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KCTD7 cDNA ORF clone, Homo sapiens (human)

Gene Symbol KCTD7
Entrez Gene ID 154881
Full Name potassium channel tetramerization domain containing 7
Synonyms CLN14, EPM3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q11.21

Summary This gene encodes a member of the potassium channel tetramerization domain-containing protein family. Family members are identified on a structural basis and contain an amino-terminal domain similar to the T1 domain present in the voltage-gated potassium channel. Mutations in this gene have been associated with progressive myoclonic epilepsy-3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]. lac of sum
Disorder MIM:

611725

Disorder Html: Epilepsy, progressive myoclonic 3, 611726 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001167961 NP_001161433 BTB/POZ domain-containing protein KCTD7 isoform 2
NM_153033 NP_694578 BTB/POZ domain-containing protein KCTD7 isoform 1


Homo sapiens (human) KCTD7 NP_694578.1
Pan troglodytes (chimpanzee) KCTD7 XP_001149057.2
Macaca mulatta (Rhesus monkey) KCTD7 XP_001092395.2
Bos taurus (cattle) KCTD7 NP_001096015.1
Mus musculus (house mouse) Kctd7 NP_766097.1
Rattus norvegicus (Norway rat) Kctd7 NP_001121666.1
Gallus gallus (chicken) KCTD7 NP_001034358.1
Danio rerio (zebrafish) kctd7 NP_001038798.1
Xenopus (Silurana) tropicalis (western clawed frog) kctd7 XP_004911762.1


The following KCTD7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCTD7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23028 NM_001167961 Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $216.30
$309.00
OHu22416 NM_153033 Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $216.30
$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23028
Clone ID Related Accession (Same CDS sequence) NM_001167961
Accession Version NM_001167961.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 867bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product BTB/POZ domain-containing protein KCTD7 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA493191.1, BC042482.1, AK055201.1, AC006001.2, BU682845.1 and BY795857.2. On Jan 21, 2011 this sequence version replaced gi:269784641. Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) is 1-aa shorter at the C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC042482.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC
ATCTATGAGT TCAAGATCAC ATGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161433.1
CDS185..1051
Misc Feature(1)119..121(+)
Misc Feature(2)341..598(+)
Exon (1)1..328
Gene:KCTD7
Gene Synonym:
Exon (2)329..498
Gene:KCTD7
Gene Synonym:
Exon (3)499..677
Gene:KCTD7
Gene Synonym:
Exon (4)678..1050
Gene:KCTD7
Gene Synonym:
Exon (5)1051..3886
Gene:KCTD7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001167961
Organism Homo sapiens (human)
Definition Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001167961

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC
ATCTATGAGT TCAAGATCAC ATGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22416
Clone ID Related Accession (Same CDS sequence) NM_153033
Accession Version NM_153033.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 870bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product BTB/POZ domain-containing protein KCTD7 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA493191.1, AK056631.1, AK055201.1, AC006001.2, BU682845.1 and BY795857.2. This sequence is a reference standard in the RefSeqGene project. On Jan 21, 2011 this sequence version replaced gi:269784640. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK056631.1, BU902852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC
ATCTATGAGT TCAAGATCAC ATGGTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_694578.1
CDS185..1054
Misc Feature(1)119..121(+)
Misc Feature(2)341..598(+)
Misc Feature(3)668..670(+)
Misc Feature(4)671..673(+)
Exon (1)1..328
Gene:KCTD7
Gene Synonym:
Exon (2)329..498
Gene:KCTD7
Gene Synonym:
Exon (3)499..677
Gene:KCTD7
Gene Synonym:
Exon (4)678..5051
Gene:KCTD7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_153033
Organism Homo sapiens (human)
Definition Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_153033

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC
ATCTATGAGT TCAAGATCAC ATGGTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system
Am. J. Hum. Genet. 91 (1), 202-208 (2012)
Staropoli JF, Karaa A, Lim ET, Kirby A, Elbalalesy N, Romansky SG, Leydiker KB, Coppel SH, Barone R, Xin W, MacDonald ME, Abdenur JE, Daly MJ, Sims KB and Cotman SL.


book

Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene
J. Med. Genet. 49 (6), 391-399 (2012)
Kousi M, Anttila V, Schulz A, Calafato S, Jakkula E, Riesch E, Myllykangas L, Kalimo H, Topcu M, Gokben S, Alehan F, Lemke JR, Alber M, Palotie A, Kopra O and Lehesjoki AE.


book

Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
BMC Med Genomics 4, 4 (2011)
Wineinger NE, Patki A, Meyers KJ, Broeckel U, Gu CC, Rao DC, Devereux RB, Arnett DK and Tiwari HK.


book

Mutation of a potassium channel-related gene in progressive myoclonic epilepsy
Ann. Neurol. 61 (6), 579-586 (2007)
Van Bogaert P, Azizieh R, Desir J, Aeby A, De Meirleir L, Laes JF, Christiaens F and Abramowicz MJ.


book

Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes
Physiol. Genomics 25 (1), 9-15 (2006)
Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS and Pang CP.


book

Neuronal Ceroid-Lipofuscinoses
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Mole,S.E. and Williams,R.E.


 
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