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GSX2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GSX2
Entrez Gene ID 170825
Full Name GS homeobox 2
Synonyms GSH2
General protein information
Preferred Names

GS homeobox 2

Names

GS homeobox 2
genetic-screened homeobox 2
homeobox protein GSH-2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q12

Disorder MIM:

616253


mRNA and Protein(s)

mRNA Protein Name
NM_133267.2 NP_573574.1 GS homeobox 2



Homo sapiens (human) GSX2 NP_573574.1
Pan troglodytes (chimpanzee) GSX2 XP_003310422.1
Bos taurus (cattle) GSX2 NP_001179129.1
Macaca mulatta (rhesus monkey) GSX2 XP_001089298.1
Mus musculus (house mouse) Gsx2 NP_573555.1
Rattus norvegicus (Norway rat) Gsx2 NP_001131035.1
Danio rerio (zebrafish) gsx2 NP_001020683.1
Xenopus tropicalis (tropical clawed frog) gsx2 NP_001017168.1
Gallus gallus (chicken) GSX2 XP_003641255.1
Canis lupus familiaris (dog) GSX2 XP_539271.3


Related articles in PubMed

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.
Di Giacomo D, La Starza R, Barba G, Pierini V, Baldazzi C, Storlazzi CT, Daniele G, Forghieri F, Borlenghi E, Testoni N, Mecucci C
British journal of haematology171(1)141-5(2015 Oct)

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kretzler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD,
Journal of the American Society of Nephrology : JASN25(12)2859-70(2014 Dec)

The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.
Méndez-Gómez HR, Vicario-Abejón C
PloS one7(1)e29799(2012)

MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.
Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S
The Journal of neuroscience : the official journal of the Society for Neuroscience31(9)3407-22(2011 Mar)

Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.
Waclaw RR, Wang B, Pei Z, Ehrman LA, Campbell K
Neuron63(4)451-65(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.
Title: 4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.

Gsx2 negatively regulates neurogenesis from postnatal progenitor cells.
Title: The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.

Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression.
Title: MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.

Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during neurogenesis in transgenic mice.
Title: Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.

ectopically expressed in myeloid leukemic cells with t(4;12)(q11-q12;p13), suggesting that expression of GSH2 was deregulated by the translocation, indicating a variant leukemogenic mechanism for translocations involving the 5' end of ETV6
Title: Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13).

The following GSX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu31865 NM_133267.2
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Homo sapiens GS homeobox 2 (GSX2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu31865
Clone ID Related Accession (Same CDS sequence) NM_133267.2
Accession Version NM_133267.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-12-24
Organism Homo sapiens(Human)
Product GS homeobox 2
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EU596451.1, BC075090.2 and AI360912.1. On Jun 28, 2008 this sequence version replaced NM_133267.1. ##Evidence-Data-START## Transcript exon combination :: AB028838.1, BC075090.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCGCGCT CCTTCTATGT CGACTCGCTC ATCATCAAGG ACACCTCACG GCCTGCGCCC 
TCGCTGCCTG AACCGCACCC CGGGCCGGAT TTCTTCATCC CGCTTGGCAT GCCGCCCCCA
TTGGTGATGT CCGTGTCCGG CCCCGGCTGC CCGTCCCGCA AGAGCGGCGC GTTCTGCGTG
TGCCCTCTCT GCGTCACTTC GCACCTGCAC TCCTCTCGGG GGTCTGTGGG CGCCGGCAGC
GGGGGCGCAG GGGCCGGGGT TACCGGGGCC GGAGGCAGTG GGGTGGCAGG GGCCGCAGGG
GCACTGCCTC TGCTTAAGAG CCAGTTCTCT TCGGCTCCTG GGGACGCGCA GTTTTGCCCG
CGGGTGAACC ATGCGCATCA TCACCACCAC CCGCCGCAGC ACCACCATCA CCATCATCAG
CCCCAGCAGC CTGGCTCGGC CGCGGCGGCG GCAGCAGCAG CAGCGGCGGC GGCGGCCGCG
GCGGCCTTGG GGCACCCGCA GCACCACGCA CCTGTCTGCA CCGCCACCAC CTACAACGTG
GCGGACCCGC GGAGATTCCA CTGCCTCACC ATGGGAGGCT CTGACGCCAG CCAGGTACCC
AATGGCAAGA GGATGAGGAC GGCGTTCACT AGCACGCAAC TCCTGGAGCT GGAGAGAGAA
TTCTCTTCCA ACATGTACCT GTCTCGACTC CGGAGGATTG AAATCGCCAC TTACCTGAAC
CTGTCGGAGA AGCAGGTGAA AATCTGGTTT CAGAACCGCC GAGTGAAGCA CAAGAAGGAG
GGGAAGGGCA CGCAGAGGAA CAGTCACGCG GGCTGCAAGT GCGTCGGGAG CCAGGTGCAC
TACGCGCGCT CCGAGGATGA GGACTCCCTG TCGCCGGCCT CAGCCAACGA TGACAAGGAG
ATTTCCCCCT TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_573574.1
CDS265..1179
Misc Feature(1)208..210
Misc Feature(2)order(871..885,889..891,940..942,958..960,997..999,1003..1008,1015..1020,1024..1032,1036..1041)
Misc Feature(3)order(877..879,886..888,1006..1008,1015..1020,1027..1029)
Misc Feature(4)880..1038
Exon (1)1..838
Exon (2)839..1212
Translation

Target ORF information:

RefSeq Version NM_133267.2
Organism Homo sapiens(Human)
Definition Homo sapiens GS homeobox 2 (GSX2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_133267.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCGCGCT CCTTCTATGT CGACTCGCTC ATCATCAAGG ACACCTCACG GCCTGCGCCC 
TCGCTGCCTG AACCGCACCC CGGGCCGGAT TTCTTCATCC CGCTTGGCAT GCCGCCCCCA
TTGGTGATGT CCGTGTCCGG CCCCGGCTGC CCGTCCCGCA AGAGCGGCGC GTTCTGCGTG
TGCCCTCTCT GCGTCACTTC GCACCTGCAC TCCTCTCGGG GGTCTGTGGG CGCCGGCAGC
GGGGGCGCAG GGGCCGGGGT TACCGGGGCC GGAGGCAGTG GGGTGGCAGG GGCCGCAGGG
GCACTGCCTC TGCTTAAGAG CCAGTTCTCT TCGGCTCCTG GGGACGCGCA GTTTTGCCCG
CGGGTGAACC ATGCGCATCA TCACCACCAC CCGCCGCAGC ACCACCATCA CCATCATCAG
CCCCAGCAGC CTGGCTCGGC CGCGGCGGCG GCAGCAGCAG CAGCGGCGGC GGCGGCCGCG
GCGGCCTTGG GGCACCCGCA GCACCACGCA CCTGTCTGCA CCGCCACCAC CTACAACGTG
GCGGACCCGC GGAGATTCCA CTGCCTCACC ATGGGAGGCT CTGACGCCAG CCAGGTACCC
AATGGCAAGA GGATGAGGAC GGCGTTCACT AGCACGCAAC TCCTGGAGCT GGAGAGAGAA
TTCTCTTCCA ACATGTACCT GTCTCGACTC CGGAGGATTG AAATCGCCAC TTACCTGAAC
CTGTCGGAGA AGCAGGTGAA AATCTGGTTT CAGAACCGCC GAGTGAAGCA CAAGAAGGAG
GGGAAGGGCA CGCAGAGGAA CAGTCACGCG GGCTGCAAGT GCGTCGGGAG CCAGGTGCAC
TACGCGCGCT CCGAGGATGA GGACTCCCTG TCGCCGGCCT CAGCCAACGA TGACAAGGAG
ATTTCCCCCT TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.
British journal of haematology171(1)141-5(2015 Oct)
Di Giacomo D,La Starza R,Barba G,Pierini V,Baldazzi C,Storlazzi CT,Daniele G,Forghieri F,Borlenghi E,Testoni N,Mecucci C


book

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
Journal of the American Society of Nephrology : JASN25(12)2859-70(2014 Dec)
Chung SA,Brown EE,Williams AH,Ramos PS,Berthier CC,Bhangale T,Alarcon-Riquelme ME,Behrens TW,Criswell LA,Graham DC,Demirci FY,Edberg JC,Gaffney PM,Harley JB,Jacob CO,Kamboh MI,Kelly JA,Manzi S,Moser-Sivils KL,Russell LP,Petri M,Tsao BP,Vyse TJ,Zidovetzki R,Kretzler M,Kimberly RP,Freedman BI,Graham RR,Langefeld CD,


book

The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.
PloS one7(1)e29799(2012)
Méndez-Gómez HR,Vicario-Abejón C


book

MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.
The Journal of neuroscience : the official journal of the Society for Neuroscience31(9)3407-22(2011 Mar)
Shibata M,Nakao H,Kiyonari H,Abe T,Aizawa S


book

Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.
Neuron63(4)451-65(2009 Aug)
Waclaw RR,Wang B,Pei Z,Ehrman LA,Campbell K


 
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