×

FUS cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FUS
Entrez Gene ID 2521
Full Name FUS RNA binding protein
Synonyms ALS6,ETM4,FUS1,HNRNPP2,POMP75,TLS
General protein information
Preferred Names

FUS RNA binding protein

Names

RNA-binding protein FUS
75 kDa DNA-pairing protein
fus-like protein
fused in sarcoma
fusion gene in myxoid liposarcoma
heterogeneous nuclear ribonucleoprotein P2
oncogene FUS
oncogene TLS
translocated in liposarcoma protein

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

16

16p11.2

Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].
Disorder MIM:

137070

Disorder Html: Amyotrophic lateral sclerosis 6, autosomal recessive, with or without

mRNA and Protein(s)

mRNA Protein Name
XM_011545782.2 XP_011544084.1 RNA-binding protein FUS isoform X2
XM_011545781.1 XP_011544083.1 RNA-binding protein FUS isoform X1
NM_001170937.1 NP_001164408.1 RNA-binding protein FUS isoform 3
XM_005255233.4 XP_005255290.1 RNA-binding protein FUS isoform X2
NM_001170634.1 NP_001164105.1 RNA-binding protein FUS isoform 2
NM_004960.3 NP_004951.1 RNA-binding protein FUS isoform 1



Related articles in PubMed

O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.
Kamemura K
Bioscience, biotechnology, and biochemistry81(3)541-546(2017 Mar)

MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines.
Wang Z, Lei H, Sun Q
Oncology reports35(5)2943-51(2016 May)

Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.
Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H
Stem cell reports6(4)496-510(2016 Apr)

Juvenile-onset Sporadic Amyotrophic Lateral Sclerosis with a Frameshift FUS Gene Mutation Presenting Unique Neuroradiological Findings and Cognitive Impairment.
Hirayanagi K, Sato M, Furuta N, Makioka K, Ikeda Y
Internal medicine (Tokyo, Japan)55(6)689-93(2016)

Mutations in FUS are the most frequent genetic cause in juvenile sporadic ALS patients of Chinese origin.
Zou ZY, Liu MS, Li XG, Cui LY
Amyotrophic lateral sclerosis & frontotemporal degeneration17(3-4)249-52(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Possible role of deregulated DNA binding function of FUS in ALS.
Title: TDP-43/FUS in motor neuron disease: Complexity and challenges.

Motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43, FUS, and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.
Title: Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.

FUS is glycosylated with a high stoichiometry not only in the neural cells but also in the non-neural cell lines.
Title: O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.

Studies provide evidence that FUS/TLS, EWS and TAF15 proteins play a major role in neurodegenerative disorders. (review).
Title: Role of FET proteins in neurodegenerative disorders.

FUS-induced reductions to ER-mitochondria associations and are linked to activation of glycogen synthase kinase-3beta (GSK-3beta), a kinase already strongly associated with ALS/FTD.
Title: ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

The following FUS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FUS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu24555 NM_004960.3
Latest version!
Homo sapiens FUS RNA binding protein (FUS), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu24541 NM_001170937.1
Latest version!
Homo sapiens FUS RNA binding protein (FUS), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $300.30
$429.00
OHu24554 NM_001170634.1
Latest version!
Homo sapiens FUS RNA binding protein (FUS), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu49109 XM_005255233.4
Latest version!
Homo sapiens FUS RNA binding protein (FUS), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu49109 XM_011545782.2
Latest version!
Homo sapiens FUS RNA binding protein (FUS), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu57863 XM_011545781.1
Latest version!
Homo sapiens FUS RNA binding protein (FUS), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24555
Clone ID Related Accession (Same CDS sequence) NM_004960.3
Accession Version NM_004960.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1581bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-22
Organism Homo sapiens(Human)
Product RNA-binding protein FUS isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC361263.1, AC009088.9, BC002459.1, AW408771.1 and AI333366.1. This sequence is a reference standard in the RefSeqGene project. On Dec 4, 2009 this sequence version replaced NM_004960.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S62140.1, AK290936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA CAGGCTATGG AACTCAGTCA ACTCCCCAGG GATATGGCTC GACTGGCGGC
TATGGCAGTA GCCAGAGCTC CCAATCGTCT TACGGGCAGC AGTCCTCCTA CCCTGGCTAT
GGCCAGCAGC CAGCTCCCAG CAGCACCTCG GGAAGTTACG GTAGCAGTTC TCAGAGCAGC
AGCTATGGGC AGCCCCAGAG TGGGAGCTAC AGCCAGCAGC CTAGCTATGG TGGACAGCAG
CAAAGCTATG GACAGCAGCA AAGCTATAAT CCCCCTCAGG GCTATGGACA GCAGAACCAG
TACAACAGCA GCAGTGGTGG TGGAGGTGGA GGTGGAGGTG GAGGTAACTA TGGCCAAGAT
CAATCCTCCA TGAGTAGTGG TGGTGGCAGT GGTGGCGGTT ATGGCAATCA AGACCAGAGT
GGTGGAGGTG GCAGCGGTGG CTATGGACAG CAGGACCGTG GAGGCCGCGG CAGGGGTGGC
AGTGGTGGCG GCGGCGGCGG CGGCGGTGGT GGTTACAACC GCAGCAGTGG TGGCTATGAA
CCCAGAGGTC GTGGAGGTGG CCGTGGAGGC AGAGGTGGCA TGGGCGGAAG TGACCGTGGT
GGCTTCAATA AATTTGGTGG CCCTCGGGAC CAAGGATCAC GTCATGACTC CGAACAGGAT
AATTCAGACA ACAACACCAT CTTTGTGCAA GGCCTGGGTG AGAATGTTAC AATTGAGTCT
GTGGCTGATT ACTTCAAGCA GATTGGTATT ATTAAGACAA ACAAGAAAAC GGGACAGCCC
ATGATTAATT TGTACACAGA CAGGGAAACT GGCAAGCTGA AGGGAGAGGC AACGGTCTCT
TTTGATGACC CACCTTCAGC TAAAGCAGCT ATTGACTGGT TTGATGGTAA AGAATTCTCC
GGAAATCCTA TCAAGGTCTC ATTTGCTACT CGCCGGGCAG ACTTTAATCG GGGTGGTGGC
AATGGTCGTG GAGGCCGAGG GCGAGGAGGA CCCATGGGCC GTGGAGGCTA TGGAGGTGGT
GGCAGTGGTG GTGGTGGCCG AGGAGGATTT CCCAGTGGAG GTGGTGGCGG TGGAGGACAG
CAGCGAGCTG GTGACTGGAA GTGTCCTAAT CCCACCTGTG AGAATATGAA CTTCTCTTGG
AGGAATGAAT GCAACCAGTG TAAGGCCCCT AAACCAGATG GCCCAGGAGG GGGACCAGGT
GGCTCTCACA TGGGGGGTAA CTACGGGGAT GATCGTCGTG GTGGCAGAGG AGGCTATGAT
CGAGGCGGCT ACCGGGGCCG CGGCGGGGAC CGTGGAGGCT TCCGAGGGGG CCGGGGTGGT
GGGGACAGAG GTGGCTTTGG CCCTGGCAAG ATGGATTCCA GGGGTGAGCA CAGACAGGAT
CGCAGGGAGA GGCCGTATTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004951.1
CDS106..1686
Misc Feature(1)4..6
Misc Feature(2)628..630
Misc Feature(3)751..753
Misc Feature(4)751..753
Misc Feature(5)757..759
Misc Feature(6)757..759
Misc Feature(7)766..768
Misc Feature(8)829..831
Misc Feature(9)835..837
Misc Feature(10)835..837
Misc Feature(11)847..849
Misc Feature(12)856..858
Misc Feature(13)880..882
Misc Feature(14)<895..>1227
Misc Feature(15)901..906
Misc Feature(16)934..936
Misc Feature(17)952..1209
Misc Feature(18)961..963
Misc Feature(19)1123..1125
Misc Feature(20)1234..1236
Misc Feature(21)1252..1254
Misc Feature(22)1261..1263
Misc Feature(23)1261..1263
Misc Feature(24)1267..1269
Misc Feature(25)1267..1269
Misc Feature(26)1285..1287
Misc Feature(27)1324..1326
Misc Feature(28)1369..1452
Misc Feature(29)1522..1524
Misc Feature(30)1531..1533
Misc Feature(31)1546..1548
Misc Feature(32)1558..1560
Misc Feature(33)1564..1566
Misc Feature(34)1564..1566
Misc Feature(35)1576..1578
Misc Feature(36)1588..1590
Misc Feature(37)1597..1599
Misc Feature(38)1612..1614
Exon (1)1..118
Exon (2)119..143
Exon (3)144..295
Exon (4)296..440
Exon (5)441..628
Exon (6)629..869
Exon (7)870..904
Exon (8)905..937
Exon (9)938..1041
Exon (10)1042..1171
Exon (11)1172..1273
Exon (12)1274..1397
Exon (13)1398..1498
Exon (14)1499..1646
Exon (15)1647..5119
Translation

Target ORF information:

RefSeq Version NM_004960.3
Organism Homo sapiens(Human)
Definition Homo sapiens FUS RNA binding protein (FUS), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004960.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA CAGGCTATGG AACTCAGTCA ACTCCCCAGG GATATGGCTC GACTGGCGGC
TATGGCAGTA GCCAGAGCTC CCAATCGTCT TACGGGCAGC AGTCCTCCTA CCCTGGCTAT
GGCCAGCAGC CAGCTCCCAG CAGCACCTCG GGAAGTTACG GTAGCAGTTC TCAGAGCAGC
AGCTATGGGC AGCCCCAGAG TGGGAGCTAC AGCCAGCAGC CTAGCTATGG TGGACAGCAG
CAAAGCTATG GACAGCAGCA AAGCTATAAT CCCCCTCAGG GCTATGGACA GCAGAACCAG
TACAACAGCA GCAGTGGTGG TGGAGGTGGA GGTGGAGGTG GAGGTAACTA TGGCCAAGAT
CAATCCTCCA TGAGTAGTGG TGGTGGCAGT GGTGGCGGTT ATGGCAATCA AGACCAGAGT
GGTGGAGGTG GCAGCGGTGG CTATGGACAG CAGGACCGTG GAGGCCGCGG CAGGGGTGGC
AGTGGTGGCG GCGGCGGCGG CGGCGGTGGT GGTTACAACC GCAGCAGTGG TGGCTATGAA
CCCAGAGGTC GTGGAGGTGG CCGTGGAGGC AGAGGTGGCA TGGGCGGAAG TGACCGTGGT
GGCTTCAATA AATTTGGTGG CCCTCGGGAC CAAGGATCAC GTCATGACTC CGAACAGGAT
AATTCAGACA ACAACACCAT CTTTGTGCAA GGCCTGGGTG AGAATGTTAC AATTGAGTCT
GTGGCTGATT ACTTCAAGCA GATTGGTATT ATTAAGACAA ACAAGAAAAC GGGACAGCCC
ATGATTAATT TGTACACAGA CAGGGAAACT GGCAAGCTGA AGGGAGAGGC AACGGTCTCT
TTTGATGACC CACCTTCAGC TAAAGCAGCT ATTGACTGGT TTGATGGTAA AGAATTCTCC
GGAAATCCTA TCAAGGTCTC ATTTGCTACT CGCCGGGCAG ACTTTAATCG GGGTGGTGGC
AATGGTCGTG GAGGCCGAGG GCGAGGAGGA CCCATGGGCC GTGGAGGCTA TGGAGGTGGT
GGCAGTGGTG GTGGTGGCCG AGGAGGATTT CCCAGTGGAG GTGGTGGCGG TGGAGGACAG
CAGCGAGCTG GTGACTGGAA GTGTCCTAAT CCCACCTGTG AGAATATGAA CTTCTCTTGG
AGGAATGAAT GCAACCAGTG TAAGGCCCCT AAACCAGATG GCCCAGGAGG GGGACCAGGT
GGCTCTCACA TGGGGGGTAA CTACGGGGAT GATCGTCGTG GTGGCAGAGG AGGCTATGAT
CGAGGCGGCT ACCGGGGCCG CGGCGGGGAC CGTGGAGGCT TCCGAGGGGG CCGGGGTGGT
GGGGACAGAG GTGGCTTTGG CCCTGGCAAG ATGGATTCCA GGGGTGAGCA CAGACAGGAT
CGCAGGGAGA GGCCGTATTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24541
Clone ID Related Accession (Same CDS sequence) NM_001170937.1
Accession Version NM_001170937.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1569bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-22
Organism Homo sapiens(Human)
Product RNA-binding protein FUS isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC361263.1, DA541747.1, U36561.1, AC009088.9 and AI333366.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA CAGGCTATGG AACTCAGTCA ACTCCCCAGG GATATGGCTC GACTGGCGGC
TATGGCAGTA GCCAGAGCTC CCAATCGTCT TACGGGCAGC AGTCCTCCTA CCCTGGCTAT
GGCCAGCAGC CAGCTCCCAG CAGCACCTCG GGAAGTTACG GTAGCAGTTC TCAGAGCAGC
AGCTATGGGC AGCCCCAGAG TGGGAGCTAC AGCCAGCAGC CTAGCTATGG TGGACAGCAG
CAAAGCTATG GACAGCAGCA AAGCTATAAT CCCCCTCAGG GCTATGGACA GCAGAACCAG
TACAACAGCA GCAGTGGTGG TGGAGGTGGA GGTAACTATG GCCAAGATCA ATCCTCCATG
AGTAGTGGTG GTGGCAGTGG TGGCGGTTAT GGCAATCAAG ACCAGAGTGG TGGAGGTGGC
AGCGGTGGCT ATGGACAGCA GGACCGTGGA GGCCGCGGCA GGGGTGGCAG TGGTGGCGGC
GGCGGCGGCG GCGGTGGTGG TTACAACCGC AGCAGTGGTG GCTATGAACC CAGAGGTCGT
GGAGGTGGCC GTGGAGGCAG AGGTGGCATG GGCGGAAGTG ACCGTGGTGG CTTCAATAAA
TTTGGTGGCC CTCGGGACCA AGGATCACGT CATGACTCCG AACAGGATAA TTCAGACAAC
AACACCATCT TTGTGCAAGG CCTGGGTGAG AATGTTACAA TTGAGTCTGT GGCTGATTAC
TTCAAGCAGA TTGGTATTAT TAAGACAAAC AAGAAAACGG GACAGCCCAT GATTAATTTG
TACACAGACA GGGAAACTGG CAAGCTGAAG GGAGAGGCAA CGGTCTCTTT TGATGACCCA
CCTTCAGCTA AAGCAGCTAT TGACTGGTTT GATGGTAAAG AATTCTCCGG AAATCCTATC
AAGGTCTCAT TTGCTACTCG CCGGGCAGAC TTTAATCGGG GTGGTGGCAA TGGTCGTGGA
GGCCGAGGGC GAGGAGGACC CATGGGCCGT GGAGGCTATG GAGGTGGTGG CAGTGGTGGT
GGTGGCCGAG GAGGATTTCC CAGTGGAGGT GGTGGCGGTG GAGGACAGCA GCGAGCTGGT
GACTGGAAGT GTCCTAATCC CACCTGTGAG AATATGAACT TCTCTTGGAG GAATGAATGC
AACCAGTGTA AGGCCCCTAA ACCAGATGGC CCAGGAGGGG GACCAGGTGG CTCTCACATG
GGGGGTAACT ACGGGGATGA TCGTCGTGGT GGCAGAGGAG GCTATGATCG AGGCGGCTAC
CGGGGCCGCG GCGGGGACCG TGGAGGCTTC CGAGGGGGCC GGGGTGGTGG GGACAGAGGT
GGCTTTGGCC CTGGCAAGAT GGATTCCAGG GGTGAGCACA GACAGGATCG CAGGGAGAGG
CCGTATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001164408.1
CDS106..1674
Misc Feature(1)4..6
Misc Feature(2)739..741
Misc Feature(3)745..747
Misc Feature(4)754..756
Misc Feature(5)817..819
Misc Feature(6)823..825
Misc Feature(7)835..837
Misc Feature(8)844..846
Misc Feature(9)868..870
Misc Feature(10)<883..>1215
Misc Feature(11)889..894
Misc Feature(12)922..924
Misc Feature(13)940..1197
Misc Feature(14)949..951
Misc Feature(15)1111..1113
Misc Feature(16)1222..1224
Misc Feature(17)1240..1242
Misc Feature(18)1249..1251
Misc Feature(19)1255..1257
Misc Feature(20)1273..1275
Misc Feature(21)1312..1314
Misc Feature(22)1357..1440
Misc Feature(23)1510..1512
Misc Feature(24)1519..1521
Misc Feature(25)1534..1536
Misc Feature(26)1546..1548
Misc Feature(27)1552..1554
Misc Feature(28)1564..1566
Misc Feature(29)1576..1578
Misc Feature(30)1585..1587
Misc Feature(31)1600..1602
Exon (1)1..118
Exon (2)119..143
Exon (3)144..295
Exon (4)296..440
Exon (5)441..616
Exon (6)617..857
Exon (7)858..892
Exon (8)893..925
Exon (9)926..1029
Exon (10)1030..1159
Exon (11)1160..1261
Exon (12)1262..1385
Exon (13)1386..1486
Exon (14)1487..1634
Exon (15)1635..5107
Translation

Target ORF information:

RefSeq Version NM_001170937.1
Organism Homo sapiens(Human)
Definition Homo sapiens FUS RNA binding protein (FUS), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001170937.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA CAGGCTATGG AACTCAGTCA ACTCCCCAGG GATATGGCTC GACTGGCGGC
TATGGCAGTA GCCAGAGCTC CCAATCGTCT TACGGGCAGC AGTCCTCCTA CCCTGGCTAT
GGCCAGCAGC CAGCTCCCAG CAGCACCTCG GGAAGTTACG GTAGCAGTTC TCAGAGCAGC
AGCTATGGGC AGCCCCAGAG TGGGAGCTAC AGCCAGCAGC CTAGCTATGG TGGACAGCAG
CAAAGCTATG GACAGCAGCA AAGCTATAAT CCCCCTCAGG GCTATGGACA GCAGAACCAG
TACAACAGCA GCAGTGGTGG TGGAGGTGGA GGTAACTATG GCCAAGATCA ATCCTCCATG
AGTAGTGGTG GTGGCAGTGG TGGCGGTTAT GGCAATCAAG ACCAGAGTGG TGGAGGTGGC
AGCGGTGGCT ATGGACAGCA GGACCGTGGA GGCCGCGGCA GGGGTGGCAG TGGTGGCGGC
GGCGGCGGCG GCGGTGGTGG TTACAACCGC AGCAGTGGTG GCTATGAACC CAGAGGTCGT
GGAGGTGGCC GTGGAGGCAG AGGTGGCATG GGCGGAAGTG ACCGTGGTGG CTTCAATAAA
TTTGGTGGCC CTCGGGACCA AGGATCACGT CATGACTCCG AACAGGATAA TTCAGACAAC
AACACCATCT TTGTGCAAGG CCTGGGTGAG AATGTTACAA TTGAGTCTGT GGCTGATTAC
TTCAAGCAGA TTGGTATTAT TAAGACAAAC AAGAAAACGG GACAGCCCAT GATTAATTTG
TACACAGACA GGGAAACTGG CAAGCTGAAG GGAGAGGCAA CGGTCTCTTT TGATGACCCA
CCTTCAGCTA AAGCAGCTAT TGACTGGTTT GATGGTAAAG AATTCTCCGG AAATCCTATC
AAGGTCTCAT TTGCTACTCG CCGGGCAGAC TTTAATCGGG GTGGTGGCAA TGGTCGTGGA
GGCCGAGGGC GAGGAGGACC CATGGGCCGT GGAGGCTATG GAGGTGGTGG CAGTGGTGGT
GGTGGCCGAG GAGGATTTCC CAGTGGAGGT GGTGGCGGTG GAGGACAGCA GCGAGCTGGT
GACTGGAAGT GTCCTAATCC CACCTGTGAG AATATGAACT TCTCTTGGAG GAATGAATGC
AACCAGTGTA AGGCCCCTAA ACCAGATGGC CCAGGAGGGG GACCAGGTGG CTCTCACATG
GGGGGTAACT ACGGGGATGA TCGTCGTGGT GGCAGAGGAG GCTATGATCG AGGCGGCTAC
CGGGGCCGCG GCGGGGACCG TGGAGGCTTC CGAGGGGGCC GGGGTGGTGG GGACAGAGGT
GGCTTTGGCC CTGGCAAGAT GGATTCCAGG GGTGAGCACA GACAGGATCG CAGGGAGAGG
CCGTATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24554
Clone ID Related Accession (Same CDS sequence) NM_001170634.1
Accession Version NM_001170634.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1578bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-22
Organism Homo sapiens(Human)
Product RNA-binding protein FUS isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC361263.1, AC009088.9 and AI333366.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK098774.1, X71428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA GCTATGGAAC TCAGTCAACT CCCCAGGGAT ATGGCTCGAC TGGCGGCTAT
GGCAGTAGCC AGAGCTCCCA ATCGTCTTAC GGGCAGCAGT CCTCCTACCC TGGCTATGGC
CAGCAGCCAG CTCCCAGCAG CACCTCGGGA AGTTACGGTA GCAGTTCTCA GAGCAGCAGC
TATGGGCAGC CCCAGAGTGG GAGCTACAGC CAGCAGCCTA GCTATGGTGG ACAGCAGCAA
AGCTATGGAC AGCAGCAAAG CTATAATCCC CCTCAGGGCT ATGGACAGCA GAACCAGTAC
AACAGCAGCA GTGGTGGTGG AGGTGGAGGT GGAGGTGGAG GTAACTATGG CCAAGATCAA
TCCTCCATGA GTAGTGGTGG TGGCAGTGGT GGCGGTTATG GCAATCAAGA CCAGAGTGGT
GGAGGTGGCA GCGGTGGCTA TGGACAGCAG GACCGTGGAG GCCGCGGCAG GGGTGGCAGT
GGTGGCGGCG GCGGCGGCGG CGGTGGTGGT TACAACCGCA GCAGTGGTGG CTATGAACCC
AGAGGTCGTG GAGGTGGCCG TGGAGGCAGA GGTGGCATGG GCGGAAGTGA CCGTGGTGGC
TTCAATAAAT TTGGTGGCCC TCGGGACCAA GGATCACGTC ATGACTCCGA ACAGGATAAT
TCAGACAACA ACACCATCTT TGTGCAAGGC CTGGGTGAGA ATGTTACAAT TGAGTCTGTG
GCTGATTACT TCAAGCAGAT TGGTATTATT AAGACAAACA AGAAAACGGG ACAGCCCATG
ATTAATTTGT ACACAGACAG GGAAACTGGC AAGCTGAAGG GAGAGGCAAC GGTCTCTTTT
GATGACCCAC CTTCAGCTAA AGCAGCTATT GACTGGTTTG ATGGTAAAGA ATTCTCCGGA
AATCCTATCA AGGTCTCATT TGCTACTCGC CGGGCAGACT TTAATCGGGG TGGTGGCAAT
GGTCGTGGAG GCCGAGGGCG AGGAGGACCC ATGGGCCGTG GAGGCTATGG AGGTGGTGGC
AGTGGTGGTG GTGGCCGAGG AGGATTTCCC AGTGGAGGTG GTGGCGGTGG AGGACAGCAG
CGAGCTGGTG ACTGGAAGTG TCCTAATCCC ACCTGTGAGA ATATGAACTT CTCTTGGAGG
AATGAATGCA ACCAGTGTAA GGCCCCTAAA CCAGATGGCC CAGGAGGGGG ACCAGGTGGC
TCTCACATGG GGGGTAACTA CGGGGATGAT CGTCGTGGTG GCAGAGGAGG CTATGATCGA
GGCGGCTACC GGGGCCGCGG CGGGGACCGT GGAGGCTTCC GAGGGGGCCG GGGTGGTGGG
GACAGAGGTG GCTTTGGCCC TGGCAAGATG GATTCCAGGG GTGAGCACAG ACAGGATCGC
AGGGAGAGGC CGTATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001164105.1
CDS106..1683
Misc Feature(1)4..6
Misc Feature(2)625..627
Misc Feature(3)748..750
Misc Feature(4)754..756
Misc Feature(5)763..765
Misc Feature(6)826..828
Misc Feature(7)832..834
Misc Feature(8)844..846
Misc Feature(9)853..855
Misc Feature(10)877..879
Misc Feature(11)<892..>1224
Misc Feature(12)898..903
Misc Feature(13)931..933
Misc Feature(14)949..1206
Misc Feature(15)958..960
Misc Feature(16)1120..1122
Misc Feature(17)1231..1233
Misc Feature(18)1249..1251
Misc Feature(19)1258..1260
Misc Feature(20)1264..1266
Misc Feature(21)1282..1284
Misc Feature(22)1321..1323
Misc Feature(23)1366..1449
Misc Feature(24)1519..1521
Misc Feature(25)1528..1530
Misc Feature(26)1543..1545
Misc Feature(27)1555..1557
Misc Feature(28)1561..1563
Misc Feature(29)1573..1575
Misc Feature(30)1585..1587
Misc Feature(31)1594..1596
Misc Feature(32)1609..1611
Exon (1)1..118
Exon (2)119..143
Exon (3)144..295
Exon (4)296..437
Exon (5)438..625
Exon (6)626..866
Exon (7)867..901
Exon (8)902..934
Exon (9)935..1038
Exon (10)1039..1168
Exon (11)1169..1270
Exon (12)1271..1394
Exon (13)1395..1495
Exon (14)1496..1643
Exon (15)1644..5116
Translation

Target ORF information:

RefSeq Version NM_001170634.1
Organism Homo sapiens(Human)
Definition Homo sapiens FUS RNA binding protein (FUS), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001170634.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA GCTATGGAAC TCAGTCAACT CCCCAGGGAT ATGGCTCGAC TGGCGGCTAT
GGCAGTAGCC AGAGCTCCCA ATCGTCTTAC GGGCAGCAGT CCTCCTACCC TGGCTATGGC
CAGCAGCCAG CTCCCAGCAG CACCTCGGGA AGTTACGGTA GCAGTTCTCA GAGCAGCAGC
TATGGGCAGC CCCAGAGTGG GAGCTACAGC CAGCAGCCTA GCTATGGTGG ACAGCAGCAA
AGCTATGGAC AGCAGCAAAG CTATAATCCC CCTCAGGGCT ATGGACAGCA GAACCAGTAC
AACAGCAGCA GTGGTGGTGG AGGTGGAGGT GGAGGTGGAG GTAACTATGG CCAAGATCAA
TCCTCCATGA GTAGTGGTGG TGGCAGTGGT GGCGGTTATG GCAATCAAGA CCAGAGTGGT
GGAGGTGGCA GCGGTGGCTA TGGACAGCAG GACCGTGGAG GCCGCGGCAG GGGTGGCAGT
GGTGGCGGCG GCGGCGGCGG CGGTGGTGGT TACAACCGCA GCAGTGGTGG CTATGAACCC
AGAGGTCGTG GAGGTGGCCG TGGAGGCAGA GGTGGCATGG GCGGAAGTGA CCGTGGTGGC
TTCAATAAAT TTGGTGGCCC TCGGGACCAA GGATCACGTC ATGACTCCGA ACAGGATAAT
TCAGACAACA ACACCATCTT TGTGCAAGGC CTGGGTGAGA ATGTTACAAT TGAGTCTGTG
GCTGATTACT TCAAGCAGAT TGGTATTATT AAGACAAACA AGAAAACGGG ACAGCCCATG
ATTAATTTGT ACACAGACAG GGAAACTGGC AAGCTGAAGG GAGAGGCAAC GGTCTCTTTT
GATGACCCAC CTTCAGCTAA AGCAGCTATT GACTGGTTTG ATGGTAAAGA ATTCTCCGGA
AATCCTATCA AGGTCTCATT TGCTACTCGC CGGGCAGACT TTAATCGGGG TGGTGGCAAT
GGTCGTGGAG GCCGAGGGCG AGGAGGACCC ATGGGCCGTG GAGGCTATGG AGGTGGTGGC
AGTGGTGGTG GTGGCCGAGG AGGATTTCCC AGTGGAGGTG GTGGCGGTGG AGGACAGCAG
CGAGCTGGTG ACTGGAAGTG TCCTAATCCC ACCTGTGAGA ATATGAACTT CTCTTGGAGG
AATGAATGCA ACCAGTGTAA GGCCCCTAAA CCAGATGGCC CAGGAGGGGG ACCAGGTGGC
TCTCACATGG GGGGTAACTA CGGGGATGAT CGTCGTGGTG GCAGAGGAGG CTATGATCGA
GGCGGCTACC GGGGCCGCGG CGGGGACCGT GGAGGCTTCC GAGGGGGCCG GGGTGGTGGG
GACAGAGGTG GCTTTGGCCC TGGCAAGATG GATTCCAGGG GTGAGCACAG ACAGGATCGC
AGGGAGAGGC CGTATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu49109
Clone ID Related Accession (Same CDS sequence) XM_011545782.2 , XM_005255233.4
Accession Version XM_011545782.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 966bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product RNA-binding protein FUS isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545782.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCAATCA AGACCAGAGT GGTGGAGGTG GCAGCGGTGG CTATGGACAG CAGGACCGTG 
GAGGCCGCGG CAGGGGTGGC AGTGGTGGCG GCGGCGGCGG CGGCGGTGGT GGTTACAACC
GCAGCAGTGG TGGCTATGAA CCCAGAGGTC GTGGAGGTGG CCGTGGAGGC AGAGGTGGCA
TGGGGCCCTC GGGACCAAGG ATCACGTCAT GACTCCGAAC AGGATAATTC AGACAACAAC
ACCATCTTTG TGCAAGGCCT GGGTGAGAAT GTTACAATTG AGTCTGTGGC TGATTACTTC
AAGCAGATTG GTATTATTAA GACAAACAAG AAAACGGGAC AGCCCATGAT TAATTTGTAC
ACAGACAGGG AAACTGGCAA GCTGAAGGGA GAGGCAACGG TCTCTTTTGA TGACCCACCT
TCAGCTAAAG CAGCTATTGA CTGGTTTGAT GGTAAAGAAT TCTCCGGAAA TCCTATCAAG
GTCTCATTTG CTACTCGCCG GGCAGACTTT AATCGGGGTG GTGGCAATGG TCGTGGAGGC
CGAGGGCGAG GAGGACCCAT GGGCCGTGGA GGCTATGGAG GTGGTGGCAG TGGTGGTGGT
GGCCGAGGAG GATTTCCCAG TGGAGGTGGT GGCGGTGGAG GACAGCAGCG AGCTGGTGAC
TGGAAGTGTC CTAATCCCAC CTGTGAGAAT ATGAACTTCT CTTGGAGGAA TGAATGCAAC
CAGTGTAAGG CCCCTAAACC AGATGGCCCA GGAGGGGGAC CAGGTGGCTC TCACATGGGG
GGTAACTACG GGGATGATCG TCGTGGTGGC AGAGGAGGCT ATGATCGAGG CGGCTACCGG
GGCCGCGGCG GGGACCGTGG AGGCTTCCGA GGGGGCCGGG GTGGTGGGGA CAGAGGTGGC
TTTGGCCCTG GCAAGATGGA TTCCAGGGGT GAGCACAGAC AGGATCGCAG GGAGAGGCCG
TATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011544084.1
CDS77..1042
Misc Feature(1)<263..>583
Misc Feature(2)308..565
Misc Feature(3)725..808
Translation

Target ORF information:

RefSeq Version XM_011545782.2
Organism Homo sapiens(Human)
Definition Homo sapiens FUS RNA binding protein (FUS), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011545782.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCAATCA AGACCAGAGT GGTGGAGGTG GCAGCGGTGG CTATGGACAG CAGGACCGTG 
GAGGCCGCGG CAGGGGTGGC AGTGGTGGCG GCGGCGGCGG CGGCGGTGGT GGTTACAACC
GCAGCAGTGG TGGCTATGAA CCCAGAGGTC GTGGAGGTGG CCGTGGAGGC AGAGGTGGCA
TGGGGCCCTC GGGACCAAGG ATCACGTCAT GACTCCGAAC AGGATAATTC AGACAACAAC
ACCATCTTTG TGCAAGGCCT GGGTGAGAAT GTTACAATTG AGTCTGTGGC TGATTACTTC
AAGCAGATTG GTATTATTAA GACAAACAAG AAAACGGGAC AGCCCATGAT TAATTTGTAC
ACAGACAGGG AAACTGGCAA GCTGAAGGGA GAGGCAACGG TCTCTTTTGA TGACCCACCT
TCAGCTAAAG CAGCTATTGA CTGGTTTGAT GGTAAAGAAT TCTCCGGAAA TCCTATCAAG
GTCTCATTTG CTACTCGCCG GGCAGACTTT AATCGGGGTG GTGGCAATGG TCGTGGAGGC
CGAGGGCGAG GAGGACCCAT GGGCCGTGGA GGCTATGGAG GTGGTGGCAG TGGTGGTGGT
GGCCGAGGAG GATTTCCCAG TGGAGGTGGT GGCGGTGGAG GACAGCAGCG AGCTGGTGAC
TGGAAGTGTC CTAATCCCAC CTGTGAGAAT ATGAACTTCT CTTGGAGGAA TGAATGCAAC
CAGTGTAAGG CCCCTAAACC AGATGGCCCA GGAGGGGGAC CAGGTGGCTC TCACATGGGG
GGTAACTACG GGGATGATCG TCGTGGTGGC AGAGGAGGCT ATGATCGAGG CGGCTACCGG
GGCCGCGGCG GGGACCGTGG AGGCTTCCGA GGGGGCCGGG GTGGTGGGGA CAGAGGTGGC
TTTGGCCCTG GCAAGATGGA TTCCAGGGGT GAGCACAGAC AGGATCGCAG GGAGAGGCCG
TATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu49109
Clone ID Related Accession (Same CDS sequence) XM_011545782.2 , XM_005255233.4
Accession Version XM_005255233.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 966bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product RNA-binding protein FUS isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005255233.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCAATCA AGACCAGAGT GGTGGAGGTG GCAGCGGTGG CTATGGACAG CAGGACCGTG 
GAGGCCGCGG CAGGGGTGGC AGTGGTGGCG GCGGCGGCGG CGGCGGTGGT GGTTACAACC
GCAGCAGTGG TGGCTATGAA CCCAGAGGTC GTGGAGGTGG CCGTGGAGGC AGAGGTGGCA
TGGGGCCCTC GGGACCAAGG ATCACGTCAT GACTCCGAAC AGGATAATTC AGACAACAAC
ACCATCTTTG TGCAAGGCCT GGGTGAGAAT GTTACAATTG AGTCTGTGGC TGATTACTTC
AAGCAGATTG GTATTATTAA GACAAACAAG AAAACGGGAC AGCCCATGAT TAATTTGTAC
ACAGACAGGG AAACTGGCAA GCTGAAGGGA GAGGCAACGG TCTCTTTTGA TGACCCACCT
TCAGCTAAAG CAGCTATTGA CTGGTTTGAT GGTAAAGAAT TCTCCGGAAA TCCTATCAAG
GTCTCATTTG CTACTCGCCG GGCAGACTTT AATCGGGGTG GTGGCAATGG TCGTGGAGGC
CGAGGGCGAG GAGGACCCAT GGGCCGTGGA GGCTATGGAG GTGGTGGCAG TGGTGGTGGT
GGCCGAGGAG GATTTCCCAG TGGAGGTGGT GGCGGTGGAG GACAGCAGCG AGCTGGTGAC
TGGAAGTGTC CTAATCCCAC CTGTGAGAAT ATGAACTTCT CTTGGAGGAA TGAATGCAAC
CAGTGTAAGG CCCCTAAACC AGATGGCCCA GGAGGGGGAC CAGGTGGCTC TCACATGGGG
GGTAACTACG GGGATGATCG TCGTGGTGGC AGAGGAGGCT ATGATCGAGG CGGCTACCGG
GGCCGCGGCG GGGACCGTGG AGGCTTCCGA GGGGGCCGGG GTGGTGGGGA CAGAGGTGGC
TTTGGCCCTG GCAAGATGGA TTCCAGGGGT GAGCACAGAC AGGATCGCAG GGAGAGGCCG
TATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005255290.1
CDS1349..2314
Misc Feature(1)<1535..>1855
Misc Feature(2)1580..1837
Misc Feature(3)1997..2080
Translation

Target ORF information:

RefSeq Version XM_005255233.4
Organism Homo sapiens(Human)
Definition Homo sapiens FUS RNA binding protein (FUS), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005255233.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCAATCA AGACCAGAGT GGTGGAGGTG GCAGCGGTGG CTATGGACAG CAGGACCGTG 
GAGGCCGCGG CAGGGGTGGC AGTGGTGGCG GCGGCGGCGG CGGCGGTGGT GGTTACAACC
GCAGCAGTGG TGGCTATGAA CCCAGAGGTC GTGGAGGTGG CCGTGGAGGC AGAGGTGGCA
TGGGGCCCTC GGGACCAAGG ATCACGTCAT GACTCCGAAC AGGATAATTC AGACAACAAC
ACCATCTTTG TGCAAGGCCT GGGTGAGAAT GTTACAATTG AGTCTGTGGC TGATTACTTC
AAGCAGATTG GTATTATTAA GACAAACAAG AAAACGGGAC AGCCCATGAT TAATTTGTAC
ACAGACAGGG AAACTGGCAA GCTGAAGGGA GAGGCAACGG TCTCTTTTGA TGACCCACCT
TCAGCTAAAG CAGCTATTGA CTGGTTTGAT GGTAAAGAAT TCTCCGGAAA TCCTATCAAG
GTCTCATTTG CTACTCGCCG GGCAGACTTT AATCGGGGTG GTGGCAATGG TCGTGGAGGC
CGAGGGCGAG GAGGACCCAT GGGCCGTGGA GGCTATGGAG GTGGTGGCAG TGGTGGTGGT
GGCCGAGGAG GATTTCCCAG TGGAGGTGGT GGCGGTGGAG GACAGCAGCG AGCTGGTGAC
TGGAAGTGTC CTAATCCCAC CTGTGAGAAT ATGAACTTCT CTTGGAGGAA TGAATGCAAC
CAGTGTAAGG CCCCTAAACC AGATGGCCCA GGAGGGGGAC CAGGTGGCTC TCACATGGGG
GGTAACTACG GGGATGATCG TCGTGGTGGC AGAGGAGGCT ATGATCGAGG CGGCTACCGG
GGCCGCGGCG GGGACCGTGG AGGCTTCCGA GGGGGCCGGG GTGGTGGGGA CAGAGGTGGC
TTTGGCCCTG GCAAGATGGA TTCCAGGGGT GAGCACAGAC AGGATCGCAG GGAGAGGCCG
TATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57863
Clone ID Related Accession (Same CDS sequence) XM_011545781.1
Accession Version XM_011545781.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1575bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product RNA-binding protein FUS isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA CAGGCTATGG AACTCAGTCA ACTCCCCAGG GATATGGCTC GACTGGCGGC
TATGGCAGTA GCCAGAGCTC CCAATCGTCT TACGGGCAGC AGTCCTCCTA CCCTGGCTAT
GGCCAGCAGC CAGCTCCCAG CAGCACCTCG GGAAGTTACG GTAGCAGTTC TCAGAGCAGC
AGCTATGGGC AGCCCCAGAG TGGGAGCTAC AGCCAGCAGC CTAGCTATGG TGGACAGCAG
CAAAGCTATG GACAGCAGCA AAGCTATAAT CCCCCTCAGG GCTATGGACA GCAGAACCAG
TACAACAGCA GCAGTGGTGG TGGAGGTGGA GGTGGAGGTA ACTATGGCCA AGATCAATCC
TCCATGAGTA GTGGTGGTGG CAGTGGTGGC GGTTATGGCA ATCAAGACCA GAGTGGTGGA
GGTGGCAGCG GTGGCTATGG ACAGCAGGAC CGTGGAGGCC GCGGCAGGGG TGGCAGTGGT
GGCGGCGGCG GCGGCGGCGG TGGTGGTTAC AACCGCAGCA GTGGTGGCTA TGAACCCAGA
GGTCGTGGAG GTGGCCGTGG AGGCAGAGGT GGCATGGGCG GAAGTGACCG TGGTGGCTTC
AATAAATTTG GTGGCCCTCG GGACCAAGGA TCACGTCATG ACTCCGAACA GGATAATTCA
GACAACAACA CCATCTTTGT GCAAGGCCTG GGTGAGAATG TTACAATTGA GTCTGTGGCT
GATTACTTCA AGCAGATTGG TATTATTAAG ACAAACAAGA AAACGGGACA GCCCATGATT
AATTTGTACA CAGACAGGGA AACTGGCAAG CTGAAGGGAG AGGCAACGGT CTCTTTTGAT
GACCCACCTT CAGCTAAAGC AGCTATTGAC TGGTTTGATG GTAAAGAATT CTCCGGAAAT
CCTATCAAGG TCTCATTTGC TACTCGCCGG GCAGACTTTA ATCGGGGTGG TGGCAATGGT
CGTGGAGGCC GAGGGCGAGG AGGACCCATG GGCCGTGGAG GCTATGGAGG TGGTGGCAGT
GGTGGTGGTG GCCGAGGAGG ATTTCCCAGT GGAGGTGGTG GCGGTGGAGG ACAGCAGCGA
GCTGGTGACT GGAAGTGTCC TAATCCCACC TGTGAGAATA TGAACTTCTC TTGGAGGAAT
GAATGCAACC AGTGTAAGGC CCCTAAACCA GATGGCCCAG GAGGGGGACC AGGTGGCTCT
CACATGGGGG GTAACTACGG GGATGATCGT CGTGGTGGCA GAGGAGGCTA TGATCGAGGC
GGCTACCGGG GCCGCGGCGG GGACCGTGGA GGCTTCCGAG GGGGCCGGGG TGGTGGGGAC
AGAGGTGGCT TTGGCCCTGG CAAGATGGAT TCCAGGGGTG AGCACAGACA GGATCGCAGG
GAGAGGCCGT ATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011544083.1
CDS78..1652
Misc Feature(1)<861..>1193
Misc Feature(2)918..1175
Misc Feature(3)1335..1418
Translation

Target ORF information:

RefSeq Version XM_011545781.1
Organism Homo sapiens(Human)
Definition Homo sapiens FUS RNA binding protein (FUS), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011545781.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCCTCAA ACGATTATAC CCAACAAGCA ACCCAAAGCT ATGGGGCCTA CCCCACCCAG 
CCCGGGCAGG GCTATTCCCA GCAGAGCAGT CAGCCCTACG GACAGCAGAG TTACAGTGGT
TATAGCCAGT CCACGGACAC TTCAGGCTAT GGCCAGAGCA GCTATTCTTC TTATGGCCAG
AGCCAGAACA CAGGCTATGG AACTCAGTCA ACTCCCCAGG GATATGGCTC GACTGGCGGC
TATGGCAGTA GCCAGAGCTC CCAATCGTCT TACGGGCAGC AGTCCTCCTA CCCTGGCTAT
GGCCAGCAGC CAGCTCCCAG CAGCACCTCG GGAAGTTACG GTAGCAGTTC TCAGAGCAGC
AGCTATGGGC AGCCCCAGAG TGGGAGCTAC AGCCAGCAGC CTAGCTATGG TGGACAGCAG
CAAAGCTATG GACAGCAGCA AAGCTATAAT CCCCCTCAGG GCTATGGACA GCAGAACCAG
TACAACAGCA GCAGTGGTGG TGGAGGTGGA GGTGGAGGTA ACTATGGCCA AGATCAATCC
TCCATGAGTA GTGGTGGTGG CAGTGGTGGC GGTTATGGCA ATCAAGACCA GAGTGGTGGA
GGTGGCAGCG GTGGCTATGG ACAGCAGGAC CGTGGAGGCC GCGGCAGGGG TGGCAGTGGT
GGCGGCGGCG GCGGCGGCGG TGGTGGTTAC AACCGCAGCA GTGGTGGCTA TGAACCCAGA
GGTCGTGGAG GTGGCCGTGG AGGCAGAGGT GGCATGGGCG GAAGTGACCG TGGTGGCTTC
AATAAATTTG GTGGCCCTCG GGACCAAGGA TCACGTCATG ACTCCGAACA GGATAATTCA
GACAACAACA CCATCTTTGT GCAAGGCCTG GGTGAGAATG TTACAATTGA GTCTGTGGCT
GATTACTTCA AGCAGATTGG TATTATTAAG ACAAACAAGA AAACGGGACA GCCCATGATT
AATTTGTACA CAGACAGGGA AACTGGCAAG CTGAAGGGAG AGGCAACGGT CTCTTTTGAT
GACCCACCTT CAGCTAAAGC AGCTATTGAC TGGTTTGATG GTAAAGAATT CTCCGGAAAT
CCTATCAAGG TCTCATTTGC TACTCGCCGG GCAGACTTTA ATCGGGGTGG TGGCAATGGT
CGTGGAGGCC GAGGGCGAGG AGGACCCATG GGCCGTGGAG GCTATGGAGG TGGTGGCAGT
GGTGGTGGTG GCCGAGGAGG ATTTCCCAGT GGAGGTGGTG GCGGTGGAGG ACAGCAGCGA
GCTGGTGACT GGAAGTGTCC TAATCCCACC TGTGAGAATA TGAACTTCTC TTGGAGGAAT
GAATGCAACC AGTGTAAGGC CCCTAAACCA GATGGCCCAG GAGGGGGACC AGGTGGCTCT
CACATGGGGG GTAACTACGG GGATGATCGT CGTGGTGGCA GAGGAGGCTA TGATCGAGGC
GGCTACCGGG GCCGCGGCGG GGACCGTGGA GGCTTCCGAG GGGGCCGGGG TGGTGGGGAC
AGAGGTGGCT TTGGCCCTGG CAAGATGGAT TCCAGGGGTG AGCACAGACA GGATCGCAGG
GAGAGGCCGT ATTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.
Bioscience, biotechnology, and biochemistry81(3)541-546(2017 Mar)
Kamemura K


book

MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines.
Oncology reports35(5)2943-51(2016 May)
Wang Z,Lei H,Sun Q


book

Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.
Stem cell reports6(4)496-510(2016 Apr)
Ichiyanagi N,Fujimori K,Yano M,Ishihara-Fujisaki C,Sone T,Akiyama T,Okada Y,Akamatsu W,Matsumoto T,Ishikawa M,Nishimoto Y,Ishihara Y,Sakuma T,Yamamoto T,Tsuiji H,Suzuki N,Warita H,Aoki M,Okano H


book

Juvenile-onset Sporadic Amyotrophic Lateral Sclerosis with a Frameshift FUS Gene Mutation Presenting Unique Neuroradiological Findings and Cognitive Impairment.
Internal medicine (Tokyo, Japan)55(6)689-93(2016)
Hirayanagi K,Sato M,Furuta N,Makioka K,Ikeda Y


book

Mutations in FUS are the most frequent genetic cause in juvenile sporadic ALS patients of Chinese origin.
Amyotrophic lateral sclerosis & frontotemporal degeneration17(3-4)249-52(2016)
Zou ZY,Liu MS,Li XG,Cui LY


 
*
*
*
*