Gene Symbol | DAGLB |
Entrez Gene ID | 221955 |
Full Name | diacylglycerol lipase beta |
Synonyms | DAGLBETA,KCCR13L |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » DAGLB cDNA ORF clone
Gene Symbol | DAGLB |
Entrez Gene ID | 221955 |
Full Name | diacylglycerol lipase beta |
Synonyms | DAGLBETA,KCCR13L |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_139179.3 | NP_631918.3 | sn1-specific diacylglycerol lipase beta isoform 1 |
NM_001142936.1 | NP_001136408.1 | sn1-specific diacylglycerol lipase beta isoform 2 |
NM_139179.4 | NP_631918.3 | sn1-specific diacylglycerol lipase beta isoform 1 |
Pan troglodytes (chimpanzee) | LOC100612262 | XP_003318317.1 |
Rattus norvegicus (Norway rat) | Daglb | NP_001100590.1 |
Danio rerio (zebrafish) | daglb | XP_693659.5 |
Homo sapiens (human) | DAGLB | NP_631918.3 |
Canis lupus familiaris (dog) | DAGLB | XP_536885.2 |
Gallus gallus (chicken) | DAGLB | NP_001025814.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012171 | XP_320362.4 |
Xenopus tropicalis (tropical clawed frog) | daglb | XP_002931999.1 |
Bos taurus (cattle) | DAGLB | NP_001076956.1 |
Mus musculus (house mouse) | Daglb | NP_659164.2 |
Caenorhabditis elegans (roundworm) | F42G9.6 | NP_741085.1 |
Arabidopsis thaliana (thale cress) | AT1G05790 | NP_001077463.1 |
Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta.
Singh PK, Markwick R, Lu L, Howell FV, Williams G, Doherty P
Biochemistry55(19)2713-21(2016 05)
Discovery and refinement of loci associated with lipid levels.
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkil? K, Hypp?nen E, Isaacs A, Jackson AU, Johansson ?, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytik?inen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, M?ller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, D?ring A, Elliott P, Epstein SE, Ingi Eyjolfsson G, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtim?ki T, Lin SY, Lindstr?m J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, M?ller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stan??kov? A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YI, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferri?res J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, J?rvelin MR, Jula A, K?h?nen M, Kaprio J, Kes?niemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, M?rz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Nj?lstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E, Abecasis GR,
Nature genetics45(11)1274-1283(2013 Nov)
Integral and associated lysosomal membrane proteins.
Schr?der B, Wrocklage C, Pan C, J?ger R, K?sters B, Sch?fer H, Els?sser HP, Mann M, Hasilik A
Traffic (Copenhagen, Denmark)8(12)1676-86(2007 Dec)
Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC
Atherosclerosis191(1)63-72(2007 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The purified DAGLbeta catalytic domain assay described here provides the basis for a relatively clean and convenient assay with the potential to be adapted for high-throughput drug discovery efforts.
Title: Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta.
This gene has been functionally characterized as a diacylglycerol-lipase (DAGL), referred to as DAGL beta. These enzymes may have a role in the biosynthesis of the endocannabinoid 2-arachidnoyl glycerol (2-AG).
Title: Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.
The following DAGLB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DAGLB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu24738 | |
Clone ID Related Accession (Same CDS sequence) | NM_139179.3 , NM_139179.4 | |
Accession Version | NM_139179.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | sn1-specific diacylglycerol lipase beta isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC304654.1, AK075128.1 and F17444.2. On Dec 30, 2008 this sequence version replaced NM_139179.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803616.206639.1, SRR1803613.277166.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGGGGA TGGTACTCTT CGGCCGGCGC TGGGCCATCG CCAGCGACGA CTTGGTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_631918.3 |
CDS | 171..2189 |
Translation |
Target ORF information:
Target ORF information:
|
NM_139179.3 |
1 | ATGCCGGGGA TGGTACTCTT CGGCCGGCGC TGGGCCATCG CCAGCGACGA CTTGGTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu24738 | |
Clone ID Related Accession (Same CDS sequence) | NM_139179.3 , NM_139179.4 | |
Accession Version | NM_139179.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Homo sapiens(human) | |
Product | sn1-specific diacylglycerol lipase beta isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC304654.1, AK075128.1 and F17444.2. On Nov 24, 2018 this sequence version replaced NM_139179.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AF450090.1, SRR1803613.277166.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297056.11/ ENSP00000297056.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCCGGGGA TGGTACTCTT CGGCCGGCGC TGGGCCATCG CCAGCGACGA CTTGGTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_631918.3 |
CDS | 113..2131 |
Translation |
Target ORF information:
Target ORF information:
|
NM_139179.4 |
1 | ATGCCGGGGA TGGTACTCTT CGGCCGGCGC TGGGCCATCG CCAGCGACGA CTTGGTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu24746 | |
Clone ID Related Accession (Same CDS sequence) | NM_001142936.1 | |
Accession Version | NM_001142936.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1632bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Homo sapiens(human) | |
Product | sn1-specific diacylglycerol lipase beta isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC304654.1, AK298955.1, AK075128.1 and F17444.2. Transcript Variant: This variant (2) lacks two alternate internal exons, compared to variant 1, resulting in a translational frameshift in the mid coding region. The encoded isoform (2) has the same N- and C-termini but is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK298955.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGGGGA TGGTACTCTT CGGCCGGCGC TGGGCCATCG CCAGCGACGA CTTGGTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001136408.1 |
CDS | 171..1802 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001142936.1 |
1 | ATGCCGGGGA TGGTACTCTT CGGCCGGCGC TGGGCCATCG CCAGCGACGA CTTGGTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta. |
Discovery and refinement of loci associated with lipid levels. |
Integral and associated lysosomal membrane proteins. |
Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |