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TMEM192 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol TMEM192
Entrez Gene ID 201931
Full Name transmembrane protein 192
General protein information
Preferred Names

transmembrane protein 192

Names

transmembrane protein 192
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

4

4q32.3

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_011531717.2 XP_011530019.1 transmembrane protein 192 isoform X1
NM_001100389.1 NP_001093859.1 transmembrane protein 192
XM_011531717.3 XP_011530019.1 transmembrane protein 192 isoform X1
XM_011531718.2 XP_011530020.1 transmembrane protein 192 isoform X2
NM_001100389.2 NP_001093859.1 transmembrane protein 192
XM_011531718.3 XP_011530020.1 transmembrane protein 192 isoform X2

Pathways from BioSystems


Homologies


Homo sapiens (human) TMEM192 NP_001093859.1
Bos taurus (cattle) TMEM192 XP_002694352.2
Mus musculus (house mouse) Tmem192 NP_082703.1
Danio rerio (zebrafish) tmem192 NP_001095863.1
Xenopus tropicalis (tropical clawed frog) tmem192 NP_001016373.1
Pan troglodytes (chimpanzee) TMEM192 XP_526719.3
LOC708459 XP_001096943.1
Rattus norvegicus (Norway rat) Tmem192 NP_001014163.1
Canis lupus familiaris (dog) TMEM192 XP_005629511.1

Gene Ontology


Bibliography

Related articles in PubMed

Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192.
Shyu RY, Wang CH, Wu CC, Chen ML, Lee MC, Wang LK, Jiang SY, Tsai FM
Molecules and cells39(12)877-887(2016 Dec)

Lysosomal membrane protein TMEM192 deficiency triggers crosstalk between autophagy and apoptosis in HepG2 hepatoma cells.
Liu Z, Lv YJ, Song YP, Li XH, Du YN, Wang CH, Hu LK
Oncology reports28(3)985-91(2012 Sep)

Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers.
Behnke J, Eskelinen EL, Saftig P, Schr?der B
The Biochemical journal434(2)219-31(2011 Mar)

Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.
Schr?der B, Wrocklage C, Hasilik A, Saftig P
Biological chemistry391(6)695-704(2010 Jun)

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O
Nature377(6547 Suppl)3-174(1995 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors found that transmembrane protein 192 (TMEM192) interacted with TIG1. Authors also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins.
Title: Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192.

TMEM192 deficiency can induce autophagy in tumor cells, and can further activate apoptosis by the mitochondrial pathway through autophagy.
Title: Lysosomal membrane protein TMEM192 deficiency triggers crosstalk between autophagy and apoptosis in HepG2 hepatoma cells.

TMEM192 was found to be strongly expressed in human kidney, liver, lung and pancreas tissue. The widespread tissue distribution could suggest an important role of TMEM192 for lysosomal function.
Title: Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.

The following TMEM192 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM192 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu06070 NM_001100389.2
Latest version!		 Homo sapiens transmembrane protein 192 (TMEM192), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
OHu77769 XM_011531717.3
Latest version!		 Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu77770 XM_011531718.3
Latest version!		 Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
View Old Accession Versions >>
OHu77769 XM_011531717.2 Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu06070 NM_001100389.1 Homo sapiens transmembrane protein 192 (TMEM192), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
OHu77770 XM_011531718.2 Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu06070
Clone ID Related Accession (Same CDS sequence) NM_001100389.1 , NM_001100389.2
Accession Version NM_001100389.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-01
Organism Homo sapiens(human)
Product transmembrane protein 192
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA346826.1, BC036301.1, AC108465.3 and AW137472.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.228340.1, BX538029.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGAAC TATTTCAAGC CTAGAAGAAA TTGTTGAAAA GCAAGGAGAC 
ACCATTGAAT ACCTGAAGCG ACACAATGCG CTGCTGAGTA AGCGATTGTT GGCTCTCACT 
TCCTCAGACC TGGGCTGTCA GCCAAGTAGA ACGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001093859.1
CDS100..915
Translation

Target ORF information:

RefSeq Version NM_001100389.1
Organism Homo sapiens(human)
Definition Homo sapiens transmembrane protein 192 (TMEM192), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001100389.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGAAC TATTTCAAGC CTAGAAGAAA TTGTTGAAAA GCAAGGAGAC 
ACCATTGAAT ACCTGAAGCG ACACAATGCG CTGCTGAGTA AGCGATTGTT GGCTCTCACT 
TCCTCAGACC TGGGCTGTCA GCCAAGTAGA ACGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu06070
Clone ID Related Accession (Same CDS sequence) NM_001100389.1 , NM_001100389.2
Accession Version NM_001100389.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-05-03
Organism Homo sapiens(human)
Product transmembrane protein 192
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA346826.1, BC036301.1, AC108465.3 and AW137472.1. On Nov 22, 2018 this sequence version replaced NM_001100389.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.187766.1, SRR1803617.228340.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306480.11/ ENSP00000305069.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGAAC TATTTCAAGC CTAGAAGAAA TTGTTGAAAA GCAAGGAGAC 
ACCATTGAAT ACCTGAAGCG ACACAATGCG CTGCTGAGTA AGCGATTGTT GGCTCTCACT 
TCCTCAGACC TGGGCTGTCA GCCAAGTAGA ACGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001093859.1
CDS88..903
Translation

Target ORF information:

RefSeq Version NM_001100389.2
Organism Homo sapiens(human)
Definition Homo sapiens transmembrane protein 192 (TMEM192), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001100389.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGAAC TATTTCAAGC CTAGAAGAAA TTGTTGAAAA GCAAGGAGAC 
ACCATTGAAT ACCTGAAGCG ACACAATGCG CTGCTGAGTA AGCGATTGTT GGCTCTCACT 
TCCTCAGACC TGGGCTGTCA GCCAAGTAGA ACGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu77769
Clone ID Related Accession (Same CDS sequence) XM_011531717.2 , XM_011531717.3
Accession Version XM_011531717.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product transmembrane protein 192 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531717.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530019.1
CDS141..821
Translation

Target ORF information:

RefSeq Version XM_011531717.2
Organism Homo sapiens(human)
Definition Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011531717.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu77769
Clone ID Related Accession (Same CDS sequence) XM_011531717.2 , XM_011531717.3
Accession Version XM_011531717.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product transmembrane protein 192 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011531717.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530019.1
CDS141..821
Translation

Target ORF information:

RefSeq Version XM_011531717.3
Organism Homo sapiens(human)
Definition Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011531717.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGG CAACACAGTG CTTCTCCTCA TACTGTGCAT GCAGCACTCC 
TTCCCAGAGC CTGGCAGATT GTATCTTGAC CTCATTCTGG CCATCTTGGC ACTGGAACTC 
ATCTGTTCCC TGATATGTCT CCTCATTTAC ACAGTGAAAA TCCGGAGATT TAATAAAGCT 
AAACCAGAGC CTGATATACT TGAAGAAGAA AAAATCTATG CTTACCCCAG CAATATTACC 
TCGGAGACTG GATTCAGGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu77770
Clone ID Related Accession (Same CDS sequence) XM_011531718.2 , XM_011531718.3
Accession Version XM_011531718.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product transmembrane protein 192 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531718.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGT GAAAATCCGG AGATTTAATA AAGCTAAACC AGAGCCTGAT 
ATACTTGAAG AAGAAAAAAT CTATGCTTAC CCCAGCAATA TTACCTCGGA GACTGGATTC 
AGAACTATTT CAAGCCTAGA AGAAATTGTT GAAAAGCAAG GAGACACCAT TGAATACCTG 
AAGCGACACA ATGCGCTGCT GAGTAAGCGA TTGTTGGCTC TCACTTCCTC AGACCTGGGC 
TGTCAGCCAA GTAGAACGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530020.1
CDS110..790
Translation

Target ORF information:

RefSeq Version XM_011531718.2
Organism Homo sapiens(human)
Definition Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011531718.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGT GAAAATCCGG AGATTTAATA AAGCTAAACC AGAGCCTGAT 
ATACTTGAAG AAGAAAAAAT CTATGCTTAC CCCAGCAATA TTACCTCGGA GACTGGATTC 
AGAACTATTT CAAGCCTAGA AGAAATTGTT GAAAAGCAAG GAGACACCAT TGAATACCTG 
AAGCGACACA ATGCGCTGCT GAGTAAGCGA TTGTTGGCTC TCACTTCCTC AGACCTGGGC 
TGTCAGCCAA GTAGAACGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu77770
Clone ID Related Accession (Same CDS sequence) XM_011531718.2 , XM_011531718.3
Accession Version XM_011531718.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product transmembrane protein 192 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011531718.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGT GAAAATCCGG AGATTTAATA AAGCTAAACC AGAGCCTGAT 
ATACTTGAAG AAGAAAAAAT CTATGCTTAC CCCAGCAATA TTACCTCGGA GACTGGATTC 
AGAACTATTT CAAGCCTAGA AGAAATTGTT GAAAAGCAAG GAGACACCAT TGAATACCTG 
AAGCGACACA ATGCGCTGCT GAGTAAGCGA TTGTTGGCTC TCACTTCCTC AGACCTGGGC 
TGTCAGCCAA GTAGAACGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530020.1
CDS110..790
Translation

Target ORF information:

RefSeq Version XM_011531718.3
Organism Homo sapiens(human)
Definition Homo sapiens transmembrane protein 192 (TMEM192), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011531718.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCGG GGGGCAGGAT GGAGGACGGT TCCTTGGATA TCACCCAGAG TATTGAAGAC 
GACCCACTTC TGGATGCCCA GCTTCTCCCA CACCACTCAT TACAAGCTCA CTTTAGACCC 
CGATTCCATC CTCTTCCTAC AGTCATCATA GTGAATCTTC TGTGGTTTAT TCATCTCGTG 
TTTGTTGTTT TAGCATTTTT AACAGGTGTG CTTTGTTCTT ATCCTAATCC AAATGAGGAC 
AAGTGCCCAG GAAATTACAC AAACCCATTG AAAGTTCAGA CGGTTATAAT CCTTGGGAAA 
GTTATTTTGT GGATTCTCCA TTTACTCCTT GAATGCTACA TCCAGTATCA CCACAGCAAA 
ATCAGAAACC GAGGCTATAA CTTGATCTAC CGATCAACAA GGCATCTCAA GAGACTTGCG 
TTGATGATAC AGTCCTCTGT GAAAATCCGG AGATTTAATA AAGCTAAACC AGAGCCTGAT 
ATACTTGAAG AAGAAAAAAT CTATGCTTAC CCCAGCAATA TTACCTCGGA GACTGGATTC 
AGAACTATTT CAAGCCTAGA AGAAATTGTT GAAAAGCAAG GAGACACCAT TGAATACCTG 
AAGCGACACA ATGCGCTGCT GAGTAAGCGA TTGTTGGCTC TCACTTCCTC AGACCTGGGC 
TGTCAGCCAA GTAGAACGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192.
Molecules and cells39(12)877-887(2016 Dec)
Shyu RY,Wang CH,Wu CC,Chen ML,Lee MC,Wang LK,Jiang SY,Tsai FM


book

Lysosomal membrane protein TMEM192 deficiency triggers crosstalk between autophagy and apoptosis in HepG2 hepatoma cells.
Oncology reports28(3)985-91(2012 Sep)
Liu Z,Lv YJ,Song YP,Li XH,Du YN,Wang CH,Hu LK


book

Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers.
The Biochemical journal434(2)219-31(2011 Mar)
Behnke J,Eskelinen EL,Saftig P,Schr?der B


book

Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.
Biological chemistry391(6)695-704(2010 Jun)
Schr?der B,Wrocklage C,Hasilik A,Saftig P


book

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Nature377(6547 Suppl)3-174(1995 Sep)
Adams MD,Kerlavage AR,Fleischmann RD,Fuldner RA,Bult CJ,Lee NH,Kirkness EF,Weinstock KG,Gocayne JD,White O