GSX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	GSX2
Entrez Gene ID	170825
Full Name	GS homeobox 2
Synonyms	GSH2
General protein information	Preferred Names GS homeobox 2 Names GS homeobox 2 genetic-screened homeobox 2 homeobox protein GSH-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q12
Disorder MIM:	616253

mRNA and Protein(s)

mRNA Protein Name

NM_133267.2 NP_573574.1 GS homeobox 2

NM_133267.3 NP_573574.2 GS homeobox 2
Pathways from BioSystems

mRNA	Protein	Name
NM_133267.2	NP_573574.1	GS homeobox 2
NM_133267.3	NP_573574.2	GS homeobox 2

Homologies

Homo sapiens (human)	GSX2	NP_573574.1
Pan troglodytes (chimpanzee)	GSX2	XP_003310422.1
Bos taurus (cattle)	GSX2	NP_001179129.1
	GSX2	XP_001089298.1
Mus musculus (house mouse)	Gsx2	NP_573555.1
Rattus norvegicus (Norway rat)	Gsx2	NP_001131035.1
Danio rerio (zebrafish)	gsx2	NP_001020683.1
Xenopus tropicalis (tropical clawed frog)	gsx2	NP_001017168.1
Gallus gallus (chicken)	GSX2	XP_003641255.1
Canis lupus familiaris (dog)	GSX2	XP_539271.3

Gene Ontology
Bibliography

Related articles in PubMed

Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1.
Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fuc? E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E
Proceedings of the National Academy of Sciences of the United States of America114(7)E1234-E1242(2017 Feb)

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.
Di Giacomo D, La Starza R, Barba G, Pierini V, Baldazzi C, Storlazzi CT, Daniele G, Forghieri F, Borlenghi E, Testoni N, Mecucci C
British journal of haematology171(1)141-5(2015 Oct)

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kretzler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD,
Journal of the American Society of Nephrology : JASN25(12)2859-70(2014 Dec)

The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.
M?ndez-G?mez HR, Vicario-Abej?n C
PloS one7(1)e29799(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.
Title: 4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.

Gsx2 negatively regulates neurogenesis from postnatal progenitor cells.
Title: The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.

Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression.
Title: MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.

Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during neurogenesis in transgenic mice.
Title: Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.

ectopically expressed in myeloid leukemic cells with t(4;12)(q11-q12;p13), suggesting that expression of GSH2 was deregulated by the translocation, indicating a variant leukemogenic mechanism for translocations involving the 5' end of ETV6
Title: Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13).

The following GSX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu107846	NM_133267.3 Latest version!	Homo sapiens GS homeobox 2 (GSX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu31865	NM_133267.2 Latest version!	Homo sapiens GS homeobox 2 (GSX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSX2 ( NM_133267.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_573574.2 Homo sapiens GS homeobox 2 (GSX2), mRNA.

Price & Availability↑

CloneID	OHu107846
Clone ID Related Accession (Same CDS sequence)	NM_133267.3
Accession Version	NM_133267.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-03
Organism	Homo sapiens(human)
Product	GS homeobox 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110298.5. On Nov 23, 2018 this sequence version replaced NM_133267.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB028838.1, BC075090.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000326902.7/ ENSP00000319118.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGCGCT CCTTCTATGT CGACTCGCTC ATCATCAAGG ACACCTCACG GCCTGCGCCC 
TCGCTGCCTG AACCGCACCC CGGGCCGGAT TTCTTCATCC CGCTTGGCAT GCCGCCCCCA 
TTGGTGATGT CCGTGTCCGG CCCCGGCTGC CCGTCCCGCA AGAGCGGCGC GTTCTGCGTG 
TGCCCTCTCT GCGTCACTTC GCACCTGCAC TCCTCTCGGG GGTCTGTGGG CGCCGGCAGC 
GGGGGCGCAG GGGCCGGGGT TACCGGGGCC GGAGGCAGTG GGGTGGCAGG GGCCGCAGGG 
GCACTGCCTC TGCTTAAGGG CCAGTTCTCT TCGGCTCCTG GGGACGCGCA GTTTTGCCCG 
CGGGTGAACC ATGCGCATCA TCACCACCAC CCGCCGCAGC ACCACCATCA CCATCATCAG 
CCCCAGCAGC CTGGCTCGGC CGCGGCGGCG GCAGCAGCAG CAGCGGCGGC GGCGGCCGCG 
GCGGCCTTGG GGCACCCGCA GCACCACGCA CCTGTCTGCA CCGCCACCAC CTACAACGTG 
GCGGACCCGC GGAGATTCCA CTGCCTCACC ATGGGAGGCT CTGACGCCAG CCAGGTACCC 
AATGGCAAGA GGATGAGGAC GGCGTTCACT AGCACGCAAC TCCTGGAGCT GGAGAGAGAA 
TTCTCTTCCA ACATGTACCT GTCTCGACTC CGGAGGATTG AAATCGCCAC TTACCTGAAC 
CTGTCGGAGA AGCAGGTGAA AATCTGGTTT CAGAACCGCC GAGTGAAGCA CAAGAAGGAG 
GGGAAGGGCA CGCAGAGGAA CAGTCACGCG GGCTGCAAGT GCGTCGGGAG CCAGGTGCAC 
TACGCGCGCT CCGAGGATGA GGACTCCCTG TCGCCGGCCT CAGCCAACGA TGACAAGGAG 
ATTTCCCCCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573574.2
CDS	183..1097
Translation	MSRSFYVDSLIIKDTSRPAPSLPEPHPGPDFFIPLGMPPPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKGQFSSAPGDAQFCPRVNHAHHHHHPPQHHHHHHQPQQPGSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRNSHAGCKCVGSQVHYARSEDEDSLSPASANDDKEISPL

Target ORF information:

RefSeq Version	NM_133267.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GS homeobox 2 (GSX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133267.3

ORF Insert Sequence:

ATGTCGCGCT CCTTCTATGT CGACTCGCTC ATCATCAAGG ACACCTCACG GCCTGCGCCC 
TCGCTGCCTG AACCGCACCC CGGGCCGGAT TTCTTCATCC CGCTTGGCAT GCCGCCCCCA 
TTGGTGATGT CCGTGTCCGG CCCCGGCTGC CCGTCCCGCA AGAGCGGCGC GTTCTGCGTG 
TGCCCTCTCT GCGTCACTTC GCACCTGCAC TCCTCTCGGG GGTCTGTGGG CGCCGGCAGC 
GGGGGCGCAG GGGCCGGGGT TACCGGGGCC GGAGGCAGTG GGGTGGCAGG GGCCGCAGGG 
GCACTGCCTC TGCTTAAGGG CCAGTTCTCT TCGGCTCCTG GGGACGCGCA GTTTTGCCCG 
CGGGTGAACC ATGCGCATCA TCACCACCAC CCGCCGCAGC ACCACCATCA CCATCATCAG 
CCCCAGCAGC CTGGCTCGGC CGCGGCGGCG GCAGCAGCAG CAGCGGCGGC GGCGGCCGCG 
GCGGCCTTGG GGCACCCGCA GCACCACGCA CCTGTCTGCA CCGCCACCAC CTACAACGTG 
GCGGACCCGC GGAGATTCCA CTGCCTCACC ATGGGAGGCT CTGACGCCAG CCAGGTACCC 
AATGGCAAGA GGATGAGGAC GGCGTTCACT AGCACGCAAC TCCTGGAGCT GGAGAGAGAA 
TTCTCTTCCA ACATGTACCT GTCTCGACTC CGGAGGATTG AAATCGCCAC TTACCTGAAC 
CTGTCGGAGA AGCAGGTGAA AATCTGGTTT CAGAACCGCC GAGTGAAGCA CAAGAAGGAG 
GGGAAGGGCA CGCAGAGGAA CAGTCACGCG GGCTGCAAGT GCGTCGGGAG CCAGGTGCAC 
TACGCGCGCT CCGAGGATGA GGACTCCCTG TCGCCGGCCT CAGCCAACGA TGACAAGGAG 
ATTTCCCCCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GSX2 ( NM_133267.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_573574.1 Homo sapiens GS homeobox 2 (GSX2), mRNA.

Price & Availability↑

CloneID	OHu31865
Clone ID Related Accession (Same CDS sequence)	NM_133267.2
Accession Version	NM_133267.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	GS homeobox 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EU596451.1, BC075090.2 and AI360912.1. On Jun 28, 2008 this sequence version replaced NM_133267.1. ##Evidence-Data-START## Transcript exon combination :: AB028838.1, BC075090.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

ATGTCGCGCT CCTTCTATGT CGACTCGCTC ATCATCAAGG ACACCTCACG GCCTGCGCCC 
TCGCTGCCTG AACCGCACCC CGGGCCGGAT TTCTTCATCC CGCTTGGCAT GCCGCCCCCA 
TTGGTGATGT CCGTGTCCGG CCCCGGCTGC CCGTCCCGCA AGAGCGGCGC GTTCTGCGTG 
TGCCCTCTCT GCGTCACTTC GCACCTGCAC TCCTCTCGGG GGTCTGTGGG CGCCGGCAGC 
GGGGGCGCAG GGGCCGGGGT TACCGGGGCC GGAGGCAGTG GGGTGGCAGG GGCCGCAGGG 
GCACTGCCTC TGCTTAAGAG CCAGTTCTCT TCGGCTCCTG GGGACGCGCA GTTTTGCCCG 
CGGGTGAACC ATGCGCATCA TCACCACCAC CCGCCGCAGC ACCACCATCA CCATCATCAG 
CCCCAGCAGC CTGGCTCGGC CGCGGCGGCG GCAGCAGCAG CAGCGGCGGC GGCGGCCGCG 
GCGGCCTTGG GGCACCCGCA GCACCACGCA CCTGTCTGCA CCGCCACCAC CTACAACGTG 
GCGGACCCGC GGAGATTCCA CTGCCTCACC ATGGGAGGCT CTGACGCCAG CCAGGTACCC 
AATGGCAAGA GGATGAGGAC GGCGTTCACT AGCACGCAAC TCCTGGAGCT GGAGAGAGAA 
TTCTCTTCCA ACATGTACCT GTCTCGACTC CGGAGGATTG AAATCGCCAC TTACCTGAAC 
CTGTCGGAGA AGCAGGTGAA AATCTGGTTT CAGAACCGCC GAGTGAAGCA CAAGAAGGAG 
GGGAAGGGCA CGCAGAGGAA CAGTCACGCG GGCTGCAAGT GCGTCGGGAG CCAGGTGCAC 
TACGCGCGCT CCGAGGATGA GGACTCCCTG TCGCCGGCCT CAGCCAACGA TGACAAGGAG 
ATTTCCCCCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573574.1
CDS	265..1179
Translation	MSRSFYVDSLIIKDTSRPAPSLPEPHPGPDFFIPLGMPPPLVMSVSGPGCPSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKSQFSSAPGDAQFCPRVNHAHHHHHPPQHHHHHHQPQQPGSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRNSHAGCKCVGSQVHYARSEDEDSLSPASANDDKEISPL

Target ORF information:

RefSeq Version	NM_133267.2
Organism	Homo sapiens(human)
Definition	Homo sapiens GS homeobox 2 (GSX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133267.2

ORF Insert Sequence:

ATGTCGCGCT CCTTCTATGT CGACTCGCTC ATCATCAAGG ACACCTCACG GCCTGCGCCC 
TCGCTGCCTG AACCGCACCC CGGGCCGGAT TTCTTCATCC CGCTTGGCAT GCCGCCCCCA 
TTGGTGATGT CCGTGTCCGG CCCCGGCTGC CCGTCCCGCA AGAGCGGCGC GTTCTGCGTG 
TGCCCTCTCT GCGTCACTTC GCACCTGCAC TCCTCTCGGG GGTCTGTGGG CGCCGGCAGC 
GGGGGCGCAG GGGCCGGGGT TACCGGGGCC GGAGGCAGTG GGGTGGCAGG GGCCGCAGGG 
GCACTGCCTC TGCTTAAGAG CCAGTTCTCT TCGGCTCCTG GGGACGCGCA GTTTTGCCCG 
CGGGTGAACC ATGCGCATCA TCACCACCAC CCGCCGCAGC ACCACCATCA CCATCATCAG 
CCCCAGCAGC CTGGCTCGGC CGCGGCGGCG GCAGCAGCAG CAGCGGCGGC GGCGGCCGCG 
GCGGCCTTGG GGCACCCGCA GCACCACGCA CCTGTCTGCA CCGCCACCAC CTACAACGTG 
GCGGACCCGC GGAGATTCCA CTGCCTCACC ATGGGAGGCT CTGACGCCAG CCAGGTACCC 
AATGGCAAGA GGATGAGGAC GGCGTTCACT AGCACGCAAC TCCTGGAGCT GGAGAGAGAA 
TTCTCTTCCA ACATGTACCT GTCTCGACTC CGGAGGATTG AAATCGCCAC TTACCTGAAC 
CTGTCGGAGA AGCAGGTGAA AATCTGGTTT CAGAACCGCC GAGTGAAGCA CAAGAAGGAG 
GGGAAGGGCA CGCAGAGGAA CAGTCACGCG GGCTGCAAGT GCGTCGGGAG CCAGGTGCAC 
TACGCGCGCT CCGAGGATGA GGACTCCCTG TCGCCGGCCT CAGCCAACGA TGACAAGGAG 
ATTTCCCCCT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1.
Proceedings of the National Academy of Sciences of the United States of America114(7)E1234-E1242(2017 Feb)
Faedo A,Laporta A,Segnali A,Galimberti M,Besusso D,Cesana E,Belloli S,Moresco RM,Tropiano M,Fuc? E,Wild S,Bosio A,Vercelli AE,Biella G,Cattaneo E

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.
British journal of haematology171(1)141-5(2015 Oct)
Di Giacomo D,La Starza R,Barba G,Pierini V,Baldazzi C,Storlazzi CT,Daniele G,Forghieri F,Borlenghi E,Testoni N,Mecucci C

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
Journal of the American Society of Nephrology : JASN25(12)2859-70(2014 Dec)
Chung SA,Brown EE,Williams AH,Ramos PS,Berthier CC,Bhangale T,Alarcon-Riquelme ME,Behrens TW,Criswell LA,Graham DC,Demirci FY,Edberg JC,Gaffney PM,Harley JB,Jacob CO,Kamboh MI,Kelly JA,Manzi S,Moser-Sivils KL,Russell LP,Petri M,Tsao BP,Vyse TJ,Zidovetzki R,Kretzler M,Kimberly RP,Freedman BI,Graham RR,Langefeld CD,

The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.
PloS one7(1)e29799(2012)
M?ndez-G?mez HR,Vicario-Abej?n C

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GSX2 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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