Gene Symbol | LTO1 |
Entrez Gene ID | 220064 |
Full Name | oral cancer overexpressed 1 |
Synonyms | TAOS1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » LTO1 cDNA ORF clone
Gene Symbol | LTO1 |
Entrez Gene ID | 220064 |
Full Name | oral cancer overexpressed 1 |
Synonyms | TAOS1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_006718470.2 | XP_006718533.1 | oral cancer-overexpressed protein 1 isoform X1 |
NM_153451.3 | NP_703152.1 | protein LTO1 homolog |
NM_153451.2 | NP_703152.1 | protein LTO1 homolog |
XM_006718470.3 | XP_006718533.1 | protein LTO1 homolog isoform X1 |
Gallus gallus (chicken) | ORAOV1 | NP_001026357.1 |
Xenopus tropicalis (tropical clawed frog) | oraov1 | NP_001123700.1 |
Pan troglodytes (chimpanzee) | ORAOV1 | XP_003313237.1 |
ORAOV1 | XP_001101386.1 | |
Mus musculus (house mouse) | Oraov1 | NP_082460.2 |
Rattus norvegicus (Norway rat) | Oraov1 | NP_001101035.1 |
Homo sapiens (human) | ORAOV1 | NP_703152.1 |
Bos taurus (cattle) | ORAOV1 | XP_002699468.1 |
Canis lupus familiaris (dog) | ORAOV1 | XP_854519.2 |
Danio rerio (zebrafish) | oraov1 | NP_001077021.1 |
The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.
Paul VD, M?hlenhoff U, St?mpfig M, Seebacher J, Kugler KG, Renicke C, Taxis C, Gavin AC, Pierik AJ, Lill R
eLife4e08231(2015 Jul)
ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma.
Li M, Cui X, Shen Y, Dong H, Liang W, Chen Y, Hu J, Li S, Kong J, Li H, Zhao J, Li F
Human pathology46(5)707-15(2015 May)
Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
Togashi Y, Arao T, Kato H, Matsumoto K, Terashima M, Hayashi H, de Velasco MA, Fujita Y, Kimura H, Yasuda T, Shiozaki H, Nishio K
Oncotarget5(10)2962-73(2014 May)
The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome.
Zhai C, Li Y, Mascarenhas C, Lin Q, Li K, Vyrides I, Grant CM, Panaretou B
Oncogene33(4)484-94(2014 Jan)
ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma.
Kang JU, Koo SH
International journal of molecular medicine29(1)81-7(2012 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
provides the first evidence of ORAOV1 overexpression in esophageal squamous cell cancer and esophageal squamous intraepithelial neoplasia
Title: ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma.
the ORAOV1 gene is frequently amplified in esophageal squamous cell cancer
Title: Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
The ORAOV1 complex could prevent ROS-induced ribosomal damage, explaining why overexpression of ORAOV1 is so common in solid tumours
Title: The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome.
An oral cancer overexpressed 1 (ORAOV1) gene was identified as a probable target within the 11q13 amplicon in lymph node metastases from gastric adenocarcinoma.
Title: ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma.
overexpression of ORAOV1 in non-tumoral margin samples can occur in absence of amplification. weak correlation between ORAOV1 amplification and expression in OSSC suggests ORAOV1 expression can be regulated by mechanisms other than gene amplification.
Title: ORAOV1 is amplified in oral squamous cell carcinoma.
The following LTO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LTO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu10506 | |
Clone ID Related Accession (Same CDS sequence) | XM_006718470.2 , NM_153451.3 , NM_153451.2 , XM_006718470.3 | |
Accession Version | NM_153451.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-04 | |
Organism | Homo sapiens(human) | |
Product | protein LTO1 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK026600.1 and AF503940.1. On Jun 2, 2019 this sequence version replaced NM_153451.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF503940.1, BC065542.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_703152.1 |
CDS | 115..528 |
Translation |
Target ORF information:
Target ORF information:
|
NM_153451.3 |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10506 | |
Clone ID Related Accession (Same CDS sequence) | XM_006718470.2 , NM_153451.3 , NM_153451.2 , XM_006718470.3 | |
Accession Version | NM_153451.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Homo sapiens(human) | |
Product | protein LTO1 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK026600.1 and AF503940.1. On Dec 16, 2004 this sequence version replaced NM_153451.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF503940.1, SRR1803611.243090.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_703152.1 |
CDS | 159..572 |
Translation |
Target ORF information:
Target ORF information:
|
NM_153451.2 |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10506 | |
Clone ID Related Accession (Same CDS sequence) | XM_006718470.2 , NM_153451.3 , NM_153451.2 , XM_006718470.3 | |
Accession Version | XM_006718470.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | oral cancer-overexpressed protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006718470.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006718533.1 |
CDS | 116..529 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006718470.2 |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10506 | |
Clone ID Related Accession (Same CDS sequence) | XM_006718470.2 , NM_153451.3 , NM_153451.2 , XM_006718470.3 | |
Accession Version | XM_006718470.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | protein LTO1 homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006718470.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006718533.1 |
CDS | 116..529 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006718470.3 |
1 | ATGGCTGGCA GTCAGGACAT ATTCGATGCC ATCGTGATGG CGGATGAGAG GTTTCATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. |
ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. |
Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. |
The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. |
ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma. |