetochore complex (SPC24), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001317032.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCCGCCT TCCGCGACAT AGAGGAGGTG AGCCAGGGGC TGCTCAGCCT GCTGGGCGCC 
AACCGCGCGG AGGCGCAGCA GCGACGGCTG CTGGGGCGCC ACGAGCAGGT GGTGGAGCGG 
CTGCTGGAAA CGCAAGACGG TGCCGAGAAG CAGCTGCGAG AGATCCTCAC CATGGAGAAG 
GAAGTGGCCC AGAGCCTTCT CAATGCGAAG GAGCAGGTGC ACCAGGGAGG CGTGGAGCTG 
CAGCAGCTGG AAGCTGGGCT TCAGGAGGCT GGGGAGGAGG ACACCCGTCT GAAGGCCAGC 
CTCCTTCAGC TCACCAGAGA GCTGGAAGAG CTCAAGGAGA TTGAGGCGGA TCTGGAGCGA 
CAGGAGAAGG AGGTCGACGA GGACACGACA GTCACAATCC CCTCGGCCGT GTACGTGGCT 
CAACTTTACC ACCAAGTTAG TAAAATTGAG TGGGATTATG AGTGTGAGCC AGGGATGGTC 
AAAGGCAGTA TCCTTTTTGG GGAGCCATTT TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW


book

SPC24 is critical for anaplastic thyroid cancer progression.
Oncotarget8(13)21884-21891(2017 Mar)
Yin H,Meng T,Zhou L,Chen H,Song D


book

A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.
Oncotarget6(38)41383-97(2015 Dec)
Zhu P,Jin J,Liao Y,Li J,Yu XZ,Liao W,He S


book

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M