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FGA cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FGA
Entrez Gene ID 2243
Full Name fibrinogen alpha chain
Synonyms Fib2
General protein information
Preferred Names

fibrinogen alpha chain

Names

fibrinogen alpha chain
fibrinogen, A alpha polypeptide

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q31.3

Summary This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016].
Disorder MIM:

134820

Disorder Html: Dysfibrinogenemia, alpha type, causing bleeding diathesis (3);

mRNA and Protein(s)

mRNA Protein Name
NM_000508.4 NP_000499.1 fibrinogen alpha chain isoform alpha-E preproprotein
NM_021871.3 NP_068657.1 fibrinogen alpha chain isoform alpha precursor



Macaca mulatta (rhesus monkey) FGA XP_001088855.2
Homo sapiens (human) FGA NP_000499.1
Canis lupus familiaris (dog) FGA XP_532697.2
Rattus norvegicus (Norway rat) Fga NP_001008724.1
Danio rerio (zebrafish) fga NP_001181918.1
Mus musculus (house mouse) Fga NP_001104518.1
Gallus gallus (chicken) FGA NP_001258840.1
Pan troglodytes (chimpanzee) FGA XP_001136067.1
Xenopus tropicalis (tropical clawed frog) fga XP_002933535.2


Related articles in PubMed

Dysfibrinogenemia-associated novel heterozygous mutation, Shanghai (FGA c.169_180+2 del), leads to N-terminal truncation of fibrinogen Aα chain and impairs fibrin polymerization.
Zhou J, Ding Q, Wu W, Ouyang Q, Xie Y, Wu X, Lu Y, Dai J, Liang Q, Wang H, Wang X, Hu Y
Journal of clinical pathology70(2)145-153(2017 Feb)

Diagnostic accuracy of fibrinogen to differentiate appendicitis from nonspecific abdominal pain in children.
Prada-Arias M, Vázquez JL, Salgado-Barreira Á, Gómez-Veiras J, Montero-Sánchez M, Fernández-Lorenzo JR
The American journal of emergency medicine35(1)66-70(2017 Jan)

A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.
Rao W, Zhou N, Zhang H, Liu R, Zhang S, Su Y, Yang G, Ma Y, Shi J, Yu Y, Yu Q
Disease markers20173104180(2017)

Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis.
González-Giraldo Y, Barreto GE, Fava C, Forero DA
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association25(9)2284-9(2016 Sep)

Congenital afibrinogenemia: Identification and characterization of two novel homozygous fibrinogen Aα and Bβ chain mutations in two Tunisian families.
Amri Y, Toumi Nel H, Hadj Fredj S, de Moerloose P
Thrombosis research14311-6(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fibrinogen A alpha-chain amyloidosis appears to be an under-recognized disorder in Braga, Portugal, where we found a high frequency of the FGA p.Glu545Val variant
Title: Unrecognized Fibrinogen A α-Chain Amyloidosis: Results From Targeted Genetic Testing.

High fibrinogen expression is associated with pancreatic carcinoma.
Title: Evaluation of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and survival prediction in resectable pancreatic carcinoma.

No association between three single nucleotide polymorphisms in the fibrinogen alpha gene and schizophrenia.
Title: A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.

Data indicate only the highest concentration of apixaban was capable to significantly reduce thrombus formation, fibrin association and platelet-aggregate formation.
Title: Differential inhibitory action of apixaban on platelet and fibrin components of forming thrombi: Studies with circulating blood and in a platelet-based model of thrombin generation.

Data indicate that repeated measurement after five hours showed a statistical significant difference for the fractional synthesis rate of fibrinogen but not for albumin.
Title: Repeated quantitative measurements of De Novo synthesis of albumin and fibrinogen.

The following FGA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19142 NM_021871.3
Latest version!
Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
$379.00
OHu19692 NM_000508.4
Latest version!
Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $615.30
$879.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19142
Clone ID Related Accession (Same CDS sequence) NM_021871.3
Accession Version NM_021871.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1935bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product fibrinogen alpha chain isoform alpha precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN393696.1, AC107385.4, BX494953.1, CB122305.1, CD608675.1, AL531808.3, AL579998.3, J00127.1 and J00128.1. On Jan 8, 2016 this sequence version replaced NM_021871.2. Transcript Variant: This variant (alpha) is alternatively spliced in the 3' coding region and 3' UTR, resulting in a shorter isoform (alpha) with a different carboxy-terminus compared to isoform alpha-E. The encoded isoform (alpha) may undergo proteolytic processing similar to isoform alpha-E. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J00128.1, AK290559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GGTATCCACA CTTCTCCTTT GGGGAAGCCT
TCCCTGTCCC CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068657.1
CDS80..2014
Misc Feature(1)143..145
Misc Feature(2)227..640
Misc Feature(3)908..910
Misc Feature(4)1169..1171
Misc Feature(5)1412..1606
Misc Feature(6)order(1460..1462,1550..1552)
Misc Feature(7)<1472..>2011
Misc Feature(8)1850..1852
Exon (1)1..133
Exon (2)134..259
Exon (3)260..443
Exon (4)444..589
Exon (5)590..2248
Translation

Target ORF information:

RefSeq Version NM_021871.3
Organism Homo sapiens(Human)
Definition Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021871.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GGTATCCACA CTTCTCCTTT GGGGAAGCCT
TCCCTGTCCC CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19692
Clone ID Related Accession (Same CDS sequence) NM_000508.4
Accession Version NM_000508.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2601bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product fibrinogen alpha chain isoform alpha-E preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN393696.1, AC107385.4, BX494953.1, BG565064.1, BQ064506.1 and AF090936.1. On Jan 8, 2016 this sequence version replaced NM_000508.3. Transcript Variant: This variant (alpha-E) represents the longer transcript and encodes the longer isoform (alpha-E). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GACTGTGATG ATGTCCTCCA AACACATCCT
TCAGGTACCC AAAGTGGCAT TTTCAATATC AAGCTACCGG GATCCAGTAA GATTTTTTCT
GTTTATTGCG ATCAAGAGAC CAGTTTGGGA GGATGGCTTT TGATCCAGCA AAGAATGGAT
GGATCACTGA ATTTTAACCG GACCTGGCAA GACTACAAGA GAGGTTTCGG CAGCCTGAAT
GACGAGGGGG AAGGAGAATT CTGGCTAGGC AATGACTACC TCCACTTACT AACCCAAAGG
GGCTCTGTTC TTAGGGTTGA ATTAGAGGAC TGGGCTGGGA ATGAAGCTTA TGCAGAATAT
CACTTCCGGG TAGGCTCTGA GGCTGAAGGC TATGCCCTCC AAGTCTCCTC CTATGAAGGC
ACTGCGGGTG ATGCTCTGAT TGAGGGTTCC GTAGAGGAAG GGGCAGAGTA CACCTCTCAC
AACAACATGC AGTTCAGCAC CTTTGACAGG GATGCAGACC AGTGGGAAGA GAACTGTGCA
GAAGTCTATG GGGGAGGCTG GTGGTATAAT AACTGCCAAG CAGCCAATCT CAATGGAATC
TACTACCCTG GGGGCTCCTA TGACCCAAGG AATAACAGTC CTTATGAGAT TGAGAATGGA
GTGGTCTGGG TTTCCTTTAG AGGGGCAGAT TATTCCCTCA GGGCTGTTCG CATGAAAATT
AGGCCCCTTG TGACCCAATA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000499.1
CDS80..2680
Misc Feature(1)143..145
Misc Feature(2)143..145
Misc Feature(3)182..187
Misc Feature(4)185..193
Misc Feature(5)212..214
Misc Feature(6)227..640
Misc Feature(7)227..229
Misc Feature(8)245..247
Misc Feature(9)377..382
Misc Feature(10)440..445
Misc Feature(11)446..451
Misc Feature(12)908..910
Misc Feature(13)920..922
Misc Feature(14)950..952
Misc Feature(15)959..961
Misc Feature(16)1169..1171
Misc Feature(17)1169..1171
Misc Feature(18)1313..1315
Misc Feature(19)1412..1606
Misc Feature(20)1430..1432
Misc Feature(21)order(1460..1462,1550..1552)
Misc Feature(22)1580..1582
Misc Feature(23)1592..1594
Misc Feature(24)1649..1651
Misc Feature(25)1757..1759
Misc Feature(26)1772..1774
Misc Feature(27)1850..1852
Misc Feature(28)1904..1906
Misc Feature(29)1967..2668
Misc Feature(30)2333..2335
Misc Feature(31)order(2450..2452,2456..2458,2462..2464)
Misc Feature(32)order(2474..2476,2483..2488,2513..2518)
Exon (1)1..133
Exon (2)134..259
Exon (3)260..443
Exon (4)444..589
Exon (5)590..1970
Exon (6)1971..3678
Translation

Target ORF information:

RefSeq Version NM_000508.4
Organism Homo sapiens(Human)
Definition Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000508.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GACTGTGATG ATGTCCTCCA AACACATCCT
TCAGGTACCC AAAGTGGCAT TTTCAATATC AAGCTACCGG GATCCAGTAA GATTTTTTCT
GTTTATTGCG ATCAAGAGAC CAGTTTGGGA GGATGGCTTT TGATCCAGCA AAGAATGGAT
GGATCACTGA ATTTTAACCG GACCTGGCAA GACTACAAGA GAGGTTTCGG CAGCCTGAAT
GACGAGGGGG AAGGAGAATT CTGGCTAGGC AATGACTACC TCCACTTACT AACCCAAAGG
GGCTCTGTTC TTAGGGTTGA ATTAGAGGAC TGGGCTGGGA ATGAAGCTTA TGCAGAATAT
CACTTCCGGG TAGGCTCTGA GGCTGAAGGC TATGCCCTCC AAGTCTCCTC CTATGAAGGC
ACTGCGGGTG ATGCTCTGAT TGAGGGTTCC GTAGAGGAAG GGGCAGAGTA CACCTCTCAC
AACAACATGC AGTTCAGCAC CTTTGACAGG GATGCAGACC AGTGGGAAGA GAACTGTGCA
GAAGTCTATG GGGGAGGCTG GTGGTATAAT AACTGCCAAG CAGCCAATCT CAATGGAATC
TACTACCCTG GGGGCTCCTA TGACCCAAGG AATAACAGTC CTTATGAGAT TGAGAATGGA
GTGGTCTGGG TTTCCTTTAG AGGGGCAGAT TATTCCCTCA GGGCTGTTCG CATGAAAATT
AGGCCCCTTG TGACCCAATA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Dysfibrinogenemia-associated novel heterozygous mutation, Shanghai (FGA c.169_180+2 del), leads to N-terminal truncation of fibrinogen Aα chain and impairs fibrin polymerization.
Journal of clinical pathology70(2)145-153(2017 Feb)
Zhou J,Ding Q,Wu W,Ouyang Q,Xie Y,Wu X,Lu Y,Dai J,Liang Q,Wang H,Wang X,Hu Y


book

Diagnostic accuracy of fibrinogen to differentiate appendicitis from nonspecific abdominal pain in children.
The American journal of emergency medicine35(1)66-70(2017 Jan)
Prada-Arias M,Vázquez JL,Salgado-Barreira Á,Gómez-Veiras J,Montero-Sánchez M,Fernández-Lorenzo JR


book

A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.
Disease markers20173104180(2017)
Rao W,Zhou N,Zhang H,Liu R,Zhang S,Su Y,Yang G,Ma Y,Shi J,Yu Y,Yu Q


book

Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association25(9)2284-9(2016 Sep)
González-Giraldo Y,Barreto GE,Fava C,Forero DA


book

Congenital afibrinogenemia: Identification and characterization of two novel homozygous fibrinogen Aα and Bβ chain mutations in two Tunisian families.
Thrombosis research14311-6(2016 Jul)
Amri Y,Toumi Nel H,Hadj Fredj S,de Moerloose P


 
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