Gene Symbol | AMER2 |
Entrez Gene ID | 219287 |
Full Name | APC membrane recruitment protein 2 |
Synonyms | FAM123A |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » AMER2 cDNA ORF clone
gRNAs
Gene Symbol | AMER2 |
Entrez Gene ID | 219287 |
Full Name | APC membrane recruitment protein 2 |
Synonyms | FAM123A |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_005266279.3 | XP_005266336.1 | APC membrane recruitment protein 2 isoform X1 |
XM_017020415.1 | XP_016875904.1 | APC membrane recruitment protein 2 isoform X1 |
NM_152704.3 | NP_689917.2 | APC membrane recruitment protein 2 isoform 1 |
XM_005266280.4 | XP_005266337.1 | APC membrane recruitment protein 2 isoform X1 |
XM_005266280.3 | XP_005266337.1 | APC membrane recruitment protein 2 isoform X1 |
NM_199138.2 | NP_954589.1 | APC membrane recruitment protein 2 isoform 2 |
XM_005266279.4 | XP_005266336.1 | APC membrane recruitment protein 2 isoform X1 |
Homo sapiens (human) | AMER2 | NP_689917.2 |
Mus musculus (house mouse) | Amer2 | NP_082389.1 |
Gallus gallus (chicken) | FAM123A | XP_004938852.1 |
Danio rerio (zebrafish) | amer2 | NP_001093622.1 |
Xenopus tropicalis (tropical clawed frog) | amer2 | NP_001263429.1 |
Pan troglodytes (chimpanzee) | FAM123A | XP_001154833.1 |
LOC708730 | XP_001091384.1 | |
Rattus norvegicus (Norway rat) | Amer2 | XP_573799.4 |
Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
Pfister AS, Hadjihannas MV, R?hrig W, Schambony A, Behrens J
The Journal of biological chemistry287(42)35333-40(2012 Oct)
FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.
Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L, Major MB
Science signaling5(240)ra64(2012 Sep)
Amer2 protein is a novel negative regulator of Wnt/?-catenin signaling involved in neuroectodermal patterning.
Pfister AS, Tanneberger K, Schambony A, Behrens J
The Journal of biological chemistry287(3)1734-41(2012 Jan)
The WTX/AMER1 gene family: evolution, signature and function.
Boutet A, Comai G, Schedl A
BMC evolutionary biology10280(2010 Sep)
Phosphoproteomic analysis of the developing mouse brain.
Ballif BA, Vill?n J, Beausoleil SA, Schwartz D, Gygi SP
Molecular & cellular proteomics : MCP3(11)1093-101(2004 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.
Title: FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.
data characterize Amer2 for the first time as a negative regulator of Wnt signaling both in cell lines and in vivo and define Amer proteins as a novel family of Wnt pathway regulators.
Title: Amer2 protein is a novel negative regulator of Wnt/?-catenin signaling involved in neuroectodermal patterning.
The following AMER2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMER2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
CloneID | OHu10483 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266279.3 , XM_017020415.1 , NM_152704.3 , XM_005266280.4 , XM_005266280.3 , XM_005266279.4 | |
Accession Version | NM_152704.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2016bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-03 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC041392.1, AK098343.1, AL359757.21, AL832586.1 and BC045677.1. On Dec 13, 2013 this sequence version replaced NM_152704.2. Transcript Variant: This variant (1) represents an unspliced transcript that encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689917.2 |
CDS | 665..2680 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu12140 | |
Clone ID Related Accession (Same CDS sequence) | NM_199138.2 | |
Accession Version | NM_199138.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-29 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK055049.1, DA210701.1, BC032653.1, AL359757.21, AL832586.1 and BC045677.1. On or before Dec 13, 2013 this sequence version replaced XM_005266281.1, NM_199138.1. Transcript Variant: This variant (2) is spliced compared to variant 1 and encodes a shorter isoform (2), which lacks an internal protein segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK055049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_954589.1 |
CDS | 356..2014 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10483 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266279.3 , XM_017020415.1 , NM_152704.3 , XM_005266280.4 , XM_005266280.3 , XM_005266279.4 | |
Accession Version | XM_005266279.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2016bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005266279.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005266336.1 |
CDS | 645..2660 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10483 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266279.3 , XM_017020415.1 , NM_152704.3 , XM_005266280.4 , XM_005266280.3 , XM_005266279.4 | |
Accession Version | XM_017020415.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2016bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875904.1 |
CDS | 319..2334 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10483 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266279.3 , XM_017020415.1 , NM_152704.3 , XM_005266280.4 , XM_005266280.3 , XM_005266279.4 | |
Accession Version | XM_005266280.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2016bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005266280.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005266337.1 |
CDS | 550..2565 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10483 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266279.3 , XM_017020415.1 , NM_152704.3 , XM_005266280.4 , XM_005266280.3 , XM_005266279.4 | |
Accession Version | XM_005266280.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2016bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005266280.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005266337.1 |
CDS | 555..2570 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10483 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266279.3 , XM_017020415.1 , NM_152704.3 , XM_005266280.4 , XM_005266280.3 , XM_005266279.4 | |
Accession Version | XM_005266279.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2016bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | APC membrane recruitment protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005266279.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005266336.1 |
CDS | 477..2492 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGACGA GCCGGAGCCG CGGCGGCGGC GGGGCTGTCA GCGAGCGCGG CGGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. |
FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. |
Amer2 protein is a novel negative regulator of Wnt/?-catenin signaling involved in neuroectodermal patterning. |
The WTX/AMER1 gene family: evolution, signature and function. |
Phosphoproteomic analysis of the developing mouse brain. |