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FGA cDNA ORF clone, Homo sapiens (human)

Gene Symbol FGA
Entrez Gene ID 2243
Full Name fibrinogen alpha chain
Synonyms Fib2
General protein information
Preferred Names
fibrinogen alpha chain
Names
fibrinogen alpha chain
fibrinogen, A alpha polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q28

Summary The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

134820

Disorder Html: Dysfibrinogenemia, alpha type, causing bleeding diathesis (3);

mRNA and Protein(s)

mRNA Protein Name
NM_000508 NP_000499 fibrinogen alpha chain isoform alpha-E preproprotein
NM_021871 NP_068657 fibrinogen alpha chain isoform alpha preproprotein



Homo sapiens (human) FGA NP_000499.1
Pan troglodytes (chimpanzee) FGA XP_001136067.1
Macaca mulatta (Rhesus monkey) FGA XP_001088855.2
Canis lupus familiaris (dog) FGA XP_532697.2
Mus musculus (house mouse) Fga NP_001104518.1
Rattus norvegicus (Norway rat) Fga NP_001008724.1
Gallus gallus (chicken) FGA NP_001258840.1
Danio rerio (zebrafish) fga NP_001181918.1
Xenopus (Silurana) tropicalis (western clawed frog) fga XP_002933535.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FGA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19692 NM_000508 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $615.30
$879.00
OHu19142 NM_021871 Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19692
Clone ID Related Accession (Same CDS sequence) NM_000508
Accession Version NM_000508.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2601bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product fibrinogen alpha chain isoform alpha-E preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX494953.1, BG565064.1, AC107385.4 and BQ064506.1. This sequence is a reference standard in the RefSeqGene project. On Jul 15, 2005 this sequence version replaced gi:11761627. Transcript Variant: This variant (alpha-E) represents the longer transcript and encodes the longer isoform (alpha-E). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GACTGTGATG ATGTCCTCCA AACACATCCT
TCAGGTACCC AAAGTGGCAT TTTCAATATC AAGCTACCGG GATCCAGTAA GATTTTTTCT
GTTTATTGCG ATCAAGAGAC CAGTTTGGGA GGATGGCTTT TGATCCAGCA AAGAATGGAT
GGATCACTGA ATTTTAACCG GACCTGGCAA GACTACAAGA GAGGTTTCGG CAGCCTGAAT
GACGAGGGGG AAGGAGAATT CTGGCTAGGC AATGACTACC TCCACTTACT AACCCAAAGG
GGCTCTGTTC TTAGGGTTGA ATTAGAGGAC TGGGCTGGGA ATGAAGCTTA TGCAGAATAT
CACTTCCGGG TAGGCTCTGA GGCTGAAGGC TATGCCCTCC AAGTCTCCTC CTATGAAGGC
ACTGCGGGTG ATGCTCTGAT TGAGGGTTCC GTAGAGGAAG GGGCAGAGTA CACCTCTCAC
AACAACATGC AGTTCAGCAC CTTTGACAGG GATGCAGACC AGTGGGAAGA GAACTGTGCA
GAAGTCTATG GGGGAGGCTG GTGGTATAAT AACTGCCAAG CAGCCAATCT CAATGGAATC
TACTACCCTG GGGGCTCCTA TGACCCAAGG AATAACAGTC CTTATGAGAT TGAGAATGGA
GTGGTCTGGG TTTCCTTTAG AGGGGCAGAT TATTCCCTCA GGGCTGTTCG CATGAAAATT
AGGCCCCTTG TGACCCAATA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000499.1
CDS59..2659
Misc Feature(1)122..124(+)
Misc Feature(2)122..124(+)
Misc Feature(3)161..166(+)
Misc Feature(4)164..172(+)
Misc Feature(5)200..616(+)
Misc Feature(6)356..361(+)
Misc Feature(7)419..424(+)
Misc Feature(8)425..430(+)
Misc Feature(9)887..889(+)
Misc Feature(10)1148..1150(+)
Misc Feature(11)1292..1294(+)
Misc Feature(12)1391..1588(+)
Misc Feature(13)1439..1531(+)
Misc Feature(14)1751..1753(+)
Misc Feature(15)1829..1831(+)
Misc Feature(16)1883..1885(+)
Misc Feature(17)1946..2647(+)
Misc Feature(18)2312..2314(+)
Misc Feature(19)2429..2443(+)
Misc Feature(20)2453..2497(+)
Exon (1)1..112
Gene:FGA
Gene Synonym:
Exon (2)113..238
Gene:FGA
Gene Synonym:
Exon (3)239..422
Gene:FGA
Gene Synonym:
Exon (4)423..568
Gene:FGA
Gene Synonym:
Exon (5)569..1949
Gene:FGA
Gene Synonym:
Exon (6)1950..3655
Gene:FGA
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000508
Organism Homo sapiens (human)
Definition Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000508

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GACTGTGATG ATGTCCTCCA AACACATCCT
TCAGGTACCC AAAGTGGCAT TTTCAATATC AAGCTACCGG GATCCAGTAA GATTTTTTCT
GTTTATTGCG ATCAAGAGAC CAGTTTGGGA GGATGGCTTT TGATCCAGCA AAGAATGGAT
GGATCACTGA ATTTTAACCG GACCTGGCAA GACTACAAGA GAGGTTTCGG CAGCCTGAAT
GACGAGGGGG AAGGAGAATT CTGGCTAGGC AATGACTACC TCCACTTACT AACCCAAAGG
GGCTCTGTTC TTAGGGTTGA ATTAGAGGAC TGGGCTGGGA ATGAAGCTTA TGCAGAATAT
CACTTCCGGG TAGGCTCTGA GGCTGAAGGC TATGCCCTCC AAGTCTCCTC CTATGAAGGC
ACTGCGGGTG ATGCTCTGAT TGAGGGTTCC GTAGAGGAAG GGGCAGAGTA CACCTCTCAC
AACAACATGC AGTTCAGCAC CTTTGACAGG GATGCAGACC AGTGGGAAGA GAACTGTGCA
GAAGTCTATG GGGGAGGCTG GTGGTATAAT AACTGCCAAG CAGCCAATCT CAATGGAATC
TACTACCCTG GGGGCTCCTA TGACCCAAGG AATAACAGTC CTTATGAGAT TGAGAATGGA
GTGGTCTGGG TTTCCTTTAG AGGGGCAGAT TATTCCCTCA GGGCTGTTCG CATGAAAATT
AGGCCCCTTG TGACCCAATA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19142
Clone ID Related Accession (Same CDS sequence) NM_021871
Accession Version NM_021871.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1935bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product fibrinogen alpha chain isoform alpha preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX494953.1, CB122305.1, CD608675.1, AL531808.3, AL579998.3 and J00127.1. This sequence is a reference standard in the RefSeqGene project. On Jul 15, 2005 this sequence version replaced gi:11761628. Transcript Variant: This variant (alpha) is alternatively spliced in the 3' coding region and 3' UTR, resulting in a shorter isoform (alpha) with a different carboxy-terminus compared to isoform alpha-E. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290559.1, J00128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GGTATCCACA CTTCTCCTTT GGGGAAGCCT
TCCCTGTCCC CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068657.1
CDS59..1993
Misc Feature(1)122..124(+)
Misc Feature(2)122..124(+)
Misc Feature(3)161..166(+)
Misc Feature(4)164..172(+)
Misc Feature(5)200..616(+)
Misc Feature(6)356..361(+)
Misc Feature(7)419..424(+)
Misc Feature(8)425..430(+)
Misc Feature(9)887..889(+)
Misc Feature(10)1148..1150(+)
Misc Feature(11)1292..1294(+)
Misc Feature(12)1391..1588(+)
Misc Feature(13)1439..1531(+)
Misc Feature(14)1751..1753(+)
Misc Feature(15)1829..1831(+)
Misc Feature(16)1883..1885(+)
Exon (1)1..112
Gene:FGA
Gene Synonym:
Exon (2)113..238
Gene:FGA
Gene Synonym:
Exon (3)239..422
Gene:FGA
Gene Synonym:
Exon (4)423..568
Gene:FGA
Gene Synonym:
Exon (5)569..2210
Gene:FGA
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_021871
Organism Homo sapiens (human)
Definition Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021871

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGTTTTCCA TGAGGATCGT CTGCCTGGTC CTAAGTGTGG TGGGCACAGC ATGGACTGCA 
GATAGTGGTG AAGGTGACTT TCTAGCTGAA GGAGGAGGCG TGCGTGGCCC AAGGGTTGTG
GAAAGACATC AATCTGCCTG CAAAGATTCA GACTGGCCCT TCTGCTCTGA TGAAGACTGG
AACTACAAAT GCCCTTCTGG CTGCAGGATG AAAGGGTTGA TTGATGAAGT CAATCAAGAT
TTTACAAACA GAATAAATAA GCTCAAAAAT TCACTATTTG AATATCAGAA GAACAATAAG
GATTCTCATT CGTTGACCAC TAATATAATG GAAATTTTGA GAGGCGATTT TTCCTCAGCC
AATAACCGTG ATAATACCTA CAACCGAGTG TCAGAGGATC TGAGAAGCAG AATTGAAGTC
CTGAAGCGCA AAGTCATAGA AAAAGTACAG CATATCCAGC TTCTGCAGAA AAATGTTAGA
GCTCAGTTGG TTGATATGAA ACGACTGGAG GTGGACATTG ATATTAAGAT CCGATCTTGT
CGAGGGTCAT GCAGTAGGGC TTTAGCTCGT GAAGTAGATC TGAAGGACTA TGAAGATCAG
CAGAAGCAAC TTGAACAGGT CATTGCCAAA GACTTACTTC CCTCTAGAGA TAGGCAACAC
TTACCACTGA TAAAAATGAA ACCAGTTCCA GACTTGGTTC CCGGAAATTT TAAGAGCCAG
CTTCAGAAGG TACCCCCAGA GTGGAAGGCA TTAACAGACA TGCCGCAGAT GAGAATGGAG
TTAGAGAGAC CTGGTGGAAA TGAGATTACT CGAGGAGGCT CCACCTCTTA TGGAACCGGA
TCAGAGACGG AAAGCCCCAG GAACCCTAGC AGTGCTGGAA GCTGGAACTC TGGGAGCTCT
GGACCTGGAA GTACTGGAAA CCGAAACCCT GGGAGCTCTG GGACTGGAGG GACTGCAACC
TGGAAACCTG GGAGCTCTGG ACCTGGAAGT ACTGGAAGCT GGAACTCTGG GAGCTCTGGA
ACTGGAAGTA CTGGAAACCA AAACCCTGGG AGCCCTAGAC CTGGTAGTAC CGGAACCTGG
AATCCTGGCA GCTCTGAACG CGGAAGTGCT GGGCACTGGA CCTCTGAGAG CTCTGTATCT
GGTAGTACTG GACAATGGCA CTCTGAATCT GGAAGTTTTA GGCCAGATAG CCCAGGCTCT
GGGAACGCGA GGCCTAACAA CCCAGACTGG GGCACATTTG AAGAGGTGTC AGGAAATGTA
AGTCCAGGGA CAAGGAGAGA GTACCACACA GAAAAACTGG TCACTTCTAA AGGAGATAAA
GAGCTCAGGA CTGGTAAAGA GAAGGTCACC TCTGGTAGCA CAACCACCAC GCGTCGTTCA
TGCTCTAAAA CCGTTACTAA GACTGTTATT GGTCCTGATG GTCACAAAGA AGTTACCAAA
GAAGTGGTGA CCTCCGAAGA TGGTTCTGAC TGTCCCGAGG CAATGGATTT AGGCACATTG
TCTGGCATAG GTACTCTGGA TGGGTTCCGC CATAGGCACC CTGATGAAGC TGCCTTCTTC
GACACTGCCT CAACTGGAAA AACATTCCCA GGTTTCTTCT CACCTATGTT AGGAGAGTTT
GTCAGTGAGA CTGAGTCTAG GGGCTCAGAA TCTGGCATCT TCACAAATAC AAAGGAATCC
AGTTCTCATC ACCCTGGGAT AGCTGAATTC CCTTCCCGTG GTAAATCTTC AAGTTACAGC
AAACAATTTA CTAGTAGCAC GAGTTACAAC AGAGGAGACT CCACATTTGA AAGCAAGAGC
TATAAAATGG CAGATGAGGC CGGAAGTGAA GCCGATCATG AAGGAACACA TAGCACCAAG
AGAGGCCATG CTAAATCTCG CCCTGTCAGA GGTATCCACA CTTCTCCTTT GGGGAAGCCT
TCCCTGTCCC CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Dermatopontin regulates fibrin formation and its biological activity
J. Invest. Dermatol. 134 (1), 256-263 (2014)
Wu W, Okamoto O, Kato A, Matsuo N, Nomizu M, Yoshioka H and Fujiwara S.


book

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease
Circulation 128 (12), 1310-1324 (2013)
Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Malarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Raikkonen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Volzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ, Wallaschofski H, Smith NL, Tregouet D, Ridker PM, Tang W, Strachan DP, Hamsten A and O'Donnell CJ.


book

A study on human serum albumin influence on glycation of fibrinogen
Biochem. Biophys. Res. Commun. 439 (1), 78-83 (2013)
Kielmas M, Szewczuk Z and Stefanowicz P.


book

Congenital fibrinogen disorders: an update
Semin. Thromb. Hemost. 39 (6), 585-595 (2013)
de Moerloose P, Casini A and Neerman-Arbez M.


book

Fibrinogen Aalpha Thr312Ala polymorphism specifically contributes to chronic thromboembolic pulmonary hypertension by increasing fibrin resistance
PLoS ONE 8 (7), E69635 (2013)
Li JF, Lin Y, Yang YH, Gan HL, Liang Y, Liu J, Yang SQ, Zhang WJ, Cui N, Zhao L, Zhai ZG, Wang J and Wang C.


book

Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA)
Blood 80 (8), 1972-1979 (1992)
Koopman J, Haverkate F, Grimbergen J, Egbring R and Lord ST.


book

Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence
Biochemistry 18 (24), 5410-5416 (1979)
Watt,K.W., Cottrell,B.A., Strong,D.D. and Doolittle,R.F.


book

Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites
Biochemistry 18 (24), 5405-5410 (1979)
Cottrell,B.A., Strong,D.D., Watt,K.W. and Doolittle,R.F.


book

Localization of the alpha-chain cross-link acceptor sites of human fibrin
J. Biol. Chem. 253 (7), 2184-2195 (1978)
Fretto,L.J., Ferguson,E.W., Steinman,H.M. and McKee,P.A.


book

Disulfide bridges in nh2 -terminal part of human fibrinogen
Thromb. Res. 8 (5), 639-658 (1976)
Blomback,B., Hessel,B. and Hogg,D.


 
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