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ALX3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ALX3
Entrez Gene ID 257
Full Name ALX homeobox 3
Synonyms FND,FND1
General protein information
Preferred Names

ALX homeobox 3

Names

homeobox protein aristaless-like 3
aristaless-like homeobox 3
frontonasal dysplasia
proline-rich transcription factor ALX3

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p13.3

Summary This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008].
Disorder MIM:

606014

Disorder Html: Frontorhiny, 136760 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_006492.2 NP_006483.2 homeobox protein aristaless-like 3



Macaca mulatta (rhesus monkey) ALX3 XP_001099295.1
Canis lupus familiaris (dog) ALX3 XP_005621859.1
Bos taurus (cattle) ALX3 NP_001179482.1
Gallus gallus (chicken) ALX3 XP_003642783.2
Homo sapiens (human) ALX3 NP_006483.2
Pan troglodytes (chimpanzee) ALX3 XP_524801.2
Mus musculus (house mouse) Alx3 NP_031467.1
Rattus norvegicus (Norway rat) Alx3 NP_001007013.1
Danio rerio (zebrafish) LOC566955 XP_005167168.1


Related articles in PubMed

Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies.
Ribeiro-Bicudo LA, Quiezi RG, Guion-Almeida ML, Legnaro C, Richieri-Costa A
American journal of medical genetics. Part A158A(5)1233-5(2012 May)

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, , , , Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB
PLoS genetics8(5)e1002695(2012)

Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.
Pham NS, Rafii A, Liu J, Boyadjiev SA, Tollefson TT
Archives of facial plastic surgery13(6)415-20(2011 Nov-Dec)

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PloS one5(7)e11493(2010 Jul)

Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.
Twigg SR, Versnel SL, Nürnberg G, Lees MM, Bhat M, Hammond P, Hennekam RC, Hoogeboom AJ, Hurst JA, Johnson D, Robinson AA, Scambler PJ, Gerrelli D, Nürnberg P, Mathijssen IM, Wilkie AO
American journal of human genetics84(5)698-705(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Exclusion of mutations in ALX3 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies
Title: Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies.

We report a novel Y214X mutation in ALX3 in frontorhiny.
Title: Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

ALX3 is essential for normal facial development in humans and that deficiency causes a clinically recognizable phenotype, which we term frontorhiny.
Title: Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.

Chromatin immunoprecipitation assays indicated that Alx3 in mouse pancreatic islets occupies the promoter of the mouse insulin genes.
Title: The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47.

The following ALX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19546 NM_006492.2
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Homo sapiens ALX homeobox 3 (ALX3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19546
Clone ID Related Accession (Same CDS sequence) NM_006492.2
Accession Version NM_006492.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1032bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-12
Organism Homo sapiens(Human)
Product homeobox protein aristaless-like 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC113428.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced NM_006492.1. ##Evidence-Data-START## Transcript exon combination :: BC113428.1, BC112007.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006483.2
CDS89..1120
Misc Feature(1)80..82
Misc Feature(2)order(548..562,566..568,617..619,635..637,674..676,680..685,692..697,701..709,713..718)
Misc Feature(3)order(554..556,563..565,683..685,692..697,704..706)
Misc Feature(4)557..715
Exon (1)1..365
Exon (2)366..682
Exon (3)683..811
Exon (4)812..1478
Translation

Target ORF information:

RefSeq Version NM_006492.2
Organism Homo sapiens(Human)
Definition Homo sapiens ALX homeobox 3 (ALX3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006492.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGACCCCG AGCACTGCGC GCCTTTCCGC GTGGGGCCTG CACCCGGCCC CTATGTGGCC 
TCGGGGGACG AGCCTCCGGG CCCGCAGGGA ACCCCCGCCG CTGCGCCTCA CCTGCACCCC
GCGCCGCCCC GCGGCCCGCG GCTGACCCGC TTTCCGGCCT GCGGGCCCCT GGAGCCCTAC
CTCCCAGAGC CGGCCAAGCC GCCCGCCAAG TACCTGCAGG ACCTCGGGCC CGGCCCGGCC
CTCAACGGCG GCCACTTCTA CGAGGGCCCC GCGGAAGCTG AGGAGAAGAC CTCCAAAGCT
GCCAGCTTCC CCCAGCTGCC CTTGGACTGC CGAGGGGGCC CCAGAGACGG GCCCTCTAAC
TTGCAAGGCT CCCCAGGCCC CTGCCTGGCC AGCCTGCATC TTCCTCTTTC CCCGGGACTC
CCTGACTCCA TGGAGTTGGC CAAGAACAAG AGCAAGAAGC GTCGTAACCG CACGACCTTC
AGCACATTCC AGCTGGAGGA GCTGGAGAAG GTCTTCCAGA AAACCCACTA TCCTGATGTG
TATGCCCGGG AGCAGCTGGC CCTGCGCACA GACCTGACTG AGGCCCGGGT ACAGGTCTGG
TTCCAGAACC GCAGAGCCAA GTGGCGGAAG CGCGAGCGTT ATGGGAAGAT CCAGGAGGGG
CGGAACCCCT TCACGGCTGC CTATGACATC TCTGTGCTGC CCCGTACTGA CAGCCACCCT
CAGCTGCAGA ACTCCCTGTG GGCCAGTCCA GGATCTGGGA GCCCTGGAGG CCCCTGCCTT
GTGTCTCCAG AGGGCATCCC CTCCCCATGC ATGTCTCCAT ATTCCCACCC CCATGGGAGT
GTGGCTGGCT TCATGGGGGT GCCAGCCCCT TCTGCGGCTC ACCCTGGCAT CTACTCCATC
CATGGCTTTC CCCCCACCCT GGGGGGCCAC AGCTTTGAGC CTTCCTCAGA TGGTGACTAT
AAGTCTCCAA GCCTCGTCTC GCTCAGGGTA AAGCCCAAGG AGCCACCCGG CCTTCTGAAC
TGGACCACGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies.
American journal of medical genetics. Part A158A(5)1233-5(2012 May)
Ribeiro-Bicudo LA,Quiezi RG,Guion-Almeida ML,Legnaro C,Richieri-Costa A


book

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
PLoS genetics8(5)e1002695(2012)
Fox CS,Liu Y,White CC,Feitosa M,Smith AV,Heard-Costa N,Lohman K,,,,Johnson AD,Foster MC,Greenawalt DM,Griffin P,Ding J,Newman AB,Tylavsky F,Miljkovic I,Kritchevsky SB,Launer L,Garcia M,Eiriksdottir G,Carr JJ,Gudnason V,Harris TB,Cupples LA,Borecki IB


book

Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management.
Archives of facial plastic surgery13(6)415-20(2011 Nov-Dec)
Pham NS,Rafii A,Liu J,Boyadjiev SA,Tollefson TT


book

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
PloS one5(7)e11493(2010 Jul)
Jugessur A,Shi M,Gjessing HK,Lie RT,Wilcox AJ,Weinberg CR,Christensen K,Boyles AL,Daack-Hirsch S,Nguyen TT,Christiansen L,Lidral AC,Murray JC


book

Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.
American journal of human genetics84(5)698-705(2009 May)
Twigg SR,Versnel SL,Nürnberg G,Lees MM,Bhat M,Hammond P,Hennekam RC,Hoogeboom AJ,Hurst JA,Johnson D,Robinson AA,Scambler PJ,Gerrelli D,Nürnberg P,Mathijssen IM,Wilkie AO


 
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