Gene Symbol | CNKSR3 |
Entrez Gene ID | 154043 |
Full Name | CNKSR family member 3 |
Synonyms | CNK3,CNK3/IPCEF1,MAGI1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » CNKSR3 cDNA ORF clone
Gene Symbol | CNKSR3 |
Entrez Gene ID | 154043 |
Full Name | CNKSR family member 3 |
Synonyms | CNK3,CNK3/IPCEF1,MAGI1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001368117.1 | NP_001355046.1 | connector enhancer of kinase suppressor of ras 3 isoform 3 |
NM_001368119.1 | NP_001355048.1 | connector enhancer of kinase suppressor of ras 3 isoform 5 |
NM_001368116.1 | NP_001355045.1 | connector enhancer of kinase suppressor of ras 3 isoform 1 |
NM_173515.4 | NP_775786.2 | connector enhancer of kinase suppressor of ras 3 isoform 2 |
XM_011535485.2 | XP_011533787.1 | connector enhancer of kinase suppressor of ras 3 isoform X1 |
NM_173515.3 | NP_775786.2 | connector enhancer of kinase suppressor of ras 3 |
XM_011535485.3 | XP_011533787.1 | connector enhancer of kinase suppressor of ras 3 isoform X1 |
NM_001368118.1 | NP_001355047.1 | connector enhancer of kinase suppressor of ras 3 isoform 4 |
Homo sapiens (human) | CNKSR3 | NP_775786.2 |
Bos taurus (cattle) | CNKSR3 | NP_001179041.1 |
CNKSR3 | XP_001095122.1 | |
Canis lupus familiaris (dog) | IPCEF1 | XP_005615587.1 |
Pan troglodytes (chimpanzee) | CNKSR3 | XP_518820.3 |
Xenopus tropicalis (tropical clawed frog) | cnksr3 | NP_001135662.1 |
Rattus norvegicus (Norway rat) | Cnksr3 | NP_001012061.1 |
Gallus gallus (chicken) | CNKSR3 | XP_419685.4 |
Danio rerio (zebrafish) | zgc:172112 | NP_001107119.1 |
Mus musculus (house mouse) | Cnksr3 | NP_766134.1 |
The Association of a Genetic Variant in
Jin L, Wang T, Jiang S, Chen M, Zhang R, Hu C, Jia W, Liu Z
Journal of diabetes research20176542689(2017)
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival.
Lake SL, Damato BE, Kalirai H, Dodson AR, Taktak AF, Lloyd BH, Coupland SE
The American journal of pathology182(3)678-87(2013 Mar)
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D
The Journal of biological chemistry287(39)33014-25(2012 Sep)
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim SC, Wong TY, Liu J, Young TL, Aung T, Seielstad M, Teo YY, Kim YJ, Lee JY, Han BG, Kang D, Chen CH, Tsai FJ, Chang LC, Fann SJ, Mei H, Rao DC, Hixson JE, Chen S, Katsuya T, Isono M, Ogihara T, Chambers JC, Zhang W, Kooner JS, , , Albrecht E, , Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Kato N, He J, Chen YT, Cho YS, Tai ES, Tanaka T
Nature genetics44(8)904-9(2012 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SCAF8-CNKSR3 variant rs955333 was not associated with diabetic kidney disease but showed association with diabetic retinopathy in Chinese type 2 diabetes patients
Title: The Association of a Genetic Variant in
Cox regression and Kaplan-Meier survival analysis identified that amplification of the CNKSR3 gene (log-rank, P = 0.022) with an associated increase in its protein expression (log-rank, P = 0.011) correlated with longer patient survival.
Title: Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival.
CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis.
Title: Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
two gene markers (CNKSR3 and SPTBN2) differentiate between aspirin-exacerbated respiratory disease and aspirin-tolerant asthma with a perfect discriminative power
Title: Differential gene expression profile in PBMCs from subjects with AERD and ATA: a gene marker for AERD.
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
Title: CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
The following CNKSR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CNKSR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13076 | |
Clone ID Related Accession (Same CDS sequence) | NM_173515.4 , NM_173515.3 | |
Accession Version | NM_173515.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL357075.17, AK055911.1, AY328893.1, AY328892.1, BC060761.1, AL590401.6 and AL033376.17. On Nov 22, 2018 this sequence version replaced NM_173515.3. ##Evidence-Data-START## Transcript exon combination :: AY328891.1, SRR1803611.222170.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000607772.6/ ENSP00000475915.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAACCCG TGACCAAGTG GAGCCCCAAA CAAGTGGTGG ACTGGACTAG AGGGTTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_775786.2 |
CDS | 572..2239 |
Translation |
Target ORF information:
Target ORF information:
|
NM_173515.4 |
1 | ATGGAACCCG TGACCAAGTG GAGCCCCAAA CAAGTGGTGG ACTGGACTAG AGGGTTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13076 | |
Clone ID Related Accession (Same CDS sequence) | NM_173515.4 , NM_173515.3 | |
Accession Version | NM_173515.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-27 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK055911.1, AY328893.1, AY328892.1 and BC060761.1. On Jan 19, 2017 this sequence version replaced NM_173515.2. ##Evidence-Data-START## Transcript exon combination :: AK055911.1, SRR1803611.222170.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAACCCG TGACCAAGTG GAGCCCCAAA CAAGTGGTGG ACTGGACTAG AGGGTTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_775786.2 |
CDS | 546..2213 |
Translation |
Target ORF information:
Target ORF information:
|
NM_173515.3 |
1 | ATGGAACCCG TGACCAAGTG GAGCCCCAAA CAAGTGGTGG ACTGGACTAG AGGGTTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu76826 | |
Clone ID Related Accession (Same CDS sequence) | XM_011535485.2 , XM_011535485.3 | |
Accession Version | XM_011535485.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011535485.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCCCC TGGTGCCTGG CGGGTTGGAT GACTGCCTGC AACAATATGT CCACAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011533787.1 |
CDS | 3019..4656 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011535485.2 |
1 | ATGGCTCCCC TGGTGCCTGG CGGGTTGGAT GACTGCCTGC AACAATATGT CCACAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu76826 | |
Clone ID Related Accession (Same CDS sequence) | XM_011535485.2 , XM_011535485.3 | |
Accession Version | XM_011535485.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011535485.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCCCC TGGTGCCTGG CGGGTTGGAT GACTGCCTGC AACAATATGT CCACAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011533787.1 |
CDS | 3018..4655 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011535485.3 |
1 | ATGGCTCCCC TGGTGCCTGG CGGGTTGGAT GACTGCCTGC AACAATATGT CCACAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107910 | |
Clone ID Related Accession (Same CDS sequence) | NM_001368118.1 | |
Accession Version | NM_001368118.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK309680.1 and AL357075.17. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK309680.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGAACT TGGTTCTGAA ACTGAGAGCA TCTTCCCACA ATTTACAGAA TTACATAAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001355047.1 |
CDS | 352..1779 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001368118.1 |
1 | ATGAAGAACT TGGTTCTGAA ACTGAGAGCA TCTTCCCACA ATTTACAGAA TTACATAAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107913 | |
Clone ID Related Accession (Same CDS sequence) | NM_001368119.1 | |
Accession Version | NM_001368119.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY328894.1 and AL357075.17. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY328894.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGATA AAGTTTTAAC TGTGGTCAAG GTTTTAAATG GCATCTGTGA CAAAACAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001355048.1 |
CDS | 314..1456 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001368119.1 |
1 | ATGGAGGATA AAGTTTTAAC TGTGGTCAAG GTTTTAAATG GCATCTGTGA CAAAACAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107911 | |
Clone ID Related Accession (Same CDS sequence) | NM_001368116.1 | |
Accession Version | NM_001368116.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL357075.17. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.127483.1, SRR1803611.234515.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGCAAACTT CTGCCGAGTG GCCTGTGCGC TCCTATCTCT CGTACCTGCT CCGAGCTCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001355045.1 |
CDS | 309..1994 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001368116.1 |
1 | ATGCAAACTT CTGCCGAGTG GCCTGTGCGC TCCTATCTCT CGTACCTGCT CCGAGCTCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107945 | |
Clone ID Related Accession (Same CDS sequence) | NM_001368117.1 | |
Accession Version | NM_001368117.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1572bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Homo sapiens(human) | |
Product | connector enhancer of kinase suppressor of ras 3 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL357075.17. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.171675.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGGAACCCG TGACCAAGTG GAGCCCCAAA CAAGTGGTGG ACTGGACTAG AGGGTTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001355046.1 |
CDS | 572..2143 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001368117.1 |
1 | ATGGAACCCG TGACCAAGTG GAGCCCCAAA CAAGTGGTGG ACTGGACTAG AGGGTTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Association of a Genetic Variant in |
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival. |
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. |
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. |