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FANCG cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FANCG
Entrez Gene ID 2189
Full Name Fanconi anemia complementation group G
Synonyms FAG,XRCC9
General protein information
Preferred Names

Fanconi anemia complementation group G

Names

Fanconi anemia group G protein
DNA repair protein XRCC9
X-ray repair complementing defective repair in Chinese hamster cells 9
X-ray repair, complementing defective, in Chinese hamster, 9
truncated Fanconi anemia group G protein

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

9

9p13.3

Summary The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008].
Disorder MIM:

602956

Disorder Html: Fanconi anemia, complementation group G (3)

mRNA and Protein(s)

mRNA Protein Name
NM_004629.1 NP_004620.1 Fanconi anemia group G protein



Pan troglodytes (chimpanzee) FANCG XP_001165190.1
Mus musculus (house mouse) Fancg NP_444311.1
Rattus norvegicus (Norway rat) Fancg XP_006238187.1
Bos taurus (cattle) FANCG NP_001095757.1
Homo sapiens (human) FANCG NP_004620.1
Xenopus tropicalis (tropical clawed frog) fancg NP_001120193.1
Canis lupus familiaris (dog) FANCG XP_854703.1
Danio rerio (zebrafish) fancg NP_991202.1
Gallus gallus (chicken) FANCG NP_989709.1
Macaca mulatta (rhesus monkey) FANCG XP_001092322.1


Related articles in PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Founder haplotype analysis of Fanconi anemia in the Korean population finds common ancestral haplotypes for a FANCG variant.
Park J, Kim M, Jang W, Chae H, Kim Y, Chung NG, Lee JW, Cho B, Jeong DC, Park IY, Park MS
Annals of human genetics79(3)153-61(2015 May)

K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.
Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H, Shao G
Oncogene34(22)2867-78(2015 May)

Hematological consequences of a FANCG founder mutation in Black South African patients with Fanconi anemia.
Feben C, Kromberg J, Wainwright R, Stones D, Poole J, Haw T, Krause A
Blood cells, molecules & diseases54(3)270-4(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a systems biology approach for elucidating the therapeutic potential of curcumin against FA and leukemia is investigated by analyzing the computational molecular interactions of curcumin ligand with FANC G of FA and seven other key disease targets of leukemia
Title: A systems biology approach for elucidating the interaction of curcumin with Fanconi anemia FANC G protein and the key disease targets of leukemia.

studied the impact of mutations on the function and structure of FANCG
Title: Characterization of two novel FANCG mutations in Indian Fanconi anemia patients.

founder haplotype analysis of FANCG for the Korean Fanconi anemia population
Title: Founder haplotype analysis of Fanconi anemia in the Korean population finds common ancestral haplotypes for a FANCG variant.

A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex.
Title: K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.

Patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with Fanconi anemia of heterogeneous genotype.
Title: Hematological consequences of a FANCG founder mutation in Black South African patients with Fanconi anemia.

The following FANCG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FANCG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25922 NM_004629.1
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Homo sapiens Fanconi anemia complementation group G (FANCG), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25922
Clone ID Related Accession (Same CDS sequence) NM_004629.1
Accession Version NM_004629.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1869bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-25
Organism Homo sapiens(Human)
Product Fanconi anemia group G protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ007669.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ007669.1, SRR1660805.59875.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGTCCCGCC AGACCACCTC TGTGGGCTCC AGCTGCCTGG ACCTGTGGAG GGAAAAGAAT 
GACCGGCTCG TTCGACAGGC CAAGGTGGCT CAGAACTCCG GTCTGACTCT GAGGCGACAG
CAGTTGGCTC AGGATGCACT GGAAGGGCTC AGAGGGCTCC TCCATAGTCT GCAAGGGCTC
CCTGCAGCTG TTCCTGTTCT TCCCTTGGAG CTGACTGTCA CCTGCAACTT CATTATCCTG
AGGGCAAGCT TGGCCCAGGG TTTCACAGAG GATCAGGCCC AGGATATCCA GCGGAGCCTA
GAGAGAGTGC TGGAGACACA GGAGCAGCAG GGGCCCAGGT TGGAACAGGG GCTCAGGGAG
CTGTGGGACT CTGTCCTTCG TGCTTCCTGC CTTCTGCCGG AGCTGCTGTC TGCCCTGCAC
CGCCTGGTTG GCCTGCAGGC TGCCCTCTGG TTGAGTGCTG ACCGTCTTGG GGACCTGGCC
TTGTTACTAG AGACCCTGAA TGGCAGCCAG AGTGGAGCCT CTAAGGATCT GCTGTTACTT
CTGAAAACTT GGAGTCCCCC AGCTGAGGAA TTAGATGCTC CATTGACCCT GCAGGATGCC
CAGGGATTGA AGGATGTCCT CCTGACAGCA TTTGCCTACC GCCAAGGTCT CCAGGAGCTG
ATCACAGGGA ACCCAGACAA GGCACTAAGC AGCCTTCATG AAGCGGCCTC AGGCCTGTGT
CCACGGCCTG TGTTGGTCCA GGTGTACACA GCACTGGGGT CCTGTCACCG TAAGATGGGA
AATCCACAGA GAGCACTGTT GTACTTGGTT GCAGCCCTGA AAGAGGGATC AGCCTGGGGT
CCTCCACTTC TGGAGGCCTC TAGGCTCTAT CAGCAACTGG GGGACACAAC AGCAGAGCTG
GAGAGTCTGG AGCTGCTAGT TGAGGCCTTG AATGTCCCAT GCAGTTCCAA AGCCCCGCAG
TTTCTCATTG AGGTAGAATT ACTACTGCCA CCACCTGACC TAGCCTCACC CCTTCATTGT
GGCACTCAGA GCCAGACCAA GCACATACTA GCAAGCAGGT GCCTACAGAC GGGGAGGGCA
GGAGACGCTG CAGAGCATTA CTTGGACCTG CTGGCCCTGT TGCTGGATAG CTCGGAGCCA
AGGTTCTCCC CACCCCCCTC CCCTCCAGGG CCCTGTATGC CTGAGGTGTT TTTGGAGGCA
GCGGTAGCAC TGATCCAGGC AGGCAGAGCC CAAGATGCCT TGACTCTATG TGAGGAGTTG
CTCAGCCGCA CATCATCTCT GCTACCCAAG ATGTCCCGGC TGTGGGAAGA TGCCAGAAAA
GGAACCAAGG AACTGCCATA CTGCCCACTC TGGGTCTCTG CCACCCACCT GCTTCAGGGC
CAGGCCTGGG TTCAACTGGG TGCCCAAAAA GTGGCAATTA GTGAATTTAG CAGGTGCCTC
GAGCTGCTCT TCCGGGCCAC ACCTGAGGAA AAAGAACAAG GGGCAGCTTT CAACTGTGAG
CAGGGATGTA AGTCAGATGC GGCACTGCAG CAGCTTCGGG CAGCCGCCCT AATTAGTCGT
GGACTGGAAT GGGTAGCCAG CGGCCAGGAT ACCAAAGCCT TACAGGACTT CCTCCTCAGT
GTGCAGATGT GCCCAGGTAA TCGAGACACT TACTTTCACC TGCTTCAGAC TCTGAAGAGG
CTAGATCGGA GGGATGAGGC CACTGCACTC TGGTGGAGGC TGGAGGCCCA AACTAAGGGG
TCACATGAAG ATGCTCTGTG GTCTCTCCCC CTGTACCTAG AAAGCTATTT GAGCTGGATC
CGTCCCTCTG ATCGTGACGC CTTCCTTGAA GAATTTCGGA CATCTCTGCC AAAGTCTTGT
GACCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004620.1
CDS493..2361
Misc Feature(1)454..456
Misc Feature(2)511..513
Misc Feature(3)order(1129..1134,1141..1146,1150..1152,1231..1233,1240..1245,1252..1257,1261..1266,1333..1335,1342..1347,1354..1359,1366..1368)
Misc Feature(4)1129..1203
Misc Feature(5)1225..1317
Misc Feature(6)1228..1329
Misc Feature(7)1522..1623
Misc Feature(8)1639..1641
Misc Feature(9)1651..1653
Misc Feature(10)1849..1950
Misc Feature(11)2032..2133
Exon (1)1..576
Exon (2)577..667
Exon (3)668..799
Exon (4)800..1002
Exon (5)1003..1138
Exon (6)1139..1269
Exon (7)1270..1416
Exon (8)1417..1568
Exon (9)1569..1635
Exon (10)1636..1925
Exon (11)1926..1972
Exon (12)1973..2128
Exon (13)2129..2252
Exon (14)2253..2631
Translation

Target ORF information:

RefSeq Version NM_004629.1
Organism Homo sapiens(Human)
Definition Homo sapiens Fanconi anemia complementation group G (FANCG), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004629.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGTCCCGCC AGACCACCTC TGTGGGCTCC AGCTGCCTGG ACCTGTGGAG GGAAAAGAAT 
GACCGGCTCG TTCGACAGGC CAAGGTGGCT CAGAACTCCG GTCTGACTCT GAGGCGACAG
CAGTTGGCTC AGGATGCACT GGAAGGGCTC AGAGGGCTCC TCCATAGTCT GCAAGGGCTC
CCTGCAGCTG TTCCTGTTCT TCCCTTGGAG CTGACTGTCA CCTGCAACTT CATTATCCTG
AGGGCAAGCT TGGCCCAGGG TTTCACAGAG GATCAGGCCC AGGATATCCA GCGGAGCCTA
GAGAGAGTGC TGGAGACACA GGAGCAGCAG GGGCCCAGGT TGGAACAGGG GCTCAGGGAG
CTGTGGGACT CTGTCCTTCG TGCTTCCTGC CTTCTGCCGG AGCTGCTGTC TGCCCTGCAC
CGCCTGGTTG GCCTGCAGGC TGCCCTCTGG TTGAGTGCTG ACCGTCTTGG GGACCTGGCC
TTGTTACTAG AGACCCTGAA TGGCAGCCAG AGTGGAGCCT CTAAGGATCT GCTGTTACTT
CTGAAAACTT GGAGTCCCCC AGCTGAGGAA TTAGATGCTC CATTGACCCT GCAGGATGCC
CAGGGATTGA AGGATGTCCT CCTGACAGCA TTTGCCTACC GCCAAGGTCT CCAGGAGCTG
ATCACAGGGA ACCCAGACAA GGCACTAAGC AGCCTTCATG AAGCGGCCTC AGGCCTGTGT
CCACGGCCTG TGTTGGTCCA GGTGTACACA GCACTGGGGT CCTGTCACCG TAAGATGGGA
AATCCACAGA GAGCACTGTT GTACTTGGTT GCAGCCCTGA AAGAGGGATC AGCCTGGGGT
CCTCCACTTC TGGAGGCCTC TAGGCTCTAT CAGCAACTGG GGGACACAAC AGCAGAGCTG
GAGAGTCTGG AGCTGCTAGT TGAGGCCTTG AATGTCCCAT GCAGTTCCAA AGCCCCGCAG
TTTCTCATTG AGGTAGAATT ACTACTGCCA CCACCTGACC TAGCCTCACC CCTTCATTGT
GGCACTCAGA GCCAGACCAA GCACATACTA GCAAGCAGGT GCCTACAGAC GGGGAGGGCA
GGAGACGCTG CAGAGCATTA CTTGGACCTG CTGGCCCTGT TGCTGGATAG CTCGGAGCCA
AGGTTCTCCC CACCCCCCTC CCCTCCAGGG CCCTGTATGC CTGAGGTGTT TTTGGAGGCA
GCGGTAGCAC TGATCCAGGC AGGCAGAGCC CAAGATGCCT TGACTCTATG TGAGGAGTTG
CTCAGCCGCA CATCATCTCT GCTACCCAAG ATGTCCCGGC TGTGGGAAGA TGCCAGAAAA
GGAACCAAGG AACTGCCATA CTGCCCACTC TGGGTCTCTG CCACCCACCT GCTTCAGGGC
CAGGCCTGGG TTCAACTGGG TGCCCAAAAA GTGGCAATTA GTGAATTTAG CAGGTGCCTC
GAGCTGCTCT TCCGGGCCAC ACCTGAGGAA AAAGAACAAG GGGCAGCTTT CAACTGTGAG
CAGGGATGTA AGTCAGATGC GGCACTGCAG CAGCTTCGGG CAGCCGCCCT AATTAGTCGT
GGACTGGAAT GGGTAGCCAG CGGCCAGGAT ACCAAAGCCT TACAGGACTT CCTCCTCAGT
GTGCAGATGT GCCCAGGTAA TCGAGACACT TACTTTCACC TGCTTCAGAC TCTGAAGAGG
CTAGATCGGA GGGATGAGGC CACTGCACTC TGGTGGAGGC TGGAGGCCCA AACTAAGGGG
TCACATGAAG ATGCTCTGTG GTCTCTCCCC CTGTACCTAG AAAGCTATTT GAGCTGGATC
CGTCCCTCTG ATCGTGACGC CTTCCTTGAA GAATTTCGGA CATCTCTGCC AAAGTCTTGT
GACCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M


book

Founder haplotype analysis of Fanconi anemia in the Korean population finds common ancestral haplotypes for a FANCG variant.
Annals of human genetics79(3)153-61(2015 May)
Park J,Kim M,Jang W,Chae H,Kim Y,Chung NG,Lee JW,Cho B,Jeong DC,Park IY,Park MS


book

K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.
Oncogene34(22)2867-78(2015 May)
Zhu B,Yan K,Li L,Lin M,Zhang S,He Q,Zheng D,Yang H,Shao G


book

Hematological consequences of a FANCG founder mutation in Black South African patients with Fanconi anemia.
Blood cells, molecules & diseases54(3)270-4(2015 Mar)
Feben C,Kromberg J,Wainwright R,Stones D,Poole J,Haw T,Krause A


 
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