FOXG1 cDNA ORF clone, Homo sapiens (human)
| Gene Symbol | FOXG1 |
| Entrez Gene ID | 2290 |
| Full Name | forkhead box G1 |
| Synonyms | BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF-3, HBF-G2, HBF2, HFK1, HFK2, HFK3, KHL2, QIN |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome | |
| Summary | This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]. lac of sum |
| Disorder MIM: | |
| Disorder Html: | Rett syndrome, congenital variant, 613454 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_005249 | NP_005240 | forkhead box protein G1 |
| Homo sapiens (human) | FOXG1 | NP_005240.3 |
| Pan troglodytes (chimpanzee) | FOXG1 | XP_003952518.1 |
| Macaca mulatta (Rhesus monkey) | LOC716287 | XP_001106922.2 |
| Bos taurus (cattle) | FOXG1 | XP_002707820.2 |
| Mus musculus (house mouse) | Foxg1 | NP_032267.1 |
| Rattus norvegicus (Norway rat) | Foxg1 | NP_036692.1 |
| Danio rerio (zebrafish) | foxg1a | NP_571142.1 |
| Xenopus (Silurana) tropicalis (western clawed frog) | foxg1 | NP_001116933.1 |
Related articles in PubMed
- 14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements. Allou L, et al. Eur J Hum Genet, 2012 Dec. PMID 22739344.
- Further delineation of the phenotype of chromosome 14q13 deletions: (positional) involvement of FOXG1 appears the main determinant of phenotype severity, with no evidence for a holoprosencephaly locus. Santen GW, et al. J Med Genet, 2012 Jun. PMID 22636604.
- Foxg1 has an essential role in postnatal development of the dentate gyrus. Tian C, et al. J Neurosci, 2012 Feb 29. PMID 22378868.
- Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival. Dastidar SG, et al. J Biol Chem, 2012 Apr 27. PMID 22354967.
- Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.
See all (45) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions What's a GeneRIF?
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In fibroblast cells, a cis-acting regulatory sequence located more than 0.6 Mb away from FOXG1 acts as a silencer at the transcriptional level.
Title: 14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements.
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FOXG1 mutations are involved in the molecular etiology of the congenital variant of Rett syndrome.
Title: FOXG1 mutations in Japanese patients with the congenital variant of Rett syndrome.
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Alterations in the kinetics of FoxG1 binding to chromatin might contribute to the pathological effects of FOXG1 mutations.
Title: Expanding the phenotype associated with FOXG1 mutations and in vivo FoxG1 chromatin-binding dynamics.
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The authors show that deletions including 14q13 result in a recognisable phenotype mainly due to haploinsufficiency of two genes (NKX2-1, PAX9). FOXG1 (on chromosome band 14q12) involvement seems to be the main determinant of phenotype severity.
Title: Further delineation of the phenotype of chromosome 14q13 deletions: (positional) involvement of FOXG1 appears the main determinant of phenotype severity, with no evidence for a holoprosencephaly locus.
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Foxg1 is critical for dentate gyrus formation, especially during the early postnatal stage.
Title: Foxg1 has an essential role in postnatal development of the dentate gyrus.
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A small increase in the dosage of FOXG1 could cause infantile spasms.
Title: West syndrome associated with mosaic duplication of FOXG1 in a patient with maternal uniparental disomy of chromosome 14.
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The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis.
Title: The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis.
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West syndrome was associated with 14q12 duplications harboring FOXG1
Title: West syndrome associated with 14q12 duplications harboring FOXG1.
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Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects in their telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression.
Title: MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.
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We report a series of seven cases of patients with FIXG1 gebe duplications in 14q associated with developmental delay/mental retardation and speech delay as predominant features, as well as developmental epilepsy in the majority.
Title: Duplications of FOXG1 in 14q12 are associated with developmental epilepsy, mental retardation, and severe speech impairment.
The following FOXG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu22100 | |
| Clone ID Related Accession (Same CDS sequence) | NM_005249 | |
| Accession Version | NM_005249.4 | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1470bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Structure | linear | |
| Update Date | 10-MAY-2014 | |
| Organism | Homo sapiens (human) | |
| Product | forkhead box protein G1 | |
| Comment | REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X74142.1, DR001113.1, BC035020.2, AL049777.5 and U44097.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2012 this sequence version replaced gi:32307176. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end. | |
1 | ATGCTGGACA TGGGAGATAG GAAAGAGGTG AAAATGATCC CCAAGTCCTC GTTCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005240.3 |
| CDS | 209..1678 |
| Misc Feature(1) | 35..37(+) |
| Misc Feature(2) | 749..982(+) |
| Misc Feature(3) | 857..961(+) |
| Misc Feature(4) | 1355..1426(+) |
| Exon (1) | 1..3206 Gene:FOXG1 Gene Synonym: |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_005249 |
ORF Insert Sequence:
1 | ATGCTGGACA TGGGAGATAG GAAAGAGGTG AAAATGATCC CCAAGTCCTC GTTCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells |
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14q12 microdeletions excluding FOXG1 give rise to a congenital variant Rett syndrome-like phenotype |
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14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements |
|
Further delineation of the phenotype of chromosome 14q13 deletions: (positional) involvement of FOXG1 appears the main determinant of phenotype severity, with no evidence for a holoprosencephaly locus |
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The oncogene qin codes for a transcriptional repressor |
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The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q |
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Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending |
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Human brain factor 1, a new member of the fork head gene family |
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The human homologue of the retroviral oncogene qin maps to chromosome 14q13 |
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The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head |
