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CYP11B1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CYP11B1
Entrez Gene ID 1584
Full Name cytochrome P450 family 11 subfamily B member 1
Synonyms CPN1,CYP11B,FHI,P450C11
General protein information
Preferred Names

cytochrome P450 family 11 subfamily B member 1

Names

cytochrome P450 11B1, mitochondrial
CYPXIB1
cytochrome P-450c11
cytochrome P450, family 11, subfamily B, polypeptide 1
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
cytochrome P450C11
cytochrome p450 XIB1
steroid 11-beta-hydroxylase
steroid 11-beta-monooxygenase

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

8

8q24.3

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

610613

Disorder Html: Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase

mRNA and Protein(s)

mRNA Protein Name
NM_000497.3 NP_000488.3 cytochrome P450 11B1, mitochondrial isoform 1 precursor
XM_011516874.2 XP_011515176.1 cytochrome P450 11B1, mitochondrial isoform X1
XM_011516875.1 XP_011515177.1 cytochrome P450 11B1, mitochondrial isoform X2
XM_017013146.1 XP_016868635.1 cytochrome P450 11B1, mitochondrial isoform X3
NM_001026213.1 NP_001021384.1 cytochrome P450 11B1, mitochondrial isoform 2 precursor



Danio rerio (zebrafish) cyp11c1 NP_001073673.1
Pan troglodytes (chimpanzee) LOC464437 XP_519994.3
Mus musculus (house mouse) Cyp11b2 NP_034121.3
Rattus norvegicus (Norway rat) Cyp11b2 NP_036670.2
Macaca mulatta (rhesus monkey) CYP11B1 XP_001084565.1
Homo sapiens (human) CYP11B1 NP_000488.3
Xenopus tropicalis (tropical clawed frog) LOC101731070 XP_004920081.1


Related articles in PubMed

Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.
Shammas C, Byrou S, Phelan MM, Toumba M, Stylianou C, Skordis N, Neocleous V, Phylactou LA
Hormones (Athens, Greece)15(2)235-42(2016 Apr)

A novel CYP11B1 mutation in a Turkish patient with 11β-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.
Yurekli BS, Kutbay NO, Onay H, Simsir IY, Kocabas GU, Erdogan M, Cetinkalp S, Ozgen G, Saygili F
Hormones (Athens, Greece)15(2)300-2(2016 Apr)

The combination of a novel 2 bp deletion mutation and p.D63H in CYP11B1 cause congenital adrenal hyperplasia due to steroid 11β-hydroxylase deficiency.
Long Y, Han S, Zhang X, Zhang X, Chen T, Gao Y, Tian H
Endocrine journal63(3)301-10(2016)

Phenotypic, metabolic, and molecular genetic characterization of six patients with congenital adrenal hyperplasia caused by novel mutations in the CYP11B1 gene.
Nguyen HH, Eiden-Plach A, Hannemann F, Malunowicz EM, Hartmann MF, Wudy SA, Bernhardt R
The Journal of steroid biochemistry and molecular biology155(Pt A)126-34(2016 Jan)

Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.
Xu L, Xia W, Wu X, Wang X, Zhao L, Nie M
Steroids10151-5(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

One known and two novel CYP11B1 mutations are associated with congenital adrenal hyperplasia in a Chinese family. The two novel CYP11B1 mutations change heme binding site and decrease 11-hydroxylase activity in vitro.
Title: Congenital adrenal hyperplasia due to 11-hydroxylase deficiency-Compound heterozygous mutations of a prevalent and two novel CYP11B1 mutations.

Data suggest that binding sites between CYP11B1/CYP11B2 and adrenodoxin/ferredoxin-1 exhibit electrostatic interactions at K370 in CYP11B1 and at K366 in CYP11B2 mutant R366K with D79 in adrenodoxin/ferredoxin-1. (CYP11B1 = cytochrome P450 family 11 subfamily B member 1; CYP11B2 = cytochrome P450 family 11 subfamily B member 2)
Title: Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.

analysis of CYP11B1 gene mutations in Turkish patients with 11-beta hydroxylase deficiency
Title: Novel and prevalent CYP11B1 gene mutations in Turkish patients with 11-β hydroxylase deficiency.

CYP11B1 mutants are a rare cause of congenital adrenal hyperplasia with hyperandrogenemia.
Title: Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.

Letter/Case Report: compound heterozygous CYP11B1 p.A199P/R448H mutation may predict severe congenital adrenal hypoplasia with severe hypokalemia leading to rhabdomyolysis.
Title: A novel CYP11B1 mutation in a Turkish patient with 11β-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.

The following CYP11B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP11B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18944
NM_000497.3
Latest version!
Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$214.50-$300.30
$429.00
OHu15073 NM_001026213.1
Latest version!
Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu57174 XM_011516874.2
Latest version!
Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu57175 XM_011516875.1
Latest version!
Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu97784 XM_017013146.1
Latest version!
Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18944
Clone ID Related Accession (Same CDS sequence) NM_000497.3
Accession Version NM_000497.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1512bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product cytochrome P450 11B1, mitochondrial isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF478474.1, X55764.1 and BX647738.1. This sequence is a reference standard in the RefSeqGene project. On Mar 24, 2005 this sequence version replaced NM_000497.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF478474.1, X55764.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCACTCA GGGCAAAGGC AGAGGTGTGC ATGGCAGTGC CCTGGCTGTC CCTGCAAAGG 
GCACAGGCAC TGGGCACGAG AGCCGCCCGG GTCCCCAGGA CAGTGCTGCC CTTTGAAGCC
ATGCCCCGGC GTCCAGGCAA CAGGTGGCTG AGGCTGCTGC AGATCTGGAG GGAGCAGGGT
TATGAGGACC TGCACCTGGA AGTACACCAG ACCTTCCAGG AACTAGGGCC CATTTTCAGG
TACGACTTGG GAGGAGCAGG CATGGTGTGT GTGATGCTGC CGGAGGACGT GGAGAAGCTG
CAACAGGTGG ACAGCCTGCA TCCCCACAGG ATGAGCCTGG AGCCCTGGGT GGCCTACAGA
CAACATCGTG GGCACAAATG TGGCGTGTTC TTGCTGAATG GGCCTGAATG GCGCTTCAAC
CGATTGCGGC TGAATCCAGA AGTGCTGTCG CCCAACGCTG TGCAGAGGTT CCTCCCGATG
GTGGATGCAG TGGCCAGGGA CTTCTCCCAG GCCCTGAAGA AGAAGGTGCT GCAGAACGCC
CGGGGGAGCC TGACCCTGGA CGTCCAGCCC AGCATCTTCC ACTACACCAT AGAAGCCAGC
AACTTGGCTC TTTTTGGAGA GCGGCTGGGC CTGGTTGGCC ACAGCCCCAG TTCTGCCAGC
CTGAACTTCC TCCATGCCCT GGAGGTCATG TTCAAATCCA CCGTCCAGCT CATGTTCATG
CCCAGGAGCC TGTCTCGCTG GACCAGCCCC AAGGTGTGGA AGGAGCACTT TGAGGCCTGG
GACTGCATCT TCCAGTACGG CGACAACTGT ATCCAGAAAA TCTATCAGGA ACTGGCCTTC
AGCCGCCCTC AACAGTACAC CAGCATCGTG GCGGAGCTCC TGTTGAATGC GGAACTGTCG
CCAGATGCCA TCAAGGCCAA CTCTATGGAA CTCACTGCAG GGAGCGTGGA CACGACGGTG
TTTCCCTTGC TGATGACGCT CTTTGAGCTG GCTCGGAACC CCAACGTGCA GCAGGCCCTG
CGCCAGGAGA GCCTGGCCGC CGCAGCCAGC ATCAGTGAAC ATCCCCAGAA GGCAACCACC
GAGCTGCCCT TGCTGCGTGC GGCCCTCAAG GAGACCTTGC GGCTCTACCC TGTGGGTCTG
TTTCTGGAGC GAGTGGCGAG CTCAGACTTG GTGCTTCAGA ACTACCACAT CCCAGCTGGG
ACATTGGTGC GCGTGTTCCT CTACTCTCTG GGTCGCAACC CCGCCTTGTT CCCGAGGCCT
GAGCGCTATA ACCCCCAGCG CTGGCTAGAC ATCAGGGGCT CCGGCAGGAA CTTCTACCAC
GTGCCCTTTG GCTTTGGCAT GCGCCAGTGC CTTGGGCGGC GCCTGGCAGA GGCAGAGATG
CTGCTGCTGC TGCACCATGT GCTGAAACAC CTCCAGGTGG AGACACTAAC CCAAGAGGAC
ATAAAGATGG TCTACAGCTT CATATTGAGG CCCAGCATGT TCCCCCTCCT CACCTTCAGA
GCCATCAACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000488.3
CDS8..1519
Misc Feature(1)131..1369
Exon (1)1..246
Exon (2)247..402
Exon (3)403..602
Exon (4)603..806
Exon (5)807..961
Exon (6)962..1128
Exon (7)1129..1207
Exon (8)1208..1405
Exon (9)1406..3535
Translation

Target ORF information:

RefSeq Version NM_000497.3
Organism Homo sapiens(Human)
Definition Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000497.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCACTCA GGGCAAAGGC AGAGGTGTGC ATGGCAGTGC CCTGGCTGTC CCTGCAAAGG 
GCACAGGCAC TGGGCACGAG AGCCGCCCGG GTCCCCAGGA CAGTGCTGCC CTTTGAAGCC
ATGCCCCGGC GTCCAGGCAA CAGGTGGCTG AGGCTGCTGC AGATCTGGAG GGAGCAGGGT
TATGAGGACC TGCACCTGGA AGTACACCAG ACCTTCCAGG AACTAGGGCC CATTTTCAGG
TACGACTTGG GAGGAGCAGG CATGGTGTGT GTGATGCTGC CGGAGGACGT GGAGAAGCTG
CAACAGGTGG ACAGCCTGCA TCCCCACAGG ATGAGCCTGG AGCCCTGGGT GGCCTACAGA
CAACATCGTG GGCACAAATG TGGCGTGTTC TTGCTGAATG GGCCTGAATG GCGCTTCAAC
CGATTGCGGC TGAATCCAGA AGTGCTGTCG CCCAACGCTG TGCAGAGGTT CCTCCCGATG
GTGGATGCAG TGGCCAGGGA CTTCTCCCAG GCCCTGAAGA AGAAGGTGCT GCAGAACGCC
CGGGGGAGCC TGACCCTGGA CGTCCAGCCC AGCATCTTCC ACTACACCAT AGAAGCCAGC
AACTTGGCTC TTTTTGGAGA GCGGCTGGGC CTGGTTGGCC ACAGCCCCAG TTCTGCCAGC
CTGAACTTCC TCCATGCCCT GGAGGTCATG TTCAAATCCA CCGTCCAGCT CATGTTCATG
CCCAGGAGCC TGTCTCGCTG GACCAGCCCC AAGGTGTGGA AGGAGCACTT TGAGGCCTGG
GACTGCATCT TCCAGTACGG CGACAACTGT ATCCAGAAAA TCTATCAGGA ACTGGCCTTC
AGCCGCCCTC AACAGTACAC CAGCATCGTG GCGGAGCTCC TGTTGAATGC GGAACTGTCG
CCAGATGCCA TCAAGGCCAA CTCTATGGAA CTCACTGCAG GGAGCGTGGA CACGACGGTG
TTTCCCTTGC TGATGACGCT CTTTGAGCTG GCTCGGAACC CCAACGTGCA GCAGGCCCTG
CGCCAGGAGA GCCTGGCCGC CGCAGCCAGC ATCAGTGAAC ATCCCCAGAA GGCAACCACC
GAGCTGCCCT TGCTGCGTGC GGCCCTCAAG GAGACCTTGC GGCTCTACCC TGTGGGTCTG
TTTCTGGAGC GAGTGGCGAG CTCAGACTTG GTGCTTCAGA ACTACCACAT CCCAGCTGGG
ACATTGGTGC GCGTGTTCCT CTACTCTCTG GGTCGCAACC CCGCCTTGTT CCCGAGGCCT
GAGCGCTATA ACCCCCAGCG CTGGCTAGAC ATCAGGGGCT CCGGCAGGAA CTTCTACCAC
GTGCCCTTTG GCTTTGGCAT GCGCCAGTGC CTTGGGCGGC GCCTGGCAGA GGCAGAGATG
CTGCTGCTGC TGCACCATGT GCTGAAACAC CTCCAGGTGG AGACACTAAC CCAAGAGGAC
ATAAAGATGG TCTACAGCTT CATATTGAGG CCCAGCATGT TCCCCCTCCT CACCTTCAGA
GCCATCAACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15073
Clone ID Related Accession (Same CDS sequence) NM_001026213.1
Accession Version NM_001026213.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1314bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product cytochrome P450 11B1, mitochondrial isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC096286.3, BC096287.3 and BX647738.1. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to transcript variant 1. This results in an isoform (2) that is missing a 66 aa segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096286.3 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGCACTCA GGGCAAAGGC AGAGGTGTGC ATGGCAGTGC CCTGGCTGTC CCTGCAAAGG 
GCACAGGCAC TGGGCACGAG AGCCGCCCGG GTCCCCAGGA CAGTGCTGCC CTTTGAAGCC
ATGCCCCGGC GTCCAGGCAA CAGGTGGCTG AGGCTGCTGC AGATCTGGAG GGAGCAGGGT
TATGAGGACC TGCACCTGGA AGTACACCAG ACCTTCCAGG AACTAGGGCC CATTTTCAGG
TACGACTTGG GAGGAGCAGG CATGGTGTGT GTGATGCTGC CGGAGGACGT GGAGAAGCTG
CAACAGGTGG ACAGCCTGCA TCCCCACAGG ATGAGCCTGG AGCCCTGGGT GGCCTACAGA
CAACATCGTG GGCACAAATG TGGCGTGTTC TTGCTGAATG GGCCTGAATG GCGCTTCAAC
CGATTGCGGC TGAATCCAGA AGTGCTGTCG CCCAACGCTG TGCAGAGGTT CCTCCCGATG
GTGGATGCAG TGGCCAGGGA CTTCTCCCAG GCCCTGAAGA AGAAGGTGCT GCAGAACGCC
CGGGGGAGCC TGACCCTGGA CGTCCAGCCC AGCATCTTCC ACTACACCAT AGAAGCCAGC
AACTTGGCTC TTTTTGGAGA GCGGCTGGGC CTGGTTGGCC ACAGCCCCAG TTCTGCCAGC
CTGAACTTCC TCCATGCCCT GGAGGTCATG TTCAAATCCA CCGTCCAGCT CATGTTCATG
CCCAGGAGCC TGTCTCGCTG GACCAGCCCC AAGGTGTGGA AGGAGCACTT TGAGGCCTGG
GACTGCATCT TCCAGTACGG CGACAACTGT ATCCAGAAAA TCTATCAGGA ACTGGCCTTC
AGCCGCCCTC AACAGTACAC CAGCATCGTG GCGGAGCTCC TGTTGAATGC GGAACTGTCG
CCAGATGCCA TCAAGGCCAA CTCTATGGAA CTCACTGCAG GGAGCGTGGA CACGACGGTG
TTTCCCTTGC TGATGACGCT CTTTGAGCTG GCTCGGAACC CCAACGTGCA GCAGGCCCTG
CGCCAGGAGA GCCTGGCCGC CGCAGCCAGC ATCAGTGAAC ATCCCCAGAA GGCAACCACC
GAGCTGCCCT TGCTGCGTGC GGCCCTCAAG GAGACCTTGC GGCTCTACCC TGTGGGTCTG
TTTCTGGAGC GAGTGGCGAG CTCAGACTTG GTGCTTCAGA ACTACCACAT CCCAGCTGGG
GTGCTGAAAC ACCTCCAGGT GGAGACACTA ACCCAAGAGG ACATAAAGAT GGTCTACAGC
TTCATATTGA GGCCCAGCAT GTTCCCCCTC CTCACCTTCA GAGCCATCAA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001021384.1
CDS8..1321
Misc Feature(1)131..>1207
Exon (1)1..246
Exon (2)247..402
Exon (3)403..602
Exon (4)603..806
Exon (5)807..961
Exon (6)962..1128
Exon (7)1129..1207
Exon (8)1208..3337
Translation

Target ORF information:

RefSeq Version NM_001026213.1
Organism Homo sapiens(Human)
Definition Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001026213.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGCACTCA GGGCAAAGGC AGAGGTGTGC ATGGCAGTGC CCTGGCTGTC CCTGCAAAGG 
GCACAGGCAC TGGGCACGAG AGCCGCCCGG GTCCCCAGGA CAGTGCTGCC CTTTGAAGCC
ATGCCCCGGC GTCCAGGCAA CAGGTGGCTG AGGCTGCTGC AGATCTGGAG GGAGCAGGGT
TATGAGGACC TGCACCTGGA AGTACACCAG ACCTTCCAGG AACTAGGGCC CATTTTCAGG
TACGACTTGG GAGGAGCAGG CATGGTGTGT GTGATGCTGC CGGAGGACGT GGAGAAGCTG
CAACAGGTGG ACAGCCTGCA TCCCCACAGG ATGAGCCTGG AGCCCTGGGT GGCCTACAGA
CAACATCGTG GGCACAAATG TGGCGTGTTC TTGCTGAATG GGCCTGAATG GCGCTTCAAC
CGATTGCGGC TGAATCCAGA AGTGCTGTCG CCCAACGCTG TGCAGAGGTT CCTCCCGATG
GTGGATGCAG TGGCCAGGGA CTTCTCCCAG GCCCTGAAGA AGAAGGTGCT GCAGAACGCC
CGGGGGAGCC TGACCCTGGA CGTCCAGCCC AGCATCTTCC ACTACACCAT AGAAGCCAGC
AACTTGGCTC TTTTTGGAGA GCGGCTGGGC CTGGTTGGCC ACAGCCCCAG TTCTGCCAGC
CTGAACTTCC TCCATGCCCT GGAGGTCATG TTCAAATCCA CCGTCCAGCT CATGTTCATG
CCCAGGAGCC TGTCTCGCTG GACCAGCCCC AAGGTGTGGA AGGAGCACTT TGAGGCCTGG
GACTGCATCT TCCAGTACGG CGACAACTGT ATCCAGAAAA TCTATCAGGA ACTGGCCTTC
AGCCGCCCTC AACAGTACAC CAGCATCGTG GCGGAGCTCC TGTTGAATGC GGAACTGTCG
CCAGATGCCA TCAAGGCCAA CTCTATGGAA CTCACTGCAG GGAGCGTGGA CACGACGGTG
TTTCCCTTGC TGATGACGCT CTTTGAGCTG GCTCGGAACC CCAACGTGCA GCAGGCCCTG
CGCCAGGAGA GCCTGGCCGC CGCAGCCAGC ATCAGTGAAC ATCCCCAGAA GGCAACCACC
GAGCTGCCCT TGCTGCGTGC GGCCCTCAAG GAGACCTTGC GGCTCTACCC TGTGGGTCTG
TTTCTGGAGC GAGTGGCGAG CTCAGACTTG GTGCTTCAGA ACTACCACAT CCCAGCTGGG
GTGCTGAAAC ACCTCCAGGT GGAGACACTA ACCCAAGAGG ACATAAAGAT GGTCTACAGC
TTCATATTGA GGCCCAGCAT GTTCCCCCTC CTCACCTTCA GAGCCATCAA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57174
Clone ID Related Accession (Same CDS sequence) XM_011516874.2
Accession Version XM_011516874.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1590bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product cytochrome P450 11B1, mitochondrial isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011516874.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCACTCA GGGCAAAGGC AGAGGTGTGC ATGGCAGTGC CCTGGCTGTC CCTGCAAAGG 
GCACAGGCAC TGGGCACGAG AGCCGCCCGG GTCCCCAGGA CAGTGCTGCC CTTTGAAGCC
ATGCCCCGGC GTCCAGGCAA CAGGTGGCTG AGGCTGCTGC AGATCTGGAG GGAGCAGGGT
TATGAGGACC TGCACCTGGA AGTACACCAG ACCTTCCAGG AACTAGGGCC CATTTTCAGG
TACGACTTGG GAGGAGCAGG CATGGTGTGT GTGATGCTGC CGGAGGACGT GGAGAAGCTG
CAACAGGTGG ACAGCCTGCA TCCCCACAGG ATGAGCCTGG AGCCCTGGGT GGCCTACAGA
CAACATCGTG GGCACAAATG TGGCGTGTTC TTGCTAAATG TGGCTGACAG GGGAAATTCC
TCCCCACCAT TCCCTGGGGG CATCCATGGA GCCCCCACGC ACTCTGGCTG TAGGAATGGG
CCTGAATGGC GCTTCAACCG ATTGCGGCTG AATCCAGAAG TGCTGTCGCC CAACGCTGTG
CAGAGGTTCC TCCCGATGGT GGATGCAGTG GCCAGGGACT TCTCCCAGGC CCTGAAGAAG
AAGGTGCTGC AGAACGCCCG GGGGAGCCTG ACCCTGGACG TCCAGCCCAG CATCTTCCAC
TACACCATAG AAGCCAGCAA CTTGGCTCTT TTTGGAGAGC GGCTGGGCCT GGTTGGCCAC
AGCCCCAGTT CTGCCAGCCT GAACTTCCTC CATGCCCTGG AGGTCATGTT CAAATCCACC
GTCCAGCTCA TGTTCATGCC CAGGAGCCTG TCTCGCTGGA CCAGCCCCAA GGTGTGGAAG
GAGCACTTTG AGGCCTGGGA CTGCATCTTC CAGTACGGCG ACAACTGTAT CCAGAAAATC
TATCAGGAAC TGGCCTTCAG CCGCCCTCAA CAGTACACCA GCATCGTGGC GGAGCTCCTG
TTGAATGCGG AACTGTCGCC AGATGCCATC AAGGCCAACT CTATGGAACT CACTGCAGGG
AGCGTGGACA CGACGGTGTT TCCCTTGCTG ATGACGCTCT TTGAGCTGGC TCGGAACCCC
AACGTGCAGC AGGCCCTGCG CCAGGAGAGC CTGGCCGCCG CAGCCAGCAT CAGTGAACAT
CCCCAGAAGG CAACCACCGA GCTGCCCTTG CTGCGTGCGG CCCTCAAGGA GACCTTGCGG
CTCTACCCTG TGGGTCTGTT TCTGGAGCGA GTGGCGAGCT CAGACTTGGT GCTTCAGAAC
TACCACATCC CAGCTGGGAC ATTGGTGCGC GTGTTCCTCT ACTCTCTGGG TCGCAACCCC
GCCTTGTTCC CGAGGCCTGA GCGCTATAAC CCCCAGCGCT GGCTAGACAT CAGGGGCTCC
GGCAGGAACT TCTACCACGT GCCCTTTGGC TTTGGCATGC GCCAGTGCCT TGGGCGGCGC
CTGGCAGAGG CAGAGATGCT GCTGCTGCTG CACCATGTGC TGAAACACCT CCAGGTGGAG
ACACTAACCC AAGAGGACAT AAAGATGGTC TACAGCTTCA TATTGAGGCC CAGCATGTTC
CCCCTCCTCA CCTTCAGAGC CATCAACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011515176.1
CDS27..1616
Misc Feature(1)150..1466
Translation

Target ORF information:

RefSeq Version XM_011516874.2
Organism Homo sapiens(Human)
Definition Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011516874.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCACTCA GGGCAAAGGC AGAGGTGTGC ATGGCAGTGC CCTGGCTGTC CCTGCAAAGG 
GCACAGGCAC TGGGCACGAG AGCCGCCCGG GTCCCCAGGA CAGTGCTGCC CTTTGAAGCC
ATGCCCCGGC GTCCAGGCAA CAGGTGGCTG AGGCTGCTGC AGATCTGGAG GGAGCAGGGT
TATGAGGACC TGCACCTGGA AGTACACCAG ACCTTCCAGG AACTAGGGCC CATTTTCAGG
TACGACTTGG GAGGAGCAGG CATGGTGTGT GTGATGCTGC CGGAGGACGT GGAGAAGCTG
CAACAGGTGG ACAGCCTGCA TCCCCACAGG ATGAGCCTGG AGCCCTGGGT GGCCTACAGA
CAACATCGTG GGCACAAATG TGGCGTGTTC TTGCTAAATG TGGCTGACAG GGGAAATTCC
TCCCCACCAT TCCCTGGGGG CATCCATGGA GCCCCCACGC ACTCTGGCTG TAGGAATGGG
CCTGAATGGC GCTTCAACCG ATTGCGGCTG AATCCAGAAG TGCTGTCGCC CAACGCTGTG
CAGAGGTTCC TCCCGATGGT GGATGCAGTG GCCAGGGACT TCTCCCAGGC CCTGAAGAAG
AAGGTGCTGC AGAACGCCCG GGGGAGCCTG ACCCTGGACG TCCAGCCCAG CATCTTCCAC
TACACCATAG AAGCCAGCAA CTTGGCTCTT TTTGGAGAGC GGCTGGGCCT GGTTGGCCAC
AGCCCCAGTT CTGCCAGCCT GAACTTCCTC CATGCCCTGG AGGTCATGTT CAAATCCACC
GTCCAGCTCA TGTTCATGCC CAGGAGCCTG TCTCGCTGGA CCAGCCCCAA GGTGTGGAAG
GAGCACTTTG AGGCCTGGGA CTGCATCTTC CAGTACGGCG ACAACTGTAT CCAGAAAATC
TATCAGGAAC TGGCCTTCAG CCGCCCTCAA CAGTACACCA GCATCGTGGC GGAGCTCCTG
TTGAATGCGG AACTGTCGCC AGATGCCATC AAGGCCAACT CTATGGAACT CACTGCAGGG
AGCGTGGACA CGACGGTGTT TCCCTTGCTG ATGACGCTCT TTGAGCTGGC TCGGAACCCC
AACGTGCAGC AGGCCCTGCG CCAGGAGAGC CTGGCCGCCG CAGCCAGCAT CAGTGAACAT
CCCCAGAAGG CAACCACCGA GCTGCCCTTG CTGCGTGCGG CCCTCAAGGA GACCTTGCGG
CTCTACCCTG TGGGTCTGTT TCTGGAGCGA GTGGCGAGCT CAGACTTGGT GCTTCAGAAC
TACCACATCC CAGCTGGGAC ATTGGTGCGC GTGTTCCTCT ACTCTCTGGG TCGCAACCCC
GCCTTGTTCC CGAGGCCTGA GCGCTATAAC CCCCAGCGCT GGCTAGACAT CAGGGGCTCC
GGCAGGAACT TCTACCACGT GCCCTTTGGC TTTGGCATGC GCCAGTGCCT TGGGCGGCGC
CTGGCAGAGG CAGAGATGCT GCTGCTGCTG CACCATGTGC TGAAACACCT CCAGGTGGAG
ACACTAACCC AAGAGGACAT AAAGATGGTC TACAGCTTCA TATTGAGGCC CAGCATGTTC
CCCCTCCTCA CCTTCAGAGC CATCAACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57175
Clone ID Related Accession (Same CDS sequence) XM_011516875.1
Accession Version XM_011516875.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1587bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product cytochrome P450 11B1, mitochondrial isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGTGTGTG TGATGCTGCC GGAGGACGTG GAGAAGCTGC AACAGGTGGA CAGCCTGCAT 
CCCCACAGGA TGAGCCTGGA GCCCTGGGTG GCCTACAGAC AACATCGTGG GCACAAATGT
GGCGTGTTCT TGCTAAATGT GGCTGACAGG GGAAATTCCT CCCCACCATT CCCTGGGGGC
ATCCATGGAG CCCCCACGCA CTCTGGCTGT AGGAATGGGC CTGAATGGCG CTTCAACCGA
TTGCGGCTGA ATCCAGAAGT GCTGTCGCCC AACGCTGTGC AGAGGTTCCT CCCGATGGTG
GATGCAGTGG CCAGGGACTT CTCCCAGGCC CTGAAGAAGA AGGTGCTGCA GAACGCCCGG
GGGAGCCTGA CCCTGGACGT CCAGCCCAGC ATCTTCCACT ACACCATAGA AGCCAGCAAC
TTGGCTCTTT TTGGAGAGCG GCTGGGCCTG GTTGGCCACA GCCCCAGTTC TGCCAGCCTG
AACTTCCTCC ATGCCCTGGA GGTCATGTTC AAATCCACCG TCCAGCTCAT GTTCATGCCC
AGGAGCCTGT CTCGCTGGAC CAGCCCCAAG GTGTGGAAGG AGCACTTTGA GGCCTGGGAC
TGCATCTTCC AGTACGGCGA CAACTGTATC CAGAAAATCT ATCAGGAACT GGCCTTCAGC
CGCCCTCAAC AGTACACCAG CATCGTGGCG GAGCTCCTGT TGAATGCGGA ACTGTCGCCA
GATGCCATCA AGGCCAACTC TATGGAACTC ACTGCAGGGA GCGTGGACAC GACGGTGTTT
CCCTTGCTGA TGACGCTCTT TGAGCTGGCT CGGAACCCCA ACGTGCAGCA GGCCCTGCGC
CAGGAGAGCC TGGCCGCCGC AGCCAGCATC AGTGAACATC CCCAGAAGGC AACCACCGAG
CTGCCCTTGC TGCGTGCGGC CCTCAAGGAG ACCTTGCGGA AGGGTGCAGA GAGCACAGGA
AGCCCCATCC AGCTGAGGAC CCTTTCTATG GATGCCCCCA CCTCCAGGCT CTACCCTGTG
GGTCTGTTTC TGGAGCGAGT GGCGAGCTCA GACTTGGTGC TTCAGAACTA CCACATCCCA
GCTGGGACAT TGGTGCGCGT GTTCCTCTAC TCTCTGGGTC GCAACCCCGC CTTGTTCCCG
AGGCCTGAGC GCTATAACCC CCAGCGCTGG CTAGACATCA GGGGCTCCGG CAGGAACTTC
TACCACGTGC CCTTTGGCTT TGGCATGCGC CAGTGCCTTG GGCGGCGCCT GGCAGAGGCA
GAGATGCTGC TGCTGCTGCA CCATCATAAT CTCTGCAACT TTGAGGGTCT GAGAAGGCTG
CACCACGTGC ATGGGCTGCG GACCAAGCCA GATGGAAACC CGGCTTCTGT CCTAGGTGCT
GAAACACCTC CAGGTGGAGA CACTAACCCA AGAGGACATA AAGATGGTCT ACAGCTTCAT
ATTGAGGCCC AGCATGTTCC CCCTCCTCAC CTTCAGAGCC ATCAACTAAT CACGTCTCTG
CACCCAGGGT CCCAGCCTGG CCACCAGCCT CCCTTTCTGC CTGACCCCAG GCCACCCCTC
TTCTCTCCCA CATGCACAGC TTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011515177.1
CDS108..1694
Misc Feature(1)108..1355
Translation

Target ORF information:

RefSeq Version XM_011516875.1
Organism Homo sapiens(Human)
Definition Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011516875.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGTGTGTG TGATGCTGCC GGAGGACGTG GAGAAGCTGC AACAGGTGGA CAGCCTGCAT 
CCCCACAGGA TGAGCCTGGA GCCCTGGGTG GCCTACAGAC AACATCGTGG GCACAAATGT
GGCGTGTTCT TGCTAAATGT GGCTGACAGG GGAAATTCCT CCCCACCATT CCCTGGGGGC
ATCCATGGAG CCCCCACGCA CTCTGGCTGT AGGAATGGGC CTGAATGGCG CTTCAACCGA
TTGCGGCTGA ATCCAGAAGT GCTGTCGCCC AACGCTGTGC AGAGGTTCCT CCCGATGGTG
GATGCAGTGG CCAGGGACTT CTCCCAGGCC CTGAAGAAGA AGGTGCTGCA GAACGCCCGG
GGGAGCCTGA CCCTGGACGT CCAGCCCAGC ATCTTCCACT ACACCATAGA AGCCAGCAAC
TTGGCTCTTT TTGGAGAGCG GCTGGGCCTG GTTGGCCACA GCCCCAGTTC TGCCAGCCTG
AACTTCCTCC ATGCCCTGGA GGTCATGTTC AAATCCACCG TCCAGCTCAT GTTCATGCCC
AGGAGCCTGT CTCGCTGGAC CAGCCCCAAG GTGTGGAAGG AGCACTTTGA GGCCTGGGAC
TGCATCTTCC AGTACGGCGA CAACTGTATC CAGAAAATCT ATCAGGAACT GGCCTTCAGC
CGCCCTCAAC AGTACACCAG CATCGTGGCG GAGCTCCTGT TGAATGCGGA ACTGTCGCCA
GATGCCATCA AGGCCAACTC TATGGAACTC ACTGCAGGGA GCGTGGACAC GACGGTGTTT
CCCTTGCTGA TGACGCTCTT TGAGCTGGCT CGGAACCCCA ACGTGCAGCA GGCCCTGCGC
CAGGAGAGCC TGGCCGCCGC AGCCAGCATC AGTGAACATC CCCAGAAGGC AACCACCGAG
CTGCCCTTGC TGCGTGCGGC CCTCAAGGAG ACCTTGCGGA AGGGTGCAGA GAGCACAGGA
AGCCCCATCC AGCTGAGGAC CCTTTCTATG GATGCCCCCA CCTCCAGGCT CTACCCTGTG
GGTCTGTTTC TGGAGCGAGT GGCGAGCTCA GACTTGGTGC TTCAGAACTA CCACATCCCA
GCTGGGACAT TGGTGCGCGT GTTCCTCTAC TCTCTGGGTC GCAACCCCGC CTTGTTCCCG
AGGCCTGAGC GCTATAACCC CCAGCGCTGG CTAGACATCA GGGGCTCCGG CAGGAACTTC
TACCACGTGC CCTTTGGCTT TGGCATGCGC CAGTGCCTTG GGCGGCGCCT GGCAGAGGCA
GAGATGCTGC TGCTGCTGCA CCATCATAAT CTCTGCAACT TTGAGGGTCT GAGAAGGCTG
CACCACGTGC ATGGGCTGCG GACCAAGCCA GATGGAAACC CGGCTTCTGT CCTAGGTGCT
GAAACACCTC CAGGTGGAGA CACTAACCCA AGAGGACATA AAGATGGTCT ACAGCTTCAT
ATTGAGGCCC AGCATGTTCC CCCTCCTCAC CTTCAGAGCC ATCAACTAAT CACGTCTCTG
CACCCAGGGT CCCAGCCTGG CCACCAGCCT CCCTTTCTGC CTGACCCCAG GCCACCCCTC
TTCTCTCCCA CATGCACAGC TTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu97784
Clone ID Related Accession (Same CDS sequence) XM_017013146.1
Accession Version XM_017013146.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 849bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product cytochrome P450 11B1, mitochondrial isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCATGTCT GCACCCCTCA CAGGGAGGTT GTCCTGGGAG GGGTGTCCCG GGGGCTGAGT 
CCTCCTGTGC AAGGTCTGAC CCTGCAGCTG TGTCTCCTGC AGACGGTGTT TCCCTTGCTG
ATGACGCTCT TTGAGCTGGC TCGGAACCCC AACGTGCAGC AGGCCCTGCG CCAGGAGAGC
CTGGCCGCCG CAGCCAGCAT CAGTGAACAT CCCCAGAAGG CAACCACCGA GCTGCCCTTG
CTGCGTGCGG CCCTCAAGGA GACCTTGCGG CTCTACCCTG TGGGTCTGTT TCTGGAGCGA
GTGGCGAGCT CAGACTTGGT GCTTCAGAAC TACCACATCC CAGCTGGGAC ATTGGTGCGC
GTGTTCCTCT ACTCTCTGGG TCGCAACCCC GCCTTGTTCC CGAGGCCTGA GCGCTATAAC
CCCCAGCGCT GGCTAGACAT CAGGGGCTCC GGCAGGAACT TCTACCACGT GCCCTTTGGC
TTTGGCATGC GCCAGTGCCT TGGGCGGCGC CTGGCAGAGG CAGAGATGCT GCTGCTGCTG
CACCATCATA ATCTCTGCAA CTTTGAGGGT CTGAGAAGGC TGCACCACGT GCATGGGCTG
CGGACCAAGC CAGATGGAAA CCCGGCTTCT GTCCTAGGTG CTGAAACACC TCCAGGTGGA
GACACTAACC CAAGAGGACA TAAAGATGGT CTACAGCTTC ATATTGAGGC CCAGCATGTT
CCCCCTCCTC ACCTTCAGAG CCATCAACTA ATCACGTCTC TGCACCCAGG GTCCCAGCCT
GGCCACCAGC CTCCCTTTCT GCCTGACCCC AGGCCACCCC TCTTCTCTCC CACATGCACA
GCTTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016868635.1
CDS264..1112
Translation

Target ORF information:

RefSeq Version XM_017013146.1
Organism Homo sapiens(Human)
Definition Homo sapiens cytochrome P450 family 11 subfamily B member 1 (CYP11B1), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017013146.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCATGTCT GCACCCCTCA CAGGGAGGTT GTCCTGGGAG GGGTGTCCCG GGGGCTGAGT 
CCTCCTGTGC AAGGTCTGAC CCTGCAGCTG TGTCTCCTGC AGACGGTGTT TCCCTTGCTG
ATGACGCTCT TTGAGCTGGC TCGGAACCCC AACGTGCAGC AGGCCCTGCG CCAGGAGAGC
CTGGCCGCCG CAGCCAGCAT CAGTGAACAT CCCCAGAAGG CAACCACCGA GCTGCCCTTG
CTGCGTGCGG CCCTCAAGGA GACCTTGCGG CTCTACCCTG TGGGTCTGTT TCTGGAGCGA
GTGGCGAGCT CAGACTTGGT GCTTCAGAAC TACCACATCC CAGCTGGGAC ATTGGTGCGC
GTGTTCCTCT ACTCTCTGGG TCGCAACCCC GCCTTGTTCC CGAGGCCTGA GCGCTATAAC
CCCCAGCGCT GGCTAGACAT CAGGGGCTCC GGCAGGAACT TCTACCACGT GCCCTTTGGC
TTTGGCATGC GCCAGTGCCT TGGGCGGCGC CTGGCAGAGG CAGAGATGCT GCTGCTGCTG
CACCATCATA ATCTCTGCAA CTTTGAGGGT CTGAGAAGGC TGCACCACGT GCATGGGCTG
CGGACCAAGC CAGATGGAAA CCCGGCTTCT GTCCTAGGTG CTGAAACACC TCCAGGTGGA
GACACTAACC CAAGAGGACA TAAAGATGGT CTACAGCTTC ATATTGAGGC CCAGCATGTT
CCCCCTCCTC ACCTTCAGAG CCATCAACTA ATCACGTCTC TGCACCCAGG GTCCCAGCCT
GGCCACCAGC CTCCCTTTCT GCCTGACCCC AGGCCACCCC TCTTCTCTCC CACATGCACA
GCTTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.
Hormones (Athens, Greece)15(2)235-42(2016 Apr)
Shammas C,Byrou S,Phelan MM,Toumba M,Stylianou C,Skordis N,Neocleous V,Phylactou LA


book

A novel CYP11B1 mutation in a Turkish patient with 11β-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.
Hormones (Athens, Greece)15(2)300-2(2016 Apr)
Yurekli BS,Kutbay NO,Onay H,Simsir IY,Kocabas GU,Erdogan M,Cetinkalp S,Ozgen G,Saygili F


book

The combination of a novel 2 bp deletion mutation and p.D63H in CYP11B1 cause congenital adrenal hyperplasia due to steroid 11β-hydroxylase deficiency.
Endocrine journal63(3)301-10(2016)
Long Y,Han S,Zhang X,Zhang X,Chen T,Gao Y,Tian H


book

Phenotypic, metabolic, and molecular genetic characterization of six patients with congenital adrenal hyperplasia caused by novel mutations in the CYP11B1 gene.
The Journal of steroid biochemistry and molecular biology155(Pt A)126-34(2016 Jan)
Nguyen HH,Eiden-Plach A,Hannemann F,Malunowicz EM,Hartmann MF,Wudy SA,Bernhardt R


book

Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.
Steroids10151-5(2015 Sep)
Xu L,Xia W,Wu X,Wang X,Zhao L,Nie M


 
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