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UBR1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol UBR1
Entrez Gene ID 197131
Full Name ubiquitin protein ligase E3 component n-recognin 1
Synonyms JBS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q13

Summary The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

605981

Disorder Html: Johanson-Blizzard syndrome, 243800 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_174916 NP_777576 E3 ubiquitin-protein ligase UBR1



Homo sapiens (human) UBR1 NP_777576.1
Pan troglodytes (chimpanzee) UBR1 XP_510341.3
Macaca mulatta (Rhesus monkey) UBR1 XP_001105721.2
Canis lupus familiaris (dog) UBR1 XP_544645.2
Bos taurus (cattle) UBR1 NP_001192826.1
Mus musculus (house mouse) Ubr1 NP_033487.2
Rattus norvegicus (Norway rat) Ubr1 NP_001171543.1
Gallus gallus (chicken) UBR1 XP_421165.3
Danio rerio (zebrafish) ubr1 XP_002665264.3
Xenopus (Silurana) tropicalis (western clawed frog) ubr1 XP_002941132.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following UBR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19665 NM_174916 Homo sapiens ubiquitin protein ligase E3 component n-recognin 1 (UBR1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 22 $923.30
$1319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19665
Clone ID Related Accession (Same CDS sequence) NM_174916
Accession Version NM_174916.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 5250bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product E3 ubiquitin-protein ligase UBR1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE873236.1, AY061886.1, AK127478.1 and BX648400.1. This sequence is a reference standard in the RefSeqGene project. On Dec 15, 2005 this sequence version replaced gi:28372496. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC113505.1, AY061886.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
ATGGCGGACG AGGAGGCTGG AGGTACTGAG AGGATGGAAA TCAGCGCGGA GTTACCCCAG 
ACCCCTCAGC GTCTGGCATC TTGGTGGGAT CAGCAAGTTG ATTTTTATAC TGCTTTCTTG
CATCATTTGG CACAATTGGT GCCAGAAATT TACTTTGCTG AAATGGACCC AGACTTGGAA
AAGCAGGAGG AAAGTGTACA AATGTCAATA TTCACTCCAC TGGAATGGTA CTTATTTGGA
GAAGATCCAG ATATTTGCTT AGAGAAATTG AAGCACAGTG GAGCATTTCA GCTTTGTGGG
AGGGTTTTCA AAAGTGGAGA GACAACCTAT TCTTGCAGGG ATTGTGCAAT TGATCCAACA
TGTGTACTCT GTATGGACTG CTTCCAGGAC AGTGTTCATA AAAATCATCG TTACAAGATG
CATACTTCTA CTGGAGGAGG GTTCTGTGAC TGTGGAGACA CAGAGGCATG GAAAACTGGC
CCTTTTTGTG TAAATCATGA ACCTGGAAGA GCAGGTACTA TAAAAGAGAA TTCACGCTGT
CCGTTGAATG AAGAGGTAAT TGTCCAAGCC AGGAAAATAT TTCCTTCAGT GATAAAATAT
GTCGTAGAAA TGACTATATG GGAAGAGGAA AAAGAACTGC CTCCTGAACT CCAGATAAGG
GAGAAAAATG AAAGATACTA TTGTGTCCTT TTCAATGATG AACACCATTC ATATGACCAC
GTCATATACA GCCTACAAAG AGCTCTTGAC TGTGAGCTCG CAGAGGCCCA GTTGCATACC
ACTGCCATTG ACAAAGAGGG TCGTCGGGCT GTTAAAGCGG GAGCTTATGC TGCTTGCCAG
GAAGCAAAGG AAGATATAAA GAGTCATTCA GAAAATGTCT CTCAACATCC ACTTCATGTA
GAAGTATTAC ACTCAGAGAT TATGGCTCAT CAGAAATTTG CTTTGCGTCT TGGTTCCTGG
ATGAACAAAA TTATGAGCTA TTCAAGTGAC TTTAGGCAGA TCTTTTGCCA AGCATGCCTT
AGAGAAGAAC CTGACTCGGA GAATCCCTGT CTCATAAGCA GGTTAATGCT TTGGGATGCA
AAGCTTTATA AAGGTGCCCG TAAGATCCTT CATGAATTGA TCTTCAGCAG TTTTTTTATG
GAGATGGAAT ACAAAAAACT CTTTGCTATG GAATTTGTGA AGTATTATAA ACAACTGCAG
AAAGAATATA TCAGTGATGA TCATGACAGA AGTATCTCTA TAACTGCACT TTCAGTTCAG
ATGTTTACTG TTCCTACTCT GGCTCGACAT CTTATTGAAG AGCAGAATGT TATCTCTGTC
ATTACTGAAA CTCTGCTAGA AGTTTTACCT GAGTACTTGG ACAGGAACAA TAAATTCAAC
TTCCAGGGTT ATAGCCAGGA CAAATTGGGA AGAGTATATG CAGTAATATG TGACCTAAAG
TATATCCTGA TCAGCAAACC CACAATATGG ACAGAAAGAT TAAGAATGCA GTTCCTTGAA
GGTTTTCGAT CTTTTTTGAA GATTCTTACC TGTATGCAGG GAATGGAAGA AATCCGAAGA
CAGGTTGGGC AACACATTGA AGTGGATCCT GATTGGGAGG CTGCCATTGC TATACAGATG
CAATTGAAGA ATATTTTACT CATGTTCCAA GAGTGGTGTG CTTGTGATGA AGAACTCTTA
CTTGTGGCTT ATAAAGAATG TCACAAAGCT GTGATGAGGT GCAGTACCAG TTTCATATCT
AGTAGCAAGA CAGTAGTACA ATCGTGTGGA CATAGTTTGG AAACAAAGTC CTACAGAGTA
TCTGAGGATC TTGTAAGCAT ACATCTGCCA CTCTCTAGGA CCCTTGCTGG TCTTCATGTA
CGTTTAAGCA GGCTGGGTGC TGTTTCAAGA CTGCATGAAT TTGTGTCTTT TGAGGACTTT
CAAGTAGAGG TACTAGTGGA ATATCCTTTA CGTTGTCTGG TGTTGGTTGC CCAGGTTGTT
GCTGAGATGT GGCGAAGAAA TGGACTGTCT CTTATTAGCC AGGTGTTTTA TTACCAAGAT
GTTAAGTGCA GAGAAGAAAT GTATGATAAA GATATCATCA TGCTTCAGAT TGGTGCATCT
TTAATGGATC CCAATAAGTT CTTGTTACTG GTACTTCAGA GGTATGAACT TGCCGAGGCT
TTTAACAAGA CCATATCTAC AAAAGACCAG GATTTGATTA AACAATATAA TACACTAATA
GAAGAAATGC TTCAGGTCCT CATCTATATT GTGGGTGAGC GTTATGTACC TGGAGTGGGA
AATGTGACCA AAGAAGAGGT CACAATGAGA GAAATCATTC ACTTGCTTTG CATTGAACCC
ATGCCACACA GTGCCATTGC CAAAAATTTA CCTGAGAATG AAAATAATGA AACTGGCTTA
GAGAATGTCA TAAACAAAGT GGCCACATTT AAGAAACCAG GTGTATCAGG CCATGGAGTT
TATGAACTAA AAGATGAATC ACTGAAAGAC TTCAATATGT ACTTTTATCA TTACTCCAAA
ACCCAGCATA GCAAGGCTGA ACATATGCAG AAGAAAAGGA GAAAACAAGA AAACAAAGAT
GAAGCATTGC CGCCACCACC ACCTCCTGAA TTCTGCCCTG CTTTCAGCAA AGTGATTAAC
CTTCTCAACT GTGATATCAT GATGTACATT CTCAGGACCG TATTTGAGCG GGCAATAGAC
ACAGATTCTA ACTTGTGGAC CGAAGGGATG CTCCAAATGG CTTTTCATAT TCTGGCATTG
GGTTTACTAG AAGAGAAGCA ACAGCTTCAA AAAGCTCCTG AAGAAGAAGT AACATTTGAC
TTTTATCATA AGGCTTCAAG ATTGGGAAGT TCAGCCATGA ATATACAAAT GCTTTTGGAA
AAACTCAAAG GAATTCCCCA GTTAGAAGGC CAGAAGGACA TGATAACGTG GATACTTCAG
ATGTTTGACA CAGTGAAGCG ATTAAGAGAA AAATCTTGTT TAATTGTAGC AACCACATCA
GGATCGGAAT CTATTAAGAA TGATGAGATT ACTCATGATA AAGAAAAAGC AGAACGAAAA
AGAAAAGCTG AAGCTGCTAG GCTACATCGC CAGAAGATCA TGGCTCAGAT GTCTGCCTTA
CAGAAAAACT TCATTGAAAC TCATAAACTC ATGTATGACA ATACATCAGA AATGCCTGGG
AAAGAAGATT CCATTATGGA GGAAGAGAGC ACCCCAGCAG TCAGTGACTA CTCTAGAATT
GCTTTGGGTC CTAAACGGGG TCCATCTGTT ACTGAAAAGG AGGTGCTGAC GTGCATCCTT
TGCCAAGAAG AACAGGAGGT GAAAATAGAA AATAATGCCA TGGTATTATC GGCCTGTGTC
CAGAAATCTA CTGCCTTAAC CCAGCACAGG GGAAAACCCA TAGAACTCTC AGGAGAAGCC
CTAGACCCAC TTTTCATGGA TCCAGACTTG GCATATGGAA CTTATACAGG AAGCTGTGGT
CATGTAATGC ACGCAGTGTG CTGGCAGAAG TATTTTGAAG CTGTACAGCT GAGCTCTCAG
CAGCGCATTC ATGTTGACCT TTTTGACTTG GAAAGTGGAG AATATCTTTG CCCTCTTTGC
AAATCTCTGT GCAATACTGT GATCCCCATT ATTCCTTTGC AACCTCAAAA GATAAACAGT
GAGAATGCAG ATGCTCTTGC TCAACTTTTG ACCCTGGCAC GGTGGATACA GACTGTTCTG
GCCAGAATAT CAGGTTATAA TATAAGACAT GCTAAAGGAG AAAACCCAAT TCCTATTTTC
TTTAATCAAG GAATGGGAGA TTCTACTTTG GAGTTCCATT CCATCCTGAG TTTTGGCGTT
GAGTCTTCGA TTAAATATTC AAATAGCATC AAGGAAATGG TTATTCTCTT TGCCACAACA
ATTTATAGAA TTGGATTGAA AGTGCCACCT GATGAAAGGG ATCCTCGAGT CCCCATGCTG
ACCTGGAGCA CCTGCGCTTT CACTATCCAG GCAATTGAAA ATCTATTGGG AGATGAAGGA
AAACCTCTGT TTGGAGCACT TCAAAATAGG CAGCATAATG GTCTGAAAGC ATTAATGCAG
TTTGCAGTTG CACAGAGGAT TACCTGTCCT CAGGTCCTGA TACAGAAACA TCTGGTTCGT
CTTCTATCAG TTGTTCTTCC TAACATAAAA TCAGAAGATA CACCATGCCT TCTGTCTATA
GATCTGTTTC ATGTTTTGGT GGGTGCTGTG TTAGCATTCC CATCCTTGTA TTGGGATGAC
CCTGTTGATC TGCAGCCTTC TTCAGTTAGT TCTTCCTATA ACCACCTTTA TCTCTTCCAT
TTGATCACCA TGGCACACAT GCTTCAGATA CTACTTACAG TAGACACAGG CCTACCCCTT
GCTCAGGTTC AAGAAGACAG TGAAGAGGCT CATTCCGCAT CTTCTTTCTT TGCAGAAATT
TCTCAATATA CAAGTGGCTC CATTGGGTGT GATATTCCTG GCTGGTATTT GTGGGTCTCA
CTGAAGAATG GCATCACCCC TTATCTTCGC TGTGCTGCAT TGTTTTTCCA CTATTTACTT
GGGGTAACTC CGCCTGAGGA ACTGCATACC AATTCTGCAG AAGGAGAGTA CAGTGCACTC
TGTAGCTATC TATCTTTACC TACAAATTTG TTCCTGCTCT TCCAGGAATA TTGGGATACT
GTAAGGCCCT TGCTCCAGAG GTGGTGTGCA GATCCTGCCT TACTAAACTG TTTGAAGCAA
AAAAACACCG TGGTCAGGTA CCCTAGAAAA AGAAATAGTT TGATAGAGCT TCCTGATGAC
TATAGCTGCC TCCTGAATCA AGCTTCTCAT TTCAGGTGCC CACGGTCTGC AGATGATGAG
CGAAAGCATC CTGTCCTCTG CCTTTTCTGT GGGGCTATAC TATGTTCTCA GAACATTTGC
TGCCAGGAAA TTGTGAACGG GGAAGAGGTT GGAGCTTGCA TTTTTCACGC ACTTCACTGT
GGAGCCGGAG TCTGCATTTT CCTAAAAATC AGAGAATGCC GAGTGGTCCT GGTTGAAGGT
AAAGCCAGAG GCTGTGCCTA TCCAGCTCCT TACTTGGATG AATATGGAGA AACAGACCCT
GGCCTGAAGA GGGGCAACCC CCTTCATTTA TCTCGTGAGC GGTATCGGAA GCTCCATTTG
GTCTGGCAAC AACACTGCAT TATAGAAGAG ATTGCTAGGA GCCAAGAGAC TAATCAGATG
TTATTTGGAT TCAACTGGCA GTTACTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_777576.1
CDS67..5316
Misc Feature(1)70..72(+)
Misc Feature(2)127..129(+)
Misc Feature(3)355..567(+)
Misc Feature(4)724..972(+)
Misc Feature(5)3601..3603(+)
Misc Feature(6)3601..3603(+)
Exon (1)1..147
Gene:UBR1
Gene Synonym:
Exon (2)148..404
Gene:UBR1
Gene Synonym:
Exon (3)405..483
Gene:UBR1
Gene Synonym:
Exon (4)484..594
Gene:UBR1
Gene Synonym:
Exon (5)595..725
Gene:UBR1
Gene Synonym:
Exon (6)726..864
Gene:UBR1
Gene Synonym:
Exon (7)865..927
Gene:UBR1
Gene Synonym:
Exon (8)928..1051
Gene:UBR1
Gene Synonym:
Exon (9)1052..1159
Gene:UBR1
Gene Synonym:
Exon (10)1160..1248
Gene:UBR1
Gene Synonym:
Exon (11)1249..1347
Gene:UBR1
Gene Synonym:
Exon (12)1348..1505
Gene:UBR1
Gene Synonym:
Exon (13)1506..1605
Gene:UBR1
Gene Synonym:
Exon (14)1606..1734
Gene:UBR1
Gene Synonym:
Exon (15)1735..1915
Gene:UBR1
Gene Synonym:
Exon (16)1916..1977
Gene:UBR1
Gene Synonym:
Exon (17)1978..2088
Gene:UBR1
Gene Synonym:
Exon (18)2089..2154
Gene:UBR1
Gene Synonym:
Exon (19)2155..2256
Gene:UBR1
Gene Synonym:
Exon (20)2257..2320
Gene:UBR1
Gene Synonym:
Exon (21)2321..2445
Gene:UBR1
Gene Synonym:
Exon (22)2446..2498
Gene:UBR1
Gene Synonym:
Exon (23)2499..2601
Gene:UBR1
Gene Synonym:
Exon (24)2602..2650
Gene:UBR1
Gene Synonym:
Exon (25)2651..2805
Gene:UBR1
Gene Synonym:
Exon (26)2806..2905
Gene:UBR1
Gene Synonym:
Exon (27)2906..3006
Gene:UBR1
Gene Synonym:
Exon (28)3007..3093
Gene:UBR1
Gene Synonym:
Exon (29)3094..3275
Gene:UBR1
Gene Synonym:
Exon (30)3276..3481
Gene:UBR1
Gene Synonym:
Exon (31)3482..3575
Gene:UBR1
Gene Synonym:
Exon (32)3576..3725
Gene:UBR1
Gene Synonym:
Exon (33)3726..3823
Gene:UBR1
Gene Synonym:
Exon (34)3824..3914
Gene:UBR1
Gene Synonym:
Exon (35)3915..4063
Gene:UBR1
Gene Synonym:
Exon (36)4064..4119
Gene:UBR1
Gene Synonym:
Exon (37)4120..4216
Gene:UBR1
Gene Synonym:
Exon (38)4217..4284
Gene:UBR1
Gene Synonym:
Exon (39)4285..4435
Gene:UBR1
Gene Synonym:
Exon (40)4436..4523
Gene:UBR1
Gene Synonym:
Exon (41)4524..4657
Gene:UBR1
Gene Synonym:
Exon (42)4658..4766
Gene:UBR1
Gene Synonym:
Exon (43)4767..4823
Gene:UBR1
Gene Synonym:
Exon (44)4824..4901
Gene:UBR1
Gene Synonym:
Exon (45)4902..5072
Gene:UBR1
Gene Synonym:
Exon (46)5073..5174
Gene:UBR1
Gene Synonym:
Exon (47)5175..7748
Gene:UBR1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_174916
Organism Homo sapiens (human)
Definition Homo sapiens ubiquitin protein ligase E3 component n-recognin 1 (UBR1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_174916

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
ATGGCGGACG AGGAGGCTGG AGGTACTGAG AGGATGGAAA TCAGCGCGGA GTTACCCCAG 
ACCCCTCAGC GTCTGGCATC TTGGTGGGAT CAGCAAGTTG ATTTTTATAC TGCTTTCTTG
CATCATTTGG CACAATTGGT GCCAGAAATT TACTTTGCTG AAATGGACCC AGACTTGGAA
AAGCAGGAGG AAAGTGTACA AATGTCAATA TTCACTCCAC TGGAATGGTA CTTATTTGGA
GAAGATCCAG ATATTTGCTT AGAGAAATTG AAGCACAGTG GAGCATTTCA GCTTTGTGGG
AGGGTTTTCA AAAGTGGAGA GACAACCTAT TCTTGCAGGG ATTGTGCAAT TGATCCAACA
TGTGTACTCT GTATGGACTG CTTCCAGGAC AGTGTTCATA AAAATCATCG TTACAAGATG
CATACTTCTA CTGGAGGAGG GTTCTGTGAC TGTGGAGACA CAGAGGCATG GAAAACTGGC
CCTTTTTGTG TAAATCATGA ACCTGGAAGA GCAGGTACTA TAAAAGAGAA TTCACGCTGT
CCGTTGAATG AAGAGGTAAT TGTCCAAGCC AGGAAAATAT TTCCTTCAGT GATAAAATAT
GTCGTAGAAA TGACTATATG GGAAGAGGAA AAAGAACTGC CTCCTGAACT CCAGATAAGG
GAGAAAAATG AAAGATACTA TTGTGTCCTT TTCAATGATG AACACCATTC ATATGACCAC
GTCATATACA GCCTACAAAG AGCTCTTGAC TGTGAGCTCG CAGAGGCCCA GTTGCATACC
ACTGCCATTG ACAAAGAGGG TCGTCGGGCT GTTAAAGCGG GAGCTTATGC TGCTTGCCAG
GAAGCAAAGG AAGATATAAA GAGTCATTCA GAAAATGTCT CTCAACATCC ACTTCATGTA
GAAGTATTAC ACTCAGAGAT TATGGCTCAT CAGAAATTTG CTTTGCGTCT TGGTTCCTGG
ATGAACAAAA TTATGAGCTA TTCAAGTGAC TTTAGGCAGA TCTTTTGCCA AGCATGCCTT
AGAGAAGAAC CTGACTCGGA GAATCCCTGT CTCATAAGCA GGTTAATGCT TTGGGATGCA
AAGCTTTATA AAGGTGCCCG TAAGATCCTT CATGAATTGA TCTTCAGCAG TTTTTTTATG
GAGATGGAAT ACAAAAAACT CTTTGCTATG GAATTTGTGA AGTATTATAA ACAACTGCAG
AAAGAATATA TCAGTGATGA TCATGACAGA AGTATCTCTA TAACTGCACT TTCAGTTCAG
ATGTTTACTG TTCCTACTCT GGCTCGACAT CTTATTGAAG AGCAGAATGT TATCTCTGTC
ATTACTGAAA CTCTGCTAGA AGTTTTACCT GAGTACTTGG ACAGGAACAA TAAATTCAAC
TTCCAGGGTT ATAGCCAGGA CAAATTGGGA AGAGTATATG CAGTAATATG TGACCTAAAG
TATATCCTGA TCAGCAAACC CACAATATGG ACAGAAAGAT TAAGAATGCA GTTCCTTGAA
GGTTTTCGAT CTTTTTTGAA GATTCTTACC TGTATGCAGG GAATGGAAGA AATCCGAAGA
CAGGTTGGGC AACACATTGA AGTGGATCCT GATTGGGAGG CTGCCATTGC TATACAGATG
CAATTGAAGA ATATTTTACT CATGTTCCAA GAGTGGTGTG CTTGTGATGA AGAACTCTTA
CTTGTGGCTT ATAAAGAATG TCACAAAGCT GTGATGAGGT GCAGTACCAG TTTCATATCT
AGTAGCAAGA CAGTAGTACA ATCGTGTGGA CATAGTTTGG AAACAAAGTC CTACAGAGTA
TCTGAGGATC TTGTAAGCAT ACATCTGCCA CTCTCTAGGA CCCTTGCTGG TCTTCATGTA
CGTTTAAGCA GGCTGGGTGC TGTTTCAAGA CTGCATGAAT TTGTGTCTTT TGAGGACTTT
CAAGTAGAGG TACTAGTGGA ATATCCTTTA CGTTGTCTGG TGTTGGTTGC CCAGGTTGTT
GCTGAGATGT GGCGAAGAAA TGGACTGTCT CTTATTAGCC AGGTGTTTTA TTACCAAGAT
GTTAAGTGCA GAGAAGAAAT GTATGATAAA GATATCATCA TGCTTCAGAT TGGTGCATCT
TTAATGGATC CCAATAAGTT CTTGTTACTG GTACTTCAGA GGTATGAACT TGCCGAGGCT
TTTAACAAGA CCATATCTAC AAAAGACCAG GATTTGATTA AACAATATAA TACACTAATA
GAAGAAATGC TTCAGGTCCT CATCTATATT GTGGGTGAGC GTTATGTACC TGGAGTGGGA
AATGTGACCA AAGAAGAGGT CACAATGAGA GAAATCATTC ACTTGCTTTG CATTGAACCC
ATGCCACACA GTGCCATTGC CAAAAATTTA CCTGAGAATG AAAATAATGA AACTGGCTTA
GAGAATGTCA TAAACAAAGT GGCCACATTT AAGAAACCAG GTGTATCAGG CCATGGAGTT
TATGAACTAA AAGATGAATC ACTGAAAGAC TTCAATATGT ACTTTTATCA TTACTCCAAA
ACCCAGCATA GCAAGGCTGA ACATATGCAG AAGAAAAGGA GAAAACAAGA AAACAAAGAT
GAAGCATTGC CGCCACCACC ACCTCCTGAA TTCTGCCCTG CTTTCAGCAA AGTGATTAAC
CTTCTCAACT GTGATATCAT GATGTACATT CTCAGGACCG TATTTGAGCG GGCAATAGAC
ACAGATTCTA ACTTGTGGAC CGAAGGGATG CTCCAAATGG CTTTTCATAT TCTGGCATTG
GGTTTACTAG AAGAGAAGCA ACAGCTTCAA AAAGCTCCTG AAGAAGAAGT AACATTTGAC
TTTTATCATA AGGCTTCAAG ATTGGGAAGT TCAGCCATGA ATATACAAAT GCTTTTGGAA
AAACTCAAAG GAATTCCCCA GTTAGAAGGC CAGAAGGACA TGATAACGTG GATACTTCAG
ATGTTTGACA CAGTGAAGCG ATTAAGAGAA AAATCTTGTT TAATTGTAGC AACCACATCA
GGATCGGAAT CTATTAAGAA TGATGAGATT ACTCATGATA AAGAAAAAGC AGAACGAAAA
AGAAAAGCTG AAGCTGCTAG GCTACATCGC CAGAAGATCA TGGCTCAGAT GTCTGCCTTA
CAGAAAAACT TCATTGAAAC TCATAAACTC ATGTATGACA ATACATCAGA AATGCCTGGG
AAAGAAGATT CCATTATGGA GGAAGAGAGC ACCCCAGCAG TCAGTGACTA CTCTAGAATT
GCTTTGGGTC CTAAACGGGG TCCATCTGTT ACTGAAAAGG AGGTGCTGAC GTGCATCCTT
TGCCAAGAAG AACAGGAGGT GAAAATAGAA AATAATGCCA TGGTATTATC GGCCTGTGTC
CAGAAATCTA CTGCCTTAAC CCAGCACAGG GGAAAACCCA TAGAACTCTC AGGAGAAGCC
CTAGACCCAC TTTTCATGGA TCCAGACTTG GCATATGGAA CTTATACAGG AAGCTGTGGT
CATGTAATGC ACGCAGTGTG CTGGCAGAAG TATTTTGAAG CTGTACAGCT GAGCTCTCAG
CAGCGCATTC ATGTTGACCT TTTTGACTTG GAAAGTGGAG AATATCTTTG CCCTCTTTGC
AAATCTCTGT GCAATACTGT GATCCCCATT ATTCCTTTGC AACCTCAAAA GATAAACAGT
GAGAATGCAG ATGCTCTTGC TCAACTTTTG ACCCTGGCAC GGTGGATACA GACTGTTCTG
GCCAGAATAT CAGGTTATAA TATAAGACAT GCTAAAGGAG AAAACCCAAT TCCTATTTTC
TTTAATCAAG GAATGGGAGA TTCTACTTTG GAGTTCCATT CCATCCTGAG TTTTGGCGTT
GAGTCTTCGA TTAAATATTC AAATAGCATC AAGGAAATGG TTATTCTCTT TGCCACAACA
ATTTATAGAA TTGGATTGAA AGTGCCACCT GATGAAAGGG ATCCTCGAGT CCCCATGCTG
ACCTGGAGCA CCTGCGCTTT CACTATCCAG GCAATTGAAA ATCTATTGGG AGATGAAGGA
AAACCTCTGT TTGGAGCACT TCAAAATAGG CAGCATAATG GTCTGAAAGC ATTAATGCAG
TTTGCAGTTG CACAGAGGAT TACCTGTCCT CAGGTCCTGA TACAGAAACA TCTGGTTCGT
CTTCTATCAG TTGTTCTTCC TAACATAAAA TCAGAAGATA CACCATGCCT TCTGTCTATA
GATCTGTTTC ATGTTTTGGT GGGTGCTGTG TTAGCATTCC CATCCTTGTA TTGGGATGAC
CCTGTTGATC TGCAGCCTTC TTCAGTTAGT TCTTCCTATA ACCACCTTTA TCTCTTCCAT
TTGATCACCA TGGCACACAT GCTTCAGATA CTACTTACAG TAGACACAGG CCTACCCCTT
GCTCAGGTTC AAGAAGACAG TGAAGAGGCT CATTCCGCAT CTTCTTTCTT TGCAGAAATT
TCTCAATATA CAAGTGGCTC CATTGGGTGT GATATTCCTG GCTGGTATTT GTGGGTCTCA
CTGAAGAATG GCATCACCCC TTATCTTCGC TGTGCTGCAT TGTTTTTCCA CTATTTACTT
GGGGTAACTC CGCCTGAGGA ACTGCATACC AATTCTGCAG AAGGAGAGTA CAGTGCACTC
TGTAGCTATC TATCTTTACC TACAAATTTG TTCCTGCTCT TCCAGGAATA TTGGGATACT
GTAAGGCCCT TGCTCCAGAG GTGGTGTGCA GATCCTGCCT TACTAAACTG TTTGAAGCAA
AAAAACACCG TGGTCAGGTA CCCTAGAAAA AGAAATAGTT TGATAGAGCT TCCTGATGAC
TATAGCTGCC TCCTGAATCA AGCTTCTCAT TTCAGGTGCC CACGGTCTGC AGATGATGAG
CGAAAGCATC CTGTCCTCTG CCTTTTCTGT GGGGCTATAC TATGTTCTCA GAACATTTGC
TGCCAGGAAA TTGTGAACGG GGAAGAGGTT GGAGCTTGCA TTTTTCACGC ACTTCACTGT
GGAGCCGGAG TCTGCATTTT CCTAAAAATC AGAGAATGCC GAGTGGTCCT GGTTGAAGGT
AAAGCCAGAG GCTGTGCCTA TCCAGCTCCT TACTTGGATG AATATGGAGA AACAGACCCT
GGCCTGAAGA GGGGCAACCC CCTTCATTTA TCTCGTGAGC GGTATCGGAA GCTCCATTTG
GTCTGGCAAC AACACTGCAT TATAGAAGAG ATTGCTAGGA GCCAAGAGAC TAATCAGATG
TTATTTGGAT TCAACTGGCA GTTACTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Recurrent Johanson-Blizzard syndrome in a triplet pregnancy complicated by urethral obstruction sequence: a clinical, molecular, and immunohistochemical approach
Pediatr. Dev. Pathol. 15 (1), 50-57 (2012)
Schoner K, Fritz B, Huelskamp G, Louwen F, Zenker M, Moll R and Rehder H.


book

Novel UBR1 gene mutation in a patient with typical phenotype of Johanson-Blizzard syndrome
Eur. J. Pediatr. 170 (2), 233-235 (2011)
Fallahi GH, Sabbaghian M, Khalili M, Parvaneh N, Zenker M and Rezaei N.


book

Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome
PLoS ONE 6 (9), E24925 (2011)
Hwang CS, Sukalo M, Batygin O, Addor MC, Brunner H, Aytes AP, Mayerle J, Song HK, Varshavsky A and Zenker M.


book

Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1
J. Biol. Chem. 285 (53), 41300-41309 (2010)
Kumar B, Lecompte KG, Klein JM and Haas AL.


book

Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing
World J. Gastroenterol. 14 (44), 6863-6866 (2008)
Alkhouri N, Kaplan B, Kay M, Shealy A, Crowe C, Bauhuber S and Zenker M.


book

Large-scale characterization of HeLa cell nuclear phosphoproteins
Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC and Gygi SP.


book

Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1
Am. J. Hum. Genet. 71 (6), 1467-1474 (2002)
Dgany O, Avidan N, Delaunay J, Krasnov T, Shalmon L, Shalev H, Eidelitz-Markus T, Kapelushnik J, Cattan D, Pariente A, Tulliez M, Cretien A, Schischmanoff PO, Iolascon A, Fibach E, Koren A, Rossler J, Le Merrer M, Yaniv I, Zaizov R, Ben-Asher E, Olender T, Lancet D, Beckmann JS and Tamary H.


book

The mouse and human genes encoding the recognition component of the N-end rule pathway
Proc. Natl. Acad. Sci. U.S.A. 95 (14), 7898-7903 (1998)
Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA and Varshavsky A.


book

The N-end rule: functions, mysteries, uses
Proc. Natl. Acad. Sci. U.S.A. 93 (22), 12142-12149 (1996)
Varshavsky A.


book

A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene
Hum. Mol. Genet. 4 (4), 717-725 (1995)
Chiannilkulchai N, Pasturaud P, Richard I, Auffray C and Beckmann JS.


 
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