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APLNR cDNA ORF clone, Homo sapiens (human)

Gene Symbol APLNR
Entrez Gene ID 187
Full Name apelin receptor
Synonyms AGTRL1, APJ, APJR, HG11
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q12

Summary This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]. lac of sum
Disorder MIM:

600052


mRNA and Protein(s)

mRNA Protein Name
NM_005161 NP_005152 apelin receptor



Homo sapiens (human) APLNR NP_005152.1
Pan troglodytes (chimpanzee) APLNR XP_521984.1
Macaca mulatta (Rhesus monkey) APLNR NP_001040591.1
Canis lupus familiaris (dog) APLNR XP_005631266.1
Mus musculus (house mouse) Aplnr NP_035914.1
Rattus norvegicus (Norway rat) Aplnr NP_112639.1
Gallus gallus (chicken) APLNR XP_001232341.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APLNR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APLNR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu11900
NM_005161 Homo sapiens apelin receptor (APLNR), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu11900
Clone ID Related Accession (Same CDS sequence) NM_005161
Accession Version NM_005161.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1143bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 16-MAR-2014
Organism Homo sapiens (human)
Product apelin receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL553350.3, BX439288.2, AK075252.1, AK315542.1, AP001786.4 and BC032688.1. On Jul 9, 2009 this sequence version replaced gi:86604722. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGAGGAAG GTGGTGATTT TGACAACTAC TATGGGGCAG ACAACCAGTC TGAGTGTGAG 
TACACAGACT GGAAATCCTC GGGGGCCCTC ATCCCTGCCA TCTACATGTT GGTCTTCCTC
CTGGGCACCA CGGGCAACGG TCTGGTGCTC TGGACCGTGT TTCGGAGCAG CCGGGAGAAG
AGGCGCTCAG CTGATATCTT CATTGCTAGC CTGGCGGTGG CTGACCTGAC CTTCGTGGTG
ACGCTGCCCC TGTGGGCTAC CTACACGTAC CGGGACTATG ACTGGCCCTT TGGGACCTTC
TTCTGCAAGC TCAGCAGCTA CCTCATCTTC GTCAACATGT ACGCCAGCGT CTTCTGCCTC
ACCGGCCTCA GCTTCGACCG CTACCTGGCC ATCGTGAGGC CAGTGGCCAA TGCTCGGCTG
AGGCTGCGGG TCAGCGGGGC CGTGGCCACG GCAGTTCTTT GGGTGCTGGC CGCCCTCCTG
GCCATGCCTG TCATGGTGTT ACGCACCACC GGGGACTTGG AGAACACCAC TAAGGTGCAG
TGCTACATGG ACTACTCCAT GGTGGCCACT GTGAGCTCAG AGTGGGCCTG GGAGGTGGGC
CTTGGGGTCT CGTCCACCAC CGTGGGCTTT GTGGTGCCCT TCACCATCAT GCTGACCTGT
TACTTCTTCA TCGCCCAAAC CATCGCTGGC CACTTCCGCA AGGAACGCAT CGAGGGCCTG
CGGAAGCGGC GCCGGCTGCT CAGCATCATC GTGGTGCTGG TGGTGACCTT TGCCCTGTGC
TGGATGCCCT ACCACCTGGT GAAGACGCTG TACATGCTGG GCAGCCTGCT GCACTGGCCC
TGTGACTTTG ACCTCTTCCT CATGAACATC TTCCCCTACT GCACCTGCAT CAGCTACGTC
AACAGCTGCC TCAACCCCTT CCTCTATGCC TTTTTCGACC CCCGCTTCCG CCAGGCCTGC
ACCTCCATGC TCTGCTGTGG CCAGAGCAGG TGCGCAGGCA CCTCCCACAG CAGCAGTGGG
GAGAAGTCAG CCAGCTACTC TTCGGGGCAC AGCCAGGGGC CCGGCCCCAA CATGGGCAAG
GGTGGAGAAC AGATGCACGA GAAATCCATC CCCTACAGCC AGGAGACCCT TGTGGTTGAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005152.1
CDS450..1592
Misc Feature(1)348..350(+)
Misc Feature(2)528..602(+)
Misc Feature(3)606..1376(+)
Misc Feature(4)648..722(+)
Misc Feature(5)750..824(+)
Misc Feature(6)882..947(+)
Misc Feature(7)1050..1112(+)
Misc Feature(8)1182..1262(+)
Misc Feature(9)1302..1373(+)
Exon (1)1..3877
Gene:APLNR
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005161
Organism Homo sapiens (human)
Definition Homo sapiens apelin receptor (APLNR), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005161

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGAGGAAG GTGGTGATTT TGACAACTAC TATGGGGCAG ACAACCAGTC TGAGTGTGAG 
TACACAGACT GGAAATCCTC GGGGGCCCTC ATCCCTGCCA TCTACATGTT GGTCTTCCTC
CTGGGCACCA CGGGCAACGG TCTGGTGCTC TGGACCGTGT TTCGGAGCAG CCGGGAGAAG
AGGCGCTCAG CTGATATCTT CATTGCTAGC CTGGCGGTGG CTGACCTGAC CTTCGTGGTG
ACGCTGCCCC TGTGGGCTAC CTACACGTAC CGGGACTATG ACTGGCCCTT TGGGACCTTC
TTCTGCAAGC TCAGCAGCTA CCTCATCTTC GTCAACATGT ACGCCAGCGT CTTCTGCCTC
ACCGGCCTCA GCTTCGACCG CTACCTGGCC ATCGTGAGGC CAGTGGCCAA TGCTCGGCTG
AGGCTGCGGG TCAGCGGGGC CGTGGCCACG GCAGTTCTTT GGGTGCTGGC CGCCCTCCTG
GCCATGCCTG TCATGGTGTT ACGCACCACC GGGGACTTGG AGAACACCAC TAAGGTGCAG
TGCTACATGG ACTACTCCAT GGTGGCCACT GTGAGCTCAG AGTGGGCCTG GGAGGTGGGC
CTTGGGGTCT CGTCCACCAC CGTGGGCTTT GTGGTGCCCT TCACCATCAT GCTGACCTGT
TACTTCTTCA TCGCCCAAAC CATCGCTGGC CACTTCCGCA AGGAACGCAT CGAGGGCCTG
CGGAAGCGGC GCCGGCTGCT CAGCATCATC GTGGTGCTGG TGGTGACCTT TGCCCTGTGC
TGGATGCCCT ACCACCTGGT GAAGACGCTG TACATGCTGG GCAGCCTGCT GCACTGGCCC
TGTGACTTTG ACCTCTTCCT CATGAACATC TTCCCCTACT GCACCTGCAT CAGCTACGTC
AACAGCTGCC TCAACCCCTT CCTCTATGCC TTTTTCGACC CCCGCTTCCG CCAGGCCTGC
ACCTCCATGC TCTGCTGTGG CCAGAGCAGG TGCGCAGGCA CCTCCCACAG CAGCAGTGGG
GAGAAGTCAG CCAGCTACTC TTCGGGGCAC AGCCAGGGGC CCGGCCCCAA CATGGGCAAG
GGTGGAGAAC AGATGCACGA GAAATCCATC CCCTACAGCC AGGAGACCCT TGTGGTTGAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking
Biochim. Biophys. Acta 1828 (6), 1471-1483 (2013)
Langelaan DN, Reddy T, Banks AW, Dellaire G, Dupre DJ and Rainey JK.


book

Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report
Arterioscler. Thromb. Vasc. Biol. 32 (11), 2640-2643 (2012)
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK and Chun HJ.


book

APELIN promotes hematopoiesis from human embryonic stem cells
Blood 119 (26), 6243-6254 (2012)
Yu QC, Hirst CE, Costa M, Ng ES, Schiesser JV, Gertow K, Stanley EG and Elefanty AG.


book

Interactive association of five candidate polymorphisms in Apelin/APJ pathway with coronary artery disease among Chinese hypertensive patients
PLoS ONE 7 (12), E51123 (2012)
Jin W, Su X, Xu M, Liu Y, Shi J, Lu L and Niu W.


book

Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin
J. Neurochem. 84 (5), 1162-1172 (2003)
Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, Herrity NC, Murdock P and Darker JG.


book

[(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man
Br. J. Pharmacol. 132 (6), 1255-1260 (2001)
Katugampola SD, Maguire JJ, Matthewson SR and Davenport AP.


book

Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues
Biochim. Biophys. Acta 1492 (1), 72-80 (2000)
O'Carroll AM, Selby TL, Palkovits M and Lolait SJ.


book

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
Biochem. Biophys. Res. Commun. 251 (2), 471-476 (1998)
Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H and Fujino M.


book

Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain
Neurosci. Lett. 219 (2), 119-122 (1996)
Matsumoto M, Hidaka K, Akiho H, Tada S, Okada M and Yamaguchi T.


book

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
Gene 136 (1-2), 355-360 (1993)
O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR and Nguyen T.


 
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