Gene Symbol | MAN2B2 |
Entrez Gene ID | 23324 |
Full Name | mannosidase alpha class 2B member 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » MAN2B2 cDNA ORF clone
Gene Symbol | MAN2B2 |
Entrez Gene ID | 23324 |
Full Name | mannosidase alpha class 2B member 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_015274.2 | NP_056089.1 | epididymis-specific alpha-mannosidase isoform 1 precursor |
NM_001292038.1 | NP_001278967.1 | epididymis-specific alpha-mannosidase isoform 2 precursor |
NM_001292038.2 | NP_001278967.1 | epididymis-specific alpha-mannosidase isoform 2 precursor |
NM_015274.3 | NP_056089.1 | epididymis-specific alpha-mannosidase isoform 1 precursor |
Pan troglodytes (chimpanzee) | MAN2B2 | XP_003310289.1 |
MAN2B2 | XP_002804053.1 | |
Bos taurus (cattle) | LOC532207 | XP_003586284.2 |
Gallus gallus (chicken) | MAN2B2 | XP_420805.2 |
Canis lupus familiaris (dog) | LOC100855835 | XP_005618789.1 |
Bos taurus (cattle) | MAN2B2 | XP_002688458.1 |
Mus musculus (house mouse) | Man2b2 | NP_032576.2 |
Canis lupus familiaris (dog) | MAN2B2 | XP_005642316.1 |
Rattus norvegicus (Norway rat) | Man2b2 | NP_001128443.1 |
Homo sapiens (human) | MAN2B2 | NP_056089.1 |
Danio rerio (zebrafish) | man2b2 | XP_001337519.3 |
Xenopus tropicalis (tropical clawed frog) | man2b2 | NP_001106515.1 |
Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanch? H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)
Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties.
Venkatesan M, Kuntz DA, Rose DR
Protein science : a publication of the Protein Society18(11)2242-51(2009 Nov)
Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism.
Park C, Meng L, Stanton LH, Collins RE, Mast SW, Yi X, Strachan H, Moremen KW
The Journal of biological chemistry280(44)37204-16(2005 Nov)
Purification and properties of major alpha-D-mannosidase in the luminal fluid of porcine epididymis.
Jin YZ, Dacheux F, Dacheux JL, Bannai S, Sugita Y, Okamura N
Biochimica et biophysica acta1432(2)382-92(1999 Jul)
Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia.
Hiramoto S, Tamba M, Kiuchi S, Jin YZ, Bannai S, Sugita Y, Dacheux F, Dacheux JL, Yoshida M, Okamura N
Biochemical and biophysical research communications241(2)439-45(1997 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Expressed MAN2B1 and MAN2B2 in Drosophila S2 cells and functionally characterized them. MAN2B1 and MAN2B2 were significantly inhibited by the class II alpha-mannosidase inhibitors, swainsonine and mannostatin A.
Title: Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties.
The following MAN2B2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAN2B2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu24659 | |
Clone ID Related Accession (Same CDS sequence) | NM_001292038.1 | |
Accession Version | NM_001292038.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2877bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-10-08 | |
Organism | Homo sapiens(human) | |
Product | epididymis-specific alpha-mannosidase isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE243063.1, AK301473.1, AL833071.2, BC033307.1, BM730115.1, BX350248.2 and AK025803.1. Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK301473.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001278967.1 |
CDS | 38..2914 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001292038.1 |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu108262 | |
Clone ID Related Accession (Same CDS sequence) | NM_001292038.2 | |
Accession Version | NM_001292038.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2877bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Homo sapiens(human) | |
Product | epididymis-specific alpha-mannosidase isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093323.3. On Jun 1, 2019 this sequence version replaced NM_001292038.1. Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK301473.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001278967.1 |
CDS | 23..2899 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001292038.2 |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu108609 | |
Clone ID Related Accession (Same CDS sequence) | NM_015274.3 | |
Accession Version | NM_015274.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3030bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-24 | |
Organism | Homo sapiens(human) | |
Product | epididymis-specific alpha-mannosidase isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093323.3. On May 17, 2019 this sequence version replaced NM_015274.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660803.58648.1, SRR1660805.30291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000285599.8/ ENSP00000285599.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_056089.1 |
CDS | 23..3052 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015274.3 |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu24671 | |
Clone ID Related Accession (Same CDS sequence) | NM_015274.2 | |
Accession Version | NM_015274.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3030bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Homo sapiens(human) | |
Product | epididymis-specific alpha-mannosidase isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE243063.1, BC033307.1, AL833071.2, BM730115.1, BX350248.2 and AK025803.1. On May 17, 2014 this sequence version replaced NM_015274.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC094773.1, SRR1803612.245311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_056089.1 |
CDS | 38..3067 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015274.2 |
1 | ATGGGGCAGC TGTGCTGGCT GCCGCTGCTG GCACCGCTCC TGTTGCTGCG ACCGCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. |
Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties. |
Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism. |
Purification and properties of major alpha-D-mannosidase in the luminal fluid of porcine epididymis. |
Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. |