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CLCA4 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CLCA4
Entrez Gene ID 22802
Full Name chloride channel accessory 4
Synonyms CaCC,CaCC2
General protein information
Preferred Names

chloride channel accessory 4

Names

calcium-activated chloride channel regulator 4
caCC-2
calcium-activated chloride channel family member 4
calcium-activated chloride channel protein 2
chloride channel regulator 4
chloride channel, calcium activated, family member 4
hCLCA4
hCaCC-2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p22.3

Summary The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008].
Disorder MIM:

616857


mRNA and Protein(s)

mRNA Protein Name
NM_012128.3 NP_036260.2 calcium-activated chloride channel regulator 4 precursor
XM_011541015.2 XP_011539317.1 calcium-activated chloride channel regulator 4 isoform X1



Homo sapiens (human) CLCA4 NP_036260.2
Mus musculus (house mouse) AI747448 NP_001028371.1
Mus musculus (house mouse) Clca6 NP_997091.3
Rattus norvegicus (Norway rat) Clca4 NP_958822.1
Pan troglodytes (chimpanzee) CLCA4 XP_524757.3
Canis lupus familiaris (dog) CLCA4 XP_005622030.1
Bos taurus (cattle) CLCA4 NP_001029472.1
Macaca mulatta (rhesus monkey) CLCA4 XP_001109489.2


Related articles in PubMed

CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine.
Kolbe EW, Tamm S, Hedtfeld S, Becker T, Tümmler B, Stanke F
European journal of human genetics : EJHG21(6)691-4(2013 Jun)

Loss of CLCA4 promotes epithelial-to-mesenchymal transition in breast cancer cells.
Yu Y, Walia V, Elble RC
PloS one8(12)e83943(2013)

The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
Ritzka M, Stanke F, Jansen S, Gruber AD, Pusch L, Woelfl S, Veeze HJ, Halley DJ, Tümmler B
Human genetics115(6)483-91(2004 Nov)

Molecular characteristics and functional diversity of CLCA family members.
Pauli BU, Abdel-Ghany M, Cheng HC, Gruber AD, Archibald HA, Elble RC
Clinical and experimental pharmacology & physiology27(11)901-5(2000 Nov)

Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.
Agnel M, Vermat T, Culouscou JM
FEBS letters455(3)295-301(1999 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CLCA4 modulates the capability to express residual chloride secretion in colonic tissue.
Title: CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine.

CLCA4 and CLCA2 play complementary but distinct roles in epithelial differentiation
Title: Loss of CLCA4 promotes epithelial-to-mesenchymal transition in breast cancer cells.

CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis
Title: The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.

The following CLCA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLCA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu06067 NM_012128.3
Latest version!
Homo sapiens chloride channel accessory 4 (CLCA4), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$339.50-$475.30
$679.00
OHu64946 XM_011541015.2
Latest version!
Homo sapiens chloride channel accessory 4 (CLCA4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $475.30
$679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu06067
Clone ID Related Accession (Same CDS sequence) NM_012128.3
Accession Version NM_012128.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2760bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-30
Organism Homo sapiens(Human)
Product calcium-activated chloride channel regulator 4 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA761219.1 and AY358470.1. On Jun 29, 2007 this sequence version replaced NM_012128.2. Transcript Variant: This variant (1) represents the longer transcript. ##Evidence-Data-START## Transcript exon combination :: AY358470.1, SRR1660809.262440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
ATGGGGTTAT TCAGAGGTTT TGTTTTCCTC TTAGTTCTGT GCCTGCTGCA CCAGTCAAAT 
ACTTCCTTCA TTAAGCTGAA TAATAATGGC TTTGAAGATA TTGTCATTGT TATAGATCCT
AGTGTGCCAG AAGATGAAAA AATAATTGAA CAAATAGAGG ATATGGTGAC TACAGCTTCT
ACGTACCTGT TTGAAGCCAC AGAAAAAAGA TTTTTTTTCA AAAATGTATC TATATTAATT
CCTGAGAATT GGAAGGAAAA TCCTCAGTAC AAAAGGCCAA AACATGAAAA CCATAAACAT
GCTGATGTTA TAGTTGCACC ACCTACACTC CCAGGTAGAG ATGAACCATA CACCAAGCAG
TTCACAGAAT GTGGAGAGAA AGGCGAATAC ATTCACTTCA CCCCTGACCT TCTACTTGGA
AAAAAACAAA ATGAATATGG ACCACCAGGC AAACTGTTTG TCCATGAGTG GGCTCACCTC
CGGTGGGGAG TGTTTGATGA GTACAATGAA GATCAGCCTT TCTACCGTGC TAAGTCAAAA
AAAATCGAAG CAACAAGGTG TTCCGCAGGT ATCTCTGGTA GAAATAGAGT TTATAAGTGT
CAAGGAGGCA GCTGTCTTAG TAGAGCATGC AGAATTGATT CTACAACAAA ACTGTATGGA
AAAGATTGTC AATTCTTTCC TGATAAAGTA CAAACAGAAA AAGCATCCAT AATGTTTATG
CAAAGTATTG ATTCTGTTGT TGAATTTTGT AACGAAAAAA CCCATAATCA AGAAGCTCCA
AGCCTACAAA ACATAAAGTG CAATTTTAGA AGTACATGGG AGGTGATTAG CAATTCTGAG
GATTTTAAAA ACACCATACC CATGGTGACA CCACCTCCTC CACCTGTCTT CTCATTGCTG
AAGATCAGTC AAAGAATTGT GTGCTTAGTT CTTGATAAGT CTGGAAGCAT GGGGGGTAAG
GACCGCCTAA ATCGAATGAA TCAAGCAGCA AAACATTTCC TGCTGCAGAC TGTTGAAAAT
GGATCCTGGG TGGGGATGGT TCACTTTGAT AGTACTGCCA CTATTGTAAA TAAGCTAATC
CAAATAAAAA GCAGTGATGA AAGAAACACA CTCATGGCAG GATTACCTAC ATATCCTCTG
GGAGGAACTT CCATCTGCTC TGGAATTAAA TATGCATTTC AGGTGATTGG AGAGCTACAT
TCCCAACTCG ATGGATCCGA AGTACTGCTG CTGACTGATG GGGAGGATAA CACTGCAAGT
TCTTGTATTG ATGAAGTGAA ACAAAGTGGG GCCATTGTTC ATTTTATTGC TTTGGGAAGA
GCTGCTGATG AAGCAGTAAT AGAGATGAGC AAGATAACAG GAGGAAGTCA TTTTTATGTT
TCAGATGAAG CTCAGAACAA TGGCCTCATT GATGCTTTTG GGGCTCTTAC ATCAGGAAAT
ACTGATCTCT CCCAGAAGTC CCTTCAGCTC GAAAGTAAGG GATTAACACT GAATAGTAAT
GCCTGGATGA ACGACACTGT CATAATTGAT AGTACAGTGG GAAAGGACAC GTTCTTTCTC
ATCACATGGA ACAGTCTGCC TCCCAGTATT TCTCTCTGGG ATCCCAGTGG AACAATAATG
GAAAATTTCA CAGTGGATGC AACTTCCAAA ATGGCCTATC TCAGTATTCC AGGAACTGCA
AAGGTGGGCA CTTGGGCATA CAATCTTCAA GCCAAAGCGA ACCCAGAAAC ATTAACTATT
ACAGTAACTT CTCGAGCAGC AAATTCTTCT GTGCCTCCAA TCACAGTGAA TGCTAAAATG
AATAAGGACG TAAACAGTTT CCCCAGCCCA ATGATTGTTT ACGCAGAAAT TCTACAAGGA
TATGTACCTG TTCTTGGAGC CAATGTGACT GCTTTCATTG AATCACAGAA TGGACATACA
GAAGTTTTGG AACTTTTGGA TAATGGTGCA GGCGCTGATT CTTTCAAGAA TGATGGAGTC
TACTCCAGGT ATTTTACAGC ATATACAGAA AATGGCAGAT ATAGCTTAAA AGTTCGGGCT
CATGGAGGAG CAAACACTGC CAGGCTAAAA TTACGGCCTC CACTGAATAG AGCCGCGTAC
ATACCAGGCT GGGTAGTGAA CGGGGAAATT GAAGCAAACC CGCCAAGACC TGAAATTGAT
GAGGATACTC AGACCACCTT GGAGGATTTC AGCCGAACAG CATCCGGAGG TGCATTTGTG
GTATCACAAG TCCCAAGCCT TCCCTTGCCT GACCAATACC CACCAAGTCA AATCACAGAC
CTTGATGCCA CAGTTCATGA GGATAAGATT ATTCTTACAT GGACAGCACC AGGAGATAAT
TTTGATGTTG GAAAAGTTCA ACGTTATATC ATAAGAATAA GTGCAAGTAT TCTTGATCTA
AGAGACAGTT TTGATGATGC TCTTCAAGTA AATACTACTG ATCTGTCACC AAAGGAGGCC
AACTCCAAGG AAAGCTTTGC ATTTAAACCA GAAAATATCT CAGAAGAAAA TGCAACCCAC
ATATTTATTG CCATTAAAAG TATAGATAAA AGCAATTTGA CATCAAAAGT ATCCAACATT
GCACAAGTAA CTTTGTTTAT CCCTCAAGCA AATCCTGATG ACATTGATCC TACACCTACT
CCTACTCCTA CTCCTACTCC TGATAAAAGT CATAATTCTG GAGTTAATAT TTCTACGCTG
GTATTGTCTG TGATTGGGTC TGTTGTAATT GTTAACTTTA TTTTAAGTAC CACCATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_036260.2
CDS45..2804
Misc Feature(1)33..35
Misc Feature(2)114..2771
Misc Feature(3)177..641
Misc Feature(4)957..1421
Misc Feature(5)order(978..980,1191..1193,1281..1283)
Misc Feature(6)2133..2138
Misc Feature(7)2727..2789
Exon (1)1..203
Exon (2)204..344
Exon (3)345..492
Exon (4)493..601
Exon (5)602..779
Exon (6)780..998
Exon (7)999..1226
Exon (8)1227..1404
Exon (9)1405..1511
Exon (10)1512..1727
Exon (11)1728..1995
Exon (12)1996..2166
Exon (13)2167..2400
Exon (14)2401..3213
Translation

Target ORF information:

RefSeq Version NM_012128.3
Organism Homo sapiens(Human)
Definition Homo sapiens chloride channel accessory 4 (CLCA4), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_012128.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
ATGGGGTTAT TCAGAGGTTT TGTTTTCCTC TTAGTTCTGT GCCTGCTGCA CCAGTCAAAT 
ACTTCCTTCA TTAAGCTGAA TAATAATGGC TTTGAAGATA TTGTCATTGT TATAGATCCT
AGTGTGCCAG AAGATGAAAA AATAATTGAA CAAATAGAGG ATATGGTGAC TACAGCTTCT
ACGTACCTGT TTGAAGCCAC AGAAAAAAGA TTTTTTTTCA AAAATGTATC TATATTAATT
CCTGAGAATT GGAAGGAAAA TCCTCAGTAC AAAAGGCCAA AACATGAAAA CCATAAACAT
GCTGATGTTA TAGTTGCACC ACCTACACTC CCAGGTAGAG ATGAACCATA CACCAAGCAG
TTCACAGAAT GTGGAGAGAA AGGCGAATAC ATTCACTTCA CCCCTGACCT TCTACTTGGA
AAAAAACAAA ATGAATATGG ACCACCAGGC AAACTGTTTG TCCATGAGTG GGCTCACCTC
CGGTGGGGAG TGTTTGATGA GTACAATGAA GATCAGCCTT TCTACCGTGC TAAGTCAAAA
AAAATCGAAG CAACAAGGTG TTCCGCAGGT ATCTCTGGTA GAAATAGAGT TTATAAGTGT
CAAGGAGGCA GCTGTCTTAG TAGAGCATGC AGAATTGATT CTACAACAAA ACTGTATGGA
AAAGATTGTC AATTCTTTCC TGATAAAGTA CAAACAGAAA AAGCATCCAT AATGTTTATG
CAAAGTATTG ATTCTGTTGT TGAATTTTGT AACGAAAAAA CCCATAATCA AGAAGCTCCA
AGCCTACAAA ACATAAAGTG CAATTTTAGA AGTACATGGG AGGTGATTAG CAATTCTGAG
GATTTTAAAA ACACCATACC CATGGTGACA CCACCTCCTC CACCTGTCTT CTCATTGCTG
AAGATCAGTC AAAGAATTGT GTGCTTAGTT CTTGATAAGT CTGGAAGCAT GGGGGGTAAG
GACCGCCTAA ATCGAATGAA TCAAGCAGCA AAACATTTCC TGCTGCAGAC TGTTGAAAAT
GGATCCTGGG TGGGGATGGT TCACTTTGAT AGTACTGCCA CTATTGTAAA TAAGCTAATC
CAAATAAAAA GCAGTGATGA AAGAAACACA CTCATGGCAG GATTACCTAC ATATCCTCTG
GGAGGAACTT CCATCTGCTC TGGAATTAAA TATGCATTTC AGGTGATTGG AGAGCTACAT
TCCCAACTCG ATGGATCCGA AGTACTGCTG CTGACTGATG GGGAGGATAA CACTGCAAGT
TCTTGTATTG ATGAAGTGAA ACAAAGTGGG GCCATTGTTC ATTTTATTGC TTTGGGAAGA
GCTGCTGATG AAGCAGTAAT AGAGATGAGC AAGATAACAG GAGGAAGTCA TTTTTATGTT
TCAGATGAAG CTCAGAACAA TGGCCTCATT GATGCTTTTG GGGCTCTTAC ATCAGGAAAT
ACTGATCTCT CCCAGAAGTC CCTTCAGCTC GAAAGTAAGG GATTAACACT GAATAGTAAT
GCCTGGATGA ACGACACTGT CATAATTGAT AGTACAGTGG GAAAGGACAC GTTCTTTCTC
ATCACATGGA ACAGTCTGCC TCCCAGTATT TCTCTCTGGG ATCCCAGTGG AACAATAATG
GAAAATTTCA CAGTGGATGC AACTTCCAAA ATGGCCTATC TCAGTATTCC AGGAACTGCA
AAGGTGGGCA CTTGGGCATA CAATCTTCAA GCCAAAGCGA ACCCAGAAAC ATTAACTATT
ACAGTAACTT CTCGAGCAGC AAATTCTTCT GTGCCTCCAA TCACAGTGAA TGCTAAAATG
AATAAGGACG TAAACAGTTT CCCCAGCCCA ATGATTGTTT ACGCAGAAAT TCTACAAGGA
TATGTACCTG TTCTTGGAGC CAATGTGACT GCTTTCATTG AATCACAGAA TGGACATACA
GAAGTTTTGG AACTTTTGGA TAATGGTGCA GGCGCTGATT CTTTCAAGAA TGATGGAGTC
TACTCCAGGT ATTTTACAGC ATATACAGAA AATGGCAGAT ATAGCTTAAA AGTTCGGGCT
CATGGAGGAG CAAACACTGC CAGGCTAAAA TTACGGCCTC CACTGAATAG AGCCGCGTAC
ATACCAGGCT GGGTAGTGAA CGGGGAAATT GAAGCAAACC CGCCAAGACC TGAAATTGAT
GAGGATACTC AGACCACCTT GGAGGATTTC AGCCGAACAG CATCCGGAGG TGCATTTGTG
GTATCACAAG TCCCAAGCCT TCCCTTGCCT GACCAATACC CACCAAGTCA AATCACAGAC
CTTGATGCCA CAGTTCATGA GGATAAGATT ATTCTTACAT GGACAGCACC AGGAGATAAT
TTTGATGTTG GAAAAGTTCA ACGTTATATC ATAAGAATAA GTGCAAGTAT TCTTGATCTA
AGAGACAGTT TTGATGATGC TCTTCAAGTA AATACTACTG ATCTGTCACC AAAGGAGGCC
AACTCCAAGG AAAGCTTTGC ATTTAAACCA GAAAATATCT CAGAAGAAAA TGCAACCCAC
ATATTTATTG CCATTAAAAG TATAGATAAA AGCAATTTGA CATCAAAAGT ATCCAACATT
GCACAAGTAA CTTTGTTTAT CCCTCAAGCA AATCCTGATG ACATTGATCC TACACCTACT
CCTACTCCTA CTCCTACTCC TGATAAAAGT CATAATTCTG GAGTTAATAT TTCTACGCTG
GTATTGTCTG TGATTGGGTC TGTTGTAATT GTTAACTTTA TTTTAAGTAC CACCATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu64946
Clone ID Related Accession (Same CDS sequence) XM_011541015.2
Accession Version XM_011541015.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2607bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product calcium-activated chloride channel regulator 4 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011541015.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
ATGGAGGATA TGGTGACTAC AGCTTCTACG TACCTGTTTG AAGCCACAGA AAAAAGATTT 
TTTTTCAAAA ATGTATCTAT ATTAATTCCT GAGAATTGGA AGGAAAATCC TCAGTACAAA
AGGCCAAAAC ATGAAAACCA TAAACATGCT GATGTTATAG TTGCACCACC TACACTCCCA
GGTAGAGATG AACCATACAC CAAGCAGTTC ACAGAATGTG GAGAGAAAGG CGAATACATT
CACTTCACCC CTGACCTTCT ACTTGGAAAA AAACAAAATG AATATGGACC ACCAGGCAAA
CTGTTTGTCC ATGAGTGGGC TCACCTCCGG TGGGGAGTGT TTGATGAGTA CAATGAAGAT
CAGCCTTTCT ACCGTGCTAA GTCAAAAAAA ATCGAAGCAA CAAGGTGTTC CGCAGGTATC
TCTGGTAGAA ATAGAGTTTA TAAGTGTCAA GGAGGCAGCT GTCTTAGTAG AGCATGCAGA
ATTGATTCTA CAACAAAACT GTATGGAAAA GATTGTCAAT TCTTTCCTGA TAAAGTACAA
ACAGAAAAAG CATCCATAAT GTTTATGCAA AGTATTGATT CTGTTGTTGA ATTTTGTAAC
GAAAAAACCC ATAATCAAGA AGCTCCAAGC CTACAAAACA TAAAGTGCAA TTTTAGAAGT
ACATGGGAGG TGATTAGCAA TTCTGAGGAT TTTAAAAACA CCATACCCAT GGTGACACCA
CCTCCTCCAC CTGTCTTCTC ATTGCTGAAG ATCAGTCAAA GAATTGTGTG CTTAGTTCTT
GATAAGTCTG GAAGCATGGG GGGTAAGGAC CGCCTAAATC GAATGAATCA AGCAGCAAAA
CATTTCCTGC TGCAGACTGT TGAAAATGGA TCCTGGGTGG GGATGGTTCA CTTTGATAGT
ACTGCCACTA TTGTAAATAA GCTAATCCAA ATAAAAAGCA GTGATGAAAG AAACACACTC
ATGGCAGGAT TACCTACATA TCCTCTGGGA GGAACTTCCA TCTGCTCTGG AATTAAATAT
GCATTTCAGG TGATTGGAGA GCTACATTCC CAACTCGATG GATCCGAAGT ACTGCTGCTG
ACTGATGGGG AGGATAACAC TGCAAGTTCT TGTATTGATG AAGTGAAACA AAGTGGGGCC
ATTGTTCATT TTATTGCTTT GGGAAGAGCT GCTGATGAAG CAGTAATAGA GATGAGCAAG
ATAACAGGAG GAAGTCATTT TTATGTTTCA GATGAAGCTC AGAACAATGG CCTCATTGAT
GCTTTTGGGG CTCTTACATC AGGAAATACT GATCTCTCCC AGAAGTCCCT TCAGCTCGAA
AGTAAGGGAT TAACACTGAA TAGTAATGCC TGGATGAACG ACACTGTCAT AATTGATAGT
ACAGTGGGAA AGGACACGTT CTTTCTCATC ACATGGAACA GTCTGCCTCC CAGTATTTCT
CTCTGGGATC CCAGTGGAAC AATAATGGAA AATTTCACAG TGGATGCAAC TTCCAAAATG
GCCTATCTCA GTATTCCAGG AACTGCAAAG GTGGGCACTT GGGCATACAA TCTTCAAGCC
AAAGCGAACC CAGAAACATT AACTATTACA GTAACTTCTC GAGCAGCAAA TTCTTCTGTG
CCTCCAATCA CAGTGAATGC TAAAATGAAT AAGGACGTAA ACAGTTTCCC CAGCCCAATG
ATTGTTTACG CAGAAATTCT ACAAGGATAT GTACCTGTTC TTGGAGCCAA TGTGACTGCT
TTCATTGAAT CACAGAATGG ACATACAGAA GTTTTGGAAC TTTTGGATAA TGGTGCAGGC
GCTGATTCTT TCAAGAATGA TGGAGTCTAC TCCAGGTATT TTACAGCATA TACAGAAAAT
GGCAGATATA GCTTAAAAGT TCGGGCTCAT GGAGGAGCAA ACACTGCCAG GCTAAAATTA
CGGCCTCCAC TGAATAGAGC CGCGTACATA CCAGGCTGGG TAGTGAACGG GGAAATTGAA
GCAAACCCGC CAAGACCTGA AATTGATGAG GATACTCAGA CCACCTTGGA GGATTTCAGC
CGAACAGCAT CCGGAGGTGC ATTTGTGGTA TCACAAGTCC CAAGCCTTCC CTTGCCTGAC
CAATACCCAC CAAGTCAAAT CACAGACCTT GATGCCACAG TTCATGAGGA TAAGATTATT
CTTACATGGA CAGCACCAGG AGATAATTTT GATGTTGGAA AAGTTCAACG TTATATCATA
AGAATAAGTG CAAGTATTCT TGATCTAAGA GACAGTTTTG ATGATGCTCT TCAAGTAAAT
ACTACTGATC TGTCACCAAA GGAGGCCAAC TCCAAGGAAA GCTTTGCATT TAAACCAGAA
AATATCTCAG AAGAAAATGC AACCCACATA TTTATTGCCA TTAAAAGTAT AGATAAAAGC
AATTTGACAT CAAAAGTATC CAACATTGCA CAAGTAACTT TGTTTATCCC TCAAGCAAAT
CCTGATGACA TTGATCCTAC ACCTACTCCT ACTCCTACTC CTACTCCTGA TAAAAGTCAT
AATTCTGGAG TTAATATTTC TACGCTGGTA TTGTCTGTGA TTGGGTCTGT TGTAATTGTT
AACTTTATTT TAAGTACCAC CATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011539317.1
CDS17..2623
Misc Feature(1)20..2590
Misc Feature(2)776..1240
Misc Feature(3)order(797..799,1010..1012,1100..1102)
Translation

Target ORF information:

RefSeq Version XM_011541015.2
Organism Homo sapiens(Human)
Definition Homo sapiens chloride channel accessory 4 (CLCA4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011541015.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
ATGGAGGATA TGGTGACTAC AGCTTCTACG TACCTGTTTG AAGCCACAGA AAAAAGATTT 
TTTTTCAAAA ATGTATCTAT ATTAATTCCT GAGAATTGGA AGGAAAATCC TCAGTACAAA
AGGCCAAAAC ATGAAAACCA TAAACATGCT GATGTTATAG TTGCACCACC TACACTCCCA
GGTAGAGATG AACCATACAC CAAGCAGTTC ACAGAATGTG GAGAGAAAGG CGAATACATT
CACTTCACCC CTGACCTTCT ACTTGGAAAA AAACAAAATG AATATGGACC ACCAGGCAAA
CTGTTTGTCC ATGAGTGGGC TCACCTCCGG TGGGGAGTGT TTGATGAGTA CAATGAAGAT
CAGCCTTTCT ACCGTGCTAA GTCAAAAAAA ATCGAAGCAA CAAGGTGTTC CGCAGGTATC
TCTGGTAGAA ATAGAGTTTA TAAGTGTCAA GGAGGCAGCT GTCTTAGTAG AGCATGCAGA
ATTGATTCTA CAACAAAACT GTATGGAAAA GATTGTCAAT TCTTTCCTGA TAAAGTACAA
ACAGAAAAAG CATCCATAAT GTTTATGCAA AGTATTGATT CTGTTGTTGA ATTTTGTAAC
GAAAAAACCC ATAATCAAGA AGCTCCAAGC CTACAAAACA TAAAGTGCAA TTTTAGAAGT
ACATGGGAGG TGATTAGCAA TTCTGAGGAT TTTAAAAACA CCATACCCAT GGTGACACCA
CCTCCTCCAC CTGTCTTCTC ATTGCTGAAG ATCAGTCAAA GAATTGTGTG CTTAGTTCTT
GATAAGTCTG GAAGCATGGG GGGTAAGGAC CGCCTAAATC GAATGAATCA AGCAGCAAAA
CATTTCCTGC TGCAGACTGT TGAAAATGGA TCCTGGGTGG GGATGGTTCA CTTTGATAGT
ACTGCCACTA TTGTAAATAA GCTAATCCAA ATAAAAAGCA GTGATGAAAG AAACACACTC
ATGGCAGGAT TACCTACATA TCCTCTGGGA GGAACTTCCA TCTGCTCTGG AATTAAATAT
GCATTTCAGG TGATTGGAGA GCTACATTCC CAACTCGATG GATCCGAAGT ACTGCTGCTG
ACTGATGGGG AGGATAACAC TGCAAGTTCT TGTATTGATG AAGTGAAACA AAGTGGGGCC
ATTGTTCATT TTATTGCTTT GGGAAGAGCT GCTGATGAAG CAGTAATAGA GATGAGCAAG
ATAACAGGAG GAAGTCATTT TTATGTTTCA GATGAAGCTC AGAACAATGG CCTCATTGAT
GCTTTTGGGG CTCTTACATC AGGAAATACT GATCTCTCCC AGAAGTCCCT TCAGCTCGAA
AGTAAGGGAT TAACACTGAA TAGTAATGCC TGGATGAACG ACACTGTCAT AATTGATAGT
ACAGTGGGAA AGGACACGTT CTTTCTCATC ACATGGAACA GTCTGCCTCC CAGTATTTCT
CTCTGGGATC CCAGTGGAAC AATAATGGAA AATTTCACAG TGGATGCAAC TTCCAAAATG
GCCTATCTCA GTATTCCAGG AACTGCAAAG GTGGGCACTT GGGCATACAA TCTTCAAGCC
AAAGCGAACC CAGAAACATT AACTATTACA GTAACTTCTC GAGCAGCAAA TTCTTCTGTG
CCTCCAATCA CAGTGAATGC TAAAATGAAT AAGGACGTAA ACAGTTTCCC CAGCCCAATG
ATTGTTTACG CAGAAATTCT ACAAGGATAT GTACCTGTTC TTGGAGCCAA TGTGACTGCT
TTCATTGAAT CACAGAATGG ACATACAGAA GTTTTGGAAC TTTTGGATAA TGGTGCAGGC
GCTGATTCTT TCAAGAATGA TGGAGTCTAC TCCAGGTATT TTACAGCATA TACAGAAAAT
GGCAGATATA GCTTAAAAGT TCGGGCTCAT GGAGGAGCAA ACACTGCCAG GCTAAAATTA
CGGCCTCCAC TGAATAGAGC CGCGTACATA CCAGGCTGGG TAGTGAACGG GGAAATTGAA
GCAAACCCGC CAAGACCTGA AATTGATGAG GATACTCAGA CCACCTTGGA GGATTTCAGC
CGAACAGCAT CCGGAGGTGC ATTTGTGGTA TCACAAGTCC CAAGCCTTCC CTTGCCTGAC
CAATACCCAC CAAGTCAAAT CACAGACCTT GATGCCACAG TTCATGAGGA TAAGATTATT
CTTACATGGA CAGCACCAGG AGATAATTTT GATGTTGGAA AAGTTCAACG TTATATCATA
AGAATAAGTG CAAGTATTCT TGATCTAAGA GACAGTTTTG ATGATGCTCT TCAAGTAAAT
ACTACTGATC TGTCACCAAA GGAGGCCAAC TCCAAGGAAA GCTTTGCATT TAAACCAGAA
AATATCTCAG AAGAAAATGC AACCCACATA TTTATTGCCA TTAAAAGTAT AGATAAAAGC
AATTTGACAT CAAAAGTATC CAACATTGCA CAAGTAACTT TGTTTATCCC TCAAGCAAAT
CCTGATGACA TTGATCCTAC ACCTACTCCT ACTCCTACTC CTACTCCTGA TAAAAGTCAT
AATTCTGGAG TTAATATTTC TACGCTGGTA TTGTCTGTGA TTGGGTCTGT TGTAATTGTT
AACTTTATTT TAAGTACCAC CATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine.
European journal of human genetics : EJHG21(6)691-4(2013 Jun)
Kolbe EW,Tamm S,Hedtfeld S,Becker T,Tümmler B,Stanke F


book

Loss of CLCA4 promotes epithelial-to-mesenchymal transition in breast cancer cells.
PloS one8(12)e83943(2013)
Yu Y,Walia V,Elble RC


book

The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
Human genetics115(6)483-91(2004 Nov)
Ritzka M,Stanke F,Jansen S,Gruber AD,Pusch L,Woelfl S,Veeze HJ,Halley DJ,Tümmler B


book

Molecular characteristics and functional diversity of CLCA family members.
Clinical and experimental pharmacology & physiology27(11)901-5(2000 Nov)
Pauli BU,Abdel-Ghany M,Cheng HC,Gruber AD,Archibald HA,Elble RC


book

Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.
FEBS letters455(3)295-301(1999 Jul)
Agnel M,Vermat T,Culouscou JM


 
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