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FOXG1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FOXG1
Entrez Gene ID 2290
Full Name forkhead box G1
Synonyms BF1,BF2,FHKL3,FKH2,FKHL1,FKHL2,FKHL3,FKHL4,FOXG1A,FOXG1B,FOXG1C,HBF-1,HBF-2,HBF-3,HBF-G2,HBF2,HFK1,HFK2,HFK3,KHL2,QIN
General protein information
Preferred Names

forkhead box G1

Names

forkhead box protein G1
brain factor 1
brain factor 2
forkhead-like 1
forkhead-like 2
forkhead-like 3
forkhead-like 4
oncogene QIN

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

14

14q12

Summary This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012].
Disorder MIM:

164874

Disorder Html: Rett syndrome, congenital variant, 613454 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_005249.4 NP_005240.3 forkhead box protein G1



Homo sapiens (human) FOXG1 NP_005240.3
Bos taurus (cattle) FOXG1 XP_002707820.2
Rattus norvegicus (Norway rat) Foxg1 NP_036692.1
Xenopus tropicalis (tropical clawed frog) foxg1 NP_001116933.1
Mus musculus (house mouse) Foxg1 NP_032267.1
Danio rerio (zebrafish) foxg1a NP_571142.1
Pan troglodytes (chimpanzee) FOXG1 XP_003952518.1
Macaca mulatta (rhesus monkey) LOC716287 XP_001106922.2


Related articles in PubMed

Visual impairment in FOXG1-mutated individuals and mice.
Boggio EM, Pancrazi L, Gennaro M, Lo Rizzo C, Mari F, Meloni I, Ariani F, Panighini A, Novelli E, Biagioni M, Strettoi E, Hayek J, Rufa A, Pizzorusso T, Renieri A, Costa M
Neuroscience324496-508(2016 Jun)

Delineation of the movement disorders associated with FOXG1 mutations.
Papandreou A, Schneider RB, Augustine EF, Ng J, Mankad K, Meyer E, McTague A, Ngoh A, Hemingway C, Robinson R, Varadkar SM, Kinali M, Salpietro V, O'Driscoll MC, Basheer SN, Webster RI, Mohammad SS, Pula S, McGowan M, Trump N, Jenkins L, Elmslie F, Scott RH, Hurst JA, Perez-Duenas B, Paciorkowski AR, Kurian MA
Neurology86(19)1794-800(2016 May)

MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1.
Zeng F, Xue M, Xiao T, Li Y, Xiao S, Jiang B, Ren C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie79294-301(2016 Apr)

An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development.
Baek ST, Copeland B, Yun EJ, Kwon SK, Guemez-Gamboa A, Schaffer AE, Kim S, Kang HC, Song S, Mathern GW, Gleeson JG
Nature medicine21(12)1445-54(2015 Dec)

The human homologue of the retroviral oncogene qin maps to chromosome 14q13.
Kastury K, Li J, Druck T, Su H, Vogt PK, Croce CM, Huebner K
Proceedings of the National Academy of Sciences of the United States of America91(9)3616-8(1994 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

describe the initial design and characterizations of novel covalent BH3-based agents that potently target Bfl-1
Title: hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.

findings demonstrate clear phenotype differences between FOXG1 and MECP2 disorders.
Title: Phenotype Differentiation of FOXG1 and MECP2 Disorders: A New Method for Characterization of Developmental Encephalopathies.

Report demonstrates the functional consequences of Foxg1 haploinsufficiency in the visual system of Foxg1+/Cre mice and a visual impairment in a cohort of Rett individuals presenting genetic alteration on FOXG1
Title: Visual impairment in FOXG1-mutated individuals and mice.

Abnormal involuntary movements are a major feature of FOXG1 mutations. Our study delineates the spectrum of movement disorders and confirms an expanding clinical phenotype. Symptomatic treatment may be considered for severe or disabling cases, although further research regarding potential treatment strategies is necessary.
Title: Delineation of the movement disorders associated with FOXG1 mutations.

Upregulated miR-200b in cervical cancer was proven to show positive regulation on cervical cancer development by directly targeting FoxG1.
Title: MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1.

The following FOXG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22100 NM_005249.4
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Homo sapiens forkhead box G1 (FOXG1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22100
Clone ID Related Accession (Same CDS sequence) NM_005249.4
Accession Version NM_005249.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1470bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product forkhead box protein G1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X74142.1, DR001113.1, BC035020.2, AL049777.5 and U44097.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2012 this sequence version replaced NM_005249.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGCTGGACA TGGGAGATAG GAAAGAGGTG AAAATGATCC CCAAGTCCTC GTTCAGCATC 
AACAGCCTGG TGCCCGAGGC GGTCCAGAAC GACAACCACC ACGCGAGCCA CGGCCACCAC
AACAGCCACC ACCCCCAGCA CCACCACCAC CACCACCACC ATCACCACCA CCCGCCGCCG
CCCGCCCCGC AACCGCCGCC GCCGCCGCAG CAGCAGCAGC CGCCGCCGCC GCCGCCCCCG
GCACCGCAGC CCCCCCAGAC GCGGGGCGCC CCGGCCGCCG ACGACGACAA GGGCCCCCAG
CAGCTGCTGC TCCCGCCGCC GCCACCGCCA CCACCGGCCG CCGCCCTGGA CGGGGCTAAA
GCGGACGGGC TGGGCGGCAA GGGCGAGCCG GGCGGCGGGC CGGGGGAGCT GGCGCCCGTC
GGGCCGGACG AGAAGGAGAA GGGCGCCGGC GCCGGGGGGG AGGAGAAGAA GGGGGCGGGC
GAGGGCGGCA AGGACGGGGA GGGGGGCAAG GAGGGCGAGA AGAAGAACGG CAAGTACGAG
AAGCCGCCGT TCAGCTACAA CGCGCTCATC ATGATGGCCA TCCGGCAGAG CCCCGAGAAG
CGGCTCACGC TCAACGGCAT CTACGAGTTC ATCATGAAGA ACTTCCCTTA CTACCGCGAG
AACAAGCAGG GCTGGCAGAA CTCCATCCGC CACAATCTGT CCCTCAACAA GTGCTTCGTG
AAGGTGCCGC GCCACTACGA CGACCCGGGC AAGGGCAACT ACTGGATGCT GGACCCGTCG
AGCGACGACG TGTTCATCGG CGGCACCACG GGCAAGCTGC GGCGCCGCTC CACCACCTCG
CGGGCCAAGC TGGCCTTCAA GCGCGGTGCG CGCCTCACCT CCACCGGCCT CACCTTCATG
GACCGCGCCG GCTCCCTCTA CTGGCCCATG TCGCCCTTCC TGTCCCTGCA CCACCCCCGC
GCCAGCAGCA CTTTGAGTTA CAACGGCACC ACGTCGGCCT ACCCCAGCCA CCCCATGCCC
TACAGCTCCG TGTTGACTCA GAACTCGCTG GGCAACAACC ACTCCTTCTC CACCGCCAAC
GGCCTGAGCG TGGACCGGCT GGTCAACGGG GAGATCCCGT ACGCCACGCA CCACCTCACG
GCCGCCGCGC TAGCCGCCTC GGTGCCCTGC GGCCTGTCGG TGCCCTGCTC TGGGACCTAC
TCCCTCAACC CCTGCTCCGT CAACCTGCTC GCGGGCCAGA CCAGTTACTT TTTCCCCCAC
GTCCCGCACC CGTCAATGAC TTCGCAGAGC AGCACGTCCA TGAGCGCCAG GGCCGCGTCC
TCCTCCACGT CGCCGCAGGC CCCCTCGACC CTGCCCTGTG AGTCTTTAAG ACCCTCTTTG
CCAAGTTTTA CGACGGGACT GTCTGGGGGA CTGTCTGATT ATTTCACACA TCAAAATCAG
GGGTCTTCTT CCAACCCTTT AATACATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005240.3
CDS209..1678
Misc Feature(1)35..37
Misc Feature(2)749..1015
Misc Feature(3)order(857..862,887..889,896..901,959..961)
Misc Feature(4)1355..1426
Exon (1)1..3206
Translation

Target ORF information:

RefSeq Version NM_005249.4
Organism Homo sapiens(Human)
Definition Homo sapiens forkhead box G1 (FOXG1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005249.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGCTGGACA TGGGAGATAG GAAAGAGGTG AAAATGATCC CCAAGTCCTC GTTCAGCATC 
AACAGCCTGG TGCCCGAGGC GGTCCAGAAC GACAACCACC ACGCGAGCCA CGGCCACCAC
AACAGCCACC ACCCCCAGCA CCACCACCAC CACCACCACC ATCACCACCA CCCGCCGCCG
CCCGCCCCGC AACCGCCGCC GCCGCCGCAG CAGCAGCAGC CGCCGCCGCC GCCGCCCCCG
GCACCGCAGC CCCCCCAGAC GCGGGGCGCC CCGGCCGCCG ACGACGACAA GGGCCCCCAG
CAGCTGCTGC TCCCGCCGCC GCCACCGCCA CCACCGGCCG CCGCCCTGGA CGGGGCTAAA
GCGGACGGGC TGGGCGGCAA GGGCGAGCCG GGCGGCGGGC CGGGGGAGCT GGCGCCCGTC
GGGCCGGACG AGAAGGAGAA GGGCGCCGGC GCCGGGGGGG AGGAGAAGAA GGGGGCGGGC
GAGGGCGGCA AGGACGGGGA GGGGGGCAAG GAGGGCGAGA AGAAGAACGG CAAGTACGAG
AAGCCGCCGT TCAGCTACAA CGCGCTCATC ATGATGGCCA TCCGGCAGAG CCCCGAGAAG
CGGCTCACGC TCAACGGCAT CTACGAGTTC ATCATGAAGA ACTTCCCTTA CTACCGCGAG
AACAAGCAGG GCTGGCAGAA CTCCATCCGC CACAATCTGT CCCTCAACAA GTGCTTCGTG
AAGGTGCCGC GCCACTACGA CGACCCGGGC AAGGGCAACT ACTGGATGCT GGACCCGTCG
AGCGACGACG TGTTCATCGG CGGCACCACG GGCAAGCTGC GGCGCCGCTC CACCACCTCG
CGGGCCAAGC TGGCCTTCAA GCGCGGTGCG CGCCTCACCT CCACCGGCCT CACCTTCATG
GACCGCGCCG GCTCCCTCTA CTGGCCCATG TCGCCCTTCC TGTCCCTGCA CCACCCCCGC
GCCAGCAGCA CTTTGAGTTA CAACGGCACC ACGTCGGCCT ACCCCAGCCA CCCCATGCCC
TACAGCTCCG TGTTGACTCA GAACTCGCTG GGCAACAACC ACTCCTTCTC CACCGCCAAC
GGCCTGAGCG TGGACCGGCT GGTCAACGGG GAGATCCCGT ACGCCACGCA CCACCTCACG
GCCGCCGCGC TAGCCGCCTC GGTGCCCTGC GGCCTGTCGG TGCCCTGCTC TGGGACCTAC
TCCCTCAACC CCTGCTCCGT CAACCTGCTC GCGGGCCAGA CCAGTTACTT TTTCCCCCAC
GTCCCGCACC CGTCAATGAC TTCGCAGAGC AGCACGTCCA TGAGCGCCAG GGCCGCGTCC
TCCTCCACGT CGCCGCAGGC CCCCTCGACC CTGCCCTGTG AGTCTTTAAG ACCCTCTTTG
CCAAGTTTTA CGACGGGACT GTCTGGGGGA CTGTCTGATT ATTTCACACA TCAAAATCAG
GGGTCTTCTT CCAACCCTTT AATACATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Visual impairment in FOXG1-mutated individuals and mice.
Neuroscience324496-508(2016 Jun)
Boggio EM,Pancrazi L,Gennaro M,Lo Rizzo C,Mari F,Meloni I,Ariani F,Panighini A,Novelli E,Biagioni M,Strettoi E,Hayek J,Rufa A,Pizzorusso T,Renieri A,Costa M


book

Delineation of the movement disorders associated with FOXG1 mutations.
Neurology86(19)1794-800(2016 May)
Papandreou A,Schneider RB,Augustine EF,Ng J,Mankad K,Meyer E,McTague A,Ngoh A,Hemingway C,Robinson R,Varadkar SM,Kinali M,Salpietro V,O'Driscoll MC,Basheer SN,Webster RI,Mohammad SS,Pula S,McGowan M,Trump N,Jenkins L,Elmslie F,Scott RH,Hurst JA,Perez-Duenas B,Paciorkowski AR,Kurian MA


book

MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie79294-301(2016 Apr)
Zeng F,Xue M,Xiao T,Li Y,Xiao S,Jiang B,Ren C


book

An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development.
Nature medicine21(12)1445-54(2015 Dec)
Baek ST,Copeland B,Yun EJ,Kwon SK,Guemez-Gamboa A,Schaffer AE,Kim S,Kang HC,Song S,Mathern GW,Gleeson JG


book

The human homologue of the retroviral oncogene qin maps to chromosome 14q13.
Proceedings of the National Academy of Sciences of the United States of America91(9)3616-8(1994 Apr)
Kastury K,Li J,Druck T,Su H,Vogt PK,Croce CM,Huebner K


 
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